ライフサイエンスコーパス: D1 receptor

1 be dependent on tonic stimulation of the DA D1 receptor.

2 upon the effects of activating the dopamine D1 receptor.

3 changes in protein levels, at least for the D1-receptor.

4 rontal cortex influence temporal control via D1 receptors.

5 P treatment down-regulated the expression of D1 receptors.

6 tive functions, acting predominantly through D1 receptors.

7 ur, in part, via activation of dopamine (DA) D1 receptors.

8 greatly reduced cell-surface localization of D1 receptors.

9 by differentially activating dopamine D2 and D1 receptors.

10 s channel-blocking effect was independent of D1 receptors.

11 whether they are agonists or antagonists for D1 receptors.

12 in-coupled receptors, and lacked activity at D1 receptors.

13 vation of norepinephrine alpha2 and dopamine D1 receptors.

14 cumbens pathway, via, in part, activation of D1 receptors.

15 its cytokine production via dopamine type 1 (D1) receptors.

16 through DA D2 and adenosine A2A, but not DA D1, receptors.

17 dopamine transporter (DAT; [(3)H]mazindol), D1 receptor ([(3)H]SCH23390), and D2 receptor ([(3)H]sul

18 NAi lead to elevated cAMP levels in dopamine D1 receptor-activated neuroblastoma cells.

19 In VTA-PFC cocultures, D1 receptor activation (10 min) increased synaptic and n

20 sis are dependent on mating-induced dopamine D1 receptor activation in the NAc.

21 Here we show that, in striatal neurons, D1 receptor activation leads to rapid trafficking of NMD

22 dose-dependent inverted U-shaped effects of D1 receptor activation on neuroplasticity of the motor c

23 In contrast, in older animals (P28) D1 receptor activation produces a potentiation of the NM

24 We show that dopamine D1 receptor activation promotes and D2 receptor activati

25 ockade following maintained illumination and D1 receptor activation result in minimal GABAA receptor

26 it reduces hyperthermia produced by dopamine D1 receptor activation.

27 ncreased TrkB surface expression by dopamine D1 receptor activation.

28 Modification of D1 receptor activity prevents the aversive response to a

29 al demonstration that 5-HT1A and D2, but not D1, receptor activity influence a behavioral analog of l

30 Sustained treatment with D1 receptor agonist (SKF38393) leads to a significant de

31 slices with NR2A antagonist (NVP-AAM077) and D1 receptor agonist augmented the increase of dendritic

32 active enantiomer of the selective and full D1 receptor agonist dihydrexidine (DAR-0100A) could atte

33 conditioning rats under the partial dopamine D1 receptor agonist SKF 38393 or the opioid antagonist n

34 Direct infusion of the D1 receptor agonist SKF-38393 into the prelimbic cortex

35 tration of a low dose of either the dopamine D1 receptor agonist SKF-38393 or the D2 receptor antagon

36 s of neonatal (P7) rat striatum the dopamine D1 receptor agonist SKF-82958 significantly decreases NM

37 hibited opposite regulatory responses to the D1 receptor agonist SKF38393 (1-phenyl-2,3,4-5-tetrahydr

38 iation of synaptic plasticity induced by the D1 receptor agonist SKF38393 in spiny neurons.

39 Using the D1 receptor agonist SKF38393, we found that Trk neurotro

40 K density in rats treated with l-DOPA or the D1 receptor agonist SKF81297.

41 nuated the hyperthermia caused by a dopamine D1 receptor agonist, SKF 38393 (10 mg/kg, s.c.), indicat

42 D1 receptor agonists suppress systemic inflammation and

43 further clinical support to the potential of D1 receptor agonists to treat schizophrenia-spectrum wor

44 n males whereas females rely more heavily on D1 receptors, an effect that could be explained by sexua

45 The effect of D1 receptor and A2A receptor agonists on the phosphoryla

46 gical roles of Gs- and Golf-coupled dopamine D1 receptor and adenosine A2A receptor in the brain and

47 d to reveal potentially therapeutic dopamine D1 receptor and adenosine A2A receptor ligands with func

