ライフサイエンスコーパス: Cl-

1 Cl-/H+ transporters of the CLC superfamily form a ubiqui

2 )(dtc-Sar-AA-O(t-Bu))] (AA = Gly, X = Br (1)/Cl (2); AA = Aib, X = Br (3)/Cl (4); AA = l-Phe, X = Br

3 ished voltage-sensitive dye, VoltageFluor2.1.Cl--or VF--capped with a dimethoxy-o-nitrobenzyl (DMNB)

4 served for Cp2Zr{N(SiHMe2)2}X (X = OTf (11), Cl (13), OMe (15), O-i-C3H7 (16)).

5 e isolation of a copper NC, [Cu25H22(PPh3)12]Cl (1), from the reaction of Cu(OAc) and CuCl with Ph2Si

6 2ZrN(SiHMe2)(SiMe2X)](+) (X = OTf ([12](+)), Cl ([14](+))) to give [Cp2Zr{N(SiHMe2)(SiMe2DMAP)}X](+)

7 .21 (rs10508881; P = 4.08x10(-7), OR = 1.19, Cl = 1.11-1.27).

8 Alexa Fluor(R) 660 tethered through FPR-CH(2)Cl ([AF660]FPR-ProT) during laser-induced thrombus forma

9 specifically labeled with D-Phe-Pro-Arg-CH(2)Cl (FPR-ProT) inhibited tissue factor-initiated thrombin

10 The iron complexes CpFe(P(Ph)(2)N(Bn)(2))Cl (1-Cl), CpFe(P(Ph)(2)N(Ph)(2))Cl (2-Cl), and CpFe(P(P

11 (2)N(Bn)(2))Cl (1-Cl), CpFe(P(Ph)(2)N(Ph)(2))Cl (2-Cl), and CpFe(P(Ph)(2)C(5))Cl (3-Cl)(where P(Ph)(2

12 )], [Fe(II)(pfp)], and [Fe(III)(tpp)(ImH)(2)]Cl (tpp = meso-tetraphenylporphyrin) which have Fe(II)S

13 estigated the photolytic dechlorination of 2-Cl- and 3-Cl-aniline to aminophenols to obtain insights

14 strates that photolytic dechlorinations of 2-Cl-, 3-Cl-, and 4-Cl-aniline isomers are each accompanie

15 hough some members transport mainly SO(4)2-, Cl-, HCO(3)- or I-.

16 Using [Cu(dap)2]Cl (1 mol %), a wide range of substrates can be cleanly

17 silyliumylidene cations 1a and 1b [RSi(NHC)2]Cl (1a, 2a; R = m-Ter = 2,6-Mes2C6H3, Mes = 2,4,6-Me3C6H

18 22.3 (rs6907340; P = 2.19x10(-7), OR = 1.20, Cl = 1.12-1.28), and HNRNPA3P1-LOC100130539 on 10q11.21

19 , and rs6757804; P = 4.05x10(-8), OR = 1.20, Cl = 1.13-1.29).

20 23.3 (rs1519761; P = 4.70x10(-8), OR = 1.20, Cl = 1.13-1.29, and rs6757804; P = 4.05x10(-8), OR = 1.2

21 SiHMe2)(SiMe2DMAP)}X](+) (X = OTf ([26](+)), Cl ([20](+))).

22 1-silacyclohexanes C5H10Si(Ph,X) (X = F (3), Cl (4)) were studied by gas-phase electron diffraction,

23 (where Ar = 2,4,6-(t)Bu3-C6H2 and X = F (3), Cl (4), Br (5), I (6); Ar = 2,6-(i)Pr2-C6H3 and X = F (7

24 Ph2(pzAnX) (X = para-OMe (1), Me (2), H (3), Cl (4), CO2Et (5), CF3 (6), CN (7)) in high yield.

25 Gly, X = Br (1)/Cl (2); AA = Aib, X = Br (3)/Cl (4); AA = l-Phe, X = Br (5)/Cl (6)) were designed on

26 and 4-C(CH3)3 (27) (23.7-71 muM) and with 3-Cl (3), 4-CH3 (21), and 4-CH(CH3)2 (26) (8.1-13.0 muM).

