ライフサイエンスコーパス: D. melanogaster

1 D. melanogaster females store sperm in two types of orga

2 D. melanogaster has a relatively simple nervous system b

3 D. melanogaster possess three types of hematopoietic cel

4 ock neurons (LN(d)'s and fifth s-LN(v)) in a D. melanogaster host.

5 tially complement the reduced fertility of a D. melanogaster Hmr mutation.

6 ests to easily view and analyse acknowledged D. melanogaster gene sets and compare them with those of

7 Three additional D. melanogaster fly lines with putative mutations in pyr

8 uired for full oral toxicity of Pf-5 against D. melanogaster, with rhizoxins being the primary determ

9 utant of Pf-5 retained full toxicity against D. melanogaster in a noninvasive feeding assay, indicati

10 Indeed, 15% of all D. melanogaster genes segregate for potentially damaged

11 The adenosine signal thus allows D. melanogaster to rapidly marshal the energy needed for

12 BMP activity profiles between M. abdita and D. melanogaster.

13 Treating newly emerged Ae. aegypti and D. melanogaster adults with recombinant bursicon (r-burs

14 s gene expression datasets of C. elegans and D. melanogaster during their embryonic development.

15 ng free energy for the entire C. elegans and D. melanogaster genomes.

16 bodies of literature such as C. elegans and D. melanogaster to identify papers with any of these dat

17 eukaryotic cells and animals (C. elegans and D. melanogaster) and the incorporation of useful unnatur

18 ical role in the longevity of C. elegans and D. melanogaster.

19 asts, D. suzukii (a pest of fresh fruit) and D. melanogaster (a saprophytic fly and a neurogenetic mo

20 se (mouse Vasa homolog), Xenopus laevis, and D. melanogaster Vasa proteins contain both symmetrical a

21 fluorescence shift toward green, in mice and D. melanogaster, as well as significantly improved struc

22 rable to conservation between D. miranda and D. melanogaster, which diverged >30 MY ago.

23 tion from genetic crosses of D. santomea and D. melanogaster, a much more divergent species, that at

24 ctivate AMP gene promoters from M. sexta and D. melanogaster.

25 he budding yeast DNA repair factor Slx4p and D. melanogaster MUS312.

26 Because dipteran insects such as D. melanogaster lack glutathione reductase, thioredoxin

27 ing to reexamine the well-studied Australian D. melanogaster cline.

28 ul comparisons against the current available D. melanogaster reference genome (dm3).

29 Because D. melanogaster is a powerful model system for studying

30 e the first comprehensive comparison between D. melanogaster and C. elegans developmental time course

31 iability of expression in comparison between D. melanogaster and the closely related D. simulans.

32 F1 hybrids of interspecific crosses between D. melanogaster and D. simulans and compare them with in

33 We transferred cytoplasm between D. melanogaster embryos carrying mitochondrial mutations

34 st, we find that sequence divergence between D. melanogaster and D. simulans is greater at regulatory

35 we show that some viruses are shared between D. melanogaster and D. simulans.

36 Given the similarity between D. melanogaster and vertebrate eye development, the larg

37 s involved in naked valley variation between D. melanogaster and D. simulans [5, 6].

38 derstanding of the genetic variation between D. melanogaster reference strains.

39 because lethality is caused specifically by D. melanogaster Hmr but not by D. simulans or D. mauriti

40 lele characteristic of African and Caribbean D. melanogaster females (more 5,9-C27:2 and less 7,11-C2

41 Here we analyze the effect of changing D. melanogaster sex comb length on the process of rotati

42 ittle as a five minute exposure to 100% CO2, D. melanogaster exhibited climbing deficits up to 24 hou

43 ated the acclimation of the widely colonized D. melanogaster (and possibly D. simulans) to temperate

44 distant Drosophila species could complement D. melanogaster roX mutants despite low homology.

45 citrifolia fruit-with its generalist cousins D. melanogaster and D. simulans.

46 y reported viral sequences will help develop D. melanogaster further as a model for molecular and evo

47 ved by testing its activity in the divergent D. melanogaster genome.

48 e performed database searches utilizing each D. melanogaster insulator protein as a query to find ort

49 n and genetic linkage experiments with eight D. melanogaster natural populations collected from Calif

50 ing four species (S. cerevisiae, C. elegans, D. melanogaster and H. sapiens).

