ライフサイエンスコーパス: Creutzfeldt-Jakob disease

1 e correct histological diagnosis of sporadic Creutzfeldt-Jakob disease.

2 e hitherto recognized phenotypic spectrum of Creutzfeldt-Jakob disease.

3 he most common human prion disease, sporadic Creutzfeldt-Jakob disease.

4 ng autoimmune encephalopathies from sporadic Creutzfeldt-Jakob disease.

5 ce of human-to-human transmission of variant Creutzfeldt-Jakob disease.

6 ted into the diagnostic criteria of sporadic Creutzfeldt-Jakob disease.

7 disease, nephrogenic diabetes insipidus, and Creutzfeldt-Jakob disease.

8 abnormalities that closely resemble sporadic Creutzfeldt-Jakob disease.

9 d either inherited prion disease or sporadic Creutzfeldt-Jakob disease.

10 me have met diagnostic criteria for sporadic Creutzfeldt-Jakob disease.

11 iduals resembled those of classical sporadic Creutzfeldt-Jakob disease.

12 observed in sporadic, iatrogenic and variant Creutzfeldt-Jakob disease.

13 nine homozygote to both sporadic and variant Creutzfeldt-Jakob disease.

14 arkinson's disease, motor neuron disease and Creutzfeldt-Jakob disease.

15 can be acquired, as is the case for variant Creutzfeldt-Jakob disease.

16 ts both between and within cases of sporadic Creutzfeldt-Jakob disease.

17 in a unique series of nine cases of variant Creutzfeldt-Jakob disease.

18 us system (CNS) in five of six patients with Creutzfeldt-Jakob disease.

19 evere acute respiratory syndrome, or variant Creutzfeldt-Jakob disease.

20 cephalopathy (BSE) prions causes new variant Creutzfeldt-Jakob disease.

21 tance of some sheep to scrapie and humans to Creutzfeldt-Jakob disease.

22 such as bovine spongiform encephalopathy and Creutzfeldt-Jakob disease.

23 uman beings affected by sporadic and variant Creutzfeldt-Jakob disease.

24 bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease.

25 of patients affected by the E200K variant of Creutzfeldt-Jakob disease.

26 s for therapy, for example, in 'new variant' Creutzfeldt-Jakob disease.

27 y of 80 to 90% for the diagnosis of sporadic Creutzfeldt-Jakob disease.

28 symmetric pattern of involvement in sporadic Creutzfeldt-Jakob disease.

29 patitis C virus, enterovirus 70, and variant Creutzfeldt-Jakob disease.

30 00% (95% CI, 90 to 100) for the detection of Creutzfeldt-Jakob disease.

31 vities in the total white matter in sporadic Creutzfeldt-Jakob disease.

32 with human prions, such as those involved in Creutzfeldt-Jakob disease.

33 disease in humans were diagnosed as variant Creutzfeldt-Jakob disease.

34 rved in experimental, acquired, and sporadic Creutzfeldt-Jakob diseases.

35 ases including Alzheimer's, Parkinson's, and Creutzfeldt-Jakob diseases.

36 nt diagnoses were Alzheimer's disease (18%), Creutzfeldt-Jakob disease (12%) and inflammatory disorde

37 kob disease (15 of 15 with definite sporadic Creutzfeldt-Jakob disease, 13 of 14 with probable sporad

38 ings were positive in 30 of 31 patients with Creutzfeldt-Jakob disease (15 of 15 with definite sporad

39 f 14 patients with the E200K genetic form of Creutzfeldt-Jakob Disease, 20 healthy carriers of this m

40 he 77 patients who have developed iatrogenic Creutzfeldt-Jakob disease, 56 have been genotyped.

41 Infection of mice with an attenuated Creutzfeldt-Jakob disease agent (SY-CJD) interferes with

42 enotype individual can propagate the variant Creutzfeldt-Jakob disease agent and that the infectious

43 s hypothalamic GT cells infected with the FU Creutzfeldt-Jakob disease agent, but not parallel mock c

44 tly demonstrated transmission of the variant Creutzfeldt-Jakob disease agent.

