ライフサイエンスコーパス: D-galactose

1 ouronium salt of 2,3,4,6-tetra-O-acetyl-beta-D-galactose.

2 orylation of the C-1 hydroxyl group of alpha-D-galactose.

3 aris developed in mice treated with low-dose D-galactose.

4 samine and N-acetylgalactosamine relative to d-galactose.

5 nterconversion of beta-D-galactose and alpha-D-galactose.

6 oside (MNPG) rather than five copies of beta-D-galactose.

7 ve for its natural substrates, d-glucose and d-galactose.

8 d is insensitive to sugars like d-glucose or d-galactose.

9 diastereomers such as L-Man, D-glucose, and D-galactose.

10 h the galactosylated E461G enzyme gives only D-galactose.

11 rowth on galactitol and in reduced growth on D-galactose.

12 e AGE breaker phenacylphiazolium bromide and D-galactose.

13 turn over dTDP-3-acetamido-3,6-dideoxy-alpha-d-galactose.

14 pressed by the repressor GalR and induced by D-galactose.

15 utarotase, be achievable by either anomer of D-galactose.

16 the operon in the absence of the gal inducer D-galactose.

17 syl aldehydes from D-glucose, D-mannose, and D-galactose.

18 AATGal is 2-acetamido-4-amino-2,4,6-trideoxy-D-galactose.

19 ize the same binding sites in the absence of d-galactose.

20 o the anthrose saccharide was developed from D-galactose.

21 alR and GalS is inhibited in the presence of d-galactose.

22 ers is lifted in the presence of the inducer D-galactose.

23 motif and harbors the binding site for beta-D-galactose.

24 altering the maximum quench with saturating D-galactose.

25 oform and complexed with its substrate, beta-d-galactose.

26 ture of Polyandrocarpa lectin complexed with D -galactose.

27 alpha- and beta-pyranosides of d-glucose and d-galactose 1-4 were prepared containing single sites of

28 usly reported structures of the Mg(2+)-alpha-d-galactose-1-phosphate-beta-PGM, Mg(2+)-phospho-beta-PG

29 The galactose analog 2-(18)F-fluoro-2-deoxy-d-galactose ((18)F-FDGal) is a suitable PET tracer for m

30 lus cells (CCs), were exposed for 4 hours to D-galactose (2 muM), galactitol (11 muM) and galactose 1

31 3-O-(beta-D-gluco-4-enepyranosyluronic acid)-D-galactose, (2) 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4

32 on aldohexose anomerization were measured in D-galactose 3 and D-talose 8 selectively (13)C- and (2)H

33 s of D-aldohexoses (D-allose 1, D-altrose 2, D-galactose 3, D-glucose 4, D-gulose 5, D-idose 6, D-man

34 with D-fucose, L-arabinose, 6-deoxy-6-fluoro-D-galactose, 6-O-methyl-D-galactose, or D-galacturonic a

35 nteraction of L-fucose with the beta-face of D-galactose), a nonconventional C-H...O hydrogen bond be

36 almost as well as D-galactose, while 2-deoxy-D-galactose affords no substrate protection, indicating

37 cose (QuiNAc), 2-deoxy-2-N-acetylamino-alpha-D-galactose (alpha-D-GalNAc), 2-deoxy-2-N-acetylamino-al

38 he critical step of a metabolic pathway--the D-galactose amphibolic pathway--changes the dynamics of

39 M, and confirmed the specificity of TC14 for D -galactose and related monosaccharides.

40 ntrasted, and it was observed that with both d-galactose and 2-deoxy-d-galactose as starting material

41 sport activities of radiolabelled D-glucose, D-galactose and 2-deoxy-D-glucose were restored, consist

42 r chemical structure consists of alternating D-galactose and 3,6-anhydro-L-galactose residues, the la

43 GLT1, and like SGLT1 the chimera transported D-galactose and 3-O-methylglucose.

44 r, specificity of hSGLT3 binding is greater (D-galactose and 4-deoxy-4-fluoro-D-galactose are not hSG

45 sm by catalyzing the interconversion of beta-D-galactose and alpha-D-galactose.

46 re of the complex of Gal3p-Gal80p with alpha-D-galactose and ATP to 2.1 A resolution.

47 in vitro experiments showing that both alpha-D-galactose and beta-D-galactose are capable of inducing

48 lactose differing at the C-1 position, alpha-D-galactose and beta-D-galactose, are widespread in natu

49 to integrate the two small molecule signals, d-galactose and cAMP, that modulate the isoregulators an

50 Transport of D-galactose and D-mannose is also up to 60% less in Atst

51 Oxepines 3 and 4, derived from d-galactose and d-mannose, largely favor alpha- over bet

52 We report the thermodynamics of binding of d-galactose and deoxy derivatives thereof to the arabino

53 In contrast, SGLT2 transports poorly D-galactose and excludes 3-O-methylglucose.

54 resorufin-beta-D-galactopyranoside to yield D-galactose and fluorescent resorufin.

