ライフサイエンスコーパス: D2 receptor

1 -stimulated beta-arrestin recruitment to the D2 receptor.

2 is mediated by the D1 receptor, but not the D2 receptor.

3 o their rapid dissociation from the dopamine D2 receptor.

4 tional selectivity relationships at dopamine D2 receptors.

5 dominant expression of either dopamine D1 or D2 receptors.

6 it the indirect striato-cortical pathway via D2 receptors.

7 s to that effected by activation of dopamine D2 receptors.

8 erived agonists on functional selectivity at D2 receptors.

9 ffinities to serotonin 5-HT(2A) and dopamine D2 receptors.

10 000-fold and 223-fold over the rat and human D2 receptors.

11 ally determined lower density of striatal DA D2 receptors.

12 ssessments and in vitro measures of dopamine D2 receptors.

13 ding and functional activities at the D3 and D2 receptors.

14 ignore irrelevant stimuli in the absence of D2 receptors.

15 d by the frontal lobes via actions on D1 and D2 receptors.

16 nterna/globus pallidus externa express D1 or D2 receptors.

17 t actions at 5-HT2A and, to a lesser extent, D2 receptors.

18 se PFC that largely lack expression of D1 or D2 receptors.

19 ) over beta-arrestin recruitment at dopamine D2 receptors.

20 metabolism, and signaling downstream of the D2 receptors.

21 cognitive functions via actions on D1 and/or D2 receptors.

22 ant (QAW039), an antagonist of prostaglandin D2 receptor 2, might reduce eosinophilic airway inflamma

23 mazindol), D1 receptor ([(3)H]SCH23390), and D2 receptor ([(3)H]sulpiride) binding in the dorsal stri

24 suggests that dopamine D1 or combined D1 and D2 receptor activation enhances cortical SNR to boost pe

25 In contrast, prolonged D2 receptor activation modestly reduced the tonic conduc

26 we aimed to determine the specific affect of D2 receptor activation on neuroplasticity in humans, bec

27 of cocaine effects requires simultaneous DA D2 receptor activation.

28 pecifically that dopamine D1 (or combined D1/D2) receptor activation enhances the cortical signal-to-

29 ver, it is currently unknown whether and how D2-receptor activation affects prefrontal representation

30 imaging to test the hypothesis that blocking D2-receptor activation enhances prefrontal representatio

31 the integrity of such representations, with D2-receptor activation rendering them flexible but weak.

32 ppa opioid receptor agonist U69593 decreased D2-receptor activation through both pathways, whereas th

33 ng outward currents were used as a sensor of D2-receptor activation.

34 e mu opioid receptor agonist DAMGO decreased D2-receptor activity only as a result of cholinergic-med

35 st that ethanol via the inhibitory action on D2S receptor activity suppresses Gi3 repression of Gs ex

36 antipsychotic medications, which demonstrate D2 receptor affinity and elicit variable, partial clinic

37 ules, incorporating ropinirole as a dopamine D2 receptor agonist and ZM 241385 as an adenosine A2A re

38 re, we combined application of the selective D2 receptor agonist bromocriptine (2.5, 10, and 20 mg or

39 istration of DA (2.5-10 muM), but not the DA D2 receptor agonist quinpirole (50-200 nM), resulted in

40 Combining D2 receptor agonist treatment with rM3Ds-dSPN stimulatio

41 Cocaine-induced and quinpirole (D2 receptor agonist)-induced locomotion was enhanced in

42 ct different concentrations of quinpirole, a D2 receptor agonist, into a brain slice containing the d

43 e compounds such as BIM-23A760, an sst2/sst5/D2 receptors-agonist, have emerged as promising new appr

44 ylin-induced hypophagia, as combined NAcC D1/D2 receptor agonists block the intake-suppressive effect

45 stering its precursor l-DOPA and/or dopamine D2-receptor agonists.

