ライフサイエンスコーパス: DAF

1 DAF revealed a significant advantage over DA in patients

2 DAF-12 acts as the main switch between gene expression p

3 DAF-16 directly regulates class I genes only, through th

4 DAF-16 expression in muscle cells, but not in neurons, i

5 DAF-16 regulates regeneration independently of lifespan,

6 DAF-18/PTEN, AMP-activated kinase and fatty acid biosynt

7 DAF-2's function in regeneration is mediated by intrinsi

8 DAF-7, in turn, activates a canonical TGF-beta signaling

9 DAF-FM fluorescence increased less during iodixanol trea

10 DAF-FM staining of NO-challenged wild-type, nor, hmp and

11 nematodes by activating the TIR-1 - JNK-1 - DAF-16 signaling pathway, and the cell wall component of

12 ppa(2)), and bridging (mu:kappa(1):kappa(1)) DAF coordination modes.

13 either a bridging or nonbridging (kappa(1)) DAF ligand coordinated to each Pd(II) center.

14 ctures consist of three isomeric Pd(kappa(1)-DAF)2(OAc)2 complexes, together with Pd(kappa(2)-DAF)(OA

15 polarized epithelial cells by echovirus 11, DAF binding appears be a key determinant in the choice o

16 rystal structures of the VEGF/angiopoietin 2 DAF in complex with its two antigens showed highly overl

17 2(OAc)2 complexes, together with Pd(kappa(2)-DAF)(OAc)2 in which the DAF exhibits a traditional biden

18 Male sperm induces germline- and DAF-9/DAF-12-dependent shrinking, osmotic stress susceptibilit

19 sured their susceptibility to infection by a DAF-binding CVB3 isolate.

20 Neuronal DAF-7/TGFbeta causes a DAF-1/TGFbetaR signaling cascade in the gonadal distal t

21 ion and high expression of the SOD-3 gene (a DAF-16-specific target gene) were observed as a result o

22 plified and propagated in the epidermis in a DAF-12 dependent manner.

23 to DAF, adaptation to RD cells resulted in a DAF-binding isolate with a single amino acid change with

24 In the presence of a DAF-blocking antibody, the reduction in C3b deposition w

25 cell niche, where it negatively regulates a DAF-3 SMAD and DAF-5 Sno-Ski.

26 These compounds do not appear to activate DAF-16 (FOXO orthologue) or mimic dietary restriction (D

27 ingle insulin-like peptide recapitulates all DAF-2-associated phenotypes, likely due to redundancy be

28 cNAc cycling mutants act in part by altering DAF-16-dependent transcription and modulating the protei

29 g a conserved role for the insulin/IGF-1 and DAF-12 pathways in LIV formation.

30 Both JNK-1 and DAF-16 appeared to act within neurons in a cell-autonomo

31 ingly, the nuclear localization of PQM-1 and DAF-16 is controlled by IIS in opposite ways and was als

32 function under the dual control of HSF-1 and DAF-16 transcription factors.

33 n neurons, and required for both DAF-16- and DAF-18-mediated regeneration.

34 a negative feedback loop between miR-34 and DAF-16/FOXO.

35 rgy transfer assays revealed that DAF-37 and DAF-38 form heterodimers, and we show that heterodimeriz

36 two G-protein-coupled receptors, DAF-37 and DAF-38, which cooperatively mediate ascaroside perceptio

37 in DPY-21 in the control of dauer arrest and DAF-2 ILS.

38 /RDVa to bind ligands in addition to CAR and DAF may be attributed to lysine residues near the icosah

39 The EBAX-type CRL and DAF-21 collaboratively regulate SAX-3-mediated axon path

40 mechanism mediated by the EBAX-type CRL and DAF-21/Hsp90 that maintains the accuracy of neuronal wir

41 d DAF S104 at the interface between CVB3 and DAF, and they demonstrate how subtle structural changes

42 Male sperm induces germline- and DAF-9/DAF-12-dependent shrinking, osmotic stress suscept

43 AKT-1/AKT kinase and DAF-16 alter the transcription of mfb-1, which encodes a

44 ch sensitivity by regulating AKT kinases and DAF-16/FOXO.

