ライフサイエンスコーパス: DC-SIGN

1 DC-SIGN (dendritic cell-specific intercellular adhesion

2 DC-SIGN (SIGN-R1) is present on mouse lung epithelial ce

3 DC-SIGN also was shown to play a role in the infection o

4 DC-SIGN and CD206 nanodomains are randomly distributed o

5 DC-SIGN efficiently reduces the amount of gp120 present

6 DC-SIGN forms remarkably stable microdomains on the plas

7 DC-SIGN has high affinity for fucosylated glycans in sev

8 DC-SIGN is a dendritic cell surface structure which part

9 DC-SIGN is a major receptor for infection of both monocy

10 DC-SIGN is thought to be crucial for the development of

11 DC-SIGN nanoclusters exhibited free, Brownian diffusion

12 DC-SIGN, a Ca(2+)-dependent transmembrane lectin, is fou

13 DC-SIGN-blocking assays were performed by incubating DCs

14 DC-SIGN-targeted transduction occurs in the presence of

15 frequency and microbiome of CD19(-)BDCA-1(+)DC-SIGN(+) blood myeloid DCs (mDCs) were analyzed in CP

16 We found that cocaine activates a DC-SIGN mediated 'signalosome' complex by enhancing its

17 tition than gp120 that was not prebound in a DC-SIGN cell surface binding assay.

18 tion and decreased T cell proliferation in a DC-SIGN-, glycosylation-, and Raf1-dependent manner.

19 alpha, production by LPS-stimulated DCs in a DC-SIGN-dependent fashion.

20 tDNA, which induces platelet activation in a DC-SIGN-dependent manner.

21 Finally, M2 macrophages induced a DC-SIGN-dependent adhesion of highly mannosylated IgM(+)

22 mtDNA induces platelet activation through a DC-SIGN dependent pathway.

23 Using a DC-SIGN-Fc chimera, food extracts were tested for bindin

24 Our data suggest that SAP activates DC-SIGN to regulate the innate immune system differently

25 In addition, DC-SIGN expression was sufficient to cause a significant

26 In addition, DC-SIGN-mediated endocytosis provided a minor alternativ

27 A polycyclic aminothiazole DC-SIGN ligand and anti-DC-SIGN antibodies mimic SAP eff

28 nnose, Fc receptor, CD11c/CD 18, DEC-205 and DC-SIGN on DC for active targeting is reviewed.

29 inhibiting gp120 interactions with 2G12 and DC-SIGN and blocking 2G12-mediated neutralization of HIV

30 characterize their interaction with 2G12 and DC-SIGN by a glycan microarray binding assay.

31 icrobicide should target both syndecan-3 and DC-SIGN on DCs to prevent transmission.

32 Thus, HIV-1 exploits both syndecan-3 and DC-SIGN to mediate HIV-1 transmission, and an effective

33 Antibodies specific for SR-BI and DC-SIGN/L-SIGN reduced B-cell transinfection, supporting

34 g antibodies against CD18, CD11a, CD11b, and DC-SIGN as well as TLR4.

35 nd CD68 expression), polarization (CD206 and DC-SIGN expression), and IL-10 secretion.

36 f HCV-induced CD68 and M2 markers (CD206 and DC-SIGN) in normal monocytes was further enhanced in the

37 mong the inflammatory markers, only CD68 and DC-SIGN were significant prognostic factors in univariat

38 nhibitory receptors (FcRL5, FcgammaRIIb, and DC-SIGN) with high avidity and specificity, whilst elimi

39 cell line decreases PU.1 protein levels and DC-SIGN at both the mRNA and protein levels.

40 ity to invade DCs, alveolar macrophages, and DC-SIGN-expressing transfectants.

41 yte-derived DCs (Mo-DCs) develop in mice and DC-SIGN/CD209a marks the cells.

42 ifically to the lectin domains of the MR and DC-SIGN and blocked signaling.

43 s indicate that the CRDs of both SIGN-R1 and DC-SIGN bind to a restricted set of primarily oligomanno

44 Mutations in dectin-1 (rs7309123) and DC-SIGN (rs11465384 and rs7248637), allogeneic stem cell

45 The genes encoding OAS1, OAS2, TLR3, and DC-SIGN, which mediate antiviral innate immunity, were w

46 Anti-DC-SIGN monoclonal antibody (MAb) inhibited HHV-8 infect

47 cyclic aminothiazole DC-SIGN ligand and anti-DC-SIGN antibodies mimic SAP effects in vitro.

48 ceptors because only the combination of anti-DC-SIGN and low-molecular-weight heparin prevented bindi

49 blocked, in part, by Raf-1 inhibitor or anti-DC-SIGN antibodies and was significantly reduced in cell

50 food extracts followed by staining with anti-DC-SIGN antibody.

51 of HIV-1 attachment factors (HAFs), such as DC-SIGN, heparan sulfate proteoglycan (HSPG), and alpha4

52 es can be mediated by C-type lectins such as DC-SIGN.

53 DC-SIGN and DC-SIGNR (collectively termed as DC-SIGN/R) using a sensitive, ratiometric Forster resona

54 oprotein from Sindbis virus engineered to be DC-SIGN-specific.

55 To understand the differences between DC-SIGN and L-SIGN that affect HIV-1 interactions, we de

56 polymers to inhibit the interactions between DC-SIGN and the HIV envelope glycoprotein gp120.