27 that photolytic dechlorinations of 2-Cl-, 3-Cl-, and 4-Cl-aniline isomers are each accompanied by di

28 time msec/echo time msec, 160/0.35) and (35)Cl (40/0.6) MR imaging of both lower legs was performed

29 ning fragment ions where interference of (35)Cl- to (37)Cl-containing ions was avoided; (ii) with tun

30 tron in 2 couples with (14)N (I = 1), (35/37)Cl (I = 3/2), and (31)P (I = 1/2) nuclei leading to mult

31 Zn = -13.7 per thousand), heavy Cl (delta(37)Cl = +15 per thousand), and high U/Pb supports the origi

32 bit any observable isotopic shifts (delta(37)Cl = -0.3 +/- 0.6 per thousand).

33 of CPO were highly (37)Cl depleted (delta(37)Cl = -12.6 +/- 0.9 per thousand); significantly more dep

34 produced organochlorine compounds (delta(37)Cl = -7 to +6 per thousand).

35 exes, e.g., [Pd(NHC)3OAc]OAc and [Pt(NHC)3Cl]Cl (NHC = 1,3-dimethyl imidazol-2-ylidene).

36 GlyT2 cotransports 3Na+/Cl-/glycine generating large rises of Na+ inside the pre

37 ralone, Pd(allyl)P(t-Bu)(2)(p-NMe(2)C(6)H(4))Cl (15) was found to be the best catalyst.

38 (2)N(Ph)(2))Cl (2-Cl), and CpFe(P(Ph)(2)C(5))Cl (3-Cl)(where P(Ph)(2)N(Bn)(2) is 1,5-dibenzyl-1,5-dia

39 b, X = Br (3)/Cl (4); AA = l-Phe, X = Br (5)/Cl (6)) were designed on purpose in order to obtain gold

40 (Et4N = tetraethylammonium; X = 5-H (1a), 5-Cl (1b), 5-CF3 (1c), 6-CH3 (1d); pyS = pyridine-2-thiola

41 In contrast, their respective 5-Cl- and 3-Cl-substituted analogues had their adverse eff

42 , I (6); Ar = 2,6-(i)Pr2-C6H3 and X = F (7), Cl (8), Br (9), I (10)), in good isolated yields of 75-8

43 complexes, [FeX(dpbz)(2)] [X = 4-tolyl (7), Cl (8a), Br (8b); dpbz = 1,2-bis(diphenylphosphino)benze

44 and also whether this protein functions as a Cl- channel, a Cl-/H+ antiporter, or as something else e

45 not contain the standard facial triad, as a Cl- ligand is coordinated in place of the carboxylate.

46 r this protein functions as a Cl- channel, a Cl-/H+ antiporter, or as something else entirely.

47 though its heterologous expression induces a Cl--specific current.

48 idify in vivo, demonstrating that ClC-7 is a Cl-/H+ antiporter, that it constitutes the major Cl- per

49 ial of the inward current, indicating that a Cl- channel was not involved.

50 Here we show that the Ca(2+)-activated Cl ((-)) channel anoctamin-1 (ANO1/TMEM16A) is located i

51 Ca(2+)-activated Cl- channels (CaCCs) perform many important functions in

52 els; in TRPM5-GFP+ OSNs, the Ca2+ -activated Cl- ANO2 (anoctamin 2) channel is not expressed, and phe

53 n may occur via activation of Ca2+-activated Cl- channels (CaCCs) or an increase in the Cl- driving f

54 ans--17beta-estradiol--reduce Ca2+-activated Cl- secretion by airway epithelial cells in culture, the

55 iminution of nasal epithelial Ca2+-activated Cl- secretion in women with CF during the menstrual cycl

56 sed by defects in the CFTR, a cAMP-activated Cl- channel of epithelia.

57 ecific chlorine and carbon isotope analysis (Cl- and C-CSIA) to assess CP biotransformation.

58 Here, isotope enrichments factors for C and Cl (i.e., epsilonC and epsilonCl) were determined for bi

59 eltaS(double dagger) = -7.2 +/- 0.8 eu), and Cl (E(a) = 16.3 +/- 0.2 kcal mol(-1), DeltaH(double dagg

60 tistical shape atlases for the PCa+, Bx- and Cl- prostates.

61 x-active tyrosine residue (YZ), and Ca2+ and Cl- cofactors.