48 We studied the dopamine D1 receptor and cocaine self-administration in mice usin

49 factor transmitting the signals derived from D1 receptors and associative pathways to the CaCRE sites

50 Simultaneous activation of dopamine D1 receptors and CPARs induced additive increases in Glu

51 Binding of D1 receptors and DAT throughout the striatum correlated

52 hat activate the direct striatal pathway via D1 receptors and inhibit the indirect striato-cortical p

53 P and cGMP, whose synthesis is stimulated by D1 receptors and inhibited by D2 receptors preferentiall

54 ics we found a strong down-regulation of the D1 receptor- and DA transporter (DAT)-binding sites, but

55 emales were less sensitive to the effects of D1-receptor antagonism as compared with their ShA counte

56 rk tyrosine kinase inhibitor, and a dopamine D1 receptor antagonist could block the effects of SKF383

57 ven an intra-mPFC infusion of vehicle or the D1 receptor antagonist SCH 23390 (0.25 or 1.0 microg) pr

58 Pretreatment with the D1 receptor antagonist SCH-23390 before optical VTA stim

59 Pretreatment with the dopamine D1 receptor antagonist SCH23390 (0.1mg/kg, ip) 30 min pr

60 two injections: first with +/-8-OH-DPAT, the D1 receptor antagonist SCH23390 or their vehicles, and s

61 ent to induce BDNF in the mPFC, and dopamine D1 receptor antagonist treatment blocked the antidepress

62 e, attenuated the action of DBS, whereas the D1 receptor antagonist, SCH-23390, was ineffective, sugg

63 a-erythroidine (DHbetaE), and also by the DA D1 receptor antagonist, SCH-23390.

64 s paper assessed the possibility that the DA D1 receptor antagonist, SCH23390, might inhibit METH-ind

65 D2 receptor antagonist, eticlopride, and the D1 receptor antagonist, SCH23390.

66 otally abolished by pre-administration of DA-D1 receptor antagonist, SCH23390.

67 ed following saline or 0.25mg/kg SCH 23390,a D1 receptor antagonist, while awake hamsters breathed no

68 n the presence of 4 mum SCH23390, a dopamine D1 receptor antagonist.

69 he AMPA-receptor antagonist CNQX or dopamine D1-receptor antagonist SCH-23390 into the DLS before tes

70 e effects of intra-accumbens infusion of the D1-receptor antagonist, SCH-23390 (0, .3, 1.0, 3.0 micro

71 r cocaine that was not blocked by a dopamine D1-receptor antagonist.

72 Dopamine D1 receptor antagonists (SCH23390 and SKF83566) blocked

73 ion and patch-clamp recordings, we show that D1 receptors are almost exclusively expressed in the str

74 Whereas D1 receptors are known to contribute to Drosophila avers

75 In conclusion, neurokinin-1 and dopamine D1 receptors are required for the METH-induced striatal

76 striatal medium spiny neurons (MSNs) marker, D1-receptor associated signaling protein dopamine-and-cA

77 Blockade of dopamine D1 receptors attenuated prolonged wakefulness and synapt

78 Importantly, systemic inhibition of dopamine D1 receptors attenuated the stroke-induced increase in o

79 nd that this mechanism is associated with DA D1 receptor availability.

80 was no correlation between striatal DAT and D1 receptor binding (R(2)=0.07, p=0.33), although DAT an

81 Mean DAT, D2, and D1 receptor binding did not differ in suicide.

82 d serotonin levels in basal ganglia; reduced D1 receptor binding in nucleus accumbens; axodendritic p

83 In the rostral cortex, D1 receptor binding was 22% lower in zQ175 than WT anima

84 inding (R(2)=0.07, p=0.33), although DAT and D1 receptor binding was positively correlated in subject

85 ocaine resulted in only transient changes in D1 receptors binding.

86 We also show that maintained darkness and D1 receptor blockade following maintained illumination a

87 ple discrete-trial procedures employed here, D1 receptor blockade preferential reduces Pavlovian and

88 We examined here whether D1 receptor blockade within striatal or frontal cortical

89 d firing is selectively attenuated following D1 receptor blockade.

