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1 Cmax, volume of distribution/bioavailability (Vd/F), and
2 ithin equivalence limits (AUC 90% CI 98-103, Cmax 90% CI 99-105), showing that lamotrigine exposures
3 r the concentration-time curve (AUC) by 35%, Cmax by 28%, and Cmin by 46%, consistent with induction
4 or log-transformed variables: AUC0-96, 2.58; Cmax, 0.64; and AUC0-infinity, 4.05; P >/= .13) and that
5 the predicted oral dose of CsA-ME produced a Cmax > 700 ng/ml in 90% of patients from days 2 to 4, an
6 the predicted oral dose of CsA-GC produced a Cmax > 700 ng/ml in only 64 and 82% of patients during t
7 met for all product comparisons for AUC and Cmax in both individuals with a kidney transplant and th
8 linearly related to the chylomicron AUC and Cmax values for alpha-carotene, lycopene, phylloquinone,
11 under the concentration-time curve (AUC) and Cmax were seen with linear increases in administered dos
12 s, resulting in relative bioavailability and Cmax values 10- and 8.4-fold higher, respectively, confi
13 ent with a CrCl of 23.8 ml/min, the Cmin and Cmax were 0.32 and 0.7 microg/ml, respectively, with an
14 /ml; with CrCl of 25-50 ml/min, the Cmin and Cmax were 0.41+/-0.27 and 1.17+/-0.32 microg/ml, respect
15 With CrCl of <10 ml/min, the mean Cmin and Cmax were 0.75+/-0.42 and 1.59+/-0.55 microg/ml, respect
16 /ml; with CrCl of 50-69 ml/min, the Cmin and Cmax were 1.93+/-0.48 and 2.57+/-0.39 microg/ml, respect
18 tration to in vitro response ratio approach (Cmax/AC50), analogous to decision-making methods for cli
23 range) plasma arsenic maximum concentration (Cmax) was 0.28 microM (0.11-0.37 microM) and at 0.2 mg/k
24 centration (Cmin) and maximum concentration (Cmax) were 0.78+/-0.46 microg/ml and 1.42+/-0.37 microg/
26 icant accumulation in maximum concentration (Cmax), and the intersubject variabilities (coefficient o
27 the curve (AUC0-24), maximum concentration (Cmax), AUC0-24/MIC, Cmax/MIC, and percentage of time tha
28 exposure (AUC(0-t) ) and peak concentration (Cmax) ratios of generic and reference formulations durin
30 d concentration (C[av]), peak concentration (Cmax), and time to Cmax (tmax) values were calculated fr
31 rates IC(50), slope, and peak concentration (Cmax), correlated with improved complete cytogenetic res
34 comparison of maximum plasma concentration (Cmax) and area under the concentration-time curve (AUC)
35 increased the maximal plasma concentration (Cmax) and area under the time-concentration curve in rat
36 se with a mean maximum plasma concentration (Cmax) of 5.97 +/- 2.25 microg/mL and an area under the c
37 The mean DSM265 peak plasma concentration (Cmax) ranged between 1310 ng/mL and 34 800 ng/mL and was
39 n steady-state maximum plasma concentration (Cmax,ss) and area under the steady-state plasma concentr
40 eight-adjusted maximum plasma concentration (Cmax/dose/kg) were detected overall such that the 25 mg
41 .359, P=.023), maximum plasma concentration (Cmax; r2=0.340, P=.028), and plasma HIV RNA decline.
42 D showed a mean maximum serum concentration (Cmax) of 1,209 +/- 430 ng/mL, with a median T1/2 beta fo
44 serum half-life (and maximum concentration [Cmax]) generally increased between the first and fourth
45 apolated to infinity, maximum concentration [Cmax], and time to Cmax) were observed on Day 10 in subj
46 geometric mean maximum plasma concentration [Cmax] and 77% and 82% lower AUC0-t [area under the curve
47 an 176 nM (the maximal plasma concentration [Cmax] with recommended adult dose) in 76% of samples, wh
48 to 72 h, as well as maximal concentrations (Cmax: 2.04 +/- 0.14 compared with 2.73 +/- 0.18 mumol/L)
50 time in which maximum plasma concentrations (Cmax) were achieved averaged 1.22 hours with an average
51 oxicity, maximum radiotracer concentrations (Cmax) in brain and vertebra were low (0.67 and 0.54 m(2)
52 d plasma d6-alpha-tocopherol concentrations (Cmax) and the areas under the curve increased 2- and 3-f
53 AUC for 4-OH-CPA, the finding that 4-OH-CPA Cmax may determine its level of myelotoxicity indicates
55 (0.11-0.37 microM) and at 0.2 mg/kg per day, Cmax was 0.40 and 0.46 microM; area under the concentrat
56 (356+/-63), and 2 hr after the morning dose (Cmax=1567+/-669), decreased from 39+/-16 to 15+/-8 and 3
58 eneral, maximal levels of DNA scission (i.e. Cmax) varied over a considerably larger range than did t
64 nce limits (lowest and highest CI limits for Cmax, 92.6% and 110.4%; for AUC0-96, 96.9% and 101.9%).