55 tructure was solved in the presence of alpha-D-galactose and inorganic phosphate.

56 Our results suggested that D-galactose and its metabolites disturbed the spindle st

57 Here, we evaluate the effect of D-galactose and its metabolites, galactitol and galactos

58 A convergent synthesis of both 2 and 3 from D-galactose and L-methionine is presented.

59 ray structure of Gal1p in complex with alpha-d-galactose and Mg-adenosine 5'-(beta,gamma-imido)tripho

60 ture of human galactokinase with bound alpha-D-galactose and Mg-AMPPNP.

61 de units composed of alternating residues of d-galactose and N-acetyl-d-glucosamine linked beta-(1-4)

62 imers with the monosaccharides D-mannose and D-galactose and the disaccharide D-lactose in their hydr

63 ely 3.2 A of the C-2 hydroxyl group of alpha-D-galactose and the guanidinium group of Arg37.

64 ucrose, trehalose, L-glucose, D-glucose, and D-galactose), and in each case larger amplitude motions

65 D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose, and (3) 2-acetamido-2-deoxy-3-O-(beta-D-glu

66 AP backtracking is sensitive to Gre factors, D-galactose, and antisense oligonucleotides.

67 poxanthine, and 75 to 100% utilized citrate, D-galactose, and D-trehalose as sole carbon sources.

68 urrent method has been applied to d-glucose, d-galactose, and d-xylose donors with a nondirecting gro

69 se, d-glucose, l-allose, d-allose, d-gulose, d-galactose, and l-mannose are delineated, and for all e

70 onding beta-galactopyranosyl derivatives and D-galactose, and the formation of the latter represents

71 showing that both alpha-D-galactose and beta-D-galactose are capable of inducing transcription of the

72 anhydro-heptitols derived from D-mannose and D-galactose are enantiomeric and are useful linkers for

73 he peptide and the alpha- or beta-anomers of d-galactose are nearly identical structurally; however,

74 is greater (D-galactose and 4-deoxy-4-fluoro-D-galactose are not hSGLT3 substrates, but have hSGLT1 K

75 Dietary sugars D-glucose and D-galactose are transported across the intestinal brush-

76 the C-1 position, alpha-D-galactose and beta-D-galactose, are widespread in nature.

77 erved that with both d-galactose and 2-deoxy-d-galactose as starting materials, the transformations i

78 rated substrates, including 1-O-methyl-alpha-D-galactose as well as unsubstituted benzyl alcohol and

79 Epimers of D-galactose at C-3 (D-gulose) and C-4 (D-glucose) or deo

80 strategy to quantify beta-D-glucose and beta-D-galactose at low micromolar to millimolar levels, with

81 The K(d) values for D-glucose and D-galactose binding to Tp38 were 152.2 +/- 20.73 nM and

82 78D formed pentamers that bound to GM(1) and D-galactose but failed to assemble with CTA to form holo

83 e of Thioglo3-labeled Cys423 was quenched by D-galactose, but only in the presence of Na(+).

84 androcarpa misakiensis specifically binds to D-galactose by coordination of the sugar to a bound calc

85 arrival assay based on labeling with [6-3H]-D-galactose combined with biochemical modification at th

86 BB) receptor is a glycoprotein with an alpha-d-galactose containing trisaccharide in the toxin-bindin

87 In classical galactosemia, d-galactose contributes to the formation of glycated pro

88 s, 5-mo-old C57BL/6 mice were given low-dose D-galactose (D-gal) for 8 wk and evaluated by AGE fluore

89 After injection of LPS/2-amino-2-deoxy-D-galactose (D-gal), CD137-/- mice had reduced serum cyt

90 A major polysaccharide containing D-galactose, D-glucose and 2-acetamido-2-deoxy-D-galacto

91 substrates, including L-arabinose, D-fucose, D-galactose, D-glucose, and D-xylose.

92 showed the presence of l-fucose, d-mannose, d-galactose, d-glucose, d-glucuronic acid, N-acetyl-d-ga

93 y relevant underivatized hexoses, d-glucose, d-galactose, d-mannose, and d-fructose, using only mass

94 Gal, GalNAc, and R represent, respectively, D-galactose, D-N-acetyl galactosamine, and reducing end)

95 With D-glucose, D-galactose, D/L-glyceraldehyde, and D-glucosamine servi

96 s exhibit 60-fold lower apparent K(d)'s than D-galactose, demonstrating that binding affinity is sign

97 The D-galactose-dependent switch from one stage of regulatio

98 version at O-2 and O-3 in an easily prepared D-galactose derivative, which proceeds regio- and stereo

99 n complex with NAD(+), UDP-glucose, and beta-D-galactose determined to 1.85-A resolution.