45 ere it negatively regulates a DAF-3 SMAD and DAF-5 Sno-Ski.

46 dy point to a specific role for VP1 T271 and DAF S104 at the interface between CVB3 and DAF, and they

47 nd point to a specific role for VP1 T271 and DAF S104 at the virus-DAF interface.

48 The contact sites between the virus and DAF clearly encompass CVB3-RD residues recently shown to

49 e DAF-2 insulin-like pathway that antagonize DAF-16/FoxO activity.

50 specific G-protein-coupled receptors such as DAF-37 with more promiscuous G-protein-coupled receptors

51 miscuous G-protein-coupled receptors such as DAF-38.

52 find evidence for direct interaction between DAF-3 and the lag-2 promoter.

53 structural integrity into old age, and both DAF-16/FOXO and heat shock factor transcription factor H

54 by DAF-16 in neurons, and required for both DAF-16- and DAF-18-mediated regeneration.

55 We further identify a 25 bp DAF-3 binding element required for the DTC lag-2 reporte

56 mu-DAF)(OAc)]2 , which features two bridging DAF ligands and two terminal acetate ligands, has been c

57 egulated by insulin/IGF1 signaling, bound by DAF-16 in neurons, and required for both DAF-16- and DAF

58 ransforming growth factor-beta ligand called DAF-7, which acts as a neuroendocrine factor that stimul

59 CD55/DAF, one of the regulators of complement activation, is

60 nt in the negative complement regulator CD55/DAF were more sensitive to the high fat diet.

61 tures of the hookworm Ancylostoma ceylanicum DAF-12 ligand binding domain in complex with DA and chol

62 In C. elegans, the highly conserved DAF-2/insulin/insulin-like growth factor 1 receptor sign

63 e known as dauer by inhibiting the conserved DAF-2 insulin-like signaling (ILS) pathway through incom

64 regulation of DA production, DHS-16 controls DAF-12 activity governing longevity in response to signa

65 We crossed DAF(-/-)CD59(-/-) mice with mice deficient in various co

66 Crry(-/-)DAF(-/-) mice were viable on a C3(-/-) background, but p

67 Thus, under in vivo conditions, Crry/DAF deficiency on platelets led to abnormal platelet tur

68 Selective survival of Crry/DAF-deficient platelets aided by factor H protection and

69 telet Crry in DAF(-/-) mice and studied Crry/DAF-deficient platelet development in vivo.

70 On the basis of the structure of the CVB3-DAF complex determined by cryo-electron microscopy, DAF

71 port a recent pseudoatomic model of the CVB3-DAF interaction obtained by cryo-electron microscopy.

72 nuclear translocation of the cytoprotective DAF-16/FOXO transcription factor and protected from para

73 r patch clamp-mediated dialysis of cytosolic DAF, the remaining NO signals (mostly mitochondrial) wer

74 The first described DAF-binding isolate was obtained during passage of the p

75 o perform cell-specific rescues, determining DAF-6/patched-related site of action during sensory-orga

76 ylamino-2',7'-difluorofluorescein diacetate (DAF) as a fluorescent NO-sensor that locates to the cyto

77 ylamino-2',7'-difluorofluorescein diacetate (DAF-FM DA).

78 ylamino-2',7'-difluorofluorescein diacetate (DAF-FM), we visualized NO production in individual plate

79 4-(N-methylamino)-2',7'-difluorofluorescein (DAF-FM) and dihydroethidium (DHE) were used for quantifi

80 ino-5-methylamino-2',7'-difluorofluorescein (DAF-FM) fluorescent dye, we found that insulin increased

81 Pd(OAc)2 reveal the formation of two dimeric DAF/Pd(OAc)2 complexes at low [DAF] and four monomeric s

82 DAF-16::GFP protein, up-regulates endogenous DAF-16 protein levels and activates the downstream targe

83 n rhabdomyosarcoma (RD) cells, which express DAF but very little CAR.

