ライフサイエンスコーパス: DBS

1 DBS could help improve access to care for HCV infection

2 DBS from the PNPO-deficient samples showed enzyme activi

3 DBS involves the surgical implantation of electrodes int

4 DBS of ventral striatum has been previously shown to inh

5 DBS sampling for the simultaneous analysis of immunosupp

6 DBS was associated with significant improvements in meas

7 DBSs have several advantages, such as easy transportatio

8 arising from this work are briefly noted: 1) DBS of the medial forebrain bundle (MFB) in humans, 2) r

9 After exclusion of 10 DBS for poor quality, and 2 for other reasons, 199, 104,

10 ndomised to active (n=12) versus sham (n=13) DBS for 16 weeks.

11 mber 2013 to August 2014 for placement of 19 DBS electrodes in cases where traditional frame-based su

12 P is composed of a dark exciton and about 60 DBSs.

13 By applying a DBS-like input we suppressed these oscillations.

14 We developed a DBS method to enrich for membrane proteins and remove so

15 ment must have the capacity to consent for a DBS clinical trial in which risks can be estimated, but

16 doxal 5'-phosphate (PLP) concentrations in a DBS before and after a 30 min incubation with pyridoxine

17 which allows to predict the hematocrit of a DBS based on its hemoglobin content, measured via noncon

18 In conclusion, mere scanning of a DBS suffices to derive its approximate hematocrit, one o

19 he tremor frequency and the application of a DBS-like input disrupts this activity, which could be on

20 t-resistant depression were implanted with a DBS system targeting bilateral subcallosal cingulate whi

21 investigated whether proximity of the active DBS contacts to it correlated with clinical improvement.

22 eral DBS, patients were randomized to active DBS or sham for 3 months, followed by crossover for anot

23 ability Index in 50% of patients with active DBS compared to sham.

24 es (n = 169 adult EDTA plasma, n = 172 adult DBS, and n = 100 infant DBS) that included group M, subt

25 asma samples and in 100 HIV-1-negative adult DBS.

26 To study circuit-wide activations after DBS of the VS, c-fos immunohistochemistry was performed

27 sments at baseline and 6 and 12 months after DBS onset.

28 s negative for its primary endpoint, VS/ALIC DBS demonstrated an acceptable safety profile and statis

29 INTERPRETATION: VS/ALIC DBS to modulate the affective sphere of pain represents

30 Although DBS might be ideal for POC, this is the first report of

31 Although DBS therapy is broadly hypothesized to work through larg

32 was tested with EDTA plasma (n = 1,301) and DBS from HIV-negative adults (n = 1,000).

33 gly, many of these transcription factors and DBS present in the TSLP promoter region are differential

34 rom TND, or <20, to 5,781,592 copies/ml, and DBS VL ranged from TND, or <400, to 467,600 copies/ml.

35 n = 300), and those viewing both the NBS and DBS movies and brochures (n = 296).

36 CAP/CTM v2.0 assay in 272 paired plasma and DBS specimens using the cell-free virus elution method a

37 ternative for HIV-1 monitoring in plasma and DBS.

38 tic interventions are needed to treat SZ and DBS is emerging as a potential intervention.

39 hematocrit from a nonvolumetrically applied DBS based on its potassium content.

40 brain during electrical stimulation, such as DBS.

41 the volume spotted was evaluated, as well as DBS homogeneity.

42 Awake DBS cohorts had a significantly greater decrease in trea

43 d to lower complication rates overall, awake DBS may lead to less treatment-induced side effects.

44 who are not candidates for traditional awake DBS or prefer the asleep alternative.

45 At <1000 copies/ml, agreement between DBS and plasma was 96.7% (kappa coefficient, 0.93; P < 0

46 The mean difference between DBS and plasma VL values was -1.06 log10 copies/ml (95%

47 One month after bilateral DBS, patients were randomized to active DBS or sham for

48 model based approach we call delta-bitscore (DBS) for identifying orthologous proteins that have dive

49 Both DBS frequencies increased c-fos expression in the infral

50 hophysiological beta generator is altered by DBS, smoothing out the beta waveform.