62 Regulation of Cl-/Cl- and Cl-/HCO(-)3 exchange by intracellular pH (pHi) or extrac

63 3 and CH2Cl2 form minor amounts of Cl2*- and Cl-.

64 A was found to consist of Cl- -dependent and Cl- -independent components, each accounting for approxi

65 ndent, ATP release, increases in [Ca2+]i and Cl- secretion.

66 I also required the presence of Na+, K+, and Cl- and was inhibited by the NKCC inhibitor, bumetanide,

67 ls occurs through the uptake of Na+, K+, and Cl- by NKCC1 and is modulated by the presence of glutami

68 ectrochemical driving force for Na+, K+, and Cl-.

69 Na+ and Cl- are accumulated in the reproductive organs and withi

70 skin interstitium sequesters excess Na+ and Cl- in salt-sensitive hypertension.

71 role in the regulated absorption of Na+ and Cl- in the kidney.

72 Inorganic ions (mainly Na+ and Cl-) may play a more important role than organic compoun

73 croelectrodes to measure fluid secretion and Cl- and HCO3- concentrations in cultured murine sealed i

74 ick channels, which are gated by [Na+]i and [Cl-]i and by changes in cytoplasmic ATP levels, are pres

75 4-methoxy-N-(2-quinolinylmethylene)aniline) ]Cl (4) displayed low micromolar IC50 values in ovarian c

76 radical, NH4, polarized by a chloride anion, Cl-.

77 surprising order (EtO)(2)(O)PO approximately Cl > CF(3)SO(3) > MeSO(3) (Phi = 0.50 to 0.16 in CF(3)CH

78 nducting ion channels, whereas others act as Cl-/H+antiporters (ClC-4 and ClC-5).

79 SLC26A7 and SLC26A9 function exclusively as Cl- channels.

80 ncluding ClC-0, ClC-1 and ClC-2) function as Cl--conducting ion channels, whereas others act as Cl-/H

81 HFFFs and produced water samples show that B/Cl (>0.001), Li/Cl (>0.002), delta11B (25-31 per thousan

82 Basal Cl--dependent HCO3- secretion, measured using a pH stat

83 A) receptor activation is inhibitory because Cl- flows into the cell.

84 r 1-butyl-3-methylimidazolium chloride (BMIM-Cl-) or 1-butylpyridinium chloride (-Bupy-Cl-)) have bee

85 IM-Cl-) or 1-butylpyridinium chloride (-Bupy-Cl-)) have been used to assemble modified screen printed

86 lpha-synuclein induces a Na+ independent but Cl--sensitive inward current in DAT-expressing cells.

87 inhibit the reaction at saturating [O2], but Cl- is a mixed inhibitor with relatively high values of

88 benefits of being free from interference by Cl (-) and dissolved organic matter.

89 4 subunit, a putative site for modulation by Cl-.

90 d/C catalyst, and in order of C-I > C-Br > C-Cl > C-F over Raney Ni catalyst.

91 of C-X bonds decreases in order of C-Br > C-Cl > C-I > C-F over Pd/C catalyst, and in order of C-I >

92 oth the Shaker K+ channel SHK-1 and the Ca2+/Cl--gated K+ channel SLO-2 play important roles in contr

93 nical or MRI indications of prostate cancer (Cl-).

94 g of the integrated function of each cardiac Cl- channel in the context of health and disease.

95 to delineate the functional role of cardiac Cl- channels in the context of health and disease.

96 or pathophysiological phenotypes of cardiac Cl- channels, however, may be complicated by the compens

97 a negatively charged Glu148 and the central Cl- ion act together to drive H+ to the extracellular si

98 Knowledge of how ATP gates the CFTR Cl- channel is critical for understanding CFTR's physiol

99 stic fibrosis transmembrane regulator (CFTR) Cl- channel and stimulation of ciliary beat frequency.

100 -perforated patch recordings to characterize Cl- transport via NKCC1, the principal neuronal Cl- accu

101 r the conversion of particle-bound chloride (Cl-) to gas-phase Cl2, the detailed processes involved r

102 In the adult brain, chloride (Cl-) influx through GABA(A) receptors is an important me

103 ts that enhanced airway epithelial chloride (Cl-) secretion plays a role in the disease.

