ライフサイエンスコーパス: Creutzfeldt

1 Creutzfeldt-Jakob disease (CJD) and autoimmune encephali

2 Creutzfeldt-Jakob disease (CJD) has been accidentally tr

3 Creutzfeldt-Jakob disease (CJD) in humans has been shown

4 Creutzfeldt-Jakob disease (CJD) is a neurodegenerative d

5 Creutzfeldt-Jakob disease (CJD) is a rare but invariably

6 Creutzfeldt-Jakob disease (CJD) is a rare progressive ne

7 Creutzfeldt-Jakob disease (CJD), the most common human p

8 nt diagnoses were Alzheimer's disease (18%), Creutzfeldt-Jakob disease (12%) and inflammatory disorde

9 rophic lateral sclerosis (FTD/ALS, n = 252), Creutzfeldt-Jakob disease (CJD, n = 239), Parkinson's di

10 cal heterogeneity, including patients with a Creutzfeldt-Jakob disease (CJD) phenotype.

11 rion protein disease with this feature after Creutzfeldt-Jakob disease, originally reported in 1920.

12 typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distingui

13 ephalopathy (BSE) and scrapie in animals and Creutzfeldt-Jakob disease (CJD) in humans.

14 ent disorders, ataxia, dystonia, chorea, and Creutzfeldt-Jakob with and Jewish.

15 arkinson's disease, motor neuron disease and Creutzfeldt-Jakob disease.

16 encephalopathy (BSE; "mad cow" disease) and Creutzfeldt-Jakob's disease, appears to be a beta-sheet-

17 cluding bovine spongiform encephalopathy and Creutzfeldt-Jakob disease, are usually characterized by

18 such as bovine spongiform encephalopathy and Creutzfeldt-Jakob disease.

19 sheep, bovine spongiform encephalopathy, and Creutzfeldt-Jakob disease in humans.

20 disease, nephrogenic diabetes insipidus, and Creutzfeldt-Jakob disease.

21 ey survive challenge with the human kuru and Creutzfeldt-Jakob agents as well as with scrapie agent i

22 ogical conditions, including Alzheimer's and Creutzfeldt-Jakob diseases and type II diabetes.

23 Conditions including Alzheimer's and Creutzfeldt-Jakob diseases represent, on this basis, pat

24 including dementias such as Alzheimer's and Creutzfeldt-Jakob's disease and other central nervous sy

25 as diverse as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease share a common pathogenetic me

26 ases including Alzheimer's, Parkinson's, and Creutzfeldt-Jakob diseases.

27 s such as Alzheimer's (AD), Parkinson's, and Creutzfeldt-Jakob, and in animal diseases such as BSE.

28 nerative diseases, and arguably, scrapie and Creutzfeldt-Jakob disease prions represent the best ther

29 His conditions were initially diagnosed as Creutzfeldt-Jakob disease (CJD).

30 Prion diseases such as Creutzfeldt-Jakob disease (CJD) are fatal, neuro-degener

31 Prion diseases such as Creutzfeldt-Jakob disease (CJD) are incurable and rapidl

32 hat cause neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD).

33 is related to various human diseases such as Creutzfeldt-Jakob disease and Gerstmann-Straussler-Schei

34 n the pathogenesis of prion diseases such as Creutzfeldt-Jakob disease and scrapie.

35 Prion diseases such as Creutzfeldt-Jakob disease are possibly caused by the con

36 Human prion diseases such as Creutzfeldt-Jakob disease are transmissible brain protei

37 en implicated both in prion diseases such as Creutzfeldt-Jakob disease, where its monomeric cellular

38 Infection of mice with an attenuated Creutzfeldt-Jakob disease agent (SY-CJD) interferes with

39 maining patients, dementia with Lewy bodies, Creutzfeldt-Jakob disease, vascular or unclassified deme

40 replication of the infectious agents causing Creutzfeldt-Jakob disease (CJD), scrapie, and bovine spo

41 pletely resistant to both kuru and classical Creutzfeldt-Jakob disease (CJD) prions (which are closel

42 b disease (to date, 1,147 cases of confirmed Creutzfeldt-Jakob disease deaths in the United Kingdom s

43 More than two hundred individuals developed Creutzfeldt-Jakob disease (CJD) worldwide as a result of

44 agnostic procedures were applied to diagnose Creutzfeldt-Jakob disease (CJD).

