ライフサイエンスコーパス: Coccidioides

1 um of diseases caused by the dimorphic fungi Coccidioides.

2 the internal transcribed spacer 2 region of Coccidioides.

3 nocarpus reesii, which is closely related to Coccidioides.

4 dy could enhance phagocytosis and killing of Coccidioides.

5 nsfected with a cDNA encoding the protective Coccidioides-Ag2/proline-rich Ag.

6 tter understand the initial response between Coccidioides and the human host.

7 Spherules are the tissue form of Coccidioides, and we determined that the MR on bone marr

8 ected meningitis, in whom CSF was tested for Coccidioides antibodies and CAg, were retrospectively re

9 a, is usually diagnosed by detection of anti-Coccidioides antibodies in cerebrospinal fluid (CSF), an

10 The MVista anti-Coccidioides antibody enzyme immunoassay offers improved

11 IgG and IgM antibodies using the MVista anti-Coccidioides antibody enzyme immunoassay.

12 was to assess the diagnostic utility of CSF Coccidioides antigen (CAg) detection for the diagnosis o

13 press an epitope(s) that is specific to anti-Coccidioides CF antibody.

14 s also been shown to react with patient anti-Coccidioides complement-fixing (CF) antibody and is a va

15 Detection of anti-Coccidioides complement-fixing (CF) antibody is a valuab

16 Coccidioides DNA was amplified from serum by a PCR using

17 manifestation of disseminated infection with Coccidioides fungal species.

18 ne of the human respiratory fungal pathogen, Coccidioides immitis (Ci) was cloned, sequenced, chromos

19 The urease (URE)-encoding gene from Coccidioides immitis (Ci), a respiratory fungal pathogen

20 (URA5) gene of the human pathogenic fungus, Coccidioides immitis (Ci), was cloned, sequenced, chromo

21 from the human respiratory fungal pathogen, Coccidioides immitis (Ci), was cloned, sequenced, chromo

22 The endochitinase from Coccidioides immitis (CiX1) is a member of the class 18

23 principally with plants, the dimorphic fungi Coccidioides immitis and Coccidioides posadasii are prim

24 f the closely related human pathogenic fungi Coccidioides immitis and Coccidioides posadasii to more

25 s with those derived from the CiCHS1 gene of Coccidioides immitis and the AnCHSC gene of Aspergillus

26 n (coccidioidin) derived from mycelial-phase Coccidioides immitis and was reactive with human, canine

27 ious experiments have provided evidence that Coccidioides immitis antigen 2 (Ag2) is a major T-cell-r

28 n G2a (IgG2a), IgG2b, and IgG3 antibodies to Coccidioides immitis antigen; and the influx of CD4(+) a

29 Coccidioides immitis antigens which stimulate a T helper

30 For this reason, identification of Coccidioides immitis antigens which stimulate T cells is

31 Coccidioides posadasii and Coccidioides immitis are dimorphic, soil-dwelling pathog

32 tablished by lumbar intrathecal injection of Coccidioides immitis arthroconidia.

33 e report the structure and expression of the Coccidioides immitis BGL2 gene which encodes a previousl

34 Coccidioides immitis causes a benign upper respiratory t

35 this immunoreactive enzyme, we constructed a Coccidioides immitis cDNA lambda ZAP expression library

36 The AccuProbe Coccidioides immitis culture identification test (CI tes

37 test reagents from three different ACCUPROBE Coccidioides immitis culture identification test lots ha

38 e in autolysis of the parasitic cell wall of Coccidioides immitis during the asexual reproductive cyc

39 been isolated from the culture filtrates of Coccidioides immitis endosporulating spherules and from

40 We report the isolation of a Coccidioides immitis gene (SOWgp) which encodes an immun

41 xpressed the proline-rich antigen (PRA) from Coccidioides immitis in Escherichia coli and evaluated i

42 infection, B6 mice had nearly 100-fold more Coccidioides immitis in their lungs than did B10 mice (l

43 there is also a difference in resistance to Coccidioides immitis infection among inbred mouse strain

44 2 decades to determine the seroincidence of Coccidioides immitis infections among U.S. military memb

45 oculate 4 x 10(3)-1 x 10(6) arthroconidia of Coccidioides immitis into the cisterna magna.

46 Coccidioides immitis is a pathogenic, dimorphic fungus f

47 pient had no travel history to an area where Coccidioides immitis is endemic.