51 The memory enhancement induced by DBS emerged gradually (over the course of weeks) and was

52 value for the clinical benefit after chronic DBS that could be used to improve intraoperative neuroph

53 We found that chronic DBS or chemically induced synaptic stimulation reduced a

54 ety and feasibility of subcallosal cingulate DBS as a treatment for treatment-resistant depression bu

55 6 months of open-label subcallosal cingulate DBS.

56 e potential therapeutic effects of combining DBS and noninvasive cortical stimulation should be inves

57 ems to be a valuable option when considering DBS for TS.

58 d may be superior to conventional continuous DBS in Parkinson's disease (PD).

59 ogel based on 1,3:2,4-dibenzylidenesorbitol (DBS), modified with acyl hydrazides which extracts gold/

60 lOFC eliminated persistent avoidance, as did DBS applied to the ventral striatum during Ext-RP.

61 cability and coherence brain measures during DBS-ON compared to DBS-OFF.

62 Here we tested the effects of EC-DBS on the progressive cognitive deficits in a genetical

63 functional connectivity profile of effective DBS to the subthalamic nucleus (STN) and test its abilit

64 We identified 1 study for DBS, 1 study for CRS and 4 studies for VNS.

65 tabilisation, patients underwent surgery for DBS and received open-label continuous stimulation for t

66 ractable TS were treated with high-frequency DBS of the ventral anterior and ventrolateral motor part

67 ic prefrontal cortex, but only low-frequency DBS increased c-fos expression in the basal amygdala and

68 In contrast, low-frequency DBS of the dorsal-VS strengthened extinction memory when

69 Analytical data from DBS prepared with a pipet and microfluidic-based samplin

70 ained by venapuncture with measurements from DBS samples simultaneously obtained by fingerprick.

71 ry of a wide range of polar metabolites from DBS extracts.

72 ositive correlation with 1-year outcome from DBS measured by improvement in the Burke-Fahn-Marsden Dy

73 ion of anti-HCV antibodies in specimens from DBS was reliable after establishment of a new signal-to-

74 Conclusion Interventional MR imaging-guided DBS electrode placement may be a safe and effective alte

75 s underwent interventional MR imaging-guided DBS placement for movement disorders from September 2013

76 ority of the closed-loop DBS to open-loop HF DBS, our results may contribute to a further development

77 nizing delayed feedback approach with the HF DBS technique.

78 was recorded intra-operatively via implanted DBS electrodes, whilst simultaneously recording muscle a

79 n in mumol/L) = (creatinine concentration in DBS in mumol/L)/0.73, with a nonclinically relevant bias

80 tudinal measurement of CD71 concentration in DBS over an 8-week period demonstrated intraindividual v

81 The neonatal 25(OH)D3 concentrations in DBS samples were assessed by using highly sensitive chro

82 There were also significant decreases in DBS complications, with fewer intracerebral haemorrhages

83 h throughput method to quantify total DNA in DBS.

84 tween relative peptide abundance measured in DBS and serum.

85 Unfortunately, protein measurement in DBS is hindered by high abundance proteins and matrix in

86 multiplexed targeted protein measurements in DBS compared to serum.

87 <20 copies/ml in plasma or <400 copies/ml in DBS), and VL of <1,000 copies/ml, and VL of <5,000 copie

88 original scale for all detected peptides in DBS was 13.2% and in Serum 8.8%.

89 crit, one of the most important variables in DBS analysis.

90 followed by fully automated, HCT-independent DBS-SPE-LC-MS/MS bioanalysis for the quantitation of the

91 Infant DBS results were 100% concordant.

92 lasma, n = 172 adult DBS, and n = 100 infant DBS) that included group M, subtypes A to H, CRF01_AE, C

93 relevant to SZ pathology in order to inform DBS targeting.

94 line visit for implantation of the dual lead DBS system.

95 to receive 3 months of optimised single-lead DBS-either VIM or VO.

96 indicating a superiority of the closed-loop DBS to open-loop HF DBS, our results may contribute to a

97 his approach for desynchronizing closed-loop DBS.

98 s a promising control signal for closed-loop DBS.

99 port of using an SPR biosensor for measuring DBS samples.

100 as used to calculate DNA quantity per 3.2 mm DBS.

