ライフサイエンスコーパス: D4 receptor

1 combinations, to the aligned residues in the D4 receptor.

2 phaoB; however, none of these coupled to the D4 receptor.

3 f "knock-out" mice lacking the DA D2, D3, or D4 receptors.

4 omatic microdomain in M2-M3-M7 of the D2 and D4 receptors.

5 f PrP(C) with both the 5HT5A and D1, but not D4 receptors.

6 NE depletion prevented the activation of DA-D4 receptors.

7 fold selectivity for dopamine D3 over D2 and D4 receptors.

8 amic regulation of many targets of CaMKII by D4 receptors.

9 er basal conditions and that it activates DA-D4 receptors.

10 ntagonist sulpiride, suggesting mediation by D4 receptors.

11 that lack the D2 receptor but express D3 and D4 receptors.

12 Thus, our results show that D4 receptor activation induces the synaptic translocatio

13 However, this did not disrupt D4 receptor activation initiated by the dopamine transpo

14 present study, we investigated the effect of D4 receptor activation on subcellular localization of Ca

15 accumulation of alpha-CaMKII in response to D4 receptor activation, a D4-induced increase in the CaM

16 Thus, the absence of D4 receptors affects adaptation, altering transmission o

17 h high neuronal activity, application of the D4 receptor agonist [4-phenylpiperazinyl)-methyl]benzami

18 Intra-mPFC injection of the selective D4 receptor agonist PD 168,077 or the selective D1 recep

19 d through the modification of known dopamine D4 receptor agonist PD 168077.

20 Application of the D4 receptor agonist PD168077 caused a reversible decreas

21 Quinpirole, a dopamine D2/D3/D4 receptor agonist, decreased cAMP synthesis in retinas

22 betic mice and acute treatment with DA D1 or D4 receptor agonists improved spatial frequency threshol

23 A new series of dopamine D4 receptor agonists, 1-aryl-3-(4-pyridinepiperazin-1-yl

24 Selective D4 receptor agonists, by specifically targeting these te

25 New dopamine D4 receptor agonists, exemplified by (E)-1-(4-chlorophen

26 )Ca(2+) influx or [Ca(2+)](i) by dopamine D2/D4 receptor agonists.

27 a new class of potent and selective dopamine D4 receptor agonists.

28 compounds have excellent selectivity over D2-D4 receptors, alpha2a receptor, and the 5-HT transporter

29 phaq-linked prostaglandin E2 and leukotriene D4 receptors also regulate APP expression.

30 lphat2, we cotransfected MN9D cells with the D4 receptor and a mutagenized Ptx-resistant Galphat2 sub

31 uced a subtype-specific antibody against the D4 receptor and localized it within specific cellular el

32 through antagonism of the host cell dopamine D4 receptor and subsequent repression of the ERK phospho

33 l, highly selective radioligand for dopamine D4 receptors and may be used to investigate the dopamine

34 a- and beta1-adrenergic, dopaminergic D3 and D4 receptors and muscarinic acetylcholine receptor 4, th

35 Cell membranes containing expressed D4 receptors and receptor mutants were reconstituted wit

36 After AMPH treatment, both DA D3 and D4 receptor (+/+) and (-/-) mice had significant disrupt

37 these changes were restricted to the D3 and D4 receptors, and localized to Brodmann area 11 (orbitof

38 ause it was unaffected by application of the D4 receptor antagonist l-745,870.

39 D1 knock-out mice and mice treated with the D4 receptor antagonist L745870 (3-[[4-(4-chlorophenyl)pi

40 f inhibitory effects on swimming, whilst the D4 receptor antagonist, L745,870, had the opposite effec

41 rrents that were inhibited by L741,742, a DA-D4-receptor antagonist, were observed in LHb neurons whe

42 nd piperidines, including potential dopamine D4 receptor antagonists 2 and 3, that have been evaluate

43 of the agonists were blocked by dopamine D2/D4 receptor antagonists or by pertussis toxin.

44 agonists were ineffective and D(2/3) but not D4 receptor antagonists reversed the effects of dopamine

45 ons, an effect that was blocked by selective D4 receptor antagonists.

