ライフサイエンスコーパス: D-mannose

1 OxA > AsA (erythorbic acid) > L-galactose > D-mannose.

2 e de novo synthesis of GDP-L-fucose from GDP-D-mannose.

3 d fully reconstituted by further addition of d-mannose.

4 nnose (TM) core, alpha1-3 or alpha1-6 DM, or D-mannose.

5 DP-linked sugar, GDP-4-amino-3,4,6-trideoxy- d-mannose.

6 for C-3 deoxygenation of GDP-4-keto-6-deoxy-D-mannose.

7 r at C(2) was synthesized in nine steps from D-mannose.

8 ng was Ca(2+)-dependent and inhibitable with d-mannose.

9 llographically the interactions of FimH with D-mannose.

10 teraction between Concanavalin A (Con A) and D-(+)-mannose.

11 begin with the formation of GDP-mannose from d-mannose 1-phosphate and GTP followed by the subsequent

12 wn to lack specificity for its physiological D-mannose 1-phosphate substrate.

13 with and without the bound substrate, alpha-D-mannose 1-phosphate.

14 acterial adhesion antagonists based on alpha-d-mannose 1-position anomeric glycosides using X-ray str

15 re required for its production starting from D-mannose-1-phosphate and GTP.

16 8)F-labeled mannose (2-deoxy-2-[(18)F]fluoro-D-mannose, [(18)F]FDM) for targeting of plaque inflammat

17 ose > D-galactose >> L-glucose approximately D-mannose), 2) inhibited by phloretin, KiPT = approximat

18 WbdD phosphorylates 2-alpha-d-mannosyl-d-mannose (2alpha-MB), a short mimic of the O9a polymer.

19 that the GER1 protein does not act as a GDP-D-mannose 3, 5-epimerase, an enzymatic activity involved

20 se plants were unchanged indicating that GDP-D-mannose 3,5-epimerase is encoded by a separate gene.

21 ar PLP-dependent enzyme, GDP-4-keto-6-deoxy- d-mannose 3-dehydratase or ColD, catalyzes a dehydration

22 of this investigation is GDP-4-keto-6-deoxy-D-mannose 3-dehydratase or ColD, which catalyzes the rem

23 bate synthesis and are interconverted by GDP-D-mannose-3,5-epimerase.

24 ed that ColD functions as GDP-4-keto-6-deoxy-D-mannose-3-dehydrase responsible for C-3 deoxygenation

25 us of this investigation, GDP-4-keto-6-deoxy-d-mannose-3-dehydratase (ColD), catalyzes the third step

26 er PLP-dependent enzyme, GDP-4-keto-6-deoxy- d-mannose-3-dehydratase (or ColD), was determined in our

27 hine decarboxylase, hyaluronan synthase, GDP-D-mannose 4,6 dehydratase, and a potassium ion channel p

28 GDP-D-mannose 4,6-dehydratase catalyzes the first step in th

29 1 gene of Arabidopsis thaliana encodes a GDP-D-mannose 4,6-dehydratase catalyzing the first step in t

30 ing one or the other or both isoforms of GDP-D-mannose 4,6-dehydratase, depending on the cell type an

31 novo synthesis of l-Fuc is catalyzed by GDP-d-mannose 4,6-dehydratase, which, in Arabidopsis, is enc

32 e the genetic locus encoding a mammalian GDP-D-mannose-4,6-dehydratase (GMD).

33 The recombinant protein exhibited GDP-D-mannose-4,6-dehydratase activity in vitro and was able

34 nucleotide sugar interconversion step, a GDP-D-mannose-4,6-dehydratase.

35 equence similarity to proposed bacterial GDP-D-mannose-4,6-dehydratases and was tightly linked to the

36 (1-azi-2,2,2-trifluoroethyl)benzoyl)-1,3-bis(D-mannose-4-yloxy)-2-p ropylamine in extensor digitorum

37 -azi-2,2, 2-trifluoroethyl)-benzoyl-1,3-bis-(D-mannose-4-yloxy)-2-propyla min e photolabel, were 26-3

38 2,2-trifluoroethyl)benzoyl-1,3-bis-[2-(3)H] (D-mannose-4-yloxy)-2-propylamine exofacial photolabeling

39 cluding beta-D-fructose 6-phosphate and beta-D-mannose 6-phosphate, a precursor and an intermediate o

40 ctose 3, D-glucose 4, D-gulose 5, D-idose 6, D-mannose 7, D-talose 8) selectively labeled with (13)C

41 D-mannose, a C-2 epimer of glucose, exists naturally in

42 lpha-D-mannose (MeMan) and mannose-alpha 1,3-D-mannose-alpha-OMe (MeMan-2) have been determined and a

43 ield (longest linear sequence) starting from d-mannose and (S)-propylene oxide as the source of the s

44 glucose/maltose, the protein also recognizes d-mannose and a variety of mannose-rich microbial ligand

45 ific and saturable and could be inhibited by d-mannose and abolished by endoglycosidase H treatment o

46 ic Janus dendrimers with the monosaccharides D-mannose and D-galactose and the disaccharide D-lactose

47 The 2,6-anhydro-heptitols derived from D-mannose and D-galactose are enantiomeric and are usefu

48 1-2Fuc linkages (where Man and Xyl represent d-mannose and d-xylose, respectively), underlying the mo

49 APK activation and AA release are blocked by d-mannose and Dectin-2-specific antibody, and overexpres

50 We found that D-mannose and L-galactose are efficient precursors for a

51 posed pathway of ascorbic acid synthesis via D-mannose and L-galactose is operational in individual P

52 C-5 epimerization of GDP-4-keto-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the r

53 ions with nonspecific substrates (L-glucose, D-mannose, and 2-deoxy-D-glucose).