84 Constitutively expressed DAF was decreased in glomeruli of Hmox1(-/-) rats and au

85 ngiopoietin 2 antibody with dual action Fab (DAF) as a potential therapeutic for neovascular age-rela

86 lifespan-promoting FOXO transcription factor DAF-16 and likely upstream of insulin/IGF signaling.

87 he activity of the FOXO transcription factor DAF-16 and the nuclear hormone receptor DAF-12 and influ

88 he activity of the FoxO transcription factor DAF-16, we isolated three mutant alleles of dpy-21, whic

89 s regulated by the FOXO transcription factor DAF-16, which contributes to the effects of DAF-2 in neu

90 -21, SET-4 and the FoxO transcription factor DAF-16, which is the main target of DAF-2 ILS.

91 proteasome, by the FOXO transcription factor DAF-16.

92 elegans also allows the transcription factor DAF-16/FOXO to induce development into dauer, a diapause

93 ongevity signals to the transcription factor DAF-16/FOXO, a key regulator of lifespan.

94 ctivity of the forkhead transcription factor DAF-16/FOXO.

95 PKC that signals to the transcription factor DAF-16/FOXO.

96 epends on the conserved transcription factor DAF-16/FOXO.

97 ing the activity of the transcription factor DAF-16/FOXO.

98 nsion required a FOXO transcriptional factor DAF-16 but not HSF-1.

99 D cell line binds decay-accelerating factor (DAF) (CD55) and CAR.

100 o iC3b as well as decay-accelerating factor (DAF) activity against the C3 convertase, than MuV.

101 enal IRI model in decay-accelerating factor (DAF) and CD59 double-knockout (DAF(-/-)CD59(-/-)) mice.

102 tein y (Crry) and decay-accelerating factor (DAF) are two murine membrane C3 complement regulators wi

103 tes bind to human decay-accelerating factor (DAF) as well as to the coxsackievirus and adenovirus rec

104 hoblasts requires decay-accelerating factor (DAF) binding and involves relocalization of the virus fr

105 protein (MCP) and decay-accelerating factor (DAF) expression on endothelial cells, giving Factor H (F

106 eceptor (CAR) and decay-accelerating factor (DAF) have been identified as cellular receptors for coxs

107 ay, which induced decay-accelerating factor (DAF) promoter activity via binding to the cAMP response

108 interaction with decay-accelerating factor (DAF), a receptor expressed on the apical cell surface.

109 ollers, including decay accelerating factor (DAF), are gaining emphasis as they minimize injury in va

110 counts of differentially abundant features (DAFs) across different conditions is large.

111 is unaltered by distorted auditory feedback (DAF), deafening gradually weakens synapses on HVCX cells

112 fers at 6 amino acids and whose affinity for DAF is apparently significantly lower remains at the api

113 and host, provide a structural framework for DAF-12 as a promising target in treating nematode parasi

114 cantly from the mode reported previously for DAF binding to echoviruses.

115 Here, we report a role for DAF-16/FOXO, a transcription factor that is active under

116 Here, we identify a novel role for DAF-18 in promoting neurite outgrowth during development

117 A flexible synthesis for DAF-12 ligands and masked ligand derivatives that enable

118 In contrast, APCs from DAF-knockout mice treated with inflammatory stimuli were

119 all-intestinal epithelial cells derived from DAF transgenic mice.

120 e a new general method to quantify gBGC from DAF spectra, incorporating polarization errors, taking s

121 Furthermore, DAF-16/FoxO, a target of insulin/insulin-like growth fac

122 alogues as inducers of functional glomerular DAF able to minimize C3b deposition.

123 strate inhibitors, also increased glomerular DAF and reduced C3b deposition after spontaneous complem

124 al Hmox substrate, hemin, induced glomerular DAF.

125 O-1 as a physiologic regulator of glomerular DAF and identify hemin analogues as inducers of function

126 his effect is partially dependent on gonadal DAF-16/FOXO activity.

127 [DAF] and four monomeric species at higher [DAF].