45 Sc) that accumulates in the brain in variant Creutzfeldt-Jakob disease also contains a minority type

46 m human post-mortem samples, of both variant Creutzfeldt-Jakob disease and Alzheimer's disease patien

47 c human neurodegenerative conditions variant Creutzfeldt-Jakob disease and Alzheimer's disease.

48 om donors who subsequently developed variant Creutzfeldt-Jakob disease and an asymptomatic red cell t

49 eases of humans and other animals, including Creutzfeldt-Jakob disease and bovine spongiform encephal

50 Familial Creutzfeldt-Jakob disease and cerebrotendinous xanthomat

51 able at low levels in some cases of sporadic Creutzfeldt-Jakob disease and conversely, that the form

52 on is believed responsible for most cases of Creutzfeldt-Jakob disease and for initiating the mad cow

53 iform encephalopathies (variant and sporadic Creutzfeldt-Jakob disease and genetic forms of prion dis

54 is related to various human diseases such as Creutzfeldt-Jakob disease and Gerstmann-Straussler-Schei

55 e only in the urine of patients with variant Creutzfeldt-Jakob disease and had the typical electropho

56 und in all of the major subtypes of sporadic Creutzfeldt-Jakob disease and in a case of iatrogenic Cr

57 samples obtained from patients with variant Creutzfeldt-Jakob disease and in none of the 224 urine s

58 m nasal brushings was accurate in diagnosing Creutzfeldt-Jakob disease and indicated substantial prio

59 Twenty-six patients with sporadic Creutzfeldt-Jakob disease and nine age- and gender-match

60 opagation of prions, the causative agents of Creutzfeldt-Jakob disease and other human prion diseases

61 re immediate candidates for the treatment of Creutzfeldt-Jakob disease and other prion diseases.

62 tes in the brains of patients suffering from Creutzfeldt-Jakob disease and related conditions, such a

63 n the pathogenesis of prion diseases such as Creutzfeldt-Jakob disease and scrapie.

64 patients with and patients without sporadic Creutzfeldt-Jakob disease and tested them using RT-QuIC,

65 the clinicopathological diversity evident in Creutzfeldt-Jakob disease and whether different prion pr

66 ogical conditions, including Alzheimer's and Creutzfeldt-Jakob diseases and type II diabetes.

67 kob disease, 13 of 14 with probable sporadic Creutzfeldt-Jakob disease, and 2 of 2 with inherited Cre

68 ion diseases, including sheep scrapie, human Creutzfeldt-Jakob disease, and cervid chronic wasting di

69 is centrally involved in the pathogenesis of Creutzfeldt-Jakob Disease, and its anatomical connection

70 tions can be detected early in the course of Creutzfeldt-Jakob Disease, and years before symptomatic

71 tions more common in the T/BG group included Creutzfeldt-Jakob disease, arbovirus, and Mycobacterium

72 Prion diseases such as Creutzfeldt-Jakob disease are possibly caused by the con

73 gregates derived from patients with sporadic Creutzfeldt-Jakob disease are taken up and degraded by i

74 Human prion diseases such as Creutzfeldt-Jakob disease are transmissible brain protei

75 either Creutzfeldt-Jakob disease or variant Creutzfeldt-Jakob disease are transmitted by transfusion

76 spongiform encephalopathies, such as variant Creutzfeldt-Jakob disease, are believed to result from i

77 cluding bovine spongiform encephalopathy and Creutzfeldt-Jakob disease, are usually characterized by

78 , in brain samples from humans with sporadic Creutzfeldt-Jakob disease, as well as in rodents with ex

79 dt-Jakob disease and in a case of iatrogenic Creutzfeldt-Jakob disease associated with growth hormone

80 and may be clinically mistaken for sporadic Creutzfeldt-Jakob disease because of a negative family h

81 ges that allowed early diagnosis of probable Creutzfeldt-Jakob disease before the characteristic clin

82 PrP(TSE)) when exposed to medium spiked with Creutzfeldt-Jakob disease brain homogenate, resulting in

83 -fold dilution of 10% (wt/vol) human variant Creutzfeldt-Jakob disease brain homogenate, with >3,800-

84 ned intensely for PrP(TSE) after exposure to Creutzfeldt-Jakob disease brain homogenate.