46 observed an 80% increase in high-affinity DA D2 receptors, an increased translocation of the dopamine

47 ias of a series of agonists for the dopamine D2 receptor and can even lead to reversals in the direct

48 83959-induced motor responses were intact in D2 receptor and Galphaq KO mice, as well as in knock-in

49 zophrenia are the gene encoding the dopamine D2 receptor and those involved in the upstream regulatio

50 s of PFC neurons that are modulated by D1 or D2 receptors and in turn interface with divergent downst

51 nsiders the microenvironment of postsynaptic D2 receptors and integrates association and dissociation

52 It displayed dual blockade of 5-HT6 and D2 receptors and negligible interactions at hERG and M1

53 confirmed their antagonism of 5-HT(7/2A) and D2 receptors and weak interactions with key antitargets

54 urons that is distinct from classical D1 and D2 receptors, and that dopamine can activate mechanisms

55 These results suggest dopamine D2 receptor antagonism holds promise as a potential neur

56 vity (S2 group) or with predominant dopamine D2 receptor antagonist activity (D2 group; HBBM, 40 mg,

57 ng task under the influence of either the DA D2 receptor antagonist amisulpride (400 mg), the NMDA re

58 ty, a group of rats received the dopamine D1/D2 receptor antagonist cis-flupenthixol (0.5 mg/kg) 30 m

59 acologic PRL mobilization using the dopamine D2 receptor antagonist domperidone prevented HCC in tumo

60 opamine D1 receptor agonist SKF-38393 or the D2 receptor antagonist eticlopride.

61 the 5-HT1A receptor agonist, 8-OH-DPAT, the D2 receptor antagonist, eticlopride, and the D1 receptor

62 effects whereas subeffective doses of the DA D2 receptor antagonist, L-741,626, rescued cocaine's abi

63 The dopamine D2 receptor antagonist, raclopride, attenuated the actio

64 Interestingly, 1 mum sulpiride, a D2 receptor antagonist, restored tLTP.

65 n humans, we combined sulpiride, a selective D2 receptor antagonist, with the dopamine precursor l-DO

66 t of breast cancer, and (-)-IBZM, a dopamine D2 receptor antagonist.

67 and placebo controlled administration of the D2-receptor antagonist amisulpride.

68 ter cAMP levels in other systems); 2) D1 and D2 receptor antagonists (SCH 23390, eticlopride, raclopr

69 Interestingly, dopamine D1 and D2 receptor antagonists have opposite effects on plastic

70 In the striatum, where D2 receptors are abundant, antipsychotic medications may

71 e receptors, where augmenting D1 and abating D2 receptors are engaged to balance cellular cAMP levels

72 sive odor learning per se, we here show that D2 receptors are specific for support of a consolidated

73 ect is primarily due to its interaction with D2 receptors, at least at low doses.

74 h baseline (placebo) measures of striatal DA D2 receptor availability did not differ between groups,

75 itron emission tomography imaging to compare D2 receptor availability in the cortex and striatal (lim

76 amphetamine challenge to measure baseline DA D2-receptor availability (BPND) and its percent change p

77 le from neighboring neurons expressing D1 or D2 receptors based on their dendritic morphology and sub

78 Glutamatergic inputs to both D1 and D2 receptor-bearing medium spiny neurons are inhibited b

79 re was a positive correlation between D1 and D2 receptor binding in the dorsal striatum of control su

80 demonstrated more significant reductions in D2 receptor binding in the salience network (insular cor

81 nectivity pattern and extrastriatal baseline D2 receptor binding potential and its change after amphe

82 concentration or are associated with reduced D2 receptor binding.

83 In humans, D2 receptor block abolishes plasticity, and the D2/D3, b

84 r activation re-establishes plasticity under D2 receptor block.

85 These results suggest that D2-receptor blockade enhances content-specific represent

86 n searchlight decoding approach we show that D2-receptor blockade enhances decoding of reward signals

87 omer did not directly stimulate the dopamine D2 receptor but potentiated the effects of dopamine.

88 isconnection approach, we reveal that D1 and D2 receptors can facilitate diverse aspects of decision

89 ional low affinity and suggest that striatal D2-receptors can encode both tonic and phasic dopamine s

90 SAR) is partly mediated by the prostaglandin D2 receptor chemoattractant receptor homologous molecule

91 Overexpression of p11 in dopamine D2 receptor-containing LHb neurons of control mice induc

92 sibly, and selectively block dopamine D1 and D2 receptors (D1R and D2R) when the PTL was conjugated t

93 majority of MSNs express either the DA D1 or D2 receptors (D1R, D2R).