90 Pharmacological blockade of D1 receptor, but not D2 receptor, in the NAc during sexu

91 hat the production of IP3 is mediated by the D1 receptor, but not the D2 receptor.

92 ests; cyclic AMP responses to stimulation of D1 receptors by dopamine was selectively impaired in PrP

93 nd tonic inhibition, the acute activation of D1 receptors (by a selective agonist or indirectly by am

94 esults indicate that stimulation of dopamine D1 receptors can be coupled to the neurotrophin receptor

95 gnificantly, prior activation of presynaptic D1 receptors caused a time-dependent attenuation of mGlu

96 rly growth response 3 (EGR3) is increased in D1 receptor containing MSNs of mice susceptible to socia

97 In particular, direct pathway (dopamine D1 receptor-containing; D1R-) spiny projection neurons (

98 chronic cocaine treatment is stable only in D1-receptor-containing neurons and that DeltaFosB expres

99 also demonstrate that activation of dopamine D1 receptors corrects these deficits, through a mechanis

100 rtical areas, substantially reduced dopamine D1 receptor coupling to G(s)-protein, and deficits in co

101 However, the roles of D1 receptors, CREB, and GluR1 in morphine dependence are

102 ovement, whereas those that express dopamine D1 receptors (D1+) project to the substantia nigra pars

103 tudy, we show that mice lacking the dopamine D1 receptor (D1R KO mice) manifest greatly reduced FAA,

104 s working memory via high levels of dopamine D1 receptor (D1R) activation of cyclic adenosine monopho

105 R stimulation impacts striatal dopamine (DA) D1 receptor (D1R) and D2 receptor (D2R) function.

106 is associated with an alteration in dopamine D1 receptor (D1R) and glutamate receptor interactions.

107 A dopamine D1 receptor (D1R) antagonist blocked ghrelin-induced cAM

108 B males, it had differential effects on NAcc D1 receptor (D1R) binding.

109 tivity of agonist and antagonist of dopamine D1 receptor (D1R) by using quartz crystal microbalance (

110 The dopamine D1 receptor (D1R) facilitates reward acquisition and its

111 transgenic mice and found that the dopamine D1 receptor (D1R) is expressed in retinal bipolar cells

112 genetic regulatory elements for the dopamine D1 receptor (D1R) or dopamine D2 receptor (D2R).

113 ressing EGFP under the control of either the D1 receptor (D1R) or the D2 receptor (D2R) gene and micr

114 aptic activity and was reduced by a dopamine D1 receptor (D1R) protein kinase A pathway.

115 However, while facilitation of D1 receptor (D1R) signaling enhances the rewarding effec

116 kinase 2 (CK2) in the modulation of dopamine D1 receptor (D1R) signaling in cells.

117 g NMDARs from MSNs that express the dopamine D1 receptor (D1R) significantly attenuated AMPH sensitiz

118 Dopamine (DA) D1 receptor (D1R) stimulation in prefrontal cortex (PFC)

119 ut approach to selectively delete GRK2 in DA D1 receptor (D1R)-, DA D2 receptor (D2R)-, adenosine 2A

120 conditional knock-out of Cav1.2 in dopamine D1 receptor (D1R)-expressing cells resulted in attenuati

121 from C57BL/6 male mice, that a dopamine (DA) D1 receptor (D1R)-mediated enhancement in glutamate syna

122 The role of dopamine D1 receptors (D1R) and D2 receptors (D2R) in the ERG res

123 ngiotensin AT1 receptors (AT1R) and dopamine D1 receptors (D1R) modulates renal sodium excretion and

124 s, increased activation of striatal dopamine-D1 receptors (D1R) results in desensitization of delta-o

125 ium spiny neurons (MSNs) expressing dopamine D1 receptors (D1R).

126 l dopamine, and possible changes in dopamine D1 receptors (D1R).

