ライフサイエンスコーパス: Cope rearrangement

1 erconvert through a [3,3] sigmatropic shift (Cope rearrangement).

2 , the [1,5]-H shift in Z-pentadiene, and the Cope rearrangement.

3 addition occurs by a tandem cyclopropanation/Cope rearrangement.

4 igmatropic shift of 1,5-hexadiene, i.e., the Cope rearrangement.

5 e negative correlation in AZ28-catalyzed oxy-Cope rearrangement.

6 a stepwise [6+4] cycloaddition followed by a Cope rearrangement.

7 hapten, which accelerate a unimolecular oxy-Cope rearrangement.

8 fragment enabled by an aromatization-driven Cope rearrangement.

9 ion of chirality to the gamma-position via a Cope rearrangement.

10 on of these adducts is possible via a facile Cope rearrangement.

11 l FA imaging that relies on a FA-induced aza-Cope rearrangement.

12 tal and theoretical evidence for an aromatic Cope rearrangement.

13 thermodynamic driving force for the aromatic Cope rearrangement.

14 monium cations capable of undergoing the aza Cope rearrangement.

15 n-allylation, enol ether hydrolysis, and the Cope rearrangement.

16 reactant confers on 1 the lowest barrier to Cope rearrangement.

17 erived from a combined C-H activation/siloxy-Cope rearrangement.

18 dienes required for an anion-accelerated oxy-Cope rearrangement.

19 reported examples of fully concerted allenyl Cope rearrangements.

20 cyclopropanation-Cope and translactonization-Cope rearrangements.

21 the development of tandem translactonization-Cope rearrangements.

22 An intramolecular anionic oxy-Cope rearrangement (44 --> 46) serves as the key step in

23 a's chiral allylzinc reagent, an anionic oxy-Cope rearrangement, a one-pot ozonolysis-reductive amina

24 ving an antibody AZ-28 that catalyses an oxy-Cope rearrangement, a pericyclic reaction that belongs t

25 hetic utility of the combined C-H activation/Cope rearrangement, achieved by dirhodium tetraprolinate

26 ies of substituted semibullvalenes and their Cope rearrangement activation barrier.

27 idered to occur by a tandem cyclopropanation/Cope rearrangement, although evidence is presented that

28 three-step sequence comprising a thermal oxy-Cope rearrangement, an iridium-catalyzed hydrogenation,

29 e by the sequential implementation of an oxy-Cope rearrangement and an intramolecular ene reaction, p

30 yrophosphate through a presumed biosynthetic Cope rearrangement and subsequent 6-exo-trig cyclization

31 ling by carbon in organic reactions, (6) the Cope rearrangement and the effect of substituents on it,

32 A diastereocontrolled (>30:1) anionic oxy-Cope rearrangement and the intramolecular rearrangement

33 e cyclopropanations, tandem cyclopropanation/Cope rearrangements and a combined C-H functionalization

34 scission, opening access to the interrupted Cope rearrangements and expanding the scope of this clas

35 ic oxidation, ketone allylation, anionic oxy-Cope rearrangement, and acid-promoted cyclization.

36 E)-cyclodeca-1,3,7-triene that are stable to Cope rearrangement, and reactions should proceed at clos

37 a's chiral allylzinc reagent, an anionic oxy-Cope rearrangement, and the Lewis acid-promoted cyclizat

38 nacol rearrangement, benzannulation, and oxy-Cope rearrangement are major pathways of transforming th

39 genic-beta-formyl amides in asymmetric 2-aza-Cope rearrangements are described.

40 plished by using the combined C-H activation/Cope rearrangement as the key step and the previously sy

41 rgies, the activation free energy of the oxy-Cope rearrangement becomes larger in the mature antibody

42 The tandem cyclopropanation/Cope rearrangement between bicyclic dienes and siloxyvin

43 of regioselectively tunable conditions for a Cope rearrangement between C3 and C4 positions.

