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1 DADLE reduced cAMP production by 70% (IC50 of approximat
5 a containing 1 mg/kg D-Ala2-Leu5-enkaphalin (DADLE), which mimics natural hibernation, or preperfusio
6 DOR agonist [d-Ala(2), d-Leu(5)]-enkephalin (DADLE) caused a decrease in the membrane abundance of DO
7 e potency of [D-Ala(2),D-Leu(5)]-enkephalin (DADLE), and decreased the potency and efficacy of 4-[(R)
10 ic AMP (cAMP) and [D-Ala2,D-Leu5]enkephalin (DADLE) inhibition of forskolin-stimulated cAMP productio
11 deltorphin and [D-Ala2, D-Leu5]-enkephalin (DADLE), elevated [Ca2+]i, measured by flow cytofluoromet
12 ephalin (DAMGO), [D-Ala2,D-Leu5]-enkephalin (DADLE), trans-(+/-)-3,4-dichloro-N-methyl-N-(2-[1-pyrrol
13 ceptor agonist, [D-ala2, D-leu5]-enkephalin (DADLE), while a minority of cells (approximately 30%) we
14 the agonist D-alanine-5-leucine-enkephalin (DADLE) in wild-type and T149A mutant-expressing clones.
15 In contrast, [D-pen2, L-Pen5] enkephalin (DADLE, 1.0 nmol), a delta-opioid selective agonist, and
19 with BK resulted in more than twice as many DADLE responsive neurons (54%) but did not affect the ef
20 ion of delta-opioid receptors with 10 microM DADLE reduced glutamate-induced injury by almost half as
25 reatment on the maximum inhibitory effect of DADLE on forskolin-stimulated cAMP formation following b
27 ochemical properties, the cyclic prodrugs of DADLE, [Ala2,D-Leu5]-Enk, [D-Ala2,Leu5]-Enk, and [Ala2,L
28 t important factor to manipulate the rate of DADLE release and, thus, the pharmacological activity; p
31 y the uptake of the synthetic opioid peptide DADLE ((H-Tyr-D-Ala-Gly-Phe-D-Leu-OH) and by its suscept
32 (OMCA) cyclic prodrug of the opioid peptide DADLE ([D-Ala2,D-Leu5]-Enk, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH
40 d bradykinin failed to cross-desensitize the DADLE-evoked response, although both agonists mobilized
45 and 5) delta-opioid receptor activation with DADLE increased GABA(A)Ralpha and GlyRalpha1 density in
46 consumption were significantly improved with DADLE pretreatment vs. all groups after storage and refl
47 cs natural hibernation, or preperfusion with DADLE, administered for 15 min at 2 mmol, 25 min prior t
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