127 lation of DORs in CINs critically influences D1-receptor (D1R)-expressing projection neurons in the N

128 ell but not the core in mice, which required D1 receptors (D1Rs) and mechanistic target of rapamycin

129 l neurons, we demonstrate here that dopamine D1 receptors (D1Rs) and NMDARs form dynamic surface clus

130 However, while dopamine D1 receptors (D1Rs) in the prefrontal cortex (PFC) have

131 the effect of D3R overexpression on dopamine D1 receptors (D1Rs) in the striatum.

132 ipulation of FEF activity either by blocking D1 receptors (D1Rs) or by stimulating D2 receptors (D2Rs

133 m spiny neurons (MSNs) that express dopamine D1 receptors (D1Rs) or D2 receptors (D2Rs), which drive

134 The dopamine D1 receptor-D3 receptor (D1R-D3R) heteromer is being con

135 triatal dopamine transporter and D2, but not D1, receptor densities.

136 n the caudate nucleus and putamen and higher D1-receptor density in the nucleus accumbens.

137 several IEGs, some of which occurred in a DA D1 receptor dependent fashion.

138 There were also delayed METH-induced DA D1 receptor-dependent effects on fosB mRNA expression.

139 sic firing, increased SC responses through a D1 receptor-dependent enhancement of excitatory transmis

140 Here we investigate the pathways involved in D1 receptor-dependent ERK1/2 activation using acute stri

141 Egr family of transcription factors in a DA D1 receptor-dependent fashion.

142 es of apical dendrites of these neurons in a D1 receptor-dependent manner.

143 nhanced cue-reward learning through dopamine D1 receptor-dependent mechanisms and suppressed task-irr

144 f the PFC, which are regulated by a dopamine D1 receptor-dependent pathway.

145 r inhibition of engrafted neurons, revealing D1 receptor-dependent regulation of host neuronal circui

146 Indeed, we observed D1 receptor-dependent synaptic potentiation only when od

147 tamine challenge reversed CPD via a dopamine D1-receptor-dependent paradoxical presynaptic potentiati

148 e rat using direct infusions of the dopamine D1 receptor (DRD1) antagonist SCH 23390 or dopamine D2 r

149 ngle nucleotide polymorphism in the dopamine D1 receptor (DRD1) gene, which was associated with ADHD

150 Cells expressing the dopamine D1 receptor (DRD1) have significant functional roles in

151 decreased dysbindin did not change dopamine D1 receptor (DRD1) levels, or its basal or dopamine-indu

152 tina, yet has been reported to do so by only D1 receptor-driven cyclic adenosine monophosphate (cAMP)

153 gest that activation of SN DA neurons and DS D1 receptors during fear extinction render fear extincti

154 e carriers, who are assumed to have a higher D1 receptor efficiency than carriers of the A allele.

155 In addition, D1 receptor electroporation into cells of the basal fore

156 av1.2 channels within the hippocampus and in D1 receptor-expressing cells in extinction of cocaine-as

157 at supports a role of Cav1.2 within dopamine D1 receptor-expressing cells of the hippocampus for exti

158 A and AMPA receptors and adenylyl cyclase in D1 receptor-expressing cells.

159 veal that in hemiparkinsonian mice, striatal D1 receptor-expressing medium spiny neurons (MSNs) direc

160 ely vulnerable to Tat exposure compared with D1 receptor-expressing MSNs.

161 citatory synaptic transmission onto dopamine D1 receptor-expressing neurons (D1+ neurons) in the nucl

162 targeted EP1 receptors on striatal dopamine D1 receptor-expressing neurons and that this signaling s

163 mouse in which Fos is primarily disrupted in D1 receptor-expressing neurons in the brain.

164 Stimulating D1 receptor-expressing neurons induced persistent reinfo

165 Our findings indicate that c-Fos produced in D1 receptor-expressing neurons integrates mechanisms to

166 with a cell-specific knockdown of mGluR5 in D1 receptor-expressing neurons.