45 m nasal brushings was accurate in diagnosing Creutzfeldt-Jakob disease and indicated substantial prio

46 between the invariably lethal prion disease Creutzfeldt-Jakob disease (CJD) and nonprion rapidly pro

47 g disease in deer and elk, and Kuru disease, Creutzfeldt-Jakob disease (CJD) and variant CJD in human

48 ation associated with one of these diseases [Creutzfeldt-Jakob disease (CJD)] that was exactly analog

49 PrP(Sc) prion causes the rare human disorder Creutzfeldt-Jakob disease (CJD).

50 There is no evidence that either Creutzfeldt-Jakob disease or variant Creutzfeldt-Jakob d

51 Familial Creutzfeldt-Jakob disease and cerebrotendinous xanthomat

52 ections with variant, sporadic, and familial Creutzfeldt-Jakob disease, in the presence of blood comp

53 sorders: fatal familial insomnia or familial Creutzfeldt-Jakob disease, depending upon the presence o

54 ile cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and part

55 A test that detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)),

56 s (PrPs) have shorter incubation periods for Creutzfeldt-Jakob disease (CJD) prions than mice express

57 PrP 129M/V polymorphism protects people from Creutzfeldt-Jakob disease, the Sup35p polymorphisms were

58 tes in the brains of patients suffering from Creutzfeldt-Jakob disease and related conditions, such a

59 ), frontotemporal lobar degeneration (FTLD), Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD

60 s hypothalamic GT cells infected with the FU Creutzfeldt-Jakob disease agent, but not parallel mock c

61 Human Creutzfeldt-Jakob disease (CJD) and similar neurodegener

62 ion diseases, including sheep scrapie, human Creutzfeldt-Jakob disease, and cervid chronic wasting di

63 were concurrently less susceptible to human Creutzfeldt-Jakob disease prions.

64 of 24 patients who have developed iatrogenic Creutzfeldt-Jakob disease in the UK since 2003.

65 he 77 patients who have developed iatrogenic Creutzfeldt-Jakob disease, 56 have been genotyped.

66 dt-Jakob disease and in a case of iatrogenic Creutzfeldt-Jakob disease associated with growth hormone

67 The incubation period of iatrogenic Creutzfeldt-Jakob disease is significantly different bet

68 , such as endotoxemia, sepsis, or iatrogenic Creutzfeldt-Jakob disease (to date, 1,147 cases of confi

69 Patients with iatrogenic Creutzfeldt-Jakob disease due to administration of cadav

70 ithin the cohort of patients with iatrogenic Creutzfeldt-Jakob disease in the UK suggests that there

71 Importance: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenera

72 pendent reports have claimed anticipation in Creutzfeldt-Jakob disease (CJD) caused by the c.598G > A

73 cephalopathy (BSE) in cattle and PrP(CJD) in Creutzfeldt-Jakob disease (CJD) in humans.

74 the clinicopathological diversity evident in Creutzfeldt-Jakob disease and whether different prion pr

75 with human prions, such as those involved in Creutzfeldt-Jakob disease.

76 uman brain extracts demonstrated that PrP in Creutzfeldt-Jakob disease (CJD) brains is cleaved by a c

77 Prion protein (PrP) plays a central role in Creutzfeldt-Jakob Disease (CJD) and other transmissible

78 Previous studies in Creutzfeldt-Jakob disease (CJD) have shown that myeloid

79 le neurodegenerative conditions that include Creutzfeldt-Jakob disease (CJD) in humans and bovine spo

80 tal neurodegenerative disorders that include Creutzfeldt-Jakob disease in humans, scrapie in sheep an

81 al, neurodegenerative diseases which include Creutzfeldt-Jakob disease (CJD) in humans and bovine spo

82 tions more common in the T/BG group included Creutzfeldt-Jakob disease, arbovirus, and Mycobacterium

83 eases of humans and other animals, including Creutzfeldt-Jakob disease and bovine spongiform encephal

84 fatal neurodegenerative conditions including Creutzfeldt-Jakob disease in humans and scrapie and bovi

85 ses numerous neurological diseases including Creutzfeldt-Jakob disease (CJD), but the aggregation mec

86 in many neurodegenerative diseases including Creutzfeldt-Jakob disease, motor neuron disease and Alzh

87 fatal neurodegenerative diseases, including Creutzfeldt-Jakob disease in humans, scrapie in sheep an

88 ssible neurodegenerative disorders including Creutzfeldt-Jakob disease (CJD) in humans, is the conver

89 cases of prion disease in humans, including Creutzfeldt-Jakob disease (CJD).