85 ldt-Jakob disease, and 2 of 2 with inherited Creutzfeldt-Jakob disease) but were negative in 43 of 43

86 ular system is a defining feature of variant Creutzfeldt-Jakob disease, but that the biochemical isof

87 cuses on transfusion-transmission of variant Creutzfeldt-Jakob disease by red cell preparations.

88 by this review, the transmission of variant Creutzfeldt-Jakob disease by transfusion has been confir

89 a precaution against transmission of variant Creutzfeldt-Jakob disease by transfusion of domestic blo

90 al prion protein that characterizes sporadic Creutzfeldt-Jakob disease can be found in certain brain

91 Recent evidence that variant Creutzfeldt-Jakob disease can be transmitted by transfus

92 and findings were followed-up in six variant Creutzfeldt-Jakob disease cases with 9.4 T high-resoluti

93 n parameters from a UK cohort of 171 variant Creutzfeldt-Jakob disease cases.

94 In an effort to prevent new variant Creutzfeldt-Jakob disease, certain "specified offals," i

95 beta null and wild-type (wt) controls with a Creutzfeldt-Jakob disease (CJD) agent.

96 Heightened awareness of Creutzfeldt-Jakob disease (CJD) among physicians and the

97 rP(Sc) aggregates extracted from 60 sporadic Creutzfeldt-Jakob disease (CJD) and 6 variant CJD brains

98 Creutzfeldt-Jakob disease (CJD) and autoimmune encephali

99 demyelinating disease, Alzheimer's disease, Creutzfeldt-Jakob disease (CJD) and Gerstmann-Straussler

100 between the invariably lethal prion disease Creutzfeldt-Jakob disease (CJD) and nonprion rapidly pro

101 Prion protein (PrP) plays a central role in Creutzfeldt-Jakob Disease (CJD) and other transmissible

102 Human Creutzfeldt-Jakob disease (CJD) and similar neurodegener

103 g disease in deer and elk, and Kuru disease, Creutzfeldt-Jakob disease (CJD) and variant CJD in human

104 typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distingui

105 ile cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and part

106 Prion diseases such as Creutzfeldt-Jakob disease (CJD) are fatal, neuro-degener

107 Prion diseases such as Creutzfeldt-Jakob disease (CJD) are incurable and rapidl

108 ns from the brains of patients with sporadic Creutzfeldt-Jakob disease (CJD) bind to very low-density

109 uman brain extracts demonstrated that PrP in Creutzfeldt-Jakob disease (CJD) brains is cleaved by a c

110 lecular data from a large number of sporadic Creutzfeldt-Jakob disease (CJD) cases.

111 pendent reports have claimed anticipation in Creutzfeldt-Jakob disease (CJD) caused by the c.598G > A

112 rm encephalopathy (BSE) to humans as variant Creutzfeldt-Jakob disease (CJD) has affected over 100 in

113 Creutzfeldt-Jakob disease (CJD) has been accidentally tr

114 Although surgical transmission of Creutzfeldt-Jakob disease (CJD) has been demonstrated, t

115 Previous studies in Creutzfeldt-Jakob disease (CJD) have shown that myeloid

116 al, neurodegenerative diseases which include Creutzfeldt-Jakob disease (CJD) in humans and bovine spo

117 le neurodegenerative conditions that include Creutzfeldt-Jakob disease (CJD) in humans and bovine spo

118 Creutzfeldt-Jakob disease (CJD) in humans has been shown

119 ssible neurodegenerative disorders including Creutzfeldt-Jakob disease (CJD) in humans, is the conver

120 ephalopathy (BSE) and scrapie in animals and Creutzfeldt-Jakob disease (CJD) in humans.

121 cephalopathy (BSE) in cattle and PrP(CJD) in Creutzfeldt-Jakob disease (CJD) in humans.

122 Importance: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenera

123 Creutzfeldt-Jakob disease (CJD) is a neurodegenerative d

124 Creutzfeldt-Jakob disease (CJD) is a rare but invariably

125 Creutzfeldt-Jakob disease (CJD) is a rare progressive ne

126 Early and accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is necessary for quickly

127 Sporadic Creutzfeldt-Jakob disease (CJD) is the most prevalent ma

128 Variant Creutzfeldt-Jakob disease (CJD) is thought to be caused

129 First, we successfully propagated various Creutzfeldt-Jakob disease (CJD) isolates (sporadic, vari

130 cal heterogeneity, including patients with a Creutzfeldt-Jakob disease (CJD) phenotype.