167 cerol lipase alpha (DGLalpha), from dopamine D1 receptor-expressing or adenosine A2a receptor-express

168 y neurons (MSSNs) giving rise to the direct (D1 receptor-expressing) and indirect (D2 receptor-expres

169 that lack M4 mAChRs specifically in dopamine D1-receptor-expressing neurons, suggesting that postsyna

170 H23390 (which has been suggested to increase D1 receptor expression in the basal ganglia) did not eli

171 iabetic model, we demonstrate that the renal D1 receptor expression is down-regulated by the extracel

172 othyroidismin hamsters (HH) altered dopamine D1 receptor expression, D1 receptor-modulated ventilatio

173 2-AR), muscarinic (M1 and M2), and dopamine (D1) receptor families.

174 In this scheme, activation of dopamine D1 receptors following light exposure triggers cAMP-medi

175 to cocaine while redistributing postsynaptic D1-receptors from endosomes to plasma membrane, consiste

176 ic spines in MSN-D1 (MSN-expressing dopamine D1 receptors) from the core and shell of nucleus accumbe

177 educed oxidative stress and thereby restored D1 receptor function and normalized BP.

178 There exists a defect in renal D1 receptor function in hypertension, diabetes, and agin

179 In contrast, CIE exposure did not alter D1 receptor function or mGluR1 modulation of firing.

180 The effect of oxidative stress on renal D1 receptor function was investigated in healthy animals

181 histamine H3 receptor-mediated inhibition of D1 receptor function.

182 sitive sodium current (INaT) as a measure of D1 receptor function.

183 se in BP, which was accompanied by defective D1 receptor G-protein coupling and loss of natriuretic r

184 xidative stress, normalized BP, and restored D1 receptor G-protein coupling and natriuretic response

185 s that down-regulate the expression of renal D1 receptor gene in diabetes are not well understood.

186 microscopy, we show that neurons expressing D1 receptors have unique morphological and physiological

187 leads to GRK-2 translocation and subsequent D1 receptor hyper-serine phosphorylation and uncoupling.

188 pathway reverse the down-regulation of renal D1 receptor in diabetes.

189 ngs demonstrate that repeated stimulation of D1 receptors in adulthood interacts with the development

190 Our results identify a role for D1 receptors in mediating the control of visual cortical

191 orylated by PKA in response to activation of D1 receptors in striatal slices.

192 s of cocaine have shown a leading role of DA D1 receptors in the cascade of cellular events elicited

193 D1 receptors in the DS are a likely target mediating the

194 Pharmacological activation of D1 receptors in the DS did not impact fear extinction ac

195 ve shown that the expression and function of D1 receptors in the kidneys are decreased in animal mode

196 Local blockade of D1 receptors in the MLR decreased locomotor frequency, b

197 investigate a potential modulatory role for D1 receptors in the mPFC in amphetamine (AMPH)- and meth

198 The results indicate an important role for D1 receptors in the postnatal development of ME and SP s

199 ates of dopamine turnover, and activation of D1 receptors in the prefrontal cortex, measures that are

200 respectively, blocked the down-regulation of D1 receptors in the primary renal cells and in the kidne

201 Dopamine D1 receptors, in contrast, stimulate GluA1 extra synapti

202 robustly and rapidly induced by cocaine via D1 receptors, in mediating cocaine-induced persistent ne

203 have shown that in the absence of functional D1 receptors, in null mice, the systolic, diastolic, and

204 Single-channel recordings show that direct D1 receptor inhibition of NMDA receptors cannot be obser

205 eliably self-administer cocaine and that the D1 receptor is critical for the reinforcing effects of c

206 Although stimulation of D1 receptors is known to enhance motor function, the glo

207 l overactivation of ERK1/2 via dopamine (DA) D1 receptors is the hallmark of a supersensitive molecul

208 Activation of D1 receptors is thought to enable working memory by enha

209 We conclude that D1 receptor knock-out mice do not reliably self-administ

210 was a significant decrease in the number of D1 receptor knock-out mice that met criteria for acquisi

211 ine in all wild-type mice but in none of the D1 receptor knock-out mice.