101 Moreover, DBS analysis can be used to comprehensively monitor the

102 NAc-DBS directly modulated neural activity within prefrontal

103 in stimulation of the nucleus accumbens (NAc-DBS) is an emerging therapy for diverse, refractory neur

104 uit and network-level neuromodulation by NAc-DBS, which should facilitate our developing understandin

105 neural circuits and networks affected by NAc-DBS.

106 (77% retention), and 221 women in the NBS + DBS group (75% retention).

107 n the NBS group (94%), followed by the NBS + DBS group (86%) and was lowest in the usual care group (

108 mple withdrawn after testing: 3 in the NBS + DBS group and 2 in the usual care group (P = .25).

109 , 79% in the NBS group, and 75% in the NBS + DBS group, a significant between-group difference (P < .

110 y group developed an infection necessitating DBS explantation, and was excluded from the assessment o

111 ls were established using archived, neonatal DBS (n = 501) and a median of 130.6 ng of DNA per DBS wa

112 We demonstrated that DNA from neonatal DBS can be successfully quantified in high throughput se

113 Quantification of DNA in neonatal DBS is not routinely performed due to technical challeng

114 proficiency test and retrospective neonatal DBS that demonstrated good agreement between MSI-CE-MS a

115 ronic treatment-refractory anorexia nervosa, DBS is well tolerated and is associated with significant

116 stic and monitoring tools in the analysis of DBS.

117 ture in order to guide future development of DBS to treat this vulnerable patient population.

118 hological network activity and the effect of DBS on such activity, we take a computational modelling

119 trongly significant and beneficial effect of DBS on TS symptoms, trait anxiety, quality of life, and

120 0.05), demonstrating a beneficial effect of DBS.

121 s into the underlying large-scale effects of DBS as well as in finding novel stimulation targets, whi

122 modeling was used to disclose the effects of DBS during resting-state functional Magnetic Resonance I

123 ts to more fully characterize the effects of DBS in the medial temporal lobe on human memory.

124 rticipates in the neuroprotective effects of DBS remains unknown.

125 ing abnormalities of human WM and effects of DBS to rodent models.SIGNIFICANCE STATEMENT Psychiatric

126 To test the safety and efficacy of DBS for treatment-resistant depression, a prospective, r

127 PBS elution of DBS offers a sensitive and specific method for monitorin

128 the debate about the ethical implications of DBS.

129 ination was possible in the vast majority of DBS.

130 here was a significantly less mean number of DBS lead passes with general anaesthesia (p=0.006).

131 ntact electrodes followed by optimization of DBS until a stable response was achieved.

132 fety, clinical, and neuroimaging outcomes of DBS of the subcallosal cingulate in a group of patients

133 Aptima assay yielded 100% detection rates of DBS in participants with plasma HIV RNA levels of >/=35

134 ized, placebo-controlled, crossover study of DBS targeting the ventral striatum/anterior limb of the

135 y, we discuss the current clinical trials of DBS for SZ, and their ethical considerations.

136 providing a rationale for therapeutic use of DBS and synaptic stimulation in tauopathies.

137 The use of DBS samples is advantageous in resource-poor regions.

138 several groups have explored the utility of DBS by focusing on protein detection, the reproducibilit

139 tion of whole blood extraction conditions on DBS filter paper cut-outs was first achieved to maximize

140 al issues, of which the hematocrit effect on DBS-based quantitation remains undoubtedly the most wide

141 Enhanced stability for mephedrone on DBS compared to liquid whole blood was observed.

142 nd calibrating the blood volume variation on DBS cards, which greatly facilitates using the DBS metho

143 The exchange integral of one DBS with the electron confined in the NC is approximatel

144 on of lateral orbitofrontal cortex (lOFC) or DBS of the ventral striatum reduced persistent avoidance

145 ehavior with respect to opting out of NBS or DBS for their child.

146 nectome age, sex, and disease matched to our DBS patients.

147 n = 501) and a median of 130.6 ng of DNA per DBS was obtained, which is in agreement with literature

148 s have shown such increases in dopamine post-DBS, this is the first study to do so using MS methodolo

149 There are two strategies to process DBS samples.

150 re review and meta-analysis of all published DBS for PD studies (n=2563) on PubMed from January 2004

151 imately half of the proposed sample received DBS implantation and completed the double-blind phase.

