ライフサイエンスコーパス: DAG kinase

1 DAG kinase (DGK) terminates DAG signaling by converting

2 DAG kinase activity was also significantly decreased (73

3 DAG kinase activity was monitored by DAG phosphorylation

4 DAG kinase and membrane PKC activities were higher in co

5 DAG kinases (DGKs) convert DAG into phosphatidic acid, r

6 DAG kinases (DGKs) metabolize DAG by converting it to ph

7 DAG kinases play an important role in controlling intrac

8 ype, but the addition of DAG together with a DAG kinase inhibitor does not result in a wild-type phen

9 then tested whether phosphorylation affected DAG kinase activity.

10 The DAG lipase and DAG kinase inhibitors, RHC80267 and R59949 respectively,

11 onic tumor tissues were examined for PKC and DAG kinase activities.

12 gh no differences were observed in the basal DAG kinase activity between control and diabetic rats.

13 is thaliana) that target an Escherichia coli DAG kinase (DAGK) to each leaflet of each chloroplast en

14 ork, we examined the phosphorylation of Dgk1 DAG kinase by casein kinase II (CKII).

15 of cyclooxygenase-2 (COX-2), diacylglycerol (DAG) kinase alpha (DGKalpha), and heme oxygenase-1 (HO-1

16 hoinositide phosphatase, and diacylglycerol (DAG) kinase.

17 d mucosal PI-PLC, as well as diacylglycerol (DAG) kinase and protein kinase C (PKC).

18 and expression of bacterial diacylglycerol (DAG) kinase.

19 ubunit, phospholipase Cbeta, diacylglycerol (DAG) kinase, and calcium/calmodulin-dependent protein ki

20 ished using Escherichia coli diacylglycerol (DAG) kinase and [gamma-(32)P]ATP.

21 ccharomyces cerevisiae, Dgk1 diacylglycerol (DAG) kinase catalyzes the CTP-dependent phosphorylation

22 y were enhanced by impairing diacylglycerol (DAG) kinase function by mutation (rdgA) or by restrictin

23 he physiological function of diacylglycerol (DAG) kinase iota (DGKiota), which converts DAG to phosph

24 DgkB is a soluble diacylglycerol (DAG) kinase that is essential for membrane lipid homeost

25 expression of leukocyte-type diacylglycerol (DAG) kinase alpha in PMN from LAP patients (4.6 +/- 1.7

26 Diacylglycerol (DAG) kinases (DGKs) are a family of enzymes that convert

27 Diacylglycerol (DAG) kinases (DGKs) regulate the intracellular levels of

28 alpha0 subunit) and DGK-1 (a diacylglycerol [DAG] kinase), both of which act in the ventral cord moto

29 ys demonstrated that it encodes a functional DAG kinase.

30 Little is known about how DAG kinase activity is regulated by posttranslational mo

31 DAG) accompanied by a pronounced decrease in DAG kinase activity.

32 ressing cells showed a 7.7-fold reduction in DAG kinase activity; the reduced enzyme activity could b

33 Treatment with d-alpha-tocopherol increased DAG kinase activity in the glomeruli of both control and

34 al secondary bile acids, and colonic mucosal DAG kinase and PKC activities during different stages of

35 icle, we report that simultaneous absence of DAG kinase alpha and zeta causes severe defects in iNKT

36 ent significantly enhanced the activities of DAG kinase and total membrane PKC activities in colonic

37 In this report, we demonstrate expression of DAG kinase zeta (DGKzeta, the enzyme that catalyzes the

38 G levels were elevated using an inhibitor of DAG kinase that converts DAG to phosphatidic acid.

39 hese results have defined a novel isoform of DAG kinase, which may have important cellular functions

40 s probably modulating the enzyme kinetics of DAG kinase.

41 ibit any difference in the protein levels of DAG kinase alpha and gamma, the effect of d-alpha-tocoph

42 pathway, the activity and protein levels of DAG kinase alpha and gamma, which metabolize DAG to phos

43 AOM and fed HFCO showed increased levels of DAG kinase and membrane PKC activities in the colonic mu

44 he stationary phase-dependent stimulation of DAG kinase activity.

45 of diacylglycerol (DAG) and the activity of DAG kinases (DGKs) in membranous structures.

46 Conversely, pharmacological inhibition of DAG kinases or expression of an inactive diacylglycerol

47 atment with inhibitors of phospholipase C or DAG kinase also altered SEB-induced TNF-alpha production

48 ous DAG, resulting from either DAG lipase or DAG kinase inhibition, completely prevented TRPC5 or TRP

49 nce of PLCgamma1 are normalized in PLCgamma1/DAG kinase zeta double null cells.

50 both PMN transendothelial migration and PMN DAG kinase alpha signaling as disordered functions in LA

51 ng this balance is the apicomplexan-specific DAG-kinase-1, which interconverts PA and DAG, and whose

52 pened by DAG and silenced by ATP, suggesting DAG-kinase (DGK) involvement.

53 We demonstrated further that DAG kinases (DGKs) alpha and zeta, which terminate DAG-m

54 By utilizing cells lacking the DAG kinase zeta, which have increased DAG levels, we dem

55 y of the phenotype caused by mutation of the DAG kinase, RDGA , indicating that Laza functions in opp

56 M) activated Icat in some cells, whereas the DAG kinase inhibitor R59949 (10 microM) never activated

57 ondary bile acids, colonic mucosal and tumor DAG kinase, and PKC that may play a role in colon carcin