48 Multinucleate parasitic cells (spherules) of Coccidioides immitis isolates produce a membranous outer

49 2 (Ag2), a major immunoreactive component of Coccidioides immitis mycelium- and spherule-phase cell w

50 n which several unusual morphologic forms of Coccidioides immitis occurred in biopsy tissue from the

51 We identified 5 patients with disseminated Coccidioides immitis or Histoplasma capsulatum with hete

52 BAL fluid specimen with a known dilution of Coccidioides immitis organism.

53 n between IL-10 levels and susceptibility to Coccidioides immitis peritonitis in C57BL/6 (B6), DBA/2,

54 h either recombinant expression protein of a Coccidioides immitis spherule-derived proline-rich antig

55 s, we used a temperature-sensitive mutant of Coccidioides immitis to immunize mice lacking subsets of

56 microsatellite loci from the human pathogen Coccidioides immitis to show that genetic diversity in t

57 oline-rich coccidioidal antigen (Ag2/PRA) of Coccidioides immitis were analyzed by comparison as vacc

58 Antibodies against a 33-kDa antigen from Coccidioides immitis were detected by ELISA in patients'

59 Frozen hyphal suspensions of Coccidioides immitis were evaluated for suitability as p

60 emic of coccidioidomycosis (etiologic agent, Coccidioides immitis) occurred between 1991 and 1994 in

61 in protection against primary infection with Coccidioides immitis, a dimorphic fungal pathogen that c

62 Most infections due to Coccidioides immitis, although causing significant illne

63 onstrate persistent colonization of soils by Coccidioides immitis, an agent of valley fever, in Washi

64 We have taken this approach in a study of Coccidioides immitis, an ascomycete fungus responsible f

65 Coccidioides immitis, cause of a recent epidemic of "Val

66 h antigen (PRA), which protects mice against Coccidioides immitis, has been analyzed for differential

67 plasma capsulatum, Blastomyces dermatitidis, Coccidioides immitis, Paracoccidioides brasiliensis, Pen

68 le, water-soluble extract from cell walls of Coccidioides immitis, protects mice against lethal chall

69 civilians who reside or train in areas where Coccidioides immitis, the causative agent, is endemic.

70 lethal challenge of laboratory animals with Coccidioides immitis, was fractionated.

71 sent in the cell wall of the fungal pathogen Coccidioides immitis, was investigated in a murine model

72 inhibitor of the fungal chitinase CiX1 from Coccidioides immitis, with a K(i) of 60 nM.

73 ALB/c mice against intranasal infection with Coccidioides immitis.

74 stern United States, is caused by the fungus Coccidioides immitis.

75 epared from formaldehyde-killed spherules of Coccidioides immitis.

76 used to facilitate genetic transformation of Coccidioides immitis.

77 ains of mice vary in their susceptibility to Coccidioides immitis.

78 t encodes the complement fixation antigen of Coccidioides immitis.

79 nt in the cell walls of the dimorphic fungus Coccidioides immitis.

80 ains which differ in their susceptibility to Coccidioides immitis.

81 ation of spores of Coccidioides posadasii or Coccidioides immitis.

82 he ACCUPROBE culture identification test for Coccidioides immitis.

83 the isolated fungus (Histoplasma capsulatum, Coccidioides immitis/posadasii, Fusarium oxysporum, Aspe

84 and was shown to elicit T-cell responses in Coccidioides-immune mice.

85 d-type footpad hypersensitivity responses in Coccidioides-immune mice.

86 s not associated with the production of anti-Coccidioides immunoglobulin G antibody.

87 own about the nature of the host response to Coccidioides in extrapulmonary tissue.

88 plasma levels of NikZ that nearly eradicate Coccidioides in mice are achievable in patients and prov

89 ions among children with JIA were 3 cases of Coccidioides (incidence rate 21 per 100,000 person-years

90 of T cells, B cells, and neutrophils to the Coccidioides-infected hypodermis com pared to wild-type

91 17A-producing CD4(+) T cells in the lungs of Coccidioides-infected mice correlated with better fungal

92 T-cell immunity in nonvaccinated mice during Coccidioides infection but does not impede the developme

93 gnal pathways are required for resistance to Coccidioides infection following subcutaneous challenge

94 ansplant recipient likely reactivated latent Coccidioides infection in the donor lungs, leading to po

95 f the early events of protective immunity to Coccidioides infection in vaccinated mice contributes to

96 We previously reported a vaccine against Coccidioides infection which contained three recombinant

97 both Th17 and Th1 cells in their lungs after Coccidioides infection.

98 ed spherules failed to acquire resistance to Coccidioides infection.

99 10 suppresses Th1, Th2, and Th17 immunity to Coccidioides infection.

100 immunity is essential for protection against Coccidioides infection.

101 ssential for protection against subcutaneous Coccidioides infection.

102 attenuated vaccine-induced immunity against Coccidioides infection.

103 sting mannose receptor involvement in the DC-Coccidioides interaction.

104 ique by inferring the source populations for Coccidioides isolates recovered from patients treated ou

105 th their dead animal hosts in soil, and that Coccidioides metabolism genes, membrane-related proteins

106 IV-infected patient with a history of recent Coccidioides pneumonia but with negative Coccidioides se

107 Coccidioides posadasii and Coccidioides immitis are dimo

108 Aspergillus nidulans and the human pathogens Coccidioides posadasii and Histoplasma capsulatum.

109 also respond to the related dimorphic fungi Coccidioides posadasii and Paracoccidioides lutzii.