54 derivatized hexoses, d-glucose, d-galactose, d-mannose, and d-fructose, using only mass spectrometry

55 a-C-glycopyranosyl aldehydes from D-glucose, D-mannose, and D-galactose.

56 nate, D-glucuronate, N-acetyl-D-glucosamine, D-mannose, and D-ribose.

57 values similar to those found with GDP-alpha-d-mannose, and decreased the K(m) of the fluorinated sub

58 espectively, for the hydrolysis of GDP-alpha-d-mannose, and showed smaller effects on K(m), suggestin

59 a branch of D-paratose from the C-3 of alpha-D-mannose, and the C-3 of beta-L-rhamnose is partially O

60 and turnover complexes of Gmm-Ca2+-GDP-alpha-d-mannose, and three cocrystal structures of an inactive

61 tic synthesis of GDP-4-amino-3,4,6-trideoxy- d-mannose are presented.

62 The application of d-mannose as a multipurpose building block from the chir

63 elease ammonia yields GDP-4-keto-3,6-dideoxy-D-mannose as the product.

64 specificity, and reveal that the presence of d-mannose at the +1 subsite renders the acid catalyst le

65 6)]Man) by generating mutants that abolished D-mannose binding but retained mannotriose binding activ

66 breast cancer cells unlike per-butanoylated-D-mannose (Bu(5)Man), a clinically tested compound that

67 was attenuated by N-acetyl-D-glucosamine or D-mannose, but not L-mannose, in a dose-dependent manner

68 Here, we show that the uptake of D-mannose by different mammalian cell lines involves a m

69 one, and have synthesized ascorbate from GDP-D-mannose by way of these intermediates in vitro.

70 es of carba-alpha-D-glucosamine, carba-alpha-D-mannose, carba-alpha-D-mannuronic acid, carba-beta-L-i

71 Unlike in the 3-O-methyl-D-mannose-containing polysaccharide (sMMP) series, the a

72 carbohydrate recognition domain of SP-A with d-mannose, D-alpha-methylmannose, and glycerol, which re

73 essentially unaltered when it was exposed to D-mannose, D-fucose, D-ribose, L-glucose, or L-galactose

74 saccharides showed the presence of l-fucose, d-mannose, d-galactose, d-glucose, d-glucuronic acid, N-

75 ts of a repeating pentasaccharide containing d-mannose, d-glucose and l-rhamnose: [See text].

76 otein showed quenching by 2-deoxy-D-glucose, D-mannose, D-glucose or D-galactose in the presence of s

77 reductive aminocyclization/lactamization of d-mannose/D-glucose derived C5-gamma-azido esters as a k

78 racetylated 2-acetylamino-2-deoxy-3-O-methyl-D-mannose decreases cell surface sialylation in Jurkat c

79 two partial ORFs similar to genes rfbD (GDP-D-mannose dehydratase) and rfbZ (first mannosyl transfer

80 of Atstp1 seed shows reduced sensitivity to D-mannose, demonstrating that AtSTP1 is active before ge

81 e multivalent systems displaying a protected d-mannose derivative or an iminosugar by way of CuAAC.

82 e de novo synthesis of GDP-L-fucose from GDP-D-mannose encompasses three catalytic steps, a 4,6-dehyd

83 KO of two isoforms of GDP-D-mannose epimerase (OsGME) reduced the foliar AsA level

84 h equatorial 4-OH groups competed as well as D-mannose for gp120 binding to DC-SIGN, regardless of ho

85 cificity of 2-acetylamino-2-deoxy-3-O-methyl-D-mannose for MNK.

86 ird, the fluorinated substrate, GDP-2F-alpha-d-mannose, for which a cationic oxocarbenium transition

87 tamin C) biosynthesis pathway occurs via GDP-D-mannose (GDP-D-Man), GDP-L-galactose (GDP-L-Gal), and

88 n in the presence of GDP-4-amino-4,6-dideoxy-D-mannose (GDP-perosamine).

89 4 --> Leu) Gmm bound to substrates GDP-alpha-d-mannose, GDP-alpha-d-glucose, and GDP-beta-l-fucose.

90 ascorbate biosynthesis pathway involving GDP-D-mannose, GDP-L-galactose, L-galactose and L-galactono-

91 The concentration of D-mannose in serum is 20-50 micron, but its physiologica

92 sity are well characterized, the function of D-mannose in T cell immune responses remains unknown.

93 rtho ester, this being readily prepared from d-mannose in three easy, high-yielding steps.