51 d in S. cerevisiae, A. thaliana, C. elegans, D. melanogaster and H. sapiens.

52 n and mRNA degradation in yeast, C. elegans, D. melanogaster, and humans by an unknown mechanism.

53 this hypothesis, mutations in four essential D. melanogaster dosage compensation genes are shown here

54 en interactions in zygomycosis and establish D. melanogaster as a promising model to study this impor

55 By comparing this new genome to the existing D. melanogaster assembly, we created a structural varian

56 Female D. melanogaster are attracted to food containing acetic

57 ide (SP) activates JH biosynthesis in female D. melanogaster after mating [14].

58 suppressive effect of reproduction in female D. melanogaster is attributable to the endocrine signal

59 ric division of neuroblasts in the fruit fly D. melanogaster.

60 A lognormal DFE best explains the data for D. melanogaster, whereas we find evidence for a bimodal

61 e lipidomic profiles have been generated for D. melanogaster, little information is available on the

62 ar-protein interactions may be important for D. melanogaster sperm storage, much as they are in many

63 The telomeric retrotransposon HeT-A from D. melanogaster has an unusual promoter near its 3' term

64 and width across species, and is absent from D. melanogaster eggshells.

65 ge population genomic Wolbachia dataset from D. melanogaster.

66 ext-generation paired-end reads derived from D. melanogaster isofemale lines.

67 in Calliphora vicina a species diverged from D. melanogaster by about 100 Myr, spatial expression of

68 d chromosome deletions and duplications from D. melanogaster to map two hybrid incompatibility loci i

69 ly consistent with most other estimates from D. melanogaster and indicate a relatively high rate of a

70 -containing mTR3 and the Cys-orthologue from D. melanogaster (DmTR) to resist inactivation by oxidati

71 s appear to have been acquired recently from D. melanogaster probably via a single horizontal transfe

72 otransposons from D. virilis, separated from D. melanogaster by 40 to 60 million years, to evaluate t

73 tome similarity of developmental stages from D. melanogaster and C. elegans using modENCODE RNA-seq d

74 In D. melanogaster, the bone morphogenetic protein (BMP) si

75 In D. melanogaster, these genes are activated just once dur

76 er updated profiles (36 in vertebrates, 3 in D. melanogaster and 4 in A. thaliana; a 9% update in tot

77 e are four TipE-homologous genes (TEH1-4) in D. melanogaster and three to four orthologs in other ins

78 With genetic approaches in D. melanogaster and C. elegans, we demonstrate the impor

79 ith the analogous sequence and spacing as in D. melanogaster, providing strong support for the spread

80 uired for the selection of neuroblasts as in D. melanogaster.

81 tant role in maintaining nutrient balance in D. melanogaster.

82 ctivities in the natalisin-specific cells in D. melanogaster induced significant defects in the matin

83 patterns of variation in male mate choice in D. melanogaster.

84 zing whole-genome data to identify clines in D. melanogaster and several other systems.

85 uired for the functions attributed to cnn in D. melanogaster.

86 ne leads to increased male-male courtship in D. melanogaster, although it leaves other aspects of mat

87 of the Accord insertion allele of CYP6G1 in D. melanogaster natural populations.

88 la and people, pharmacochaperoning of DAT in D. melanogaster may allow us to bridge that gap.

89 ndrially localized aldehyde dehydrogenase in D. melanogaster has two important functions: detoxifying

90 s to our understanding of eye development in D. melanogaster and humans.

91 trast to knowledge of antenna development in D. melanogaster, insight into the likely ancestral mode

92 function required for proper development in D. melanogaster.

93 s and low level of linkage disequilibrium in D. melanogaster enabled identification of many small, di

94 me-wide studies of TE population dynamics in D. melanogaster.

95 enome-wide quantification of such effects in D. melanogaster and D. simulans.

96 ype virus but also replicates efficiently in D. melanogaster after removal of the bacterial endosymbi

97 These elements in D. melanogaster differ from nontelomeric retrotransposon

98 For example, in D. melanogaster, the microbiome is reported as flexible

99 When willin is expressed in D. melanogaster epithelial tissues, it has the same subc

100 performed cap analysis of gene expression in D. melanogaster and D. pseudoobscura.