104 In the presence of chloride (Cl-), melatonin inactivated MPO at two points in the cla

105 nt studies have identified several chloride (Cl-) channel genes in the heart, including CFTR, ClC-2,

106 tent secretogogue, stimulating cholangiocyte Cl- and fluid secretion via binding to membrane P2 recep

107 vious models implicating CFTR in cholinergic Cl- secretion may be explained by substantial downregula

108 of commercially available (SIPr)Pd(cinnamyl)Cl (SIPr = 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimi

109 c finger proteins, the complexes [Pt(dien)Cl]Cl (dien = diethylenetriamine) and [Pt(terpy)Cl]Cl (terp

110 odium proton-reduction catalyst, [Cp*Rh(P)Cl]Cl (1), and a rhenium CO2-reduction catalyst, Re(P)(CO)3

111 (dien = diethylenetriamine) and [Pt(terpy)Cl]Cl (terpy = 2,2':6',2''-terpyridine) were exposed to the

112 at has the defining characteristics of a CLC Cl-/H+ antiporter and show that this transporter is the

113 A fundamental question concerning the ClC Cl-/H+ antiporters is the nature of their proton transpo

114 ith a series of alkyl chloronitriles, RCH(CN)Cl (R = methyl, ethyl, isopropyl, tert-butyl) were inves

115 highest selectivity over chloride (logK(CN-,Cl-)(pot) = -3.71, as opposed to -0.36 for an ionophore-

116 In neurons in the developing CNS, [Cl-]in is elevated, E(GABA) is depolarizing, and GABA co

117 tenance of intracellular Cl- concentration ([Cl-]in) at low levels.

118 he formation of regulated chloro-bromo-DBPs (Cl-/Br-DBPs).

119 sion (Cl0), Cl at 72 hours (Cl72), and delta Cl (DeltaCl = Cl72 - Cl0) were the independent variables

120 l conductance of endogenous Ca(2+)-dependent Cl- channels by lowering the energy barriers for ion tra

121 e that hClCa1 does not form Ca(2+)-dependent Cl- channels per se or enhance the trafficking/insertion

122 lines express constitutive Ca(2+)-dependent Cl- currents and show that hClCa1 increases the amplitud

123 increases the amplitude of Ca(2+)-dependent Cl- currents in those cells.

124 ween the hClCa1 protein and Ca(2+)-dependent Cl- currents using heterologous expression of hClCa1 in

125 chloride channels mediating Ca(2+)-dependent Cl- currents.

126 lular chloride and, therefore, a depolarized Cl- equilibrium potential (E(Cl)).

127 gulated CFTR activity, leading to diminished Cl- and water secretion from airway epithelial cells and

128 e air-stable complex Pd(eta(3)-allyl)(DTBNpP)Cl (DTBNpP = di(tert-butyl)neopentylphosphine) serves as

129 olarizable halogen substituents: Dye-F < Dye-Cl < Dye-Br < Dye-I.

130 nion binding site that is occupied by either Cl- or Br- and is located close to but not within bondin

131 and Slc26a6 function as coupled electrogenic Cl-/HCO(3)- exchangers or as bona fide anion channels.

132 while Slc26a4 functions as an electroneutral Cl-/I-/HCO(3)- exchanger.

133 ng species is proposed to be a Lys-epsilonNH-Cl (lysine chloramine) from reaction of enzyme-generated

134 r that was prevented when the extracellular [Cl-] was maintained at 10 mm during reoxygenation.

135 The reaction of FADH2, Cl-, and O2 in the active site generates the powerful ox

136 1/2 = 63 h at 4 degrees C) when RebH, FADH2, Cl-, and O2 react in the absence of substrate tryptophan

137 pyridine ligands, R = -CH3 (mhp), -F (fhp), -Cl (chp)}.

138 es in neuronal E(Cl) (reversal potential for Cl-) did not alter vmax or Km of NKCC1.

139 his transporter is the predominant route for Cl- through the lysosomal membrane.