94 oblast growth factor (FGF2) and the dopamine D2 receptor (D2).

95 in medium spiny neurons expressing dopamine D2 receptors (D2-MSNs) in the nucleus accumbens (NAc) of

96 ium spiny neurons (MSNs) expressing dopamine D2 receptors (D2-MSNs), with opposite regulation occurri

97 ion, and physiological responses to dopamine D2-receptor (D2) autoinhibition.

98 usly described a phenomenon whereby dopamine D2 receptor (D2R) activation elicits afterdepolarization

99 Aberrant dopamine D2 receptor (D2R) activity is associated with neuropsych

100 heteroarylhomopiperazines with high dopamine D2 receptor (D2R) affinity.

101 ing by mu-opioid receptor (MOR) and dopamine D2 receptor (D2R) and are implicated in drug addiction,

102 more recent studies have shown that dopamine D2 receptor (D2R) antagonism, paired with a motor task,

103 emale rats received injections of a dopamine D2 receptor (D2R) antagonist (eticlopride), D2R agonist

104 uble-blind, placebo-controlled pharmacology [D2 receptor (D2R) antagonist amisulpride] in humans with

105 ound that prochlorperazine (PCZ), a dopamine D2 receptor (D2R) antagonist approved to treat nausea, v

106 Because many APDs are dopamine (DA) D2 receptor (D2R) antagonists, such a mechanism would be

107 opioid receptor (MOR) and decreased dopamine D2 receptor (D2R) availability in addictive disorders, t

108 Brain DA D2 receptor (D2R) availability was measured with positro

109 associated with diminished striatal dopamine D2 receptor (D2R) availability, likely reflecting their

110 Altered dopamine D2 receptor (D2R) binding in the striatum has been assoc

111 A decrease in dopamine D2 receptor (D2R) binding in the striatum is one of the

112 aberrant motor learning induced by dopamine D2 receptor (D2R) blockade in mice.

113 ss beta-arrestin-biased agonists of dopamine D2 receptor (D2R) by extensively exploring multiple regi

114 Evidence indicating an increase in dopamine D2 receptor (D2R) density and occupancy in patients with

115 69652 (1) engages one protomer of a dopamine D2 receptor (D2R) dimer in a bitopic mode to allosterica

116 a bitopic pose at one protomer of a dopamine D2 receptor (D2R) dimer to negatively modulate the bindi

117 th validation in GPCR structure and dopamine D2 receptor (D2R) function.

118 The dopamine D2 receptor (D2R) has received much attention in obesity

119 Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key modulators of stria

120 nted binding of radioligands to the dopamine D2 receptor (D2R) in the striatum as well as neurochemic

121 The dopamine D2 receptor (D2R) is a G protein-coupled receptor that i

122 The dopamine D2 receptor (D2R) is a major component of the dopamine s

123 uggested that biased agonism at the dopamine D2 receptor (D2R) may be advantageous for the treatment

124 Striatal dopamine D2 receptor (D2R) relies upon G protein- and beta-arrest

125 Here we report that the modulation of DA D2 receptor (D2R) signaling bidirectionally regulates th

126 s and determined if these related to central D2 receptor (D2R) specific binding independent of BMI.

127 enhance motor function, the global effect of D2 receptor (D2R) stimulation or blockade remains highly

128 ed medications target primarily the dopamine D2 receptor (D2R) to inhibit G(i/o)-mediated adenylyl cy

129 ulator dopamine signals through the dopamine D2 receptor (D2R) to modulate central nervous system fun

130 ortem studies suggest impaired dopamine (DA)-D2 receptor (D2R) trafficking in patients with schizophr

131 e for the dopamine D3 receptor over dopamine D2 receptor (D2R), despite high sequence identity (78% i

132 The dopamine D2 receptor (D2R), like many G-protein-coupled receptors

133 e G-protein-coupled receptor (GPCR) dopamine D2 receptor (D2R), regulating its internalization and su

134 eceptor family comprises three subtypes: the D2 receptor (D2R), with short and long isoform variants

135 ely delete GRK2 in DA D1 receptor (D1R)-, DA D2 receptor (D2R)-, adenosine 2A receptor (A2AR)-, or DA

136 y influenced by cannabinoids and by dopamine D2 receptor (D2R)-mediated regulation of fast-firing par

137 advantages to ligands targeting the dopamine D2 receptor (D2R).