101 ave newly acquired male-biased expression in D. melanogaster are less likely to be dosage compensated

102 S2) fails to drive appreciable expression in D. melanogaster However, we found that a large transgene

103 t gene family show male-biased expression in D. melanogaster, largely in non-reproductive tissues.

104 hat resulted in high levels of expression in D. melanogaster.

105 in the recent past and swept to fixation in D. melanogaster.

106 , with the ancestral deletion state fixed in D. melanogaster and the derived insertion state at very

107 r COX activity and mitochondrial function in D. melanogaster, thus providing a new tool that may help

108 data are used to detect male-biased genes in D. melanogaster and to measure their expression levels.

109 Instead, knockdown of these genes in D. melanogaster via RNA interference caused male-biased

110 ate Hippo-pathway-dependent tissue growth in D. melanogaster and that they do this in parallel to the

111 magnitude of crossover rate heterogeneity in D. melanogaster and highlight potential features mediati

112 investigated the possible function of Hmr in D. melanogaster females using stronger mutant alleles.

113 germline cyst formation can be identified in D. melanogaster oogenesis.

114 the first example of allelic inactivation in D. melanogaster.

115 physiological and genetic interrogations in D. melanogaster to uncover the 'glucome', the complete s

116 ate for behavioral reproductive isolation in D. melanogaster.

117 ellular basis of male embryonic lethality in D. melanogaster induced by Spiroplasma.

118 sk alleles caused near-complete lethality in D. melanogaster, with no effect of the G0 nonrisk APOL1

119 Decreased Indy activity extends lifespan in D. melanogaster without significant reduction in fecundi

120 studies on individual neuroblast lineages in D. melanogaster and T. castaneum and additional markers

121 ric imaging (MALDI-MSI) to profile lipids in D. melanogaster tissue sections.

122 ication of a duplication at the Rdl locus in D. melanogaster.

123 iological role of the single Piezo member in D. melanogaster (Dmpiezo; also known as CG8486).

124 ciated with diet-specific gut microbiomes in D. melanogaster Despite observing replicable differences

125 x additional candidate 3' tailed mirtrons in D. melanogaster.

126 Levels of queuosine modification in D. melanogaster reflect bioavailability of the precursor

127 1% and 2% of new nonsynonymous mutations in D. melanogaster are positively selected, with a scaled s

128 at the tissue tropism of BTV-1/NS3mCherry in D. melanogaster resembles that described previously for

129 cleotides in humans, 24 to 30 nucleotides in D. melanogaster, and uniformly 21 nucleotides in C. eleg

130 of the early postmating changes observed in D. melanogaster females are not caused by large modifica

131 cate that the HIP gene is duplicated only in D. melanogaster.

132 y positive selection in paralogs of Or67b in D. melanogaster.

133 Additionally, knock-down of MENA ortholog in D. melanogaster eyeful and sensitized eye cancer fly mod

134 etic locus determining diapause phenotype in D. melanogaster and independently confirmed this ability

135 ccessfully rescue RNAi-induced phenotypes in D. melanogaster, both in cell culture and in vivo.

136 as a repressor of abdominal pigmentation in D. melanogaster.

137 transducers in C. elegans and potentially in D. melanogaster; however, a direct role of its mammalian

138 are all required for humidity preference in D. melanogaster.

139 artly explained by a higher mutation rate in D. melanogaster, we also find significant heterogeneity

140 tonically affects protein evolution rates in D. melanogaster.

141 Examination of the Cyp12d1 region in D. melanogaster wildtype and isoline populations reveale

142 mmon mechanism for desiccation resistance in D. melanogaster.

143 netic variation in desiccation resistance in D. melanogaster.

144 es on both lifespan and stress resistance in D. melanogaster.

145 sters, elicited strong antennal responses in D. melanogaster, but weak antennal responses in electroa

146 fluorescent protein enhancer trap screen in D. melanogaster and expression profiling of developing m

147 In addition, we conducted an RNAi screen in D. melanogaster to investigate if positional and express

148 and then again during late stages as seen in D. melanogaster.

149 gins of replication, similar to that seen in D. melanogaster.

150 essential role in chromosome segregation in D. melanogaster since the gene's origin less than 15 mil

151 gh genetic perturbations of BMP signaling in D. melanogaster.