128 quire insulin signaling via the FOXO homolog DAF-16 or the insulin/IGF-1-receptor homolog DAF-2.

129 tagonizing the insulin receptor-like homolog DAF-2 in the postsynaptic neurons RIA, which play an ess

130 DAF-16 or the insulin/IGF-1-receptor homolog DAF-2.

131 ulated by the phosphatase and tensin homolog DAF-18/PTEN.

132 As with its mammalian homologues, DAF-12 function is regulated by bile acid-like steroidal

133 Human DAF permitted CVB3 to bind to the intestinal surface ex

134 generated transgenic mice that express human DAF specifically on intestinal epithelium and measured t

135 However, expression of human DAF did not facilitate infection by the enteral route ei

136 apical cell surface, and expression of human DAF on murine intestinal epithelial cells permits their

137 However, expression of human DAF on the intestinal surface of transgenic mice did not

138 cules in which specific regions of the human DAF molecule were replaced by the corresponding murine s

139 fically eliminated virus attachment to human DAF but had no effect on attachment to CAR or replicatio

140 h murine SCR2 ablated virus binding to human DAF, as did deletion of human SCR2.

141 erstand why CVB3 binds specifically to human DAF, we constructed a series of chimeric molecules in wh

142 CB3-RD binds to human DAF, whereas CB3-Nancy does not.

143 Murine DAF, unlike human DAF, does not bind virus, and we hypothesized that the a

144 implified collection of equilibrating Pd(II)-DAF complexes.

145 Our results implicate DAF-3 repressor complex activity as a key molecular mech

146 view the emerging literature that implicates DAF-12 and potentially other nuclear receptors as novel

147 he cre-lox system to delete platelet Crry in DAF(-/-) mice and studied Crry/DAF-deficient platelet de

148 C5aR significantly ameliorated renal IRI in DAF(-/-)CD59(-/-) mice, whereas deficiency of C4, Ig, or

149 can largely be explained by perturbations in DAF-16/FOXO target gene expression.

150 rapy in combination was sufficient to induce DAF on murine aortic endothelium.

151 span decrease, whereas seminal fluid induces DAF-16-dependent life-span decrease and fat loss.

152 Although the role of intestinal DAF in human infection has not been directly examined, t

153 One such nuclear receptor is DAF-12, which is required for normal nematode developmen

154 ating factor (DAF) and CD59 double-knockout (DAF(-/-)CD59(-/-)) mice.

155 ated that biosynthesis of two bile acid-like DAF-12 ligands, named dafachronic acids (DA), controls d

156 f two dimeric DAF/Pd(OAc)2 complexes at low [DAF] and four monomeric species at higher [DAF].

157 resent crystal structures of human RCA (MCP, DAF, and CR1) and a smallpox virus homolog (SPICE) bound

158 plex determined by cryo-electron microscopy, DAF S104 is in close contact with a viral capsid residue

159 The dimeric Pd(I) complex, [Pd(I) (mu-DAF)(OAc)]2 , which features two bridging DAF ligands an

160 Murine DAF, unlike human DAF, does not bind virus, and we hypot

161 04) with the proline residue found in murine DAF eliminated virus binding.

162 ver, the virus does not interact with murine DAF.

163 We demonstrate that expression of the mutant DAF-28 insulin peptide results in endoplasmic reticulum

164 ely lost in backgrounds containing a mutated DAF-16 gene.

165 hat induces expression of the neuromodulator DAF-7/TGF-beta.

166 Neuronal DAF-7/TGFbeta causes a DAF-1/TGFbetaR signaling cascade

167 enhanced chemiluminescence) and elevated NO (DAF-FM diacetate) levels in NOS1(-/-) myocytes.

168 1 signalling, requiring DAF-18/PTEN, but not DAF-16/FOXO.

169 tively, the results highlight the ability of DAF to equilibrate rapidly among multiple coordination m

170 Activation of DAF-12 by cholestenoic acid and the cholestenoic acid co

171 ved in the phosphorylation and activation of DAF-16.