152 cline newborn screening or withdraw residual DBS.

153 es to their cognate DNA-binding sequence(s) (DBS) in the TSLP promoter regulatory region.

154 f a prospective connectomic approach for SCC DBS surgery, this pilot study used the four-bundle tract

155 s a connectomic approach to guide future SCC DBS studies.

156 llosal cingulate deep brain stimulation (SCC DBS) for depression demonstrated the common impact of th

157 the HAM-D-17 scores between active and sham DBS.

158 and randomised to 6 months of active or sham DBS, followed by 6 months of open-label subcallosal cing

159 r model as a framework, artificial in silico DBS was applied to find potential alternative target are

160 A simplified DBS extraction technique for cell-free virus elution usi

161 B, activator protein 1 (AP1), STAT, and Smad DBS in the TSLP promoter region.

162 ical orientation of the dangling-bond spins (DBSs) that result from dangling-bond-assisted radiative

163 A fixed area punch in dried blood spot (DBS) analysis is assumed to contain a fixed amount of bl

164 Aptima results for paired dried blood spot (DBS) and plasma specimens archived from participants in

165 The dried blood spot (DBS) matrix has significant utility for applications in

166 Monitoring by dried blood spot (DBS) provides patients the opportunity to sample a drop

167 rations in stored neonatal dried blood spot (DBS) samples are associated with pediatric fracture risk

168 easured in either serum or dried blood spot (DBS) samples.

169 ing interest in the use of dried blood spot (DBS) sampling and multiple reaction monitoring in proteo

170 Dried blood spot (DBS) sampling is recognized as a valuable alternative sa

171 antial experience with the dried blood spot (DBS) technique as an alternative.

172 The dried blood spot (DBS) technique can be used to collect, store, and ship w

173 termine subtype B DRMs in dried blood spots (DBS) collected from patients on antiretroviral therapy.

174 -based enzyme assay using dried blood spots (DBS) for the diagnosis of pyridox(am)ine 5'-phosphate ox

175 In total, dried blood spots (DBS) were collected from 276 individuals.

176 of metabolism (IEM) from dried blood spots (DBS) with quality assurance.

177 -fold diluted extracts of dried blood spots (DBS), and LOD achieved was below 2 ng/mL.

178 ant diagnosis of HIV from dried blood spots (DBS), viral load monitoring with this system is not prac

179 A extracted from neonatal dried blood spots (DBS).

180 te more widespread use of dried blood spots (DBS).

181 inal fluid (CSF; n = 36), dried blood spots (DBS; n = 104), and dried plasma spots (DPS; n = 104).

182 Dried blood spots (DBSs) have had a long history in disease screening in ne

183 Deep brain stimulation (DBS) allows for direct recordings of neuronal activity f

184 targeting errors of deep-brain stimulation (DBS) electrodes placed under interventional magnetic res

185 TN) in patients with deep brain stimulation (DBS) electrodes.

186 children undergoing deep brain stimulation (DBS) for dystonia and investigate whether GPi and GPe fi

187 The experience with deep brain stimulation (DBS) for pain is largely based on uncontrolled studies t

188 The benefit of deep brain stimulation (DBS) for Parkinson disease (PD) may depend on connectivi

189 efficacy of 'awake' deep brain stimulation (DBS) for Parkinson's disease (PD) under local or general

190 p approach to tuning deep brain stimulation (DBS) for Parkinson's disease (PD).

191 Deep brain stimulation (DBS) for Parkinson's disease is a highly effective treat

192 Furthermore, deep-brain stimulation (DBS) for psychiatric disorders targets these fibers.

193 ed on the success of deep brain stimulation (DBS) for treating movement disorders, there is growing i

194 Deep brain stimulation (DBS) has been used to treat a variety of brain disorders

195 r using lesioning or deep brain stimulation (DBS) has been variable.