152 hromosome rDNA array is normally silenced in D. melanogaster males, while the Y chromosome rDNA array

153 derlie the evolution of naked valley size in D. melanogaster through repression of shavenoid (sha) [9

154 r evidence suggests that intronic AT skew in D. melanogaster is not affected by proximity to intron e

155 Five decades after the spread in D. melanogaster, we provide evidence that the P-element

156 n levels vary across developmental stages in D. melanogaster, and, consistent with a causal effect, g

157 ent from all known cytoplasmic structures in D. melanogaster, are evenly electron-dense spheres 1.5 m

158 Genetic studies in D. melanogaster have shown that larval oenocytes synthes

159 A previous study in D. melanogaster used a reporter gene driven by a testis-

160 sion in Drosophila virilis parallels that in D. melanogaster, suggesting that transcriptional regulat

161 he nucleolus formation is precisely timed in D. melanogaster embryos and follows the transcription of

162 ypes for six ecologically relevant traits in D. melanogaster wild-derived inbred lines.

163 alyses of interacting sex-specific traits in D. melanogaster with comparative analyses of the conditi

164 asonia vitripennis activate transcription in D. melanogaster cells.

165 ation to transcription start sites (TSSs) in D. melanogaster but not in Anopheles gambiae, Apis melli

166 aspecific differences in the naked valley in D. melanogaster and found that neither Ubx nor shavenbab

167 icular, expression of APOL1 risk variants in D. melanogaster nephrocytes caused cell-autonomous accum

168 structure of recombination rate variation in D. melanogaster.

169 is and earlier studies of a related virus in D. melanogaster, we conclude that vertically transmitted

170 t receptors, which detect yeast volatiles in D. melanogaster and mediate critical host-choice behavio

171 in tissues from human and mouse, as well in D. melanogaster and S. cerevisiae.

172 orms are not present in Dipterans, including D. melanogaster, except for an embryo-specific, distantl

173 ppeared in the melanogaster group (including D. melanogaster, D. yakuba, and D. erecta) >13 million y

174 zontal transfer of P elements, which invaded D. melanogaster early last century, demonstrated that ho

175 cies and branches other than those involving D. melanogaster, confirming the pervasiveness of gene mo

176 control, is capable of infecting and killing D. melanogaster larvae.

177 e results from earlier experiments in larval D. melanogaster using naturally occurring alleles.

178 Here, we show that male D. melanogaster detect rivals by using a suite of cues a

179 light chain on the actin cones that mediate D. melanogaster spermatid individualization.

180 te for being part of what could be a natural D. melanogaster and D. simulans core microbiome.

181 at GRK from D. willistoni rescues a grk-null D. melanogaster fly and, remarkably, it is also sufficie

182 ult Drosophila we show that more than 30% of D. melanogaster carry a detectable virus, and more than

183 Alternate splicing was observed in 31% of D. melanogaster genes, a 38% increase over previous esti

184 To further investigate the ability of D. melanogaster to balance nutrient intake, we examined

185 Our assembly of D. melanogaster revealed previously unknown heterochroma

186 differences in the dig-and-dive behavior of D. melanogaster and the fruit-pest D. suzukii.

187 as 65% CO2 affected the motor capability of D. melanogaster.

188 igene family resident on the X chromosome of D. melanogaster by chromosome engineering and found that

189 small, heterochromatic fourth chromosome of D. melanogaster is governed mainly by dSETDB1, whereas d

190 r analysis shows that the dot chromosomes of D. melanogaster and D. virilis have higher repeat densit

191 e them with intraspecific control crosses of D. melanogaster.

192 rent size; and (iii) that purified dimers of D. melanogaster F-ATPase reconstituted into lipid bilaye

193 t wit is expressed dynamically in the FCs of D. melanogaster in an evolutionary conserved pattern.

194 anipulations of tkv expression in the FCs of D. melanogaster that successfully recapitulated the sign

195 nd that the functions of a large fraction of D. melanogaster enhancers are conserved for their orthol

196 The ran-like gene of D. melanogaster and D. simulans has undergone recurrent

197 scura neo-X chromosome and microRNA genes of D. melanogaster.

198 ological novelty present in the genitalia of D. melanogaster employs an ancestral Hox-regulated netwo

199 this sequence is enriched in the genomes of D. melanogaster (58 copies versus approximately the thre

200 ionships based on the demographic history of D. melanogaster.