172 This activity of DAF-16 in promoting outgrowth is isoform-specific, being

173 We also demonstrate that the capacity of DAF-16/FOXO in regulating neuron morphology is conserved

174 resent the complex coordination chemistry of DAF and palladium(II) carboxylate salts.

175 ives that enable precise temporal control of DAF-12 function was developed.

176 The time course of DAF-T fluorescence in contracting muscle is predicted by

177 at this role is separable from the effect of DAF-16/FOXO on organismal aging.

178 DAF-16, which contributes to the effects of DAF-2 in neuronal aging.

179 O target genes by promoting the exclusion of DAF-16/FoxO from nuclei.

180 ion can be used to trigger the expression of DAF-12 target genes and initiate development from dauer

181 y, dpy-21 mutation reduced the expression of DAF-16/FoxO target genes by promoting the exclusion of D

182 le, given the diverse cellular expression of DAF.

183 s interactions, providing a new footprint of DAF that bridges two adjacent protomers.

184 weak stimuli did not require the function of DAF-16/FOXO.

185 activates the downstream targeting genes of DAF-16.

186 diated lifespan extension was independent of DAF-16/FOXO and SKN-1/Nrf2 signaling, but tryptophan and

187 rprisingly, SGK-1 functions independently of DAF-16/FoxO; instead, SGK-1 promotes the cytoplasmic loc

188 time in a manner dependent on inhibition of DAF-16/FOXO by insulin/IGF-1 signalling (IIS).

189 uctive development through the inhibition of DAF-16/FoxO nuclear translocation.

190 ith DAF-knockout mice, we found that lack of DAF on T cells did not affect their responses to antigen

191 High levels of DAF-16 (in the daf-16 (mu86); muIs61 strain) nuclear acc

192 pathogen resistance conferred by the loss of DAF-2/16 pathway components.

193 study investigated whether up-regulation of DAF by heme oxygenase 1 (HO-1) is an underlying mechanis

194 pensation complex (DCC) in the regulation of DAF-2 insulin-like signaling.

195 The in vivo release of DAF-12 ligands and other small-molecule signals by using

196 ble for species-specific ligand responses of DAF-12.

197 Titration studies of DAF and Pd(OAc)2 reveal the formation of two dimeric DAF

198 n factor DAF-16, which is the main target of DAF-2 ILS.

199 ethargus results in nuclear translocation of DAF-16.

200 ion of asm-3 causes nuclear translocation of DAF-16::GFP protein, up-regulates endogenous DAF-16 prot

201 Treatment of DAF(-/-)CD59(-/-) mice with an anti-C5 mAb reduced renal

202 The use of DAF in combination with other carboxylate ligands (CF3CO

203 rovide valuable insights into the utility of DAF as a ligand in Pd-catalyzed oxidation reactions.

204 to correct an error in our previous view of DAF-virus interactions, providing a new footprint of DAF

205 amount of difference in total abundances of DAFs across different conditions.

206 Based on DAF-8 immunoprecipitation, we here identify two G-protei

207 human intestinal epithelial cells depends on DAF at the apical cell surface, and expression of human

208 oth reactions employ 4,5-diazafluoren-9-one (DAF) as an ancillary ligand.

209 4,5-Diazafluoren-9-one (DAF) has been identified as a highly effective ligand in

210 alyzed by a Pd(OAc)2/4,5-diazafluoren-9-one (DAF) system and takes place in acetic or pivalic acid as

211 opment are not repressed by DPY-21, SET-4 or DAF-16/FoxO.

212 us cytarabine), DAC (DA plus cladribine), or DAF (DA plus fludarabine).

213 in1 acts independently of the GLP-1/Notch or DAF-7/TGF-beta pathways but together with the DAF-2/insu

214 l cues by modulating autocrine and paracrine DAF-2 ILS.