131 pletely resistant to both kuru and classical Creutzfeldt-Jakob disease (CJD) prions (which are closel

132 s (PrPs) have shorter incubation periods for Creutzfeldt-Jakob disease (CJD) prions than mice express

133 More than two hundred individuals developed Creutzfeldt-Jakob disease (CJD) worldwide as a result of

134 ), frontotemporal lobar degeneration (FTLD), Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD

135 myoclonic jerks develop in individuals with Creutzfeldt-Jakob disease (CJD), an incurable brain diso

136 nd deer with those in subjects with sporadic Creutzfeldt-Jakob disease (CJD), as well as CJD-affected

137 ses numerous neurological diseases including Creutzfeldt-Jakob disease (CJD), but the aggregation mec

138 e most common human prion disorder, sporadic Creutzfeldt-Jakob disease (CJD), in which prions are for

139 giform encephalopathy to people as a variant Creutzfeldt-Jakob disease (CJD), it becomes critical to

140 replication of the infectious agents causing Creutzfeldt-Jakob disease (CJD), scrapie, and bovine spo

141 Compared with a mouse model of transmissible Creutzfeldt-Jakob disease (CJD), the ataxia of Tg(A116V)

142 Creutzfeldt-Jakob disease (CJD), the first transmissible

143 Creutzfeldt-Jakob disease (CJD), the most common human p

144 hat cause neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD).

145 en done aside from a small sample of variant Creutzfeldt-Jakob disease (CJD).

146 tic fluid, in a pregnant woman with sporadic Creutzfeldt-Jakob disease (CJD).

147 The most common human prion disease is Creutzfeldt-Jakob disease (CJD).

148 agnostic procedures were applied to diagnose Creutzfeldt-Jakob disease (CJD).

149 e and specific cerebrospinal fluid marker of Creutzfeldt-Jakob disease (CJD).

150 to mRNA expression in three rodent models of Creutzfeldt-Jakob disease (CJD).

151 cases of prion disease in humans, including Creutzfeldt-Jakob disease (CJD).

152 PrP(Sc) prion causes the rare human disorder Creutzfeldt-Jakob disease (CJD).

153 His conditions were initially diagnosed as Creutzfeldt-Jakob disease (CJD).

154 sceptible to prions from humans with variant Creutzfeldt-Jakob disease (CJD); on second passage in Tg

155 re classified as either familial or sporadic Creutzfeldt-Jakob disease (CJD); there was no case of va

156 ation associated with one of these diseases [Creutzfeldt-Jakob disease (CJD)] that was exactly analog

157 rophic lateral sclerosis (FTD/ALS, n = 252), Creutzfeldt-Jakob disease (CJD, n = 239), Parkinson's di

158 maging to study the white matter in sporadic Creutzfeldt-Jakob disease compared to healthy control su

159 samples obtained from patients with variant Creutzfeldt-Jakob disease contained minute quantities of

160 b disease (to date, 1,147 cases of confirmed Creutzfeldt-Jakob disease deaths in the United Kingdom s

161 sorders: fatal familial insomnia or familial Creutzfeldt-Jakob disease, depending upon the presence o

162 In sporadic Creutzfeldt-Jakob disease, disease-associated PrP(Sc) is

163 Patients with iatrogenic Creutzfeldt-Jakob disease due to administration of cadav

164 Back-calculation analysis of the variant Creutzfeldt-Jakob disease epidemic in the United Kingdom

165 f growth hormone derived from a patient with Creutzfeldt-Jakob disease expressing prion protein valin

166 urodegenerative disorders that include Kuru, Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinke

167 The recent emergence of variant Creutzfeldt-Jakob disease has led to major public health

168 The outbreak of new variant Creutzfeldt-Jakob disease has raised the specter of a po

169 fusion recipient, who did not die of variant Creutzfeldt-Jakob disease, has been identified with prio

170 Three cases of variant Creutzfeldt-Jakob disease have been identified following

171 vious definite and probable cases of variant Creutzfeldt-Jakob disease have been methionine homozygot

172 ephalopathy to humans in the form of variant Creutzfeldt Jakob disease, have raised concerns about th