94 via high-affinity (1 nM), Ca(2+)-dependent, D-mannose-inhibited binding to the major envelope glycop

95 2-Acetylamino-2-deoxy-3-O-methyl-D-mannose inhibits the human ManNAc kinase domain of the

96 e route developed involves the conversion of D-mannose into a suitably protected diene (13), which is

97 uired for optimal expression of levFGX; (ii) D-mannose is a potent inducer of the levD and fruA opero

98 Transport of D-galactose and D-mannose is also up to 60% less in Atstp1 seedlings com

99 Perosamine or 4-amino-4,6-dideoxy- d-mannose is an unusual sugar found in the O-antigens of

100 the free energy landscape of isolated alpha-D-mannose is molded on enzyme to only allow one conforma

101 that the binding of the monosaccharide alpha-D-mannose is the primary bladder cell receptor for uropa

102 epines 3 and 4, derived from d-galactose and d-mannose, largely favor alpha- over beta-epoxidation.

103 aldehyde function introduced on the glycans D-mannose (Man) and D-N-acetyl glucosamine (GlcNAc) by t

104 amphiphilic Janus glycodendrimers (GDs) with d-mannose (Man) headgroups, a known routing signal for l

105 The effect of D-mannose (Man) on plant cells was studied in two differ

106 ly unrecognized immunoregulatory function of D-mannose may have clinical applications for immunopatho

107 tructures of GNA complexed with methyl-alpha-D-mannose (MeMan) and mannose-alpha 1,3-D-mannose-alpha-

108 Adherence was inhibited either by 4% D-mannose or by anti-type 1 fimbrial rabbit serum.

109 s selectivity, responding strongly to either D-mannose or D-glucose in a cAMP-independent manner.

110 No alteration in affinity was observed for D-mannose or for alpha1-3- or alpha1-6-linked DM; howeve

111 g(2+), catalyzes the hydrolysis of GDP-alpha-D-mannose or GDP-alpha-D-glucose to yield sugar and GDP.

112 Perosamine (4-amino-4,6-dideoxy- d-mannose), or its N-acetylated form, is one of several

113 The D-mannose pathway appears to be predominant in leaf tiss

114 t and possibly circumvent other steps in the D-mannose pathway to synthesize vitamin C.

115 egions with similarity to dolichol phosphate-D-mannose:protein O-D-mannosyltransferases.

116 In agreement with this finding, D-mannose proved to be a potent axon-promoting factor fo

117 starting from commercially available methyl-D-mannose pyranoside.

118 nction to remove GDP-D-glucose formed by GDP-D-mannose pyrophosphorylase, an enzyme that has previous

119 ow that binding of type 1 fimbriae (pili) to d-mannose receptors triggers a cross talk that leads to

120 His-259 abstracts the H2 proton of the d-mannose residue at the reducing end, and consistently

121 reversibly converts d-glucose residues into d-mannose residues at the reducing end of unmodified bet

122 .08) or fecal strains (P < 0.001) to exhibit D-mannose-resistant hemagglutination of human erythrocyt

123 However, E. coli 83972 did not express D-mannose-resistant or D-mannose-sensitive hemagglutinat

124 Addition of d-mannose restored MICA/B surface expression after 2DG t

125 re we show that supraphysiological levels of D-mannose safely achievable by drinking-water supplement

126 83972 did not express D-mannose-resistant or D-mannose-sensitive hemagglutination after growth under

127 ell adherence was observed in vivo, and weak D-mannose-sensitive hemagglutination was detected after

128 In vitro, D-mannose stimulated Treg cell differentiation in human

129 hanism that can be alleviated by addition of d-mannose; this does not, however, affect the inhibition

130 which catalyzes the hydrolysis of GDP-alpha-D-mannose to GDP and the beta-sugar by nucleophilic subs

131 the MUR1 and GER1 gene products converts GDP-D-mannose to GDP-L-fucose in vitro demonstrating that th

132 rther decreased the k(cat) with GDP-2F-alpha-d-mannose to values similar to those found with GDP-alph

133 Here we identify a metformin-stimulated d-mannose transport (MSMT) activity in dermal fibroblast

134 ST1) has been previously identified as a GDP-d-mannose transporter.

135 ion and demonstrated the requirement for GDP-d-mannose, UDP-d-glucose and dTDP-l-rhamnose in Psl prod

136 H(2) showed about 2.0-fold-increased [(14)C]d-mannose uptake compared to the cells grown without H(2

137 D-mannose was also identified as a substrate.

138 The binding activity of the mono-saccharide D-mannose was delineated from this of mannotriose (Man(a

139 The unique site binding pocket occupied by D-mannose was probed using site-directed mutagenesis.

140 mannoside, 3,6-di-O-(alpha-d-mannopyranosyl)-d-mannose, which is found in the core region of all aspa

141 saccharide 3,6-di-O-(alpha-D-mannopyranosyl)-D-mannose, which is present in all asparagine-linked car

142 accharide, 3,6-di-O-(alpha-D-mannopyranosyl)-D-mannose, which is present in the core region of all as