212 or and grooming behaviors were eliminated in D1 receptor knockout (KO) mice, verifying a key role for

213 Furthermore, using D1 receptor knockout mice, we verified that this channel

214 D1-receptor knockout (D1R-KO) mice had impaired acquisit

215 D1 receptor KO mice had normal sodium appetite, indicati

216 triatal slices have shown that activation of D1 receptors leads to cAMP-dependent dephosphorylation o

217 P stimulation was unaffected in Fmr1 KO, but D1 receptor levels were reduced in these animals.

218 bright-light-induced activation of dopamine D1 receptors located on ON-center cone bipolar cell dend

219 ing the part of visual space affected by the D1 receptor manipulation.

220 Here we show that dopamine D1 receptors mediate prefrontal control of signals in th

221 Therefore, we propose that D1 receptor-mediated dendritic growth in mPFC excitatory

222 Single social defeat stress (S-SDS) induces D1 receptor-mediated extracellular signal-regulated kina

223 Importantly, we show that although D1 receptor-mediated functions are preserved and even en

224 ure results in subsensitivity of the INaT to D1 receptor-mediated inhibition because of a possible in

225 nd co-localized with DeltaFosB, suggesting a D1 receptor-mediated mechanism supporting the LHb involv

226 ulated striatal N/OFQ receptors opposing the D1 receptor-mediated overactivation of the striatonigral

227 We pharmacologically altered D1-receptor-mediated activity in the frontal eye field o

228 of any other NF subunit, amplifies dopamine D1-receptor-mediated motor responses to cocaine while re

229 HH) altered dopamine D1 receptor expression, D1 receptor-modulated ventilation, and ventilatory chemo

230 This finding of robust D1 receptor modulation in only a subpopulation of neuron

231 was a pronounced reduction in dopamine (DA) D1 receptor modulation of both intrinsic firing and evok

232 Here we study D1 receptor modulation of layer 5 pyramidal neurons in a

233 D1 receptor modulation of sEPSCs was absent in D1-YAC128

234 c excitability, glutamatergic signaling, and D1 receptor modulation of these cells.

235 was decreased specifically in D1 cells, and D1 receptor modulation was normal in D1-YAC128 cells.

236 Moreover, D1 receptor-modulation of breathing at rest and during g

237 g is related to changes in expression of the D1 receptor mRNA, suppression in expression of serotoner

238 ive reinforcers in wild-type mice but not in D1 receptor mutant mice, whereas food and intravenous in

239 Total D1 receptor number was indistinguishable in neurons from

240 ltures, suggesting that DA agonists acted on D1 receptors on PFC neurons, altering their excitatory t

241 (an agonist that does not activate homomeric D1 receptors or alter cAMP levels in other systems); 2)

242 sequence of activation of either presynaptic D1 receptors or mGluR2/3 receptors may critically regula

243 recognition performance further suggest that D1 receptors place constraints on the responsiveness of

244 Dopamine D1 receptors play an important role in movement, reward,

245 To determine the role postsynaptic DA D1 receptors play in this effect, we used whole-cell pat

246 What is known is that the dopamine D1 receptor plays an important role.

247 Renal dopamine, via activation of D1 receptors, plays a role in maintaining sodium homeost

248 Ablation of CK2 in D1 receptor-positive striatal neurons caused enhanced lo

249 At low cortical frequencies, dopamine D1 receptors promote glutamate release to both D1 and D2

250 eptors enabling flexible decision making and D1 receptors promoting persistence in choice biases.

251 By analyzing D1 receptor protein expression, we show that development

252 Furthermore, in HH D1 receptor protein levels are decreased in several brai

253 hyroid hamsters (EH), HH exhibited decreased D1 receptor protein levels in carotid bodies, striatum,

254 horylated in response to dopamine acting via D1 receptor/protein kinase A (PKA) signaling.

255 the striatum correlated negatively with age (D1 receptor: R(2)=0.12, p<0.05; DAT: R(2)=0.36, p<0.001)

256 E10A radioligand (18)F-MNI-659, the dopamine D1 receptor radioligand (11)C-NNC 112, and the 5-HT2A ra

257 E10A radioligand (18)F-MNI-659, the dopamine D1 receptor radioligand (11)C-NNC 112, and the 5-HT2A ra

258 nt with a specific modulatory role of NFM in D1-receptor recycling.