46 The D4-receptor antibody labelled GABAergic neurons in the c

47 ese findings demonstrate that the D1, D2 and D4 receptors are the major subtypes of DA receptors in t

48 ta support the utility of drugs targeting D3/D4 receptors as potential treatments for cocaine addicti

49 We also made the reciprocal mutations in a D4 receptor background.

50 Several compounds with combined D3/D4 receptor binding selectivity were also identified.

51 We found that activation of D4 receptors, but not D2 receptors, induced a rapid tran

52 CHO cells transfected with human D2, D3, or D4 receptor cDNAs.

53 developed a cell-based assay where activated D4 receptors coupled to a Pertussis toxin-sensitive path

54 To test the hypothesis that the D4 receptor couples to Galphat2, we cotransfected MN9D c

55 t (KO) mice completely lacking DA D2, D3, or D4 receptors (D2R, D3R, or D4R KO mice) and their wild-t

56 2-type dopamine receptors, we found that the D4 receptor (D4R) agonist PD168077, but not D1/D5 and D2

57 ted that polymorphisms of the human dopamine D4 receptor (D4R) gene are associated with personality i

58 ants (D2SR and D2LR), D3 receptor (D3R), and D4 receptor (D4R), with several polymorphic variants.

59 na, causing uncoupling of photoreceptors via D4 receptors (D4R), which inhibit adenylyl cyclase (AC)

60 Recently, retinal dopamine D4 receptors (D4Rs) have been implicated in modulating c

61 eceptors) was the same in both wild-type and D4 receptor-deficient mice.

62 firing, depressed the SC response through a D4 receptor-dependent enhancement of feedforward inhibit

63 Our results also suggest that D3 and D4 receptors do not play major roles in the modulation o

64 ders, and a polymorphism within the dopamine D4 receptor (DRD4) gene has been frequently implicated i

65 In particular, the dopamine D4 receptor (DRD4) has been shown to moderate the impact

66 667 bound specifically to the human dopamine D4 receptor expressed in HEK cells and saturation analys

67 ptors expressed in HEK293 cells and dopamine D4 receptors expressed in CHO cells.

68 asthmatic airways, modulates leukotriene (LT)D4 receptor expression and contractile responses in cult

69 Moreover, D4 receptors failed to induce CaMKII translocation in th

70 The precise role of loop i3 in D4 receptor function is not known.

71 The dopamine D4 receptor garnered a great deal of interest in the ear

72 ndophenotypes, and variation in the dopamine D4 receptor gene (DRD4) explains at least a portion of t

73 rphisms in some dopamine genes (the dopamine D4 receptor gene and the dopamine transporter gene).

74 ice with targeted disruption of the dopamine D4 receptor gene.

75 The closely related D2 and D4 receptors have been shown to inhibit adenylyl cyclase

76 onic kidney (HEK) cells expressing the human D4 receptor (hD4 HEK) with an EC50 value of 80 nM.

77 A unique feature of the human D4 receptor (hD4 R) gene is the existence of a large num

78 How an optimal level of human dopamine D4 receptor (hD4R) is maintained in synaptic membranes i

79 The dopamine D4 receptor in prefrontal cortex (PFC) plays a key role

80 Previously, we showed that activation of D4 receptors in a mouse mesencephalic neuronal cell line

81 [125I]L-750,667, bound to D4 receptors in a stereoselective manner with (+)-butacl

82 In this study, we found that activation of D4 receptors in PFC exerts a complex regulation of Ca2+/

83 ogether, our results show that activation of D4 receptors in PFC pyramidal neurons inhibits GABA(A) c

84 s of D4 receptors, we examined the impact of D4 receptors in PFC pyramidal neurons on GABAergic inhib

85 aclopride has been used to quantify dopamine D4 receptors in postmortem schizophrenic brain studies.

86 One of the important targets of dopamine D4 receptors in prefrontal cortex (PFC) is the multifunc

87 ctional regulation of CaMKII activity by PFC D4 receptors in response to changes in neuronal activity

88 ely low selectivity of drugs for D2, D3, and D4 receptors in vivo.

89 opamine D2-like receptors (i.e., D2, D3, and D4 receptors) in the nucleus accumbens (NAcc) for the fo

90 ents using transgenic mice lacking D2, D3 or D4 receptors indicated that the reduction of K+ current

91 ith selective affinity for the dopamine (DA) D4 receptor is described.

92 nes with selective affinity for the dopamine D4 receptor is described.

93 nes with selective affinity for the dopamine D4 receptor is described.

94 the previously detected elevation of D2 and D4 receptor levels in schizophrenia, elevation of D3 rec

95 rs in PFC pyramidal neurons, suggesting that D4 receptors may play an important role in modulating sy

96 T)1A receptors, suggesting a D3 and possibly D4 receptor mechanism of action for buspirone.

97 revious work suggested that dopamine type 4 (D4) receptors modulate neurohypophysial K+ current, so t

98 cells (approximately 50%) coexpressed D3 or D4 receptor mRNA.