173 long been used in the diagnosis of sporadic Creutzfeldt-Jakob disease; however, the characteristic w

174 orts (FTLD, ALS, Alzheimer disease, sporadic Creutzfeldt-Jakob disease, Huntington disease-like syndr

175 fatal neurodegenerative conditions including Creutzfeldt-Jakob disease in humans and scrapie and bovi

176 tal neurodegenerative disorders that include Creutzfeldt-Jakob disease in humans, scrapie in sheep an

177 fatal neurodegenerative diseases, including Creutzfeldt-Jakob disease in humans, scrapie in sheep an

178 ly occurring scrapie in sheep and of variant Creutzfeldt-Jakob disease in humans.

179 sheep, bovine spongiform encephalopathy, and Creutzfeldt-Jakob disease in humans.

180 Definite diagnosis of sporadic Creutzfeldt-Jakob disease in living patients remains a c

181 olfactory epithelium in diagnosing sporadic Creutzfeldt-Jakob disease in living patients.

182 of 24 patients who have developed iatrogenic Creutzfeldt-Jakob disease in the UK since 2003.

183 ithin the cohort of patients with iatrogenic Creutzfeldt-Jakob disease in the UK suggests that there

184 for three individuals diagnosed with variant Creutzfeldt-Jakob disease in the USA and Canada.

185 ections with variant, sporadic, and familial Creutzfeldt-Jakob disease, in the presence of blood comp

186 d with other transmission studies in variant Creutzfeldt-Jakob disease, including those on the spleen

187 t were negative in 43 of 43 patients without Creutzfeldt-Jakob disease, indicating a sensitivity of 9

188 r significant numbers of subclinical variant Creutzfeldt-Jakob disease individuals in at least the Un

189 Sporadic Creutzfeldt-Jakob disease is considered primarily a dise

190 The incubation period of iatrogenic Creutzfeldt-Jakob disease is significantly different bet

191 Sporadic Creutzfeldt-Jakob disease is the most common of the huma

192 of humans and animals, one of which (variant Creutzfeldt-Jakob disease) is known to be a zoonotic for

193 novel acquired human prion disease, variant Creutzfeldt-Jakob disease, is thought to result from ora

194 t disease phenotypes, identified as sporadic Creutzfeldt-Jakob disease (M/M2 sCJD) and sporadic fatal

195 n the white matter of patients with sporadic Creutzfeldt-Jakob disease, mainly in the left hemisphere

196 in many neurodegenerative diseases including Creutzfeldt-Jakob disease, motor neuron disease and Alzh

197 59) and compare these with cases of sporadic Creutzfeldt-Jakob disease (n = 170) in the United Kingdo

198 PrP(Sc) from autopsy-proved cases of variant Creutzfeldt-Jakob disease (n = 59) and compare these wit

199 also highly susceptible to a new variant of Creutzfeldt-Jakob disease (nvCJD) and natural sheep scra

200 35 deaths had been attributed to new variant Creutzfeldt-Jakob disease (nvCJD) in the United Kingdom,

201 re was no evidence of any death from variant Creutzfeldt-Jakob disease or from conditions that could

202 There is no evidence that either Creutzfeldt-Jakob disease or variant Creutzfeldt-Jakob d

203 an occur as an idiopathic disorder (sporadic Creutzfeldt-Jakob disease) or can be acquired, as is the

204 rion protein disease with this feature after Creutzfeldt-Jakob disease, originally reported in 1920.

205 Risk assessments for transmission of variant Creutzfeldt-Jakob disease predicted that leukocyte reduc

206 In variant Creutzfeldt-Jakob disease, prion replication is thought

207 Evidence suggests that variant Creutzfeldt-Jakob disease prions circulate in body fluid

208 it was ineffective in slowing propagation of Creutzfeldt-Jakob disease prions in transgenic mice.

209 nerative diseases, and arguably, scrapie and Creutzfeldt-Jakob disease prions represent the best ther

210 were concurrently less susceptible to human Creutzfeldt-Jakob disease prions.