44 ization process, the combined C-H activation/Cope rearrangement, between methyl (E)-2-diazo-3-penteno

45 ese reactions was shown to occur by 2-oxonia-Cope rearrangements by way of a (Z)-oxocarbenium ion int

46 Oxonia-Cope rearrangements can be disfavored by destabilizing t

47 -assisted asymmetric anion-accelerated amino-Cope rearrangement cascades.

48 The combined C-H activation/Cope rearrangement (CHCR) is an effective C-H functional

49 g affinity and the catalytic rate of the oxy-Cope rearrangement compared to the germ line catalytic a

50 A rapid Cope rearrangement converts the [6+4] adduct into the ob

51 conjugative propargylation, 2) one-pot enyne Cope rearrangement/deconjugative propargylation, and 3)

52 yclohexenone followed by methylation and oxy-Cope rearrangement delivered enantiomerically enriched 2

53 on of a cyclic enone followed by anionic oxy-Cope rearrangement delivered the ketone as a mixture of

54 However, the analogous base-promoted oxy-aza-Cope rearrangement does take place to form cis-hydroisoq

55 al cavity is capable of catalyzing the 3-aza-Cope rearrangement enantioselectively, with yields of 21

56 mation, [2,3]-sigmatropic rearrangement, oxy-Cope rearrangement, enol-keto tautomerization and finall

57 The oxy-anion Cope rearrangement followed by protonation of the enolat

58 icyclic spirolactams resulting from aromatic Cope rearrangements followed by ene reactions.

59 wt DMATS and FgaPT2) versus an indole C3-C4 "Cope" rearrangement followed by rearomatization (for mut

60 Reduction of the latter, followed by Cope rearrangement generates cycloheptadienylmethanols.

61 itial products can be induced to undergo oxy-Cope rearrangements giving 2,5-hexadienals (9).

62 etheno bridge in 3 makes the barrier for its Cope rearrangement higher than that for 4 and also contr

63 ect C-H insertion product undergoes a siloxy-Cope rearrangement in a stereoselective manner.

64 panantion and/or the combined C-H activation/Cope rearrangement in good overall yield and with good d

65 Since the discovery of the Cope rearrangement in the 1940s, no asymmetric variant o

66 method favors the concerted mechanism of the Cope rearrangement involving an aromatic transition stat

67 barrier of approximately 6 kcal/mol for the Cope rearrangement is consistent with the stepwise mecha

68 A detailed examination of the use of aza-Cope rearrangement-Mannich cyclization sequences for ass

69 the synthesis utilizes a tandem cationic aza-Cope rearrangement/Mannich cyclization reaction for acce

70 Using a sequential base-promoted oxy-aza-Cope rearrangement/Mannich cyclization sequence, gram qu

71 The 2-oxonia Cope rearrangement may be a factor in the regioselectivi

72 The route begins with the tandem anionic oxy-Cope rearrangement/methylation/transannular ene cyclizat

73 Previous studies have shown that the allenyl Cope rearrangement of 1,2, 6-heptatriene (1) to 3-methyl

74 opropanation and the combined C-H activation/Cope rearrangement of 1,2-dihydronaphthalenes are methyl

75 ve been used to examine the mechanism of the Cope rearrangement of 1,5-hexadiene.

76 However, the relatively low barrier to the Cope rearrangement of 2 is largely due to the TS for thi

77 Oxy-Cope rearrangement of 8 followed by a secondary addition

78 tion at C-1, (ii) Wittig reaction, and (iii) Cope rearrangement of a 1,5-diene derivative, is reporte

79 Gold(I) catalysts effectively promote the Cope rearrangement of acyclic 1,5-dienes bearing a termi

80 lecular tetrahedron that catalyzes the 3-aza-Cope rearrangement of allyl enammonium cations.

81 s employed as a catalytic host for the 3-aza Cope rearrangement of allyl enammonium cations.

82 adien-3-ol, we have found that the gas-phase Cope rearrangement of both tertiary and secondary alkoxi

83 The Cope rearrangement of cyclo-biphenalenyl 9 is studied by

84 The degenerate Cope rearrangement of semibullvalene, a pericyclic react

85 atom tunneling is involved in the degenerate Cope rearrangement of semibullvalenes at cryogenic tempe

86 The low activation barrier to the Cope rearrangement of semibullvalenes has been attribute

87 state analogue (TSA) 1 and catalyzes the oxy-Cope rearrangement of substrate 2 to product 3.