140 CCl3CN mostly forms Cl- in collisions slightly favoring the CCl3 end with a

141 - conductance while decreasing the G(SCN-)/G(Cl-) conductance ratio from approximately 2-3 to approxi

142 eceptor activation excites neurons by gating Cl- efflux because the intracellular Cl- concentration (

143 akly basic arylamine (aniline) was: I > Br > Cl > F (with 5 equiv of aniline in MeCN at 70 degrees C)

144 displacement reactivity order was: F > Br > Cl > I (with BuNH2/MeCN), F > Cl approximately Br > I (w

145 period, and the order then was F > I > Br > Cl (with 5 equiv of aniline and 2 equiv of TFA in MeCN a

146 .0]undec-7-ene (DBU)/MeCN), and F > Br > I > Cl [with K+ -SCOCH3/dimethyl sulfoxide (DMSO)].

147 activity of the phenylacetylenes: F > OCH3 > Cl > H.

148 quence: NO3- approximately I- > NO2- > Br- > Cl- > SO4(2-) approximately HCO3- approximately gluconat

149 omplexes in solution is in the order -CH3 > -Cl > -F, in accord with the more electron rich bridging

150 304A anion conductance was SCN->>NO3->I->Br->Cl->Mes-.

151 An investigation of the use of Cp2Zr(H)Cl (Schwartz's reagent) to reduce a variety of amides to

152 MP2/aug-cc-pVDZ, are used to determine C-H...Cl- hydrogen bond energies for a series of XCH3 donor gr

153 ) or enzymatic methods (myeloperoxidase/H2O2/Cl- and myeloperoxidase/H2O2/NO2-).

154 rbocations C(20)H(10)CH(2)CH(2)Hal(+) (Hal = Cl (1) and Br (2)) with an -CH(2)CH(2)Hal moiety attache

155 Zn (delta(66)Zn = -13.7 per thousand), heavy Cl (delta(37)Cl = +15 per thousand), and high U/Pb suppo

156 teroventral cochlear nucleus, maintain high [Cl-]i and depolarize in response to GABA.

157 complexes, Re(O)(htz)2Cl and Re(O)(hoz)(htz)Cl (htz = thiazolinyl-phenolato bidentate ligand), signi

158 ius sufficient to permit passage of hydrated Cl- ions in the OWF but not the IWF model.

159 dy, 615 patients (31.7%) had hyperchloremia (Cl >/= 110 mEq/L) on ICU admission.

160 septic patients manifesting hyperchloremia (Cl >/= 110 mEq/L) on ICU admission, higher Cl levels and

161 Photolysis of LAu(I)Cl (L = RNC or CO) complexes leads to free L, Au(III), a

162 (2)-N,O-(1R,2S)-cis-1-amino-2-indanol)]Ru(II)Cl (2) on edge-plane graphite exhibits an onset current

163 the remaining DIA was virtually abolished in Cl- -free media.

164 ge-gated channels rather than on a change in Cl- reversal potential.

165 jected mice, with a simultaneous increase in Cl--independent HCO3- secretion that was also inhibited

166 of Cl- transport inhibitors on the rises in [Cl-]i during and after OGD.

167 he presence of other common anions including Cl-, Br-, I-, NO3-, OAc-, H2PO4-, and HSO4-.

168 ent of CF lung disease because they increase Cl- secretion in the airways.

169 We found that IL-13 treatment increased Cl- secretion in the airways of wild-type but not Slc26a

170 well as CFTR-dependent and CFTR-independent Cl- secretion, ciliary beating, and mucin secretion.

171 ll as about the complexity of the intestinal Cl- and HCO3- transport in health and disease.

172 ts that both extracellular and intracellular Cl- facilitate transporter turnover in contrast to the c

173 we observe a dynamic shift in intracellular Cl- levels, which determines the reversal potential of G

174 depends on the maintenance of intracellular Cl- concentration ([Cl-]in) at low levels.

175 gating Cl- efflux because the intracellular Cl- concentration (Cl(i)) is elevated.

176 orter KCC2 establishes the low intraneuronal Cl- levels required for the hyperpolarizing inhibitory p

177 leaving-group order with a control amine is Cl (1) < Br (71) < I (160), whereas the leaving-group or

178 achieved by dehydrochlorination of Cp*Ru(IXy)Cl (1) with KCH2Ph.

179 annels that mediate this influx, to the K+ , Cl- and transient receptor potential channels that set t

180 Expression of the K+Cl- cotransporter 2 (KCC2) also increased across these a

181 ng observations suggest that O2 activates K+-Cl- cotransport (KCC) and deactivates Na+-K+-2Cl- cotran

182 ase in K+ efflux was fully inhibited by a K+/Cl- transport blocker.