138 ce homology between the D3R and the dopamine D2 receptor (D2R).

139 sera were found to react with human dopamine D2 receptor (D2R).

140 Dopamine D2 receptors (D2R) are G protein-coupled receptors that

141 Striatal dopamine D2 receptors (D2R) are major regulators of motor activit

142 tum, and both sweet preferences and striatal D2 receptors (D2R) decline with age and may be altered i

143 itional mutant mice that selectively lack DA D2 receptors (D2R) from pituitary lactotropes (lacDrd2KO

144 The role of dopamine D1 receptors (D1R) and D2 receptors (D2R) in the ERG responses was evaluated in

145 we found that CaMKIIalpha binds to dopamine D2 receptors (D2R) in vitro.

146 MSNs expressing dopamine D1 (D1R-MSN) vs. D2 receptors (D2R-MSN) can exert antagonistic effects in

147 Blocking dopamine D2-receptors (D2R) altered generalization behavior as re

148 Striatal DA D2 receptors (D2Rs) also regulate reinforcement learning

149 ction, we examined the roles of dopaminergic D2 receptors (D2Rs) and cannabinoid CB1 receptors (CB1Rs

150 ct that in deep layers of the mPFC, dopamine D2 receptors (D2Rs) are mainly expressed by SC neurons,

151 Here we show that selective deletion of DA D2 receptors (D2Rs) from indirect-pathway medium spiny n

152 Despite overwhelming evidence for D2 receptors (D2Rs) in maintaining proper striatal funct

153 ibed to D2Rs.SIGNIFICANCE STATEMENT Dopamine D2 receptors (D2Rs) in the prefrontal cortex (PFC) are t

154 at selectively and reversibly overexpress DA D2 receptors (D2Rs) in the striatum (D2R-OE mice).

155 Low availability of dopamine (DA) D2 receptors (D2Rs) in the striatum is associated with h

156 ocking D1 receptors (D1Rs) or by stimulating D2 receptors (D2Rs) increased the tendency to choose tar

157 Dopamine D2 receptors (D2Rs) play a major role in the function of

158 Dopamine D2 receptors (D2Rs) suppress lateral inhibition from iMS

159 Although partial agonists at DA D2 receptors (D2Rs), like aripiprazole, were developed t

160 that express dopamine D1 receptors (D1Rs) or D2 receptors (D2Rs), which drive "Go" or "No-Go" behavio

161 of adult mice that is regulated by dopamine D2 receptors (D2Rs).

162 Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopa

163 icated in impulsivity, encoding the dopamine D2 receptor (DA D2R) and the 5-HT2c receptor (5-HT2cR),

164 onses previously found to relate to dopamine D2 receptor density (responsivity to tactile stimuli, pe

165 rast, A1 allele carriers, who have decreased D2 receptor density, show a positive association between

166 dation homologue FXR1 and regulates dopamine D2 receptor density.

167 ontal cortex of awaken mice induces dopamine D2 receptor dependent persistent changes of CDK5 and PSD

168 This is associated with dopamine D2 receptor-dependent increased striatal protein kinase

169 indicate approaches that normalize GABA and D2 receptor-dependent synaptic plasticity may be useful

170 However, the cocaine-induced plasticity of D2 receptor desensitization observed in wild type mice w

171 ligands also resulted in a large increase in D2 receptor dimers.

172 ovides an important determinant of dendritic D2 receptor distribution and mitochondrial availability

173 lso increased the expression of the dopamine D2 receptor, dopamine transporter, and adenosine A1 rece

174 (AGN 211377), that antagonizes prostaglandin D2 receptors (DPs) DP1 (49) and DP2 (558), prostaglandin

175 adenosine monophosphate (cAMP) increases or D2 receptor-driven cAMP decreases.