215 ide receptor NPR-1, and the TGF-beta peptide DAF-7 each have stage-specific effects on behavioral tra

216 r of PI3K signaling is the lipid phosphatase DAF-18/PTEN, which can modulate PI3K pathway activity du

217 ion with the nitric oxide (NO)-imaging probe DAF-FM we find that all blood cells form NO intracellula

218 an increase in fluorescence of the NO probe DAF-FM after its conversion to DAF-T.

219 t expansion, and the Patched-related protein DAF-6, which restricts compartment growth.

220 FOXO partner bar-1/beta-catenin and putative DAF-16-regulated gene ucp-4, the sole mitochondrial unco

221 expression of the G protein-coupled receptor DAF-37 in specific chemosensory neurons.

222 ough the insulin-like growth factor receptor DAF-2.

223 ctor DAF-16 and the nuclear hormone receptor DAF-12 and influences metabolic pathways such as develop

224 rough the conserved nuclear hormone receptor DAF-12, a homolog of mammalian sterol-regulated receptor

225 e controlled by the nuclear hormone receptor DAF-12, an important model for the vertebrate vitamin D

226 nal activity of the nuclear hormone receptor DAF-12.

227 bited by the conserved insulin/IGF1 receptor DAF-2.

228 lins, signaling through the insulin receptor DAF-2, functionally switched the AWC olfactory sensory n

229 on steroidal ligands of the nuclear receptor DAF-12, a homolog of the mammalian vitamin D receptor an

230 abditis elegans through the nuclear receptor DAF-12.

231 uced function in the insulin/IGF-1 receptor, DAF-2, various insulins (INS-1 and INS-18), and molecule

232 ngly, we find that the type II BMP receptor, DAF-4 (dauer formation-defective-4), is retromer-indepen

233 r (IIS) pathway comprises a single receptor, DAF-2.

234 re identify two G-protein-coupled receptors, DAF-37 and DAF-38, which cooperatively mediate ascarosid

235 alate depended upon the longevity regulators DAF-16 and SIR-2.1.

236 Replacing DAF with the structurally related, but more-electron-ric

237 uppressed branching, and this delay required DAF-16/FOXO activity.

238 ation of insulin/IGF-1 signalling, requiring DAF-18/PTEN, but not DAF-16/FOXO.

239 S is virulent to normally pathogen-resistant DAF-2/16 insulin-like signaling pathway mutants.

240 r the first time, the engineering of several DAF variants with sub-nanomolar affinity against two str

241 nalysis of derived allele frequency spectra (DAF), but this approach is sensitive to a number of conf

242 agonist of the parasite nuclear receptor Ss-DAF-12, significantly reduced the worm burden in MPA-tre

243 ificantly increased endothelial cell surface DAF and enhanced protection against complement-mediated

244 ings in singing zebra finches, we found that DAF failed to perturb singing-related synaptic activity

245 In addition, we found that DAF-18/PTEN inhibits regeneration independently of age a

246 Our data indicate that DAF-16/FOXO activity in certain somatic gonad cells is r

247 rescent energy transfer assays revealed that DAF-37 and DAF-38 form heterodimers, and we show that he

248 h cell-specific overexpression, we show that DAF-37 regulates dauer when expressed in ASI neurons and

249 Here, we show that DAF-7/TGFbeta signaling promotes expression of lag-2 in

250 irectly examined, these results suggest that DAF is not the critical factor in mice.

251 after passage through dauer, suggesting that DAF-16/FoxO coordinates environment and life history wit

252 thermosensitive membrane TRP channel and the DAF-16/FOXO transcription factor, but in more complex or

253 itions via the action of AKT kinases and the DAF-16/FOXO transcription factor.

254 cant difference in early outcome between the DAF and DA arms.

255 different signaling cascades, especially the DAF-16 cascade, on lifespan extension by LAB.

256 We show that, in the presence of food, the DAF-2 insulin-like receptor signals through the RAS-ERK

257 esponse programs by controlling noise in the DAF-16/FOXO-regulated gene network.

258 ding a glutamate/glutamine dimorphism in the DAF-binding region of the capsid.

259 ffer significantly for the comparison of the DAF and DA arms.