183 Electroneutral K+/Cl- cotransport was demonstrated in SiHa cells, in which

184 E(GABA), expression of the Cl- extruding K+/Cl- cotransporter, KCC2 was decreased.

185 pzAnX), (X = para-OMe (L1), Me (L2), H (L3), Cl (L4), CO2Et (L5), CF3 (L6), CN (L7)) and triphenylbor

186 ed water samples show that B/Cl (>0.001), Li/Cl (>0.002), delta11B (25-31 per thousand) and delta7Li

187 rder with the macrocyclic amine is I (0.4) < Cl (1) < Br (8.5).

188 ormation increases in the order X = I < Br < Cl < F, with exclusively C(aryl)-I bond formation when X

189 ed ductal pNBC1 and CFTR activities, luminal Cl- absorption and HCO3- secretion, and the associated f

190 ng RNA can essentially ablate this lysosomal Cl-/H+ antiport activity and can strongly diminish the a

191 orming heterogeneous [M + zH + n(Na - H) + m(Cl + H)](z+) ions, while the integrated protein ion inte

192 H+ antiporter, that it constitutes the major Cl- permeability of lysosomes, and that it is important

193 perforated patch-clamp techniques to measure Cl- reversal potential, GABAergic synaptic responses, an

194 optogenetics study delineates one mechanism: Cl- shifts causing seconds-long excitability changes aft

195 Decreased KCC2-mediated Cl- extrusion and impaired hyperpolarizing GABAAR- and/o

196 (i) at which there was no net NKCC1-mediated Cl- transport.

197 flammation and suggest that SLC26A9-mediated Cl- secretion is essential for preventing airway obstruc

198 uridine triphosphate-mediated (UTP-mediated) Cl- secretion was reduced during the periovulatory estro

199 ted with an increase in [Ca2+]i and membrane Cl- permeability, which were both dependent on extracell

200 electrodes containing 145 mm instead of 5 mm Cl- failed to shift the reversal potential of the inward

201 tal and phosphorylated thiazide-sensitive Na+Cl- cotransporter (NCC) levels were increased in KO kidn

202 taneous lymph capillaries and increased Na+, Cl-, and water retention in skin and salt-sensitive hype

203 minor role in driving the transport of Na+, Cl- and HCO3(-).

204 o increased the fractional excretion of Na+, Cl- and water, but this was observed in both wild-type a

205 ad an increased fractional excretion of Na+, Cl-, HCO3(-) and water.

206 ms that link aldosterone to NCC-mediated Na+/Cl- reabsorption remain elusive.

207 rom 0 to 2 mM and was insensitive to [Na+], [Cl-], or pH.

208 P) by phosphorylating and stimulating the Na-Cl (NCC) and Na-K-2Cl (NKCC2) co-transporters, which reg

209 plication site, even in neurons with natural Cl- concentration (patch pipette removed).

210 quilibrium, and there was no evidence of net Cl- transport.

211 transport via NKCC1, the principal neuronal Cl- accumulator, in neonatal CA1 pyramidal neurons.

212 negativity of the substituent (F > OH > NH2, Cl > SH, H, CN).

213 d constrained geometry complexes, (CGC)M(NR2)Cl (CGC = [Me2Si(eta5-Me4C5)(tBuN)]2-; M = Th, 1-Cl; U,

214 e tungsten oxo chloride species [CF3-ONO]W(O)Cl (4) and disubstituted alkynes.

215 eases the bicarbonate permeability (P HC O3/ Cl ) of anion channels by reducing energy barriers of si

216 eases the bicarbonate permeability (P HC O3/ Cl ) of CFTR, ANO1 and GlyR.

217 t of elimination of the inhibitory effect of Cl (-).

218 to previous reports claiming the absence of Cl- currents in HEK293 cells, we find that HEK293 and NC

219 In the absence of Cl-, melatonin served as a 1e- substrate for MPO compoun

220 ning 30% INTERPRETATION: Thus, alteration of Cl- transport by bumetanide enables the anticonvulsant a

221 Blockade of Cl- currents (including tonic and synaptic currents) wit

222 , which would not be expected in the case of Cl- anion formation (symmetric charge accumulation on Cl

223 The DIA was found to consist of Cl- -dependent and Cl- -independent components, each acc

224 Cl- accumulation, we examined the effects of Cl- transport inhibitors on the rises in [Cl-]i during a

225 alyze stoichiometrically coupled exchange of Cl- and H+ across biological membranes.

