ライフサイエンスコーパス: Cinchona

1 ansition states when PR is used with (8S,9S)-cinchona.

2 ities comparable with those reported for the Cinchona alkaloid ammonium salts derivatives (83-96% ee)

3 The zwitterionic adduct between a cinchona alkaloid and ketone is adsorbed on Pt through t

4 ide, using a catalytic amount of a silylated cinchona alkaloid as a source of chirality.

5 discovery that, upon proper modification, a cinchona alkaloid bearing a thiourea functionality at 6'

6 is demonstrated for noncovalent complexes of cinchona alkaloid carbamate chiral selectors with N-dini

7 ogen bonding transition state (TS) model for cinchona alkaloid catalysis that we recently showed to b

8 The cinchona alkaloid catalyst benzoylquinine (BQ) mediates

9 and hydroperoxides and an easily accessible cinchona alkaloid catalyst, this novel reaction will ope

10 The reaction requires 10 mol % of the cinchona alkaloid catalyst, which serves as a general ba

11 reported by MacMillan, which uses a modified cinchona alkaloid catalyst.

12 oles with imines catalyzed by a bifunctional cinchona alkaloid catalyst.

13 C-9 arylated cinchona alkaloid catalysts have been found to be consid

14 ic anhydrides (AMMA) catalyzed by a class of cinchona alkaloid catalysts involves an oxyanion hole co

15 Predicted enantioselectivities of three cinchona alkaloid catalysts, namely DHQD-PHN, DHQD-MEQ,

16 n of the reactivity of acid chlorides, using cinchona alkaloid catalysts, results in chiral alpha,bet

17 performance achieved by the use of a proline cinchona alkaloid conjugate designed in a de novo fashio

18 imal catalytic system was determined to be a cinchona alkaloid derivative (TMS-quinine or Me-quinidin

19 conformation studies with a designed, rigid cinchona alkaloid derivative as a probe.

20 The reaction is simply catalyzed by cinchona alkaloid derivatives affording the final alkyla

21 alcohol dichlorination catalyzed by dimeric cinchona alkaloid derivatives and employing aryl iododic

22 e, commercially available acid halides using cinchona alkaloid derivatives as catalysts and polychlor

23 Chiral cinchona alkaloid derivatives work best when paired with

24 The reactions herein are catalyzed by cinchona alkaloid derivatives, with the best performance

25 self-assembled in situ from amino acids and cinchona alkaloid derivatives.

26 of Lewis acids were screened in tandem with cinchona alkaloid derivatives; surprisingly, trans-(Ph(3

27 The Cinchona alkaloid derived chiral ammonium salt developed

28 Reaction of dimethylsulfonium methylide with Cinchona alkaloid ketones proceeds with complete diaster

29 vities of reductions of activated ketones on cinchona alkaloid modified platinum is proposed and is s

30 onformational interconversion barrier of the cinchona alkaloid scaffold.

31 sembled from both enantiomers of proline and cinchona alkaloid thiourea derivatives.

32 Os) that are self-assembled from proline and cinchona alkaloid thioureas (such as a quinidine-derived

33 Bifunctional Cinchona alkaloid thioureas efficiently catalyze asymmet

34 nitroolefins in the presence of 1-6 mol % of cinchona alkaloid urea derivatives, and provided access

35 his dynamic kinetic resolution, the modified cinchona alkaloid was found to serve dual catalytic role

36 kyl-9-BBN derivatives in the presence of the Cinchona alkaloid, cinchonidine, and base.

37 alysis via a complex of silver acetate and a cinchona alkaloid, particularly hydroquinine, with compl

38 The reactions are catalyzed by a modified cinchona alkaloid, which can function as a bifunctional,

39 First, our kinetic studies indicate that the cinchona alkaloid-catalyzed alcoholysis proceeds by a ge

40 dioxolanediones was realized via a modified cinchona alkaloid-catalyzed alcoholytic opening of the d

41 antioenriched dihydropyrimidone core was the Cinchona alkaloid-catalyzed Mannich reaction of beta-ket

42 The highly enantioselective cinchona alkaloid-catalyzed Mannich reaction of dicarbon

43 Cinchona alkaloid-catalyzed reaction of ethyl glyoxylate

44 ic induction in aldol reactions catalyzed by cinchona alkaloid-derived amines, and chiral vicinal dia

45 t matching effect between the chirality of a cinchona alkaloid-derived aminophosphine ligand for the

46 ed heterocycles can also be prepared using a Cinchona alkaloid-derived bifunctional organocatalyst fo

47 Furthermore, the active conformer of the cinchona alkaloid-derived catalyst DHQD-PHN was clarifie

48 terization of the active conformation of the cinchona alkaloid-derived catalyst for a desymmetrizatio

49 greater than that of a widely used thiourea cinchona alkaloid-derived catalyst.

