ライフサイエンスコーパス: Clp protease

1 dy, we report that PSY is a substrate of the Clp protease.

2 cted the degradation activity of the stromal Clp protease.

3 symmetry mismatch is a universal feature of Clp proteases.

4 ure; a result in contrast to other bacterial Clp proteases.

5 nce to the family of heat-shock proteins and Clp proteases.

6 usceptible to ATP-dependent degradation by a Clp protease, a finding that supports a proposed mechani

7 ot all stromal ClpC functions as part of the Clp protease; a proposal supported by the near abolition

8 Inactivation of components of the Clp protease alters abundance of several Isd proteins, i

9 The Clp protease and Isd complex are widely conserved in bac

10 Clp proteases and chaperones are ubiquitous among prokar

11 x with ClpC (the HSP100 chaperone partner of Clp proteases) and phycobiliproteins in vitro.

12 ured by expression of heat shock protein 60, Clp protease, and Lon peptidase 1.

13 the regulatory partner for the ATP-dependent Clp protease, and yet this and many other important char

14 Clp proteases are found in prokaryotes, mitochondria, an

15 lpC appears to function primarily within the Clp protease, as the principle stromal protease responsi

16 The Clp protease ATPase subunit and chaperone ClpX is dispen

17 ized PAA2 transporter for degradation by the Clp protease, but not several other chloroplast protease

18 s in ClpPR core subunits, indicating reduced Clp protease capacity.

19 he proteolytic component of the caseinolytic Clp protease (ClpP) from E. coli at 2.3 A resolution usi

20 Collectively, these results show that the Clp protease complex and chaperones control several proc

21 The Clp protease complex in Mycobacterium tuberculosis is un

22 We have applied this strategy to the Clp protease complex of tobacco (Nicotiana tabacum) and

23 the proteolytic subunits of the chloroplast Clp protease complex, was identified and validated as th

24 The Clp protease complexes provide a means for quality contr

25 Likewise, Clp protease constitutes a central part of the plastid p

26 Tetradecameric Clp protease core complexes in non-photosynthetic plasti

27 Plastids contain tetradecameric Clp protease core complexes, with five ClpP Ser-type pro

28 in one subunit of the chloroplast-localized Clp protease core, ClpR1.

29 is proposed that the proteolytic activity of Clp protease counteracts GBP binding to assure the appro

30 s lactis clpE gene, encoding a member of the Clp protease family; and the third product showed no sig

31 The Clp protease gene regulator, Rv2745c (clgR), is induced

32 The ATP-dependent Clp protease has been well-characterized in Escherichia

33 Although the structure and function of the Clp protease have been studied in great detail in both b

34 R4 null allele demonstrate a central role of Clp protease in chloroplast biogenesis and protein homeo

35 ein turnover, further supporting the role of Clp protease in degrading PSY protein.

36 The Clp protease in the chloroplasts of plant cells is a lar

37 oteolytic subunit, ClpP4, of the chloroplast Clp protease in vivo, and ubiquitylates ClpP4 in vitro.

38 tion of protein degradation by mycobacterial Clp proteases in vitro and describe novel features of th

39 Upon hypoxic and reaeration conditions, Clp protease induction occurred within wild-type Mtb, in

40 ivation of clgR, which subsequently leads to Clp protease induction, is crucial for degradation of mi

41 ms should facilitate identification of novel Clp protease inhibitors and activators.

42 Protein degradation by Clp proteases is regulated primarily by substrate recogn

43 , the proteolytic component of ATP-dependent Clp proteases, is a hollow-cored particle composed of tw

44 s study sought to identify the effect of the Clp protease on the iron-regulated surface determinant (

45 ClpP protein (a component of the cytoplasmic Clp protease) participates in biofilm formation in this

46 g these are regulatory components of Lon and Clp proteases, proteins involved in DNA replication, rec

47 The role of such an envelope membrane Clp protease remains unclear although it appears uninvol

48 ncovered to physically interact with various Clp protease subunits (i.e., ClpS1, ClpC1, and ClpD).

49 as well as most of the chloroplast-localized Clp protease subunits, is inhibited in clpR1-1.

50 Thus, the Clp protease system and GBP contribute to GluTR accumula

51 The caseinolytic protease (Clp) protease system has been expanded in plant plastids

52 ely acts as an adaptor protein that guides a Clp protease to the phycobiliproteins, thereby initiatin

53 These results indicate that the Lon and Clp proteases use the same mechanism of substrate discri

54 We found that Clp proteases, widely reported to form biologically rele