196 Deep brain stimulation (DBS) has shown promise for treating a range of brain dis

197 potential benefit of deep brain stimulation (DBS) in reducing symptoms of otherwise treatment-refract

198 aring active to sham deep brain stimulation (DBS) in the anterior limb of the ventral capsule/ventral

199 Deep brain stimulation (DBS) is a clinical therapy used to alleviate the symptom

200 Deep brain stimulation (DBS) is a promising treatment for these patients, but pr

201 Deep brain stimulation (DBS) is a surgical procedure used to treat the neurologi

202 d by the standard HF deep brain stimulation (DBS) is modulated by the smooth feedback signals.

203 repeated pairing of deep-brain stimulation (DBS) of the BG with M1 stimulation using TMS.

204 Deep brain stimulation (DBS) of the subcallosal cingulate white matter has shown

205 sleep disorders and deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been reported

206 Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a highly effect

207 Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is the most common

208 Deep brain stimulation (DBS) of the subthalamic nucleus in Parkinson's disease i

209 explored the use of deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VS) as a p

210 ment processing, and deep brain stimulation (DBS) of these structures has been associated with change

211 Remarkably, deep brain stimulation (DBS) provides beneficial effects in AD patients, and rep

212 ntrol is a promising deep brain stimulation (DBS) strategy that could be used to suppress high-amplit

213 r the application of deep brain stimulation (DBS) within circuits that modulate motor function.

214 and off subthalamic deep brain stimulation (DBS), focussing on adaptive sensory-motor responses to a

215 Chronic forniceal deep brain stimulation (DBS), recently shown to rescue hippocampus-dependent lea

216 s during therapeutic deep brain stimulation (DBS), the peak frequency of this signal shifts to half t

217 l techniques such as deep brain stimulation (DBS).

218 and rodent models of deep brain stimulation (DBS).

219 s observed following deep brain stimulation (DBS).

220 (PD) implanted with a deep brain stimulator (DBS) to test the hypothesis that the beta waveform becom

221 STN DBS did not protect against alpha-syn-mediated deficits

222 STN DBS is neuroprotective against neurotoxicants in animal

223 Long-term trkB blockade abolished STN DBS-mediated neuroprotection of SN neurons following pro

224 akinesia improvement normally induced by STN DBS.

225 ervation or loss of SNpc neuron, nor did STN DBS elevate p-rpS6 levels further.

226 INTERPRETATION: Effective STN DBS for PD is associated with a specific connectivity pr

227 We evaluated STN DBS in a parkinsonian model that displays alpha-synuclei

228 ggesting a noncanonical role for trkB in STN DBS-mediated behavioral effects.

229 In preclinical models, STN DBS provides neuroprotection for substantia nigra (SN) d

230 ctedly reduced the functional benefit of STN DBS on a short timescale that is inconsistent with canon

231 three weeks later received four weeks of STN DBS or electrode implantation that remained inactive.

232 icacy and disease-modifying potential of STN DBS.

233 roprotective and symptomatic efficacy of STN DBS.SIGNIFICANCE STATEMENT Subthalamic nucleus deep brai

234 thalamic nucleus deep brain stimulation (STN DBS) is increasingly used in mid- to late-stage Parkinso

235 thalamic nucleus deep brain stimulation (STN DBS) protects dopaminergic neurons of the substantia nig

236 These results demonstrate that STN DBS does not protect the nigrostriatal system against al

237 We demonstrate that STN DBS in male rats activates signaling downstream of tropo

238 These results suggest that STN DBS increases BDNF-trkB signaling to contribute to the n

239 Whether STN DBS can be protective in other models of synucleinopathy

240 training dataset of 51 PD patients with STN DBS was combined with publicly available human connectom

241 epeated pairing of subthalamic nucleus (STN)-DBS and M1-TMS at specific time intervals will lead to p

242 We applied STN-DBS in an adeno-associated virus (AAV) 1/2-driven human

243 e interstimulus intervals (ISIs) between STN-DBS and TMS that produced cortical facilitation were det

244 otective and disease-modifying effect of STN-DBS in a mechanistically relevant model of PD.