201 f discovery using these and other hybrids of D. melanogaster and D. simulans, resulting in an advance

202 array platform to survey the daily levels of D. melanogaster miRNAs in adult heads of wildtype flies

203 bab1 and bab2 genes from 94 inbred lines of D. melanogaster sampled from a single location.

204 lopmental stages, tissues, and cell lines of D. melanogaster, yielding a comprehensive atlas of 62,

205 patterns resemble those of Pdf(01) mutant of D. melanogaster.

206 20 individuals from a Ugandan population of D. melanogaster.

207 f variability in the ancestral population of D. melanogaster.

208 opulation size in the Zimbabwe population of D. melanogaster.

209 yed Y-linked variation in six populations of D. melanogaster spread across the globe.

210 valley size also varies among populations of D. melanogaster, ranging from 1,000 up to 30,000 mum(2).

211 on between Rwandan and French populations of D. melanogaster.

212 indings indicate that the mCrC is the PTP of D. melanogaster and that the signature conductance of F-

213 hod was used to determine the redox ratio of D. melanogaster and validated substantial decrease of re

214 (also known as the neurokinin K receptor of D. melanogaster), now has been recognized as a bona fide

215 FDY is absent in the closest relatives of D. melanogaster, and DNA sequence divergence indicates t

216 Although the high resistance of D. melanogaster may make it uniquely suited to exploit c

217 udates of D. simulans, the sister species of D. melanogaster, are not attractive to other larvae.

218 ding sites for 324 TFs across five stages of D. melanogaster embryo development.

219 ution of Q for G in different life stages of D. melanogaster, D. pseudoobscura, and D. willistoni.

220 utilize a common laboratory raised strain of D. melanogaster to characterize adaptation abilities to

221 We used a field strain of D. melanogaster to test whether surviving parasitism by

222 s of two commonly used laboratory strains of D. melanogaster (Canton-S and Oregon R) influence the fe

223 d targetRT insertions across nine strains of D. melanogaster, we verified these theoretical predictio

224 simulans, D. sechellia, and three strains of D. melanogaster.

225 The structure of D. melanogaster DJ-1beta is similar to that of human DJ-

226 hput data for population genomics studies of D. melanogaster.

227 cleotide variability, but a formal survey of D. melanogaster Y chromosome variation had yet to be per

228 s were significantly different from those of D. melanogaster.

229 s shaping the developmental transcriptome of D. melanogaster.

230 and proliferation of the two major types of D. melanogaster blood cells, plasmatocytes and crystal c

231 is is an important finding, given the use of D. melanogaster as a model system for the evolution of i

232 ints, providing tools for future research on D. melanogaster inversions as well as a framework for de

233 comparison to the most recent RNAz screen on D. melanogaster, REAPR predicts twice as many high-confi

234 eralist wasp than a wasp that specializes on D. melanogaster.

235 for eight species: R. sphaeroides, S. pombe, D. melanogaster, C. elegans, Xenopus, zebra fish, mouse

236 f five organisms, S. cerevisiae, H. sapiens, D. melanogaster, A. thaliana, and E. coli, and confirm s

237 s data sets for three organisms--H. sapiens, D. melanogaster, and S. cerevisiae--and show that, as co

238 is of hybrid rescue associated with a second D. melanogaster hybrid rescue allele, In(1)AB.

239 e and explore how natural history has shaped D. melanogaster in order to advance our understanding of

240 Intriguingly, some D. melanogaster nuclear genetic backgrounds can fully re

241 as no apparent phenotype within pure-species D. melanogaster.

242 e in two closely related Drosophila species (D. melanogaster and D. sechellia) and their F(1) hybrids

243 We used five standard D. melanogaster laboratory reference strains (Oregon R,

244 In this study, D. melanogaster is investigated as a model for the repli

245 ch higher levels of male-male courtship than D. melanogaster.

246 We conclude that D. melanogaster is a good model for studying cyanide pro

247 Here, we show that D. melanogaster females eject male ejaculates from the u

248 replication of E. chaffeensis suggests that D. melanogaster is a suitable host for E. chaffeensis.

249 ata within and between populations along the D. melanogaster genome.

250 imulans dosage compensation proteins and the D. melanogaster X chromosome.