90 ldt-Jakob disease, and 2 of 2 with inherited Creutzfeldt-Jakob disease) but were negative in 43 of 43

91 The most common human prion disease is Creutzfeldt-Jakob disease (CJD).

92 hown to have pathology-proven sporadic Jakob-Creutzfeldt disease.

93 urodegenerative disorders that include Kuru, Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinke

94 his case report from the Australian National Creutzfeldt-Jakob Disease Registry concerns a 61-year-ol

95 review of patients referred to the National Creutzfeldt-Jakob Disease Research & Surveillance Unit d

96 opagation of prions, the causative agents of Creutzfeldt-Jakob disease and other human prion diseases

97 Heightened awareness of Creutzfeldt-Jakob disease (CJD) among physicians and the

98 on is believed responsible for most cases of Creutzfeldt-Jakob disease and for initiating the mad cow

99 tions can be detected early in the course of Creutzfeldt-Jakob Disease, and years before symptomatic

100 00% (95% CI, 90 to 100) for the detection of Creutzfeldt-Jakob disease.

101 Early and accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is necessary for quickly

102 The sporadic form of Creutzfeldt-Jakob disease (sCJD) has been classified on

103 umans have since developed a variant form of Creutzfeldt-Jakob disease (vCJD), also mostly in the Uni

104 f 14 patients with the E200K genetic form of Creutzfeldt-Jakob Disease, 20 healthy carriers of this m

105 sion and the appearance of a variant form of Creutzfeldt-Jakob disease, which has been linked to cons

106 evels of ERp57 increase mainly in neurons of Creutzfeldt-Jacob patients.

107 is centrally involved in the pathogenesis of Creutzfeldt-Jakob Disease, and its anatomical connection

108 it was ineffective in slowing propagation of Creutzfeldt-Jakob disease prions in transgenic mice.

109 e hitherto recognized phenotypic spectrum of Creutzfeldt-Jakob disease.

110 Although surgical transmission of Creutzfeldt-Jakob disease (CJD) has been demonstrated, t

111 re immediate candidates for the treatment of Creutzfeldt-Jakob disease and other prion diseases.

112 ges that allowed early diagnosis of probable Creutzfeldt-Jakob disease before the characteristic clin

113 s (NDs), including Alzheimer's, Parkinson's, Creutzfeldt-Jakob, and Lou Gehrig's diseases, as well as

114 , diseases such as Alzheimer's, Parkinson's, Creutzfeldt-Jakob, and others display remarkable phenoty

115 Sporadic Creutzfeldt-Jakob disease (CJD) is the most prevalent ma

116 Sporadic Creutzfeldt-Jakob disease is considered primarily a dise

117 Sporadic Creutzfeldt-Jakob disease is the most common of the huma

118 rP(Sc) aggregates extracted from 60 sporadic Creutzfeldt-Jakob disease (CJD) and 6 variant CJD brains

119 iform encephalopathies (variant and sporadic Creutzfeldt-Jakob disease and genetic forms of prion dis

120 rved in experimental, acquired, and sporadic Creutzfeldt-Jakob diseases.

121 t disease phenotypes, identified as sporadic Creutzfeldt-Jakob disease (M/M2 sCJD) and sporadic fatal

122 o neuronal antigens misdiagnosed as sporadic Creutzfeldt-Jakob disease (sCJD).

123 Cases diagnosed as sporadic Creutzfeldt-Jakob disease with atypical neuropathology w

124 ding, the most common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive

125 with the most common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive

126 al prion protein that characterizes sporadic Creutzfeldt-Jakob disease can be found in certain brain

127 iduals resembled those of classical sporadic Creutzfeldt-Jakob disease.

128 und PrP species present in control, sporadic Creutzfeldt-Jakob disease (sCJD), or variant CJD (vCJD)

129 kob disease (15 of 15 with definite sporadic Creutzfeldt-Jakob disease, 13 of 14 with probable sporad

130 olfactory epithelium in diagnosing sporadic Creutzfeldt-Jakob disease in living patients.