211 Cumulatively, the data show that sporadic Creutzfeldt-Jakob disease PrP(Sc) is not a single confor

212 phic codon in humans associated with variant Creutzfeldt-Jakob disease, pulls the N terminus into the

213 his case report from the Australian National Creutzfeldt-Jakob Disease Registry concerns a 61-year-ol

214 ders, the solution structure of the familial Creutzfeldt-Jakob disease-related E200K variant of human

215 Conditions including Alzheimer's and Creutzfeldt-Jakob diseases represent, on this basis, pat

216 review of patients referred to the National Creutzfeldt-Jakob Disease Research & Surveillance Unit d

217 thought to confer susceptibility to sporadic Creutzfeldt-Jakob disease (rs1029273), all patients were

218 n clinic who were suspected to have sporadic Creutzfeldt-Jakob disease (sCJD) and yet were found to h

219 cerebrospinal fluid (CSF) tests for sporadic Creutzfeldt-Jakob disease (sCJD) are based on the detect

220 The sporadic form of Creutzfeldt-Jakob disease (sCJD) has been classified on

221 tal insomnia (sFI) and a subtype of sporadic Creutzfeldt-Jakob disease (sCJD) identified as sCJDMM2,

222 A case of sporadic Creutzfeldt-Jakob disease (sCJD) is described in a young

223 QuIC differentiated 94% of cases of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 from the sCJD MM2 p

224 studies confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype.

225 both hamster Sc237 prions and human sporadic Creutzfeldt-Jakob disease (sCJD) prions.

226 ding, the most common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive

227 with the most common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive

228 ct subtypes have been identified in sporadic Creutzfeldt-Jakob disease (sCJD), based on the methionin

229 brains of two patients, who died of sporadic Creutzfeldt-Jakob disease (sCJD), contained either sCJD(

230 Human sporadic Creutzfeldt-Jakob disease (sCJD), endemic sheep scrapie,

231 und PrP species present in control, sporadic Creutzfeldt-Jakob disease (sCJD), or variant CJD (vCJD)

232 the heart tissue of a patient with sporadic Creutzfeldt-Jakob Disease (sCJD), the most common form o

233 nic differences in individuals with sporadic Creutzfeldt-Jakob disease (sCJD).

234 ptible to prions from patients with sporadic Creutzfeldt-Jakob disease (sCJD).

235 o neuronal antigens misdiagnosed as sporadic Creutzfeldt-Jakob disease (sCJD).

236 rP species has been also claimed in sporadic Creutzfeldt-Jakob disease (sCJD).

237 as diverse as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease share a common pathogenetic me

238 fusivity within the white matter in sporadic Creutzfeldt-Jakob disease, suggesting possible primary i

239 s a single PrP(Sc) molecular type in variant Creutzfeldt-Jakob disease (termed type 2B), presumably r

240 PrP(Sc) was found in all 21 cases of variant Creutzfeldt-Jakob disease tested, irrespective of brain

241 A test that detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)),

242 PrP 129M/V polymorphism protects people from Creutzfeldt-Jakob disease, the Sup35p polymorphisms were

243 As of mid-2016, 231 cases of variant Creutzfeldt-Jakob disease-the human form of a prion dise

244 The results show PrP(Sc) in variant Creutzfeldt-Jakob disease to be remarkably stereotyped.

245 , such as endotoxemia, sepsis, or iatrogenic Creutzfeldt-Jakob disease (to date, 1,147 cases of confi

246 xamined, and was also present in the variant Creutzfeldt-Jakob disease tonsil.

247 rent understanding of the risks of (variant) Creutzfeldt-Jakob disease transmission via dental practi

248 Variant Creutzfeldt-Jakob disease (variant CJD) is difficult to

249 maining patients, dementia with Lewy bodies, Creutzfeldt-Jakob disease, vascular or unclassified deme

250 Variant Creutzfeldt-Jakob disease (vCJD) and bovine spongiform e

251 he fatal neurodegenerative condition variant Creutzfeldt-Jakob disease (vCJD) and, based on recent hu

252 dy indicates a prototype blood-based variant Creutzfeldt-Jakob disease (vCJD) assay has sufficient se

253 truments from, a deceased carrier of variant Creutzfeldt-Jakob disease (vCJD) can be followed up to q

254 as a result of the rising number of variant Creutzfeldt-Jakob disease (vCJD) cases.

