ライフサイエンスコーパス: Cl HCO3 exchanger

1 encodes a human, electroneutral Na(+)-driven Cl-HCO3 exchanger.

2 , a K+/HCO3- cotransporter, and a Na+-driven Cl- -HCO3- exchanger.

3 (CFTR) and solute carrier family 26 (SLC26) Cl(-)/HCO3(-) exchangers.

4 phosphate and intracellular pH responses and Cl-/HCO3- exchanger activity was enhanced by secretion i

5 ressing cells is mediated by the action of a Cl-/HCO3- exchanger (AE), in the present work we examine

6 and is the major HCO3 (-) supplier of ductal Cl(-) -HCO3 (-) exchanger AE2, but not of NBCe1-B.

7 secretion and works by activating the ductal Cl(-) -HCO3 (-) exchanger AE2.

8 aracteristics of the somatic Na(+)-dependent Cl(-)-HCO3- exchanger, although sperm and somatic mechan

9 e polarity of several proteins including the Cl/HCO3 exchanger (an alternately spliced form of band 3

10 ss activates the extracellular Na+-dependent Cl(-)-HCO3- exchanger and the Na+-H+ exchanger and incre

11 n be explained by the parallel activity of a Cl-/HCO3- exchanger and a Cl- conductance, either the cy

12 a+-driven HCO3- transporters, the Na+-driven Cl-/HCO3- exchanger and the electroneutral Na+/HCO3- cot

13 ation of an apical H,K-ATPase with an apical Cl-HCO3 exchanger and that the H,K-ATPase can function,

14 xtreme, beta cells secrete HCO3 by an apical Cl/HCO3 exchanger and a basolateral H+ ATPase.

15 In contrast, secretion receptor, Cl-/HCO3- exchanger, and cystic fibrosis transmembrane c

16 and reducing the activity of the basolateral Cl(-) /HCO3(-) exchanger (anion exchanger 2; AE2).

17 is sparse on HCO3- transporters, apart from Cl- -HCO3- exchangers ('anion exchangers'), whose comple

18 + antiport pathway and the Na(+)-independent Cl(-)-HCO3- exchanger are not major regulators of mouse

19 ese results support a model in which the AE3 Cl(-)/HCO3(-) exchanger, coupled with parallel Cl(-) and

20 nts in the CA2 binding site were inactive as Cl-/HCO3- exchangers despite exhibiting normal Cl-/Cl- e

21 e NF-kappaB, which reduced expression of the Cl(-) / HCO3(-) exchanger DRA (SLC26A3), via direct bind

22 Pendrin is a Cl(-)/HCO3(-) exchanger expressed in type B and non-A, n

23 Another solute carrier (Cl(-)/HCO3- exchanger) gene, Ae3, is in this reduced int

24 a HCO3- channel that works in concert with a Cl:HCO3- exchanger in the apical membrane to affect tran

25 The AE2 Cl-/HCO3- exchanger is expressed in numerous cell types,

26 The electroneutral Na(+)-driven Cl-HCO3 exchanger is a key mechanism for regulating intr

27 , which may normally be coupled with the AE2 Cl-/HCO3- exchanger, is important for normal levels of g

28 This Cl:HCO3 exchanger, kAE1, is an alternately spliced form

29 xpression of both renin and the AE1 (Slc4a1) Cl-/HCO3- exchanger mRNAs are induced in kidney.

30 Multiple AE2 Cl-/HCO3- exchanger mRNAs have been identified in rat.

31 drin acts in tandem with the Na(+)-dependent Cl(-)/HCO3(-) exchanger (NDCBE) encoded by Slc4a8 to med

32 These include the AE1 Cl(-)/HCO3(-) exchanger of the basolateral membrane and

33 g diarrhea is caused by mutations in the DRA Cl(-)/HCO3(-) exchanger of the ileocolonic apical membra

34 resulting from the parallel operation of the Cl(-)/HCO3(-) exchanger pendrin and the Na(+)-driven Cl(

35 is review summarizes the contribution of the Cl(-)/HCO3(-) exchanger pendrin in distal nephron functi

36 egulator (CFTR) and AE2, a Cl- channel and a Cl-/HCO3- exchanger, respectively.

37 Loss of the AE3 Cl(-)/HCO3(-) exchanger (Slc4a3) in mice causes an impai

38 HCO3- exchange (mediated by the AE family of Cl-/HCO3- exchangers), sodium-dependent Cl-/HCO3- exchan

39 (+) -HCO3(-) cotransporter (NBC1) and apical Cl(-) /HCO3(-) exchanger (solute carrier family 26 membe

40 Pendrin is a Na(+)-independent Cl(-)/HCO3(-) exchanger that localizes to type B and non

41 The AE1 gene encodes two Cl-/HCO3- exchangers that are expressed in the erythrocy

42 tional family of HCO3- transporters includes Cl- -HCO3- exchangers, three Na+/HCO3- cotransporters, a

43 n-conductive pathways intrinsic to two other Cl-HCO3- exchangers, trout AE1 and mammalian SLC26A7.

44 exchanger AE1 (band 3) is an electroneutral Cl-HCO3- exchanger with 12-14 transmembrane spans (TMs).