110 the dimorphic fungi Coccidioides immitis and Coccidioides posadasii are primary pathogens of immunoco

111 Coccidioides posadasii causes coccidioidomycosis, or Val

112 we describe the identification of endogenous Coccidioides posadasii contamination in commercial rhesu

113 us Hypothesizing that the homologous gene in Coccidioides posadasii could be important for virulence,

114 Coccidioides posadasii Deltachs5 is a satisfactory quali

115 Coccidioides posadasii Deltachs5 is a strain that is exc

116 y of recombinant T-cell-reactive proteins of Coccidioides posadasii in a murine model of coccidioidom

117 ch can stimulate protective immunity against Coccidioides posadasii infection in mice.

118 Coccidioides posadasii is a fungal respiratory pathogen

119 Coccidioides posadasii is a fungal respiratory pathogen

120 Coccidioides posadasii is a pathogenic fungus that cause

121 ugh the amino acid sequence of the urease of Coccidioides posadasii lacks a predicted signal peptide,

122 erminally truncated Aspergillus nidulans and Coccidioides posadasii mtTyrRSs.

123 infection caused by inhalation of spores of Coccidioides posadasii or Coccidioides immitis.

124 an pathogenic fungi Coccidioides immitis and Coccidioides posadasii to more clearly elucidate populat

125 from the heat shock protein gene (HSP60) of Coccidioides posadasii was used to control the transcrip

126 genic preparation derived from spherules (of Coccidioides posadasii), activate peripheral blood monon

127 nsible for such infections in North America (Coccidioides posadasii, Histoplasma capsulatum, and Blas

128 vaccinated with a live, attenuated mutant of Coccidioides posadasii, referred to as the DeltaT vaccin

129 both CD8(+) and CD4(+) T cells recruited to Coccidioides posadasii-infected lungs of nonvaccinated a

130 tected mice against pulmonary infection with Coccidioides posadasii.

131 c infections, including an increased rate of Coccidioides, Salmonella, and herpes zoster compared to

132 ent Coccidioides pneumonia but with negative Coccidioides serology determined by enzyme immunoassay a

133 ticles and then challenged intranasally with Coccidioides showed early lung infiltration of activated

134 An analysis of 40 Coccidioides sp. clinical isolates grown in culture demo

135 patients treated outside the endemic area of Coccidioides sp., the etiological agents of human coccid

136 Overall, the results suggest that Coccidioides species are not soil saprophytes, but that

137 sitivity in persons with past infection with Coccidioides species is again available for clinical use

138 tin synthase inhibitor with activity against Coccidioides species that is being developed as a first-

139 in a community hospital setting to identify Coccidioides species using the new Becton Dickinson mole

140 for defense against pulmonary infection with Coccidioides species.

141 internalizing, and presenting antigens from Coccidioides spherules and suggest that DC may play a cr

142 The endemic fungi Histoplasma capsulatum, Coccidioides spp, Blastomyces dermatitidis, and Paracocc

143 tested and demonstrated 100% specificity for Coccidioides spp.

144 ure are the most common means of identifying Coccidioides spp.

145 ed by the desert soil-borne fungal pathogens Coccidioides spp.

146 Coccidioides spp. (immitis and posadasii) are the causat

147 pp. (n = 9), Paracoccidioides spp. (n = 10), Coccidioides spp. (n = 9), Histoplasma spp. (n = 7) and

148 Coccidioides spp. are dimorphic fungal pathogens endemic

149 d 100% sensitivity and 98.4% specificity for Coccidioides spp. compared with culture.

150 A rapid method for the detection of Coccidioides spp. directly from clinical material will g

151 s to develop a real-time PCR assay to detect Coccidioides spp. directly from clinical specimens.

152 s been reported to harbor parasitic cells of Coccidioides spp. in collective cases of the disseminate

153 ne, correlate with susceptibility of mice to Coccidioides spp. infection.

154 owth in the saprobic and parasitic phases of Coccidioides spp. is partly responsible for production o

155 Susceptibility to Coccidioides spp. varies widely in humans and other mamm

156 ly sensitive and specific means of detecting Coccidioides spp., growth in culture may take up to 3 we

157 g an RT-PCR method on the BD Max to identify Coccidioides spp., with sensitivity equivalent to cultur

158 les genomes revealed evolutionary changes in Coccidioides that may underlie its infectious phenotype,

159 eses about the life history and evolution of Coccidioides, the genomes of several Onygenales, includi

160 We report a case of Coccidioides thyroiditis in an HIV-infected patient with

161 Diagnosis of Coccidioides thyroiditis was made based on histopatholog

162 s an airborne infection caused by the fungus Coccidioides, which is endemic to the southwestern Unite

163 ilar outcomes after pulmonary infection with Coccidioides, while vaccinated IL-1r1(-/-) mice revealed