88 tly, the conformationally restricted allenyl Cope rearrangement of syn-7-allenylnorbornene (7) has al

89 (pi)2 cycloadditions and, especially, rapid Cope rearrangement of the products, but, in many cases,

90 proceeds by a cyclopropanation followed by a Cope rearrangement of the resulting divinylcyclopropane.

91 tallo-Nazarov cyclization/1,6-enyne addition/Cope rearrangement of the substrate was found to selecti

92 The effects of fluorine substitution on the Cope rearrangements of 1,5-hexadiene and 2,2'-bis-methyl

93 relative barrier heights for the degenerate Cope rearrangements of semibullvalene (1), barbaralane (

94 /(6,6)CASSCF/6-31G level calculations on the Cope rearrangements of syn-5-ethenylbicyclo[2.1.0]pent-2

95 for the conformationally restricted allenyl Cope rearrangements of syn-5-propadienylbicylco[2.1.0]pe

96 [3,3]-Sigmatropic shifts (hetero-Cope rearrangements) of the corresponding allyl, proparg

97 e synthesis include a diastereoselective oxy-Cope rearrangement/oxidation sequence to install the C(1

98 lude a strategy-level diastereoselective oxy-Cope rearrangement/oxidation sequence, a Petasis-Ferrier

99 acts as the 4pi component, and a subsequent Cope rearrangement produces the formal [6F + 4T] adduct.

100 nown for its anticancer activity, and of its Cope rearrangement product curzerene, was achieved by HP

101 The oxy-Cope rearrangement reaction in the antibody AZ28 is inve

102 hose formed from the tandem cyclopropanation/Cope rearrangement reaction of vinylcarbenes with dienes

103 y undergo the combined C-H functionalization/Cope rearrangement reaction via an s-cis/boat transition

104 The key step is a tandem Ireland Claisen/Cope rearrangement sequence, wherein the Ireland Claisen

105 ed our understanding of the cyclopropanation-Cope rearrangement sequence.

106 ) to have transition structures for boatlike Cope rearrangement that are equal to or lower in energy

107 n in turn drives a highly efficient silyloxy-Cope rearrangement that delivers the tetracyclic core of

108 barriers to cyclization, leads to a stepwise Cope rearrangement that is, nevertheless, stereoselectiv

109 Unlike the TS in the Cope rearrangement, the TS for a 1,5-hydrogen shift in 1

110 anomer of the 1,5-diene derivative underwent Cope rearrangement to afford 2-deoxy-2-C-glycal derivati

111 intermediate which rapidly undergoes a 1-aza-Cope rearrangement to generate fused dihydroazepine deri

112 t relies on a diastereoselective anionic oxy-Cope rearrangement to set the relative configuration of

113 This convergent synthesis utilizes oxonia Cope rearrangements to prepare two key homoallylic alcoh

114 he first step of this sequence, cationic aza-Cope rearrangement, to form cis-hydroisoquinolinium ions

115 BDTS, HCDTS, and BTS and the chair and boat Cope rearrangement TSs (CCTS and BCTS) are discussed.

116 red ring, and that strain in turn drives the Cope rearrangement under unusually mild thermal conditio

117 The mechanism of the amino-Cope rearrangement was explored with density functional

118 The oxonia-Cope rearrangement was shown to occur rapidly under typi

119 An oxonia-Cope rearrangement was used as an internal clock reactio

120 gements and a combined C-H functionalization/Cope rearrangement were achieved using Rh(2)(R-BTPCP)(4)

121 n a low-temperature anion-accelerated alkoxy-Cope rearrangement which proceeds by way of a strained c

122 halene undergoes the combined C-H activation/Cope rearrangement while the other undergoes cyclopropan

123 They undergo fast, nearly degenerate Cope rearrangement with an activation barrier similar to