176 tent with markedly reduced signaling through D2 receptors during intoxication in active cocaine abuse

177 ors within the prefrontal cortex (PFC), with D2 receptors enabling flexible decision making and D1 re

178 ms of schizophrenia by antagonizing dopamine D2 receptors expressed by striatal spiny projection neur

179 PrL, p11 is highly concentrated in dopamine D2 receptor-expressing (D2(+)) glutamatergic neurons.

180 ne (cNIC) on synaptic plasticity in dopamine D2 receptor-expressing medium-spiny neurons in the indir

181 imulation of dorsal striatal dopamine D1 and D2 receptor-expressing neurons during decision-making in

182 ersistent reinforcement, whereas stimulating D2 receptor-expressing neurons induced transient punishm

183 Here, we selectively stimulated D1 or D2 receptor-expressing neurons while visualizing whole-b

184 vidence for the opposing influence of D1 and D2 receptor-expressing striatal neurons on brain-wide ci

185 enic mice, we found that dopamine subtype 2 (D2) receptor-expressing medium spiny neurons (MSNs) are

186 amine subtype 1 (D1) and dopamine subtype 2 (D2) receptor-expressing striatal medium spiny neurons (M

187 pulation-level Ca(2+) activities of dopamine D2-receptor-expressing medium spiny neurons (D2-MSNs), o

188 paraventricular nucleus of the thalamus and D2-receptor-expressing medium spiny neurons via synaptic

189 wo morphologically indistinguishable D1- and D2-receptor-expressing medium spiny neurons.

190 We demonstrate that both dopamine D1- and D2-receptor-expressing MSNs (D-MSNs) additionally harbor

191 s in signaling processes in dopamine D1- and D2-receptor-expressing neurons using drd2-eGFP mice, and

192 ere GSK3beta was deleted in either DA D1- or D2-receptor-expressing neurons.

193 y, and to relate its projection pattern with D2 receptor expression in particular.

194 ion is bi-directional, and that low striatal D2 receptor expression may represent a predisposing fact

195 erta, as well as the organization of D1- and D2-receptor expression in the SC.

196 ivo cocaine exposure, the desensitization of D2 receptors from neurons expressing only the D2S varian

197 ed NMDA currents in pyramidal cells, whereas D2 receptor function was unaltered.

198 Pharmacological manipulation of dopamine D2 receptor function with quinpirole (agonist) or eticlo

199 A SNP (rs17601612) in the dopamine D2 receptor gene (DRD2) was significantly associated wit

200 ms, rs2283265 and rs1076560, in the dopamine D2 receptor gene (DRD2) were found to be significantly a

201 ings imply that future studies investigating D2 receptor genes should covary for genetic ancestry or

202 y, suppression of GABAergic transmission via D2 receptor-glycogen synthase kinase-3beta signaling dra

203 In contrast, quinpirole (an agonist at D2 receptors) had no significant effect on the capsaicin

204 The dopamine D2 receptor has two splice variants, D2S (Short) and D2L

205 We show that blockade of dopamine D2 receptors has profound effects on the functional conn

206 duced FAA, whereas mice lacking the dopamine D2 receptor have normal FAA.

207 In particular, dopamine D1 and D2 receptors have been proposed to form hetero-oligomers

208 a signaling-deficient form of human dopamine D2 receptor (hD2R).

209 preference formation: it decreased OT and DA D2 receptor immunoreactivity in the medial prefrontal co

210 st sulpiride with genetic analysis of the DA D2 receptor in a behavioral study of reinforcement learn

211 date for a causal modulatory role of the DA D2 receptor in choice performance that might be distinct

212 stimulation of JNK also inactivates dopamine D2 receptors in a PRDX6-dependent manner.

213 f D2 receptors to DANs or CINs revealed that D2 receptors in CINs mediate a fast inhibition observed

214 thways are modulated through dopamine D1 and D2 receptors in lamprey and in mammals.

