1                                              Crigler-Najjar syndrome (CN) is a very rare genetic diso

2                                              Crigler-Najjar syndrome is a recessively inherited disor

3                                              Crigler-Najjar syndrome type 1 (CN-1) is a recessively i

4                                              Crigler-Najjar syndrome type I is characterized by uncon

5 utation in the UGT1A1 (HUG-Br1) isozyme of a Crigler-Najjar (CN) Type I patient.

6 h hepatic bilirubin glucuronidation, causing Crigler-Najjar syndrome type 1 or 2, respectively.

7                                 In contrast, Crigler-Najjar syndrome types I and II are rare genetic

8 easing the risk of bilirubin encephalopathy (Crigler-Najjar syndrome).

9                                          For Crigler-Najjar syndrome, an inherited disorder that resu

10 ly difficult, is now accepted management for Crigler-Najjar type I disease but remains controversial

11 yperbilirubinemia in humans that suffer from Crigler-Najjar type I disease results from lesions in th

12                                           In Crigler-Najjar type II patients and, recently, in Crigle

13 er-Najjar type II patients and, recently, in Crigler-Najjar type I patients treated with human hepato

14 o liver transplantation in the management of Crigler-Najjar syndrome, type 1.

15  hyperbilirubinemia in the Gunn rat model of Crigler-Najjar syndrome can be achieved with one injecti

16 cient hyperbilirubinemic Gunn rats (model of Crigler-Najjar syndrome type 1) resulted in hUGT1A1 expr

17 The Gunn rat is an excellent animal model of Crigler-Najjar syndrome, type 1.

18 Gunn rats (n = 3), and patients (n = 4) with Crigler-Najjar type I (CN-I) syndrome.

19 his case report describes a young adult with Crigler-Najjar syndrome type II in whom kernicterus deve

20 egion of both alleles, whereas patients with Crigler-Najjar syndrome are homozygous for a defect that

21 to the induced levels noted in patients with Crigler-Najjar type 1 disease, is fatal in neonatal Ugt1