259 response in the subcellular distribution of D1 receptors, resulting in alterations in signaling capa

260 A decrease in the expression or function of D1 receptors results in increased sodium retention which

261 ing, whereas optimal stimulation of dopamine D1 receptors sculpts network inputs to refine mental rep

262 ity and expression, GRK-2 sequestration, and D1 receptor serine phosphorylation.

263 nase-2 (GRK-2) membranous translocation, and D1 receptor serine phosphorylation.

264 STDP in MSNs expressing dopamine D1 receptors shifted from spike-timing-dependent long-te

265 sm of the oxidative stress-mediated impaired D1 receptor signaling and hypertension is not known.

266 the protective H3 receptor-mediated brake on D1 receptor signaling and prevents the cell death from e

267 Both protein kinase A and dopamine D1 receptor signaling are required for the functional ex

268 eral lines of evidence suggest that dopamine D1 receptor signaling enhances dendritic excitability an

269 ulation by postsynaptic protein kinase A and D1 receptor signaling were determined in two distinct ag

270 ng and prevents the cell death from elevated D1 receptor signaling.

271 gh considerable evidence implicates dopamine D1-receptor signaling in the nucleus accumbens in motiva

272 These results suggest that the role of D1-receptor signaling, although critical in "nonaddicted

273 authors found that modulation of D2, but not D1, receptors significantly affected rats' odor discrimi

274 energic alpha1-adrenoceptor and dopaminergic D1 receptor stimulation activate feedforward calcium-pro

275 In rodents, dopamine D1 receptor stimulation causes a complex behavioral supe

276 dynorphin-B expression mediated by dopamine D1 receptor stimulation in the development of 3,4-dihydr

277 hole-cell INaT density and in the ability of D1 receptor stimulation to inhibit INaT.

278 mechanisms that regulate the consequences of D1 receptor stimulation, favoring activation of GluR1 ra

279 fects were demonstrated to be independent of D1 receptor stimulation.

280 Collectively, our findings show that D1 receptor subtype and related signaling in mPFC excita

281 mice, here we identified a role of dopamine D1 receptor subtype in mPFC excitatory neurons in suppre

282 eat stress (R-SDS) reduces the expression of D1 receptor subtype in mPFC of mice susceptible to R-SDS

283 Knockdown of D1 receptor subtype in whole neuronal populations or exc

284 refractoriness was associated with decreased D1 receptor surface expression.

285 hanges in modulatory functions of prefrontal D1 receptor systems.

286 ne-mediated disruption leaves an uninhibited D1 receptor that activates Gs, freely recruits beta-arre

287 ically or genetically, reduced the amount of D1 receptor that was internalized in response to dopamin

288 /substantia nigra, preferentially expressing D1 receptors that stimulate cAMP/cGMP synthesis.

289 -methyl-D-aspartate receptor potentiation by D1 receptor to trigger ERK1/2 activation and its subsequ

290 ippocampal pyramidal cells, dopamine acts at D1 receptors to reduce peak Na(+) currents by activation

291 e of ethanol inhibition may be influenced by D1 receptor tone.

292 ors, and extends this notion by showing that D1 receptor transmission within the striatum strongly su

293 Interestingly, the dopaminergic D1 receptor was overexpressed only on the lesioned side

294 The D1-receptor was predominant over the D2-receptor in the

295 n the mPFC of the brief access animals while D1 receptors were elevated in the N.Acc shell of the ext

296 CPARs and dopamine D1 receptors were required in vivo for elevated locomoti

297 We also show that a mutant dopamine D1 receptor, which has likewise been described as lackin

298 Combining the previously described D1 receptor with its putative function for activating an

299 ng GABAergic input is controlled by dopamine D1 receptors, with horizontal cells serving as a plausib

300 osphorylation of a peptide from the dopamine D1 receptor without ATP preincubation.