226 This outward flow of Cl- in neonatal neurons is excitatory and contributes to

227 This results in the outward flux of Cl- through GABA(A) channels, the opposite direction com

228 The integrated function of Cl- channels may involve multi-protein complexes of the

229 ted (CNG) channel, leading to Ca2+ gating of Cl- channels; in TRPM5-GFP+ OSNs, the Ca2+ -activated Cl

230 nic goblet cells, not the apical membrane of Cl--secreting enterocytes.

231 rnover in contrast to the classical model of Cl- as a cotransported ion.

232 Regulation of Cl-/Cl- and Cl-/HCO(-)3 exchange by intracellular pH (pH

233 nown action of lubiprostone is simulation of Cl- dependent fluid secretion.

234 To investigate sources of Cl- accumulation, we examined the effects of Cl- transpo

235 tested the effect of RP-causing variants on Cl- channel activity and cellular localization of bestro

236 termediate, which eliminates either Cl2*- or Cl- and Cl*.

237 transporter with bumetanide prevents outward Cl- flux and causes a more negative GABA equilibrium pot

238 p-NO(2) (1a); p-NO(2) (1b); m-NO(2) (1c); p-Cl (1d); unsubstituted (1e)).

239 rted mononuclear Fe(III) complex, Fe(III)(Pc)Cl (Pc = pthalocyaninate), highlighting the role of swit

240 , [Ru(gly)(pdto)]Cl (2), and [Ru(acac)(pdto)]Cl (3), where pdto = 2,2'-[1,2-ethanediylbis-(sulfanediy

241 pounds [Ru(en)(pdto)]Cl2 (1), [Ru(gly)(pdto)]Cl (2), and [Ru(acac)(pdto)]Cl (3), where pdto = 2,2'-[1

242 Solution structural analysis reveals a ppi Cl [Formula: see text] Cu(II) LMCT (22,026 cm(-1)) for C

243 Members of the family are primarily Cl- transporters, although some members transport mainly

244 el used in the X-ray structure that produced Cl- binding to the amino terminus of the helix halide bi

245 lipid bilayer coating and are named Lipid-Pt-Cl (LPC) NPs, which showed significant antitumor activit

246 es, mediated by Kv1.3 and outward rectifying Cl- channels.

247 e of CFTR results in a double hit of reduced Cl-/HCO3- and H2O secretion as well as ENaC hyperactivit

248 We summarise what is known regarding Cl- channels in the ER/SR and the non-selective cation c

249 ng geochemical fingerprint in the salinized (Cl > 20 mg/L) groundwater sampled from the Alluvium, Cat

250 he epithelial Na+ channel (ENaC) and secrete Cl- through the cystic fibrosis transmembrane conductanc

251 rs via NBCe1, and a parallel DIDS-sensitive, Cl- -dependent mechanism.

252 ous lymphatic capillary density, led to skin Cl- accumulation, and induced salt-sensitive hypertensio

253 Our data demonstrate that the SLC26A9 Cl- channel is activated in airway inflammation and sugg

254 solute carrier family 26, member 9 (SLC26A9) Cl- channel in asthma, we induced Th2-mediated inflammat

255 luable in the phenotypic studies of specific Cl- channels by limiting the effect of compensation on t

256 nsport to the transport of anions other than Cl-.

257 consistent with the experimental result that Cl- binding to the central site facilitates the proton m

258 bacterial ClC-ec1 transporter revealed that Cl- binding to the central anion-binding site (Scen) is

259 Here, we show that Cl-, F-, NO3-, and SCN- display distinct binding coordin

260 It has been shown that Cl- channels may contribute to cardiac arrhythmogenesis,

261 For the Cl + CHD(3) --> HCl + CD(3) reaction at low collision en

262 ee of electronic and nuclear coupling in the Cl + H2 reaction has become a vexing problem in chemical

263 atic effects, in this critical region of the Cl + H2 reaction, and suggests strongly that these effec

264 The Cl- -independent component was postulated to arise from

265 The Cl- presence enhanced the affinity of MPO toward melaton

266 es were noted at the apex when comparing the Cl- and PCa+ prostates.