68 91.4% and yield of 68.3%, and 4-fold higher Cmax and AUC over the slow-releasing ATRA formulation.
69 imiting neutropenia had significantly higher Cmax values than patients who did not, whereas nonhemato
70 ent of variation [CV], approximately 40%) in Cmax and area under the concentration-time curve from 0
71 AMP resulted in a dose-dependent increase in Cmax and AUC(0-24h) of 2F-ara-A and achieved an AUC(0-24
72 consumption correlated with the increase in Cmax when felodipine was taken with either the 1st or th
75 okinetic evaluation in dogs showed increased Cmax (39.18 +/- 7.34 vs 21.68 +/- 6.3 mug.dL-1), higher
76 te prodrugs led to a substantially increased Cmax and prolonged availability of FimH antagonists in u
78 a with no subject x formulation interaction (Cmax, 0.00; AUC0-96, 0.54; and AUC0-infinity, 0.36; P >/
79 fied negative interactions between isoniazid Cmax and rifampicin Cmax/MIC ratio on 2-month culture co
80 /PD analyses using MARS identified isoniazid Cmax and rifampicin Cmax/MIC thresholds below which ther
84 time of 48 hours and concentration maximum (Cmax) of 4000- to 15,000-fold higher than their therapeu
85 125 was rapidly absorbed with geometric mean Cmax and AUC0-24 h values of 1417 ng/mL and 16 727 h ng/
88 , maximum concentration (Cmax), AUC0-24/MIC, Cmax/MIC, and percentage of time that concentrations per
89 ng/h per mL), Caverage (8.8 +/- 4.2 ng/mL), Cmax (19.2 +/- 9.7 ng/mL), apparent Half-life (11.7 +/-
95 VOO, FVOO increased IRH (P<0.05) and plasma Cmax of hydroxytyrosol sulphate, a metabolite of OOPC 2h
96 MEC ratio, and peak concentration in plasma [Cmax]:MEC ratio) at clinically achievable exposures.
97 In our Neoral-treated sample population, Cmax was associated with the least variable "cyclosporin
98 curve (AUC), maximum concentration postdose (Cmax), minimum concentration postdose (Cmin), time to ma
99 nt toxicokinetic (TK) model to first predict Cmax for in vivo corroboration using therapeutic scenari
100 lted in an improved pharmacokinetic profile (Cmax = 359 ng.h/mL; AUC0-t = 2436 ng.h/mL) and a desirab
101 evealed that poor systemic exposure in rats (Cmax = 44 ng/mL; AUC0-t = 359 ng . h/mL) at 10 mg/kg was
102 isoniazid Cmax was <4.6 mg/L and rifampicin Cmax/MIC <28, the isoniazid concentration had an antagon
104 ARS identified isoniazid Cmax and rifampicin Cmax/MIC thresholds below which there is concentration-d
106 mus peak concentration (Cmax), and sirolimus Cmax and area under the concentration-time curve were de
108 ated by greater values of the initial slope, Cmax, AUC, and shorter T1/2 than men (all ps<0.04).
113 (90% confidence interval, 1.10-1.23) and the Cmax ratio was 1.49 (90% confidence interval, 1.35-1.65)
114 1/2 for 4-OH-CPA was increased 1.8-fold, the Cmax reduced 1.7-fold, and the AUC remained unchanged.
115 ; the t1/2 +/- SE was 9.1 +/- 1.3 hours, the Cmax was 2,549 +/- 291 ng/mL, the Vd was 3.97 +/- 0.95 L
116 cellized lutein, PLGA-NP lutein improved the Cmax in rat plasma by 15.6-fold and in selected tissues
117 r-individual variability was observed in the Cmax and Tmax of many of these compounds in both plasma
123 av]), peak concentration (Cmax), and time to Cmax (tmax) values were calculated from paired intraveno
125 y, maximum concentration [Cmax], and time to Cmax) were observed on Day 10 in subjects receiving tedu
127 he curve from 0-8 hours (AUC0-8), time until Cmax (Tmax), and half-life for moxifloxacin were 3.08 (I
128 in pharmacokinetic parameters estimated were Cmax, Tmax, t1/2, elimination rate constant, AUC0-t and
130 at specific sites correlated inversely with Cmax values, indicating that maximal levels of etoposide
131 files were very similar in both species with Cmax decreasing and Tmax increasing with increasing fatt
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