245 thalamic nucleus deep-brain stimulation (STN-DBS) with motor cortical transcranial magnetic stimulati

246 thalamic nucleus deep brain stimulation (STN-DBS), while they performed an instrumental learning task

247 These results show that STN-DBS can modulate cortical plasticity.

248 FP) recordings in PD subjects undergoing STN-DBS over the course of a full-night's sleep.

249 c deficits had developed, rats underwent STN-DBS electrode implantation ipsilateral to the vector-inj

250 Ten PD human patients with STN-DBS were studied in the on-medication state with DBS set

251 motor improvement through pallidal long-term DBS correlated with theta peak amplitude (rho = 0.38, p

252 he safety and efficacy of dual-lead thalamic DBS (one targeting the ventralis intermedius-ventralis o

253 INTERPRETATION: Dual lead thalamic DBS might be a safe and effective option for improving s

254 We found that DBS shifts global brain dynamics of patients towards a H

255 we explored the local and global impact that DBS has in creating asynchronous, stable or critical osc

256 We previously showed that DBS of the entorhinal cortex (EC) enhances spatial memor

257 Initial results suggest that DBS of the subcallosal cingulate is safe and associated

258 The DBS method was applied to the quantification of four cel

259 h SZ and the scientific rationale behind the DBS targets proposed in the literature in order to guide

260 e training dataset, connectivity between the DBS electrode and a distributed network of brain regions

261 d for the quantification results between the DBS samples and the conventionally used plasma samples (

262 ed in 82 individuals, counts obtained by the DBS method demonstrated good agreement with flow cytomet

263 polysomnography and LFP recordings from the DBS electrodes, for an average of 7.5 hours in 'off' dop

264 Many of the DBS targets proposed in the literature may modulate stri

265 in the chromatogram, the blood volume on the DBS cards can be calculated and further calibrated.

266 nd correcting blood volume variations on the DBS cards.

267 Patients and all clinicians other than the DBS programming nurse were masked to the choice of lead.

268 We demonstrate that the DBS method counts low abundance cell types such as immat

269 S cards, which greatly facilitates using the DBS method for therapeutic drug monitoring (TDM) for imp

270 at whole-blood specimens collected using the DBS technique can be confidently used to diagnose and mo

271 nd whole-blood specimens collected using the DBS technique from >500 patients were tested for virolog

272 Though DBS is effective for treating ET, the mechanism through

273 ed thus far about movement disorders through DBS.

274 Thus, DBS under general anaesthesia can be considered at exper

275 PhaBS provides a closed-loop approach to DBS that can be optimized for each patient.

276 nce brain measures during DBS-ON compared to DBS-OFF.

277 by evoked-fMRI was relatively insensitive to DBS frequency.

278 With respect to DBS, 5 participants indicated that they contacted the he

279 gery, but this was judged to be unrelated to DBS implantation.

280 D (12 with an ICD and 31 without) undergoing DBS electrode placement surgery.

281 t into the biophysical mechanisms underlying DBS, allowing a description in terms of alteration of th

282 mber, 2011, and January, 2014, and underwent DBS of the subcallosal cingulate between November, 2011,

283 rs of the centre, and enacted by an unmasked DBS programming nurse).

284 ggest that refined methods are needed to use DBS in these regions to improve memory.

285 ve decline and memory impairment in AD using DBS of hippocampal afferents.

286 isorders, there is growing interest in using DBS to treat schizophrenia (SZ).

287 zed crossover design corroborates that vALIC DBS causes symptom reduction rather than sham.

288 mpling device for the creation of volumetric DBS.

289 These data suggest that VC/VS DBS in patients with TRD does not significantly affect n

290 n sites and frequencies to determine whether DBS of the VS could facilitate the extinction of morphin

291 tion of the physiological mechanism by which DBS reduces PD-related motor symptoms, but more broadly

292 fect could radically change the way in which DBS is used in PD.

293 Our meta-analysis demonstrates that while DBS under general anaesthesia may lead to lower complica

294 Although many advantages are associated with DBS sampling, its more widespread use is hampered by sev

295 Rats were implanted with DBS electrodes in the dorsal or ventral subregions of th

296 isorder amenable to striatal modulation with DBS.

297 We demonstrate the use of such probes with DBS extracts.

298 at the beta waveform becomes less sharp with DBS, suggesting that M1 input synchrony may be decreased

299 were studied in the on-medication state with DBS set to 3 Hz.

300 ical disorder which is commonly treated with DBS therapy.