215 models emphasizing a role of postsynaptic DA D2 receptors in motivational aspects of reinforcement le

216 tter results demonstrate that blockade of DA D2 receptors in mPFC or activation of 5-HT1A receptors i

217 ntify a surrogate biomarker for the Dopamine D2 receptors in the brain by comparing patients diagnose

218 that the segregated expression of the D1 and D2 receptors in the direct and indirect striatal project

219 ts demonstrate a role of DMS dopamine D1 and D2 receptors in the incubation of methamphetamine cravin

220 macological blockade of D1 receptor, but not D2 receptor, in the NAc during sexual behavior attenuate

221 dendritic calcium signals in the presence of D2-receptor inhibition.

222 mulation of dopamine terminals evoked robust D2-receptor inhibitory postsynaptic currents (IPSCs) in

223 Likewise, the D2 receptor is expressed in the striatum, but little is

224 r these data suggest that functional loss of D2 receptors is a critical mechanism mediating cocaine-i

225 sence of the pertussis toxin (PTX)-sensitive D2S receptor is critical to mediate the ethanol stimulat

226 btypes, those enriched in dopamine D1 versus D2 receptors, is implicated in the behavioral responses

227 However, the role of each of these D2 receptor isoforms and its coupled G protein in mediat

228 ng selective antagonists and dopamine D1 and D2 receptor knock-out animals, we show that the producti

229 s study we used viral receptor expression in D2 receptor knockout mice to show distinct effects of ca

230 pressing the isoforms in dopamine neurons of D2 receptor knockout mice, this study assessed the calci

231 amine release acting locally on metabotropic D2 receptors leading to the activation of a G protein-co

232 Stress and dopamine D2 receptor levels (DRD2) have been shown to play a cent

233 that of unliganded receptors, agonist-bound D2 receptor-ligand complexes resulted in an increase in

234 Addition of bivalent D2 receptor ligands also resulted in a large increase in

235 because the ganglion cell layer binds D1 and D2 receptor ligands, and displays changes in signaling c

236 Thus, optimizing binding kinetics at the D2 receptor may result in APDs with improved therapeutic

237 lin-8-ol) is a highly efficacious agonist at D2 receptor-mediated G protein-linked signaling, but doe

238 e ventral tegmental area, the time course of D2-receptor-mediated IPSCs (D2-IPSCs) was consistent bet

239 ce, but they do exhibit clear alterations to D2-receptor-mediated short-term synaptic plasticity, beh

240 sk taking was associated with lower striatal D2 receptor mRNA expression, and pharmacological activat

241 ous work has shown opposing roles for D1 and D2 receptor MSN subtypes in depression-like outcomes to

242 estigations of bivalent ligands for dopamine D2 receptor/neurotensin NTS1 receptor (D2R/NTS1R) hetero

243 herapeutic functional adaptation to dopamine D2 receptor occupancy required for medication effects on

244 d lack of agonist-induced internalization of D2 receptors on dopamine neurons indicate a purposefully

245 s compacta activates inhibitory postsynaptic D2-receptors on dopaminergic neurons.

246 Together, the results indicate that D2-receptors on MSNs exhibit functional low affinity and

247 To examine how dopamine release activates D2-receptors on MSNs, G protein activated inwardly recti

248 Although D2 receptors paradoxically increased glutamate release f

249 Antagonism of GABA(B) receptors or dopamine D2 receptors partially reversed the reduction in alcohol

250 oration at baseline, whereas CK2 ablation in D2 receptor-positive neurons caused increased locomotion

251 consistent with the cortical distribution of D2 receptors, post hoc analyses showed enhanced decoding

252 stimulated by D1 receptors and inhibited by D2 receptors preferentially expressed in striatoentopedu

253 ing are tightly regulated by dopamine D1 and D2 receptors present in basal ganglia circuits.