131 orts (FTLD, ALS, Alzheimer disease, sporadic Creutzfeldt-Jakob disease, Huntington disease-like syndr

132 he most common human prion disease, sporadic Creutzfeldt-Jakob disease.

133 an occur as an idiopathic disorder (sporadic Creutzfeldt-Jakob disease) or can be acquired, as is the

134 e most common human prion disorder, sporadic Creutzfeldt-Jakob disease (CJD), in which prions are for

135 cerebrospinal fluid (CSF) tests for sporadic Creutzfeldt-Jakob disease (sCJD) are based on the detect

136 and may be clinically mistaken for sporadic Creutzfeldt-Jakob disease because of a negative family h

137 me have met diagnostic criteria for sporadic Creutzfeldt-Jakob disease.

138 ng autoimmune encephalopathies from sporadic Creutzfeldt-Jakob disease.

139 n clinic who were suspected to have sporadic Creutzfeldt-Jakob disease (sCJD) and yet were found to h

140 both hamster Sc237 prions and human sporadic Creutzfeldt-Jakob disease (sCJD) prions.

141 Human sporadic Creutzfeldt-Jakob disease (sCJD), endemic sheep scrapie,

142 ct subtypes have been identified in sporadic Creutzfeldt-Jakob disease (sCJD), based on the methionin

143 rP species has been also claimed in sporadic Creutzfeldt-Jakob disease (sCJD).

144 maging to study the white matter in sporadic Creutzfeldt-Jakob disease compared to healthy control su

145 In sporadic Creutzfeldt-Jakob disease, disease-associated PrP(Sc) is

146 fusivity within the white matter in sporadic Creutzfeldt-Jakob disease, suggesting possible primary i

147 symmetric pattern of involvement in sporadic Creutzfeldt-Jakob disease.

148 vities in the total white matter in sporadic Creutzfeldt-Jakob disease.

149 lecular data from a large number of sporadic Creutzfeldt-Jakob disease (CJD) cases.

150 59) and compare these with cases of sporadic Creutzfeldt-Jakob disease (n = 170) in the United Kingdo

151 tal insomnia (sFI) and a subtype of sporadic Creutzfeldt-Jakob disease (sCJD) identified as sCJDMM2,

152 A case of sporadic Creutzfeldt-Jakob disease (sCJD) is described in a young

153 QuIC differentiated 94% of cases of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 from the sCJD MM2 p

154 studies confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype.

155 brains of two patients, who died of sporadic Creutzfeldt-Jakob disease (sCJD), contained either sCJD(

156 able at low levels in some cases of sporadic Creutzfeldt-Jakob disease and conversely, that the form

157 und in all of the major subtypes of sporadic Creutzfeldt-Jakob disease and in a case of iatrogenic Cr

158 Definite diagnosis of sporadic Creutzfeldt-Jakob disease in living patients remains a c

159 e correct histological diagnosis of sporadic Creutzfeldt-Jakob disease.

160 ted into the diagnostic criteria of sporadic Creutzfeldt-Jakob disease.

161 ts both between and within cases of sporadic Creutzfeldt-Jakob disease.

162 y of 80 to 90% for the diagnosis of sporadic Creutzfeldt-Jakob disease.

163 long been used in the diagnosis of sporadic Creutzfeldt-Jakob disease; however, the characteristic w

164 re classified as either familial or sporadic Creutzfeldt-Jakob disease (CJD); there was no case of va

165 d either inherited prion disease or sporadic Creutzfeldt-Jakob disease.

166 kob disease, 13 of 14 with probable sporadic Creutzfeldt-Jakob disease, and 2 of 2 with inherited Cre

167 abnormalities that closely resemble sporadic Creutzfeldt-Jakob disease.

168 Cumulatively, the data show that sporadic Creutzfeldt-Jakob disease PrP(Sc) is not a single confor

169 thought to confer susceptibility to sporadic Creutzfeldt-Jakob disease (rs1029273), all patients were

170 ns from the brains of patients with sporadic Creutzfeldt-Jakob disease (CJD) bind to very low-density

171 nd deer with those in subjects with sporadic Creutzfeldt-Jakob disease (CJD), as well as CJD-affected

172 tic fluid, in a pregnant woman with sporadic Creutzfeldt-Jakob disease (CJD).