100 eficient for lipoprotein lipase treated with D-galactose did not retain lipoproteins to any measureab

101 P-D-Quip3N or dTDP-3-amino-3,6-didexoy-alpha-D-galactose (dTDP-D-Fucp3N).

102 the conversion of beta-d-galactose to alpha-d-galactose during normal galactose metabolism.

103 se prevention group (LDP), respectively; 50% D-galactose for 4 or 8 months and then intervention by a

104 tervention group (8IN), respectively; or 50% D-galactose for 4 or 8 months and then intervention by w

105 ly 14 mg/kg per day) (prevention [PRV]), 50% D-galactose for 6 months followed by intervention with t

106 h the inhibitor (intervention [INT]), or 50% D-galactose for 6 months followed by replacement with th

107 The Km for D-galactose for W290H is similar to that of the wild typ

108 producing the galactokinase substrate alpha-D-galactose from its beta-anomer.

109 terization of six bifunctional UDP-l-Rha/UDP-d-galactose (Gal) transporters (URGTs).

110 Galactomannans [(1-->6)-alpha-D-galactose (Gal)-substituted (1-->4)-beta-D-mannans] ar

111 (#5001) plus 50% starch (control [CON]), 50% D-galactose (galactose [GAL]), 50% D-galactose with AL-3

112 ow plus 50% starch, control group (CON); 50% D-galactose, galactose-fed group (GAL); 50% D-galactose

113 methyl alpha-D-glucopyranoside > D-glucose > D-galactose >> D-mannitol.

114 of Na+: 1) selective (alphaMDG > D-glucose > D-galactose >> L-glucose approximately D-mannose), 2) in

115 in orthogonally protected D-idopyranose from D-galactose has been developed, which is the first metho

116 haracter, it can metabolize D-glucose and/or D-galactose in both oxidative and fermentative pathways

117 blished Leloir pathway for the catabolism of d-galactose in fungi, the oxidoreductive pathway has bee

118 ThioGlo3 or pyrene maleimide was reduced by D-galactose in Na(+) buffer.

119 the conversion of beta-D-galactose to alpha-D-galactose in the Leloir pathway for galactose metaboli

120 y 2-deoxy-D-glucose, D-mannose, D-glucose or D-galactose in the presence of sodium ions.

121 ,6-O-ethylidene derivatives of d-glucose and d-galactose in which values of omega and theta; were con

122 esence of D-glucose, and to a lesser extent, D-galactose, indicating binding.

123 hibit wild-type growth, even at up to 100 mM D-galactose, indicating that active transport by AtSTP1

124 peptide Ac-(Gly-Pro-Thr)(10)-NH(2) with beta-d-galactose induces the formation of a collagen triple h

125 the high-affinity substrates, D-glucose and D-galactose, inhibited uptake of radioactive sugar trace

126 igonucleotides were used to study OEDNA-GalR-d-galactose interactions.

127 The D -galactose is bound through coordination of the 3 and

128 lue of k(cat)/K(m) for the reaction of alpha-D-galactose is 10 times that for alpha-D-glucose, and th

129 The metabolic pathway by which beta-D-galactose is converted to glucose 1-phosphate is known

130 In this oxidoreductive pathway, D-galactose is converted via a series of NADPH-dependent

131 s related to altered Ca(2+) homeostasis when d-galactose is utilized as the carbon source.

132 Ac, where Fuc4NAc is 4-acetamido-4,6-dideoxy-D-galactose, ManNAcA is N-acetyl-D-mannosaminuronic acid

133 Ac, where Fuc4NAc is 4-acetamido-4,6-dideoxy-D-galactose, ManNAcA is N-acetyl-D-mannosaminuronic acid

134 Mutarotase and other D-galactose-metabolizing enzymes are coded by genes that

135 complex with the 4,6-pyruvate acetal of beta-D-galactose (MObetaDG) were prepared.

136 ecules and two 3-acetamido-3,6-dideoxy-alpha-d-galactose moieties (abbreviated as Fucp3NAc).

137 mposed of L-rhamnose and 2-acetamido-2-deoxy-D-galactose (molar ratio, 2:1) with the structure -->2)-

138 urs, including uniform responses (d-lactose, d-galactose, N-acetylglucosamine, N-acetylneuraminic aci

139 We tested the effect of D-galactose on various DNA-protein and protein-protein i

140 In an inhibition ELISA, d-(+)-galactose or 26404lgt2 LOS showed no inhibition.

141 Culture in medium containing either 10 mM D-galactose or 30 mM D-glucose resulted in the accumulat

142 nth-old C57Bl6 mice were injected daily with D-galactose or control buffer for 8 weeks.