99 l amygdaloid subnuclei, although D1, D2, and D4 receptor mRNAs were more abundant than D3 and D5 mRNA

100 and functional properties against a panel of D4 receptor mutations in the aromatic microdomain to asc

101 These findings indicate that dopamine D4 receptors normally play a major role in regulating ph

102 The results suggest that dopamine, via D4 receptors, normally modulates the cascade that couple

103 e examined whether GBR12935 activation of DA-D4 receptors occurred in slices depleted of norepinephri

104 omplete loss of the modulatory actions of D2/D4 receptors on cell firing and neurotransmission in sli

105 Activation of dopamine D4 receptors on photoreceptor cells reduces a light-sens

106 the differential actions of dopamine D1 and D4 receptors on specific retinal functions and appear to

107 tor antagonist with high affinity for D3 and D4 receptors, on the relative reinforcing strength of co

108 type glutamate receptors by the PFC dopamine D4 receptor (one of the principal targets of antipsychot

109 ning residues that differ between the D2 and D4 receptors, only 20 were found to be accessible, and 6

110 consistent observation of striatal dopamine D4 receptors or D4-like binding sites was observed in th

111 genes and found no significant effect of the D4 receptor polymorphisms on antagonist or agonist bindi

112 and may be used to investigate the dopamine D4 receptor population in the central nervous system.

113 emic or intra-mPFC blockade of dopamine (DA) D4 receptors prevented this emotional associative learni

114 me-dependent changes in dopamine D2, D3, and D4 receptor protein and mRNA levels in unilaterally MPTP

115 transmission in PFC pyramidal neurons by the D4 receptor, providing a potential mechanism for D4 in s

116 ular mechanisms and physiological actions of D4 receptors remain elusive.

117 hibited high affinity antagonist activity at D4 receptors, reversing dopamine (1 microM)-induced inhi

118 long, or D3 dopamine receptors as well as a D4 receptor-selective antagonist to address the function

119 t least in part through disruption of D2 and D4 receptor signaling in mPFC.

120 ride binding may represent sigma rather than D4 receptor sites.

121 learning and that this process depends on DA D4 receptor stimulation in the mPFC.

122 at the decrease of cAMP elicited by dopamine D4 receptor stimulation may be secondary to decreased [C

123 so redistributed to postsynaptic sites after D4 receptor stimulation.

124 binding to cloned human dopamine D2, D3, and D4 receptor subtypes expressed in Chinese hamster ovary

125 onging to the D2 receptor subfamily (D2, D3, D4 receptor subtypes).

126 D2-like receptors, including the D2, D3, and D4 receptor subtypes, have all been implicated in the co

127 ted via the DA D2 receptor and not the D3 or D4 receptor subtypes.

128 Dopamine and agonists of dopamine D4 receptors suppressed K(+)-stimulated uptake of (45)Ca

129 Photoreceptor cells express dopamine D4 receptors that regulate cAMP metabolism.

130 Thus, loop i3 is required for D4 receptors to activate G proteins.

131 provides a unique and flexible mechanism for D4 receptors to regulate CaMKII activity, which could le

132 transmission in stress conditions may enable D4 receptors to serve as a synaptic stabilizer in normal

133 The results show that each D4 receptor variant is capable of coupling to several G(

134 nstructed synthetic genes for the three main D4 receptor variants.

135 are, at least in part, mediated by dopamine D4 receptors via the regulation of cGMP-operated Ca(2+)

136 he response to U101958 (a drug that binds to D4 receptors) was the same in both wild-type and D4 rece

137 ar mechanisms and functional implications of D4 receptors, we examined the impact of D4 receptors in

138 To prevent DA activation of D4 receptors, we repeated this experiment in LHb slices

139 Mutant D4 receptors were constructed by substituting the noncon

140 us striatum and cerebral cortex, the D3- and D4-receptors were the only receptors that showed marked

141 The dopamine D4 receptor, which is enriched in PFC, has been implicat

142 The dopamine D4 receptor, which is highly enriched in the PFC, is one

143 digit nanomolar Ki values for binding to the D4 receptor with several hundred-fold selectivities towa

144 is a nanomolar antagonist at human dopamine D4 receptors with > 500-fold selectivity over hD2 and >

145 nist to weak partial agonist activity at the D4 receptor, with intrinsic activities ranging from 0 to

146 ed subnanomolar Ki values for binding to the D4 receptor, with several 100-fold selectivities toward