251 ree D. simulans clade species as well as the D. melanogaster reference sequence.

252 Hmr was identified by the D. melanogaster partial loss-of-function allele Hmr1, wh

253 In contrast, the D. melanogaster TART (TART(mel)) promoter initiates tran

254 The applications of MiMIC vastly extend the D. melanogaster toolkit.

255 a G-protein coupled receptor (GPCR) for the D. melanogaster capa neuropeptides, Drm-capa-1 and -2 (c

256 heterogeneous and able to substitute for the D. melanogaster CTD in supporting fly development to adu

257 For the D. melanogaster genome, MGEScan-non-LTR found all known

258 incompatible with a nuclear genome from the D. melanogaster strain Oregon-R (OreR), resulting in imp

259 The modENCODE project has improved the D. melanogaster genome annotation by using deep and dive

260 ing multivariate statistical analysis in the D. melanogaster extracts and mouse serum.

261 quantified variation in CHC profiles in the D. melanogaster Genetic Reference Panel (DGRP) and ident

262 Mutations in the D. melanogaster Insulin Receptor (InR) alter SGP cell nu

263 Thus, studies in the D. melanogaster model system can identify candidate susc

264 characterize the hydrocarbon profile of the D. melanogaster cuticle, we applied direct ultraviolet l

265 ca (Cameroon and Zimbabwe) across 63% of the D. melanogaster genome and then sequenced representative

266 and reproduce experimental hallmarks of the D. melanogaster genome organization from independent and

267 The mammalian homologs of the D. melanogaster Grainyhead gene, Grainyhead-like 1-3 (GR

268 Using small segments of the D. melanogaster X chromosome duplicated onto the Y chrom

269 d lethality to a small 24-gene region of the D. melanogaster X.

270 and show that most male-biased genes on the D. melanogaster X are located outside dosage compensated

271 f crossover events in a 1.2-Mb region on the D. melanogaster X chromosome using a classic genetic map

272 incompatible with one or more factors on the D. melanogaster X chromosome, causing hybrid lethality.

273 ant incompatible partner locus exists on the D. melanogaster X.

274 reds of enhancers have been gained since the D. melanogaster-Drosophila yakuba split about 11 million

275 significantly lower ovariole number than the D. melanogaster Oregon R strain.

276 ) that were inserted randomly throughout the D. melanogaster genome.

277 us amount of information now attached to the D. melanogaster genome in public repositories and indivi

278 After aligning the reads to the D. melanogaster genome with TopHat2, we used Cuffdiff2 t

279 The original model simulations fit well the D. melanogaster wild type, but not mutant conditions.

280 RanGAP duplication arose recently within the D. melanogaster lineage, exploiting the preexisting and

281 lower TE content in D. simulans compared to D. melanogaster correlates with stronger epigenetic effe

282 Furthermore, in contrast to D. melanogaster, neuroblasts are not selected from prone

283 les can produce viable hybrids when mated to D. melanogaster females enables us to use the armamentar

284 resenting a significant increase relative to D. melanogaster and suggesting the presence of enhanced

285 Relative to D. melanogaster, M. domestica has also evolved an expand

286 these exoproducts and also lacks toxicity to D. melanogaster.

287 how that EPNs vary in their virulence toward D. melanogaster and that Drosophila species vary in thei

288 Wild-type D. melanogaster males innately possess the ability to pe

289 Here we use D. melanogaster ovarian GSCs to demonstrate that the dif

290 Using D. melanogaster retina, we demonstrate that Cindr links

291 s study demonstrate the feasibility of using D. melanogaster as a genetic model to investigate BTV-in

292 Hybridization tests using D. melanogaster deficiencies that include tan show no ev

293 in a four-field olfactometer assay, whereas D. melanogaster was strongly attracted to these volatile

294 viruses and a DNA virus associated with wild D. melanogaster.

295 causes lethality in F(1) hybrid females with D. melanogaster.

296 Nucleolar dominance within D. melanogaster is only partially dependent on known com

297 ajority of readthrough events evolved within D. melanogaster and were not predicted phylogenetically.

298 her drosophilids and low polymorphism within D. melanogaster.

299 nome-wide signals of recent selection within D. melanogaster.

300 deficient in either carbohydrates or yeast, D. melanogaster show a strong preference for the deficie