173 the heart tissue of a patient with sporadic Creutzfeldt-Jakob Disease (sCJD), the most common form o

174 nic differences in individuals with sporadic Creutzfeldt-Jakob disease (sCJD).

175 ptible to prions from patients with sporadic Creutzfeldt-Jakob disease (sCJD).

176 Twenty-six patients with sporadic Creutzfeldt-Jakob disease and nine age- and gender-match

177 gregates derived from patients with sporadic Creutzfeldt-Jakob disease are taken up and degraded by i

178 , in brain samples from humans with sporadic Creutzfeldt-Jakob disease, as well as in rodents with ex

179 n the white matter of patients with sporadic Creutzfeldt-Jakob disease, mainly in the left hemisphere

180 patients with and patients without sporadic Creutzfeldt-Jakob disease and tested them using RT-QuIC,

181 ned intensely for PrP(TSE) after exposure to Creutzfeldt-Jakob disease brain homogenate.

182 tance of some sheep to scrapie and humans to Creutzfeldt-Jakob disease.

183 Compared with a mouse model of transmissible Creutzfeldt-Jakob disease (CJD), the ataxia of Tg(A116V)

184 Variant Creutzfeldt-Jakob disease (CJD) is thought to be caused

185 Variant Creutzfeldt-Jakob disease (vCJD) and bovine spongiform e

186 Variant Creutzfeldt-Jakob disease (vCJD) differs from other huma

187 Variant Creutzfeldt-Jakob disease (vCJD) has a pathogenesis dist

188 Variant Creutzfeldt-Jakob disease (vCJD) has been recognized to

189 Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegener

190 Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegener

191 Variant Creutzfeldt-Jakob disease (vCJD) is a novel human prion

192 Variant Creutzfeldt-Jakob disease (vCJD) is a unique and highly

193 Variant Creutzfeldt-Jakob disease (vCJD) was first described in

194 Variant Creutzfeldt-Jakob Disease (vCJD) was first reported in 1

195 Variant Creutzfeldt-Jakob disease (vCJD), a novel form of human

196 n parameters from a UK cohort of 171 variant Creutzfeldt-Jakob disease cases.

197 giform encephalopathy to people as a variant Creutzfeldt-Jakob disease (CJD), it becomes critical to

198 r relative human exposure levels and variant Creutzfeldt-Jakob disease (vCJD) incidence.

199 spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) prions are faithfully m

200 observed in sporadic, iatrogenic and variant Creutzfeldt-Jakob disease.

201 nine homozygote to both sporadic and variant Creutzfeldt-Jakob disease.

202 uman beings affected by sporadic and variant Creutzfeldt-Jakob disease.

203 bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease.

204 patitis C virus, enterovirus 70, and variant Creutzfeldt-Jakob disease.

205 rm encephalopathy (BSE) to humans as variant Creutzfeldt-Jakob disease (CJD) has affected over 100 in

206 spongiform encephalopathies, such as variant Creutzfeldt-Jakob disease, are believed to result from i

207 disease in humans were diagnosed as variant Creutzfeldt-Jakob disease.

208 dy indicates a prototype blood-based variant Creutzfeldt-Jakob disease (vCJD) assay has sufficient se

209 m human post-mortem samples, of both variant Creutzfeldt-Jakob disease and Alzheimer's disease patien

210 vine spongiform encephalopathy (BSE)/variant Creutzfeldt-Jakob disease (vCJD), Nipah virus, several v

211 ease reputed to be zoonotic, causing variant Creutzfeldt-Jakob disease (vCJD) in humans and having gu

212 he fatal neurodegenerative condition variant Creutzfeldt-Jakob disease (vCJD) and, based on recent hu

213 c human neurodegenerative conditions variant Creutzfeldt-Jakob disease and Alzheimer's disease.

214 om donors who subsequently developed variant Creutzfeldt-Jakob disease and an asymptomatic red cell t

215 novel acquired human prion disease, variant Creutzfeldt-Jakob disease, is thought to result from ora

216 athy (BSE) and its human equivalent, variant Creutzfeldt-Jakob disease (vCJD), are caused by the same

217 can be acquired, as is the case for variant Creutzfeldt-Jakob disease.