267 uggesting that NBCe1 was responsible for the Cl- -independent DIA.

268 gap photoluminescence (PL) was weak from the Cl- and hydrazine- or sulfide-terminated nanocrystals, b

269 d Cl- channels (CaCCs) or an increase in the Cl- driving force through CFTR after activation of Ca2+-

270 the permeability sequence but increases the Cl- conductance while decreasing the G(SCN-)/G(Cl-) cond

271 s may involve multi-protein complexes of the Cl- channel subproteome and similar phenotypes can be at

272 period of shifted E(GABA), expression of the Cl- extruding K+/Cl- cotransporter, KCC2 was decreased.

273 e progenitors by premature expression of the Cl- transporter KCC2, as confirmed by the changes in the

274 asurements revealed that the surfaces of the Cl-, hydrazine-, and sulfide-treated nanocrystals were A

275 molecules and remains unaltered through the Cl- plasma level.

276 enyl; 1) reacted with 1 or 2 equiv of Au(tht)Cl (tht = tetrahydrothiophene) to produce the stable mon

277 ism occurs exclusively from the sites cis to Cl (E(a) = 19.0 +/- 0.3 kcal mol(-1), DeltaH(double dagg

278 echanisms, one- and two-electron transfer to Cl (strain CBDB1) or H (strain 14DCB1) are compatible wi

279 In addition to Cl- and Br-, two non-halide ions, NO3- and SCN-, are sho

280 the heme-catalyzed decomposition of ClO2- to Cl- and O2, an unusual transformation with biotechnologi

281 ivity for reducing the ClO3- intermediate to Cl-, thereby preventing ClOx- buildup and lowering Re co

282 tration to stimulate an alternate pathway to Cl- secretion.

283 s of NKCC1 revealed reversible transmembrane Cl- transport characterized by a large maximum velocity

284 the presence of physiologically transported Cl-, binding of F- or NO3- leads to the formation of pse

285 nformation, and the U=N imido (1.97(1) A), U-Cl (2.60(2) A), and U-C5Me5 (2.84(1) A) distances were c

286 However, the molecular mechanism underlying Cl- secretion and its relevance in asthma pathophysiolog

287 ss, and ants in choice experiments underused Cl (as KCl, MgCl(2), and CaCl(2)) relative to NaCl and t

288 e of the halogen substituent (IC(50) values, Cl < I = Br << F = H) and the ring position of the halog

289 oxide (NO) binding to MPO was plotted versus Cl- concentration.

290 When Cl- exceeded the plasma level, the NO combination rate b

291 ed in amplitude between E14 and E18, whereas Cl- reversal potential and synaptic conductances remaine

292 at higher IS (NaCl) due to complexation with Cl-.

293 ntially different from the wires formed with Cl-.

294 1,1/t,t-spermidine, BBR3571); R = CH 3 , X = Cl ( 2); R = CH 2 Cl, X = ClO 4 ( 3); R = CF 3 , X = Cl

295 R = CH 2 Cl, X = ClO 4 ( 3); R = CF 3 , X = Cl ( 4)) are compared with their carbamate analogues.

296 ic salts, (4-chloropyridinium) 2[CoX 4], X = Cl ( 1), Br ( 2), have each been determined at nine temp

297 es of monomeric ((tBu)PBP)NiX complexes (X = Cl (5), OTf (6), H (7), OC(H)O (8)) have been prepared.

298 2(CH 2) 3N(COR)(CH 2) 4NH 2]X 2 (R = H, X = Cl (1,1/t,t-spermidine, BBR3571); R = CH 3 , X = Cl ( 2)

299 X( identical withCPh)(IPr)(P(i)Pr3)]OTf (X = Cl (1), F (4); OTf = CF3SO3) undergo deprotonation with

300 s OsX( identical withCPh)(IPr)(P(i)Pr3) (X = Cl (2), F (5)).

301 2Me)X( identical withCPh)(IPr)(P(i)Pr3) (X = Cl (8), F (9)).

302 -4 halogen (Z) becomes more nucleophilic (Z: Cl < Br < I).