260 Based on the new structure, the mode of the DAF interaction with CVB3 differs significantly from the

261 To achieve sufficient affinity of the DAF to block both angiogenic factors, we turned to deep

262 duces a key feature in the structures of the DAF-12 ligands, closing a major gap in the DA biosynthes

263 rimarily does so through the activity of the DAF-16 transcription factor (forkhead box O (FOXO) homol

264 ilization resulting in the activation of the DAF-16/FOXO and SKN-1/Nrf2 stress response pathways.

265 strong stimuli required the function of the DAF-16/FOXO transcription factor in neurons, but not tha

266 luding four genes encoding components of the DAF-2 insulin-like pathway that antagonize DAF-16/FoxO a

267 est that UNC-104 functions downstream of the DAF-2-signaling pathway and is regulated by the FOXO tra

268 ASM functions as a positive regulator of the DAF-2/IIS pathway in C. elegans.

269 habditis elegans is under the control of the DAF-7/TGF-beta ligand that is secreted from sensory neur

270 unequivocally validated by detection of the DAF-FM reaction product with NO using HPLC and LC-MS/MS.

271 his neuroprotective effect also requires the DAF-16/FOXO partner bar-1/beta-catenin and putative DAF-

272 ike infective larval stage, and as such, the DAF-12 ligand binding domain has been identified as an i

273 ly regulates class I genes only, through the DAF-16-binding element (DBE).

274 16.2/ATG16L exert their function through the DAF-16/FOXO transcription factor.

275 velopment (class II) genes by binding to the DAF-16-associated element (DAE).

276 her with Pd(kappa(2)-DAF)(OAc)2 in which the DAF exhibits a traditional bidentate coordination mode.

277 AF-7/TGF-beta pathways but together with the DAF-2/insulin IGF-1 receptor (IIR) signaling pathway to

278 ontrast, ATG-7 functions in concert with the DAF-7/TGF-beta pathway to promote germline proliferation

279 AF, which regulates stress induction through DAF-16/FOXO, does not contribute to ESRE gene expression

280 and binds multiple molecules in addition to DAF and CAR.

281 reporter response to the environment and to DAF-7/TGFbeta signaling.

282 recently shown to be required for binding to DAF; these residues interact with DAF short consensus re

283 Furthermore, DA binds to DAF-12 mechanistically and is structurally similar to bi

284 ng of FoxO6 We then show that FoxO6 binds to DAF-16-binding elements in the Plexin A4 (Plxna4) promot

285 ubiquitin ligase (CRL), EBAX-1 also binds to DAF-21, a cytosolic Hsp90 chaperone.

286 Screen), we demonstrate that ascr#2 binds to DAF-37.

287 the NO probe DAF-FM after its conversion to DAF-T.

288 wed it to ameliorate renal IRI when given to DAF(-/-)CD59(-/-) mice 24 h before, but not 4 or 8 h aft

289 rus isolate that does not bind measurably to DAF, adaptation to RD cells resulted in a DAF-binding is

290 ctor) orthologue SKN-1 acting in parallel to DAF-16.

291 enome-wide mRNA expression responsiveness to DAF-16 with genome-wide in vivo binding data for a compe

292 Similar to DAF-2/IIR, BEC-1/BECN1/Beclin1, ATG-18/WIPI1/2, and ATG-

293 e results support the current model of virus-DAF interaction and point to a specific role for VP1 T27

294 role for VP1 T271 and DAF S104 at the virus-DAF interface.

295 rry deletion is embryonically lethal whereas DAF-deficient mice are generally healthy.

296 ted in cold sensation in C. elegans, whereby DAF-16/FOXO gets activated via complementary kinase sign

297 opy reconstruction of CVB3-RD complexed with DAF has been refined to 9.0 A.

298 binding to DAF; these residues interact with DAF short consensus repeat 2 (SCR2), which is known to b

299 nd OT-I T-cell receptor transgenic mice with DAF-knockout mice, we found that lack of DAF on T cells

300 centration of NO available for reaction with DAF-FM during bouts of muscle contraction.