254 We show here that the D2 receptor, primarily the D2S isoform, is critically in

255 Dopamine D2 receptor-promoted activation of Galpha(o) over Galpha

256 s accumbens, even in neurons in which D1 and D2 receptor promoters are both active, the receptor prot

257 BL/6J) animals were imaged with the dopamine D2 receptor radioligand (11)C-raclopride, the PDE10A rad

258 BL/6J) animals were imaged with the dopamine D2 receptor radioligand (11)C-raclopride, the PDE10A rad

259 sitron emission tomography with the dopamine D2 receptor radiotracer carbon 11-labeled FLB457 before

260 substance abuse disorders may share dopamine D2 receptor-related vulnerabilities, and opposite findin

261 ermore, these findings suggest that striatal D2 receptors represent a therapeutic target for attenuat

262 pallidal SPNs, which express dopamine D1 and D2 receptors, respectively.

263 ulations selectively express dopamine D1 and D2 receptors, respectively.

264 mate and dopamine transmission, and aberrant D2-receptor responses.

265 d a more serial processing mode, whereas the D2 receptors seem to promote a shift in the opposite dir

266 ified an increase in dopamine binding at the D2 receptor selectively in the striatum.

267 for sucrose reward, blockade of either D1 or D2 receptors selectively attenuates excitation, but not

268 lness and also corroborate an enhancement of D2 receptor signaling in the arousing effects of methylp

269 cal studies identified a deficit in dopamine D2 receptor signaling in the BLA of Lmo4-deficient mice.

270 Here we assessed the balance between D1 or D2 receptor signaling in the human brain and how it is a

271 Our findings suggest that both D1 and D2 receptor signaling regulate motor cortex plasticity,

272 We further discovered that dopamine D1 and D2 receptor signaling selectively and distinctly regulat

273 to investigate cocaine-induced plasticity in D2 receptor signaling.

274 ex (mPFC) and (3) the dependence of these on D2-receptor stimulation.

275 onstrated the involvement of dopamine D4 and D2 receptor subtypes in the effects of pramipexole.

276 treated with ACEA, binding of haloperidol to D2 receptors switched CB1 coupling from Galphai to Galph

277 functional consequence of dopamine release, D2-receptor synaptic activity was assessed via virally o

278 riers, who have a higher striatal density of D2 receptors than C-allele carriers, we found a less eff

279 e segment (residues 212-215) of the dopamine D2 receptor that is necessary for arrestin binding in an

280 o globus pallidus, preferentially expressing D2 receptors that inhibit cAMP/cGMP synthesis.

281 In MSNs presumably expressing dopamine D2 receptors, tLTP, the main form of plasticity in naive

282 eriments with mice with targeted deletion of D2 receptors to DANs or CINs revealed that D2 receptors

283 This study used tagged D2 receptors to identify the localization and distributi

284 reversed in the adult animal after restoring D2 receptors to wild-type levels, demonstrating a remark

285 tional switch between intra-BLA DA D1 versus D2 receptor transmission are not currently understood.

286 rthermore, the ability of intra-BLA DA D1 or D2 receptor transmission to modulate the motivational sa

287 suggesting that dopamine signaling involving D2 receptors underlies the effect of NAS DBS.

288 al, and anatomical consequences of selective D2 receptor upregulation in the striatum.

289 coupling to homomers or heteromers of D1 or D2 receptors using a variety of biosensors.

290 dopamine function--dopamine transporter and D2 receptors--was significantly associated with the lear

291 the highly therapeutically relevant dopamine D2 receptor, we synthesized a collection of agonists bas

292 When tagged D2 receptors were expressed in locus coeruleus neurons,

293 GFP-tagged D2 receptors were found to be unevenly clustered on the

294 nexpectedly, upon desensitization the tagged D2 receptors were not internalized.

295 f positive symptoms through antagonism of DA-D2 receptors, whereas D-Govadine improves impairments in

296 cell types, those expressing dopamine D1 or D2 receptors, which exert opposing roles on motivated be

297 iny neurons (MSNs) expressing dopamine D1 or D2 receptors, which form direct and indirect pathways, r

298 correlate with drug association rates to the D2 receptor, while dissociation rates correlate with pro

299 n of dopamine signaling through the dopamine D2 receptor with the use of gene knockouts in Caenorhabd

300 es that potently antagonize 5-HT(6/7/2A) and D2 receptors, without interacting with M1 receptors and