143 of alkene-terminated C-linked glycosides of D-galactose or D-glucose to L-cysteine using thiol-ene "

144 e-deficient mice were injected with low-dose D-galactose or PBS subcutaneously for 8 weeks to induce

145 se, 6-deoxy-6-fluoro-D-galactose, 6-O-methyl-D-galactose, or D-galacturonic acid, suggesting that the

146 with UDP-mannose, UDP-4-deoxy-4-fluoro-alpha-D-galactose, or UDP-4-deoxy-4-fluoro-alpha-D-glucose hav

147 4-dihydropyrimidin-4-one dihydrochloride and D-galactose phenylhydrazone to give the pyranopterin (5a

148 ine, N-acetyl-D-galactosamine, D-glucose and D-galactose, present on the cell surface.

149 lactofuranose (Gal(f)), the furanoic form of d-galactose produced by UDP-galactopyranose mutases (UGM

150 of peritoneal implants by targeting the beta-d-galactose receptors highly expressed on the cell surfa

151 In these structures, the d-galactose residue in the -1 subsite is distorted into

152 icated that N-acetylglucosamine (GlcNAc) and D-galactose residues were exposed.

153 The C-1 hydroxyl group of alpha-D-galactose sits within 3.3 A of the gamma-phosphorus of

154 fructose, 1-thio-beta-d-glucose sodium salt, d-(+)-galactose, sorbitol, glycerol, and dextrose.

155 dlings grow effectively on concentrations of D-galactose that inhibit wild-type growth, even at up to

156 robiose (3,6-anhydro-l-galactose-alpha-(1,3)-d-galactose) that are beta-(1,4)-linked.

157 lso indicated that upon binding of Na(+) and d-galactose, the alpha-helical content increased to 53%.

158 cell can make only one of the two anomers of D-galactose, the cell must also convert one anomer to th

159 mutarotase catalyzes the conversion of beta-d-galactose to alpha-d-galactose during normal galactose

160 mutarotase catalyzes the conversion of beta-D-galactose to alpha-D-galactose in the Leloir pathway f

161 l interest as it catalyzes the conversion of D-galactose to D-tagatose in vitro.

162 g the ATP-dependent phosphorylation of alpha-D-galactose to galactose 1-phosphate.

163 m where it catalyzes the conversion of alpha-d-galactose to galactose 1-phosphate.

164 bolism by catalyzing the conversion of alpha-d-galactose to galactose 1-phosphate.

165 Mice treated with D-galactose to induce AGE formation in Bruch's membrane

166 In D-galactose-treated animals, the RPE had dilated and few

167 an either PBS- or phenacylphiazolium bromide/D-galactose-treated mice at 24 and 72 hours after inject

168 iglycan, and lipoprotein lipase was found in D-galactose-treated mice only.

169 D-galactose-treated mice retained lipoproteins in the re

170 Low-dose D-galactose treatment in mice induces accelerated aging

171 D-Galactose treatment induced AGE-specific fluorescence

172 e, UGE4, which is involved in channeling UDP-D-galactose (UDP-D-Gal) into cell wall polymers.

173 inose-binding protein (ABP) with its ligand, d-galactose, using NMR relaxation and molecular dynamics

174 study, binding of 31 structural analogues of D-galactose was examined by site-directed N-[(14)C]ethyl

175 bond between H-C(5) of L-fucose and O(5) of D-galactose was identified.

176 galactose, D-glucose and 2-acetamido-2-deoxy-D-galactose was obtained after mild acid hydrolysis of t

177 nd k(cat)/K(m) for the mutarotation of alpha-D-galactose were found to be 1.84 x 10(4) s(-1) and 4.6

178 The anomeric form of D-galactose, when present in complex carbohydrates, e.g.

179 D-gluco-4-enepyranosyluronic acid)-6-O-sulfo-D-galactose, when treated with chondroitinase.

180 pimer alpha-D-talose binds almost as well as D-galactose, while 2-deoxy-D-galactose affords no substr

181 of a ternary complex of OEDNA with GalR and D-galactose with a different conformation than the GalR-

182 ON]), 50% D-galactose (galactose [GAL]), 50% D-galactose with AL-3152 (approximately 14 mg/kg per day

183 Alkylation of Cys148 is blocked by D-galactose with an apparent affinity of approximately 3

184 D-galactose, galactose-fed group (GAL); 50% D-galactose with ARI-509 at 25 mg/kg or 10 mg/kg body wt

185 to 10 mM decreased the apparent affinity for d-galactose without altering the maximum quench with sat

186 natural substrate to CDP-4,6-dideoxy-4-amino-D-galactose without E3.

187 he xylosides by galactosyltransferase I (UDP-D-galactose:xylose beta1-4-galactosyltransferase) in vit