255 Variant Creutzfeldt-Jakob disease (vCJD) differs from other huma

256 Variant Creutzfeldt-Jakob disease (vCJD) has a pathogenesis dist

257 Variant Creutzfeldt-Jakob disease (vCJD) has been recognized to

258 Person-to-person transmission of variant Creutzfeldt-Jakob disease (vCJD) has occurred through bl

259 Infections with variant Creutzfeldt-Jakob disease (vCJD) have almost exclusively

260 A small number of patients with variant Creutzfeldt-Jakob disease (vCJD) have been treated with

261 We report a case of preclinical variant Creutzfeldt-Jakob disease (vCJD) in a patient who died f

262 ease reputed to be zoonotic, causing variant Creutzfeldt-Jakob disease (vCJD) in humans and having gu

263 relevant to the current outbreak of variant Creutzfeldt-Jakob disease (vCJD) in the United Kingdom,

264 The development of variant Creutzfeldt-Jakob disease (vCJD) in three recipients of

265 r relative human exposure levels and variant Creutzfeldt-Jakob disease (vCJD) incidence.

266 Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegener

267 Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegener

268 Variant Creutzfeldt-Jakob disease (vCJD) is a novel human prion

269 Variant Creutzfeldt-Jakob disease (vCJD) is a unique and highly

270 lity to, and clinical expression of, variant Creutzfeldt-Jakob disease (vCJD) is essential for future

271 Concerns have been raised that variant Creutzfeldt-Jakob disease (vCJD) might be transmissible

272 cal variation in the distribution of variant Creutzfeldt-Jakob disease (vCJD) might indicate the tran

273 mples, from prion-affected patients (variant Creutzfeldt-Jakob disease (vCJD) n = 20, iatrogenic CJD

274 spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) prions are faithfully m

275 The transmission of variant Creutzfeldt-Jakob disease (vCJD) through blood transfusi

276 o be a reservoir for transmission of variant Creutzfeldt-Jakob disease (vCJD) to humans.

277 reasing concern since the reports of variant Creutzfeldt-Jakob disease (vCJD) transmission through bl

278 Interindividual variant Creutzfeldt-Jakob disease (vCJD) transmission through bl

279 fication of possible transmission of variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion h

280 timates for the risk of transmitting variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion h

281 Variant Creutzfeldt-Jakob disease (vCJD) was first described in

282 Variant Creutzfeldt-Jakob Disease (vCJD) was first reported in 1

283 Variant Creutzfeldt-Jakob disease (vCJD), a novel form of human

284 umans have since developed a variant form of Creutzfeldt-Jakob disease (vCJD), also mostly in the Uni

285 The onset of variant Creutzfeldt-Jakob disease (vCJD), and the unknown preval

286 athy (BSE) and its human equivalent, variant Creutzfeldt-Jakob disease (vCJD), are caused by the same

287 has been described in cases of human variant Creutzfeldt-Jakob disease (vCJD), experimental ovine bov

288 vine spongiform encephalopathy (BSE)/variant Creutzfeldt-Jakob disease (vCJD), Nipah virus, several v

289 in lymphoid tissues of patients with variant Creutzfeldt-Jakob disease (vCJD), sheep with natural scr

290 hy (BSE) prions, the causal agent of variant Creutzfeldt-Jakob disease (vCJD).

291 sychological profile associated with variant Creutzfeldt-Jakob disease (vCJD).

292 ate non-invasive diagnostic test for variant Creutzfeldt-Jakob disease (vCJD).

293 detect clinically silent carriers of variant Creutzfeldt-Jakob disease (vCJD).

294 We report a case of variant Creutzfeldt-Jakob disease(vCJD) in a 74-year old man in

295 Transmission of variant Creutzfeldt-Jakob disease was observed from the MV blood

296 en PrP(Sc) types was maintained when variant Creutzfeldt-Jakob disease was transmitted to wild-type m

297 tected in the urine of patients with variant Creutzfeldt-Jakob disease, we used the protein misfoldin

298 en implicated both in prion diseases such as Creutzfeldt-Jakob disease, where its monomeric cellular

299 sion and the appearance of a variant form of Creutzfeldt-Jakob disease, which has been linked to cons

300 Cases diagnosed as sporadic Creutzfeldt-Jakob disease with atypical neuropathology w