218 re was no evidence of any death from variant Creutzfeldt-Jakob disease or from conditions that could

219 has been described in cases of human variant Creutzfeldt-Jakob disease (vCJD), experimental ovine bov

220 -fold dilution of 10% (wt/vol) human variant Creutzfeldt-Jakob disease brain homogenate, with >3,800-

221 s a single PrP(Sc) molecular type in variant Creutzfeldt-Jakob disease (termed type 2B), presumably r

222 Sc) that accumulates in the brain in variant Creutzfeldt-Jakob disease also contains a minority type

223 The results show PrP(Sc) in variant Creutzfeldt-Jakob disease to be remarkably stereotyped.

224 d with other transmission studies in variant Creutzfeldt-Jakob disease, including those on the spleen

225 In variant Creutzfeldt-Jakob disease, prion replication is thought

226 Interindividual variant Creutzfeldt-Jakob disease (vCJD) transmission through bl

227 es the fatal prion disease named new variant Creutzfeldt-Jacob disease in humans.

228 35 deaths had been attributed to new variant Creutzfeldt-Jakob disease (nvCJD) in the United Kingdom,

229 The outbreak of new variant Creutzfeldt-Jakob disease has raised the specter of a po

230 In an effort to prevent new variant Creutzfeldt-Jakob disease, certain "specified offals," i

231 cephalopathy (BSE) prions causes new variant Creutzfeldt-Jakob disease.

232 ephalopathy to humans in the form of variant Creutzfeldt Jakob disease, have raised concerns about th

233 en done aside from a small sample of variant Creutzfeldt-Jakob disease (CJD).

234 PrP(Sc) from autopsy-proved cases of variant Creutzfeldt-Jakob disease (n = 59) and compare these wit

235 truments from, a deceased carrier of variant Creutzfeldt-Jakob disease (vCJD) can be followed up to q

236 as a result of the rising number of variant Creutzfeldt-Jakob disease (vCJD) cases.

237 Person-to-person transmission of variant Creutzfeldt-Jakob disease (vCJD) has occurred through bl

238 relevant to the current outbreak of variant Creutzfeldt-Jakob disease (vCJD) in the United Kingdom,

239 The development of variant Creutzfeldt-Jakob disease (vCJD) in three recipients of

240 cal variation in the distribution of variant Creutzfeldt-Jakob disease (vCJD) might indicate the tran

241 The transmission of variant Creutzfeldt-Jakob disease (vCJD) through blood transfusi

242 o be a reservoir for transmission of variant Creutzfeldt-Jakob disease (vCJD) to humans.

243 reasing concern since the reports of variant Creutzfeldt-Jakob disease (vCJD) transmission through bl

244 fication of possible transmission of variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion h

245 The onset of variant Creutzfeldt-Jakob disease (vCJD), and the unknown preval

246 hy (BSE) prions, the causal agent of variant Creutzfeldt-Jakob disease (vCJD).

247 detect clinically silent carriers of variant Creutzfeldt-Jakob disease (vCJD).

248 cuses on transfusion-transmission of variant Creutzfeldt-Jakob disease by red cell preparations.

249 by this review, the transmission of variant Creutzfeldt-Jakob disease by transfusion has been confir

250 a precaution against transmission of variant Creutzfeldt-Jakob disease by transfusion of domestic blo

251 The recent emergence of variant Creutzfeldt-Jakob disease has led to major public health

252 Three cases of variant Creutzfeldt-Jakob disease have been identified following

253 vious definite and probable cases of variant Creutzfeldt-Jakob disease have been methionine homozygot

254 ly occurring scrapie in sheep and of variant Creutzfeldt-Jakob disease in humans.

255 Risk assessments for transmission of variant Creutzfeldt-Jakob disease predicted that leukocyte reduc

256 PrP(Sc) was found in all 21 cases of variant Creutzfeldt-Jakob disease tested, irrespective of brain

257 Transmission of variant Creutzfeldt-Jakob disease was observed from the MV blood

258 We report a case of variant Creutzfeldt-Jakob disease(vCJD) in a 74-year old man in

259 ular system is a defining feature of variant Creutzfeldt-Jakob disease, but that the biochemical isof

260 fusion recipient, who did not die of variant Creutzfeldt-Jakob disease, has been identified with prio

261 As of mid-2016, 231 cases of variant Creutzfeldt-Jakob disease-the human form of a prion dise

262 ce of human-to-human transmission of variant Creutzfeldt-Jakob disease.