50 A series of Cinchona alkaloid-derived dimers were obtained in high y

51 Cinchona alkaloid-derived organocatalysts as Bronsted ba

52 ines and enones under the catalysis of a new cinchona alkaloid-derived phase-transfer catalyst.

53 s reaction, disclosed by List et al. using a cinchona alkaloid-derived primary amine (cinchona amine)

54 Using cinchona alkaloid-derived primary amines as catalysts an

55 -fluorination of cyclic ketones catalyzed by cinchona alkaloid-derived primary amines is determined w

56 th phenylglyoxal hydrates were realized with cinchona alkaloid-derived thiourea catalysts.

57 The cinchona alkaloid-derived urea-catalyzed asymmetric conj

58 lfa-Michael addition reaction catalyzed by a cinchona alkaloid-squaramide bifunctional organocatalyst

59 nding model, which works for cinchonidine or cinchona alkaloid-urea catalyzed sulfa-Michael addition

60 model involves nucleophilic catalysis by the cinchona alkaloid.

61 ration of supercoiled plasmid topoisomers on cinchona-alkaloid modified silica-based stationary phase

62 In comparison to traditional cinchona-alkaloid-based phase-transfer catalysts, these

63 A cinchona-alkaloid-derived chiral primary-amine-catalyzed

64 The first cinchona-alkaloid-organocatalyzed enantioselective synth

65 Cinchona alkaloids and their derivatives are widely used

66 mperature adsorption of four closely related cinchona alkaloids and three reference quinoline-based c

67 In particular, sulfonamide derivatives of cinchona alkaloids are highly enantioselective desymmetr

68 rt the discovery of novel N,N'-disubstituted cinchona alkaloids as efficient phase-transfer catalysts

69 Wynberg's report from 1977 that natural cinchona alkaloids catalyze the asymmetric conjugate add

70 es have been enantioselectively catalyzed by Cinchona alkaloids functionalized with a hydrogen bond d

71 The 9-amino(9-deoxy)epi cinchona alkaloids have expanded the synthetic potential

72 f solvent-induced conformational behavior of cinchona alkaloids in their reactivity.

73 modification the conformational behavior of cinchona alkaloids in various solvents can be convenient

74 The series of Cinchona alkaloids includes known C6' (thio)urea and sul

75 We also demonstrate that the cinchona alkaloids quinidine and quinine give rise to pr

76 ia include glycoprotein IIb/IIIa inhibitors, cinchona alkaloids, antibiotics, anticonvulsants, and he

77 and quaternary ammonium bromide derived from cinchona alkaloids, provided nonracemic allene derivativ

78 gs (X-ray) were obtained via modification of Cinchona alkaloids.

79 echanistic studies of reactions catalyzed by cinchona alkaloids.

80 insight into the conformational behavior of cinchona alkaloids.

81 laced from the surface by any of those other cinchona alkaloids.

82 del of stereoselectivity is proposed for the cinchona amine catalysis of this reaction.

83 tes, structure-activity relationships of the cinchona amine catalyst, and rationalization of the abso

84 chiral iridium phosphoramidites PR/S-Ir and cinchona amine is established through transition-state m

85 g a cinchona alkaloid-derived primary amine (cinchona amine) organocatalyst, have been determined wit

86 lketenes, providing a model for catalysis by cinchona and related alkaloids in stereoselective additi

87 larial compounds are quinine, extracted from cinchona bark, and artemisinin (qinghao), extracted from

88 of basic understanding of the mechanisms of cinchona-based primary aminocatalysis.

89 es using a combination of pseudoenantiomeric cinchona-based thiourea catalysts.

90 bonding interactions offered by the thiourea-cinchona bifunctional framework.

91 Bis-cinchona catalyst 3b activates the Michael addition reac

92 yl moiety in the case of PR with the (8R,9R)-cinchona catalyst combination, whereas a series of C-H..

93 on of the quinuclidine tertiary amine of the cinchona catalyst on MK.

94 alyst is uncovered: upon condensation of the cinchona catalyst with the enone, the resulting covalent

95 (MPK) in the presence of pseudoenantiomeric cinchona catalysts (trimethylsilylquinine (TMSQ) or meth

96 When 10 mol % of a cinchona derived quaternary ammonium salt was employed a

97 When a combination of a cinchona-derived aminophosphine precatalyst and silver o

98 he quinoline ring at the C8 chiral carbon of cinchona-enamine plays an anchoring role.

99 A stepwise pathway wherein the MK-cinchona enolate (enolate-A) adds to MPK in the selectiv

100 unds, as most prominently represented by the cinchona-modified Pt and Pd catalysts for the asymmetric

101 provides a new, general model for asymmetric cinchona organocatalysis.

102 We have also investigated the corresponding cinchona squaramide-catalyzed reaction and found that it

103 y of Soos' landmark discovery from 2005 that cinchona thioureas catalyze the asymmetric Michael addit

104 nt the first detailed mechanistic study of a cinchona urea-catalyzed reaction.