263 in a unique series of nine cases of variant Creutzfeldt-Jakob disease.

264 ee cases of probable transmission of variant Creutzfeldt-Jakob infectivity by transfusion of red cell

265 lity to, and clinical expression of, variant Creutzfeldt-Jakob disease (vCJD) is essential for future

266 either Creutzfeldt-Jakob disease or variant Creutzfeldt-Jakob disease are transmitted by transfusion

267 evere acute respiratory syndrome, or variant Creutzfeldt-Jakob disease.

268 mples, from prion-affected patients (variant Creutzfeldt-Jakob disease (vCJD) n = 20, iatrogenic CJD

269 We report a case of preclinical variant Creutzfeldt-Jakob disease (vCJD) in a patient who died f

270 and findings were followed-up in six variant Creutzfeldt-Jakob disease cases with 9.4 T high-resoluti

271 r significant numbers of subclinical variant Creutzfeldt-Jakob disease individuals in at least the Un

272 Concerns have been raised that variant Creutzfeldt-Jakob disease (vCJD) might be transmissible

273 Recent evidence that variant Creutzfeldt-Jakob disease can be transmitted by transfus

274 Evidence suggests that variant Creutzfeldt-Jakob disease prions circulate in body fluid

275 enotype individual can propagate the variant Creutzfeldt-Jakob disease agent and that the infectious

276 tly demonstrated transmission of the variant Creutzfeldt-Jakob disease agent.

277 Back-calculation analysis of the variant Creutzfeldt-Jakob disease epidemic in the United Kingdom

278 xamined, and was also present in the variant Creutzfeldt-Jakob disease tonsil.

279 cell preparations are applicable to variant Creutzfeldt-Jakob in humans then a method for rendering

280 timates for the risk of transmitting variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion h

281 en PrP(Sc) types was maintained when variant Creutzfeldt-Jakob disease was transmitted to wild-type m

282 of humans and animals, one of which (variant Creutzfeldt-Jakob disease) is known to be a zoonotic for

283 sceptible to prions from humans with variant Creutzfeldt-Jakob disease (CJD); on second passage in Tg

284 Infections with variant Creutzfeldt-Jakob disease (vCJD) have almost exclusively

285 A small number of patients with variant Creutzfeldt-Jakob disease (vCJD) have been treated with

286 in lymphoid tissues of patients with variant Creutzfeldt-Jakob disease (vCJD), sheep with natural scr

287 sychological profile associated with variant Creutzfeldt-Jakob disease (vCJD).

288 e only in the urine of patients with variant Creutzfeldt-Jakob disease and had the typical electropho

289 samples obtained from patients with variant Creutzfeldt-Jakob disease and in none of the 224 urine s

290 samples obtained from patients with variant Creutzfeldt-Jakob disease contained minute quantities of

291 for three individuals diagnosed with variant Creutzfeldt-Jakob disease in the USA and Canada.

292 phic codon in humans associated with variant Creutzfeldt-Jakob disease, pulls the N terminus into the

293 tected in the urine of patients with variant Creutzfeldt-Jakob disease, we used the protein misfoldin

294 rent understanding of the risks of (variant) Creutzfeldt-Jakob disease transmission via dental practi

295 First, we successfully propagated various Creutzfeldt-Jakob disease (CJD) isolates (sporadic, vari

296 myoclonic jerks develop in individuals with Creutzfeldt-Jakob disease (CJD), an incurable brain diso

297 f growth hormone derived from a patient with Creutzfeldt-Jakob disease expressing prion protein valin

298 ings were positive in 30 of 31 patients with Creutzfeldt-Jakob disease (15 of 15 with definite sporad

299 us system (CNS) in five of six patients with Creutzfeldt-Jakob disease.

300 PrP(TSE)) when exposed to medium spiked with Creutzfeldt-Jakob disease brain homogenate, resulting in

301 t were negative in 43 of 43 patients without Creutzfeldt-Jakob disease, indicating a sensitivity of 9