57 In THP-1 cells and human MDDCs, BG60-DC-SIGN interaction led to the activation of Raf-1 and E

58 The QD probes specifically bind DC-SIGN, but not its closely related receptor DC-SIGNR,

59 of glycomimetic compounds were able to block DC-SIGN-dependent HIV infection in cervical explant mode

60 Blocking DC-SIGN signaling allows RLR activation and suppresses M

61 Blocking DC-SIGN with HIV-1 gp120 prevents the uptake of minor fi

62 However, combination targeting to both DC-SIGN and BDCA3(+) DCs led to significantly greater ac

63 led to endocytosis in vitro as expected, but DC-SIGN, even when cross-linked, did not lead to signifi

64 further intracellular pathways activated by DC-SIGN in a range of primary FL cells with detection of

65 Activation by DC-SIGN occurred in both IgM(+) and IgG(+) cases and led

66 udding is due to internalization of gp120 by DC-SIGN.

67 t internalization of virus-like particles by DC-SIGN.

68 rom DCs to T cells was mediated primarily by DC-SIGN.

69 alled MDDC differentiation, as quantified by DC-SIGN/CD14 expression ratios, showing cooperative invo

70 ht differences between pathogen targeting by DC-SIGN and receptors in which binding sites at fixed sp

71 ing factor (M-CSF)-dependent, CD14(+)CD11b(+)DC-SIGN(+) monocyte-derived DCs.

72 eclampsia, both CD14(+)DC-SIGN(+) and CD14(+)DC-SIGN(-) APCs induced iTreg cells poorly.

73 Conversely, in preeclampsia, both CD14(+)DC-SIGN(+) and CD14(+)DC-SIGN(-) APCs induced iTreg cell

74 We show that decidual CD14(+)DC-SIGN(+) APCs are closely associated with Foxp3(+) Tre

75 These results suggest that decidual CD14(+)DC-SIGN(+) APCs may play important roles in iTreg cell i

76 Furthermore, CD14(+)DC-SIGN(+) cells display a distinct phenotype compared w

77 s significantly more efficiently than CD14(+)DC-SIGN(-) APCs.

78 istinct phenotype compared with their CD14(+)DC-SIGN(-) counterparts.

79 In vitro, CD14(+)DC-SIGN(+) APCs from healthy pregnant women induced iTre

80 there is a complete deficiency of CD209(+) (DC-SIGN) human dendritic cells.

81 CD206/macrophage mannose receptor and CD209/DC-SIGN, as well as costimulatory molecules CD86 and CD4

82 -SIGN (CD209) or its isoform L-SIGN (CD299) (DC-SIGN/R).

83 HIV-1 gp120-specific attachment factors CD4, DC-SIGN, and syndecans, were attenuated in their ability

84 s of DCs is based on the expression of CD83, DC-SIGN, and DC-LAMP, which are nonspecific markers of D

85 We sought to characterize DC-SIGN-binding glycoproteins in a panel of allergenic a

86 On the contrary, DC-SIGN enhances HIV trans-infection of T lymphocytes.

87 e 2 is the functional receptor for SARS-CoV; DC-SIGN and CD209L (L-SIGN) can enhance viral entry.

88 lack of the expression of CD4, CCR5, CXCR4, DC-SIGN, or mannose receptors in tubular cells.

89 Both BDCA3(+) and monocyte-derived DC-SIGN(+) NP-loaded DCs were equally effective at gener

90 loped Raji B cell lines expressing different DC-SIGN/L-SIGN chimeras.

91 ing of gp120 to 2G12 and recombinant dimeric DC-SIGN with IC(50) in the nanomolar range.

92 irus bearing 134mut exhibited less efficient DC-SIGN-mediated infection in trans.

93 core LPS is naturally exposed, might exploit DC-SIGN to invade APCs.

94 Dendritic cells express DC-SIGN, a C-type lectin (CTL) that binds a variety of p

95 ut not in B-cell lines transduced to express DC-SIGN lacking the transmembrane domain, demonstrating

96 es from peripheral blood and tonsils express DC-SIGN and that this expression increases after B-cell

97 dendritic cells (DCs), many of which express DC-SIGN (DC-specific ICAM-3 grabbing nonintegrin; CD209)

98 of feline monocyte-derived cells expressing DC-SIGN, indicating a role for FIPV infection in vivo.

99 Although human B cell lines expressing DC-SIGN efficiently capture and transmit HIV-1 to suscep

100 ood myeloid DCs, and B-cell lines expressing DC-SIGN.

101 D) displayed the highest binding avidity for DC-SIGN.

102 Thus, selectivity gain for DC-SIGN versus langerin is observed with pseudo-1,2-mann

103 minor peanut allergen, is a novel ligand for DC-SIGN.

104 ligomannose glycans are also the ligands for DC-SIGN, a C-type lectin found on the surface of dendrit

105 ssentially undetectable lateral mobility for DC-SIGN but an appreciable mobility for HA within their

106 ange similar to that previously observed for DC-SIGN.

107 ereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on

108 ther, our data support an important role for DC-SIGN-expressing infiltrating cells in the biology of

109 described for Lewis X, a ligand specific for DC-SIGN among the C-type lectin family.

110 ment of the cells with antibody specific for DC-SIGN or with mannan but not antibody specific for xCT

111 high-resolution structure of a glycomimetic/DC-SIGN complex by X-ray crystallography.

112 which are CD11b(+)F4/80(+)CD11c(+)MHCII(high)DC-SIGN(high)Ly6c(+) and express high levels of CCR5, CX

113 ls can be rescued by the expression of human DC-SIGN (hDC-SIGN) and that infection of a permissive fe

114 This study shows that human DC-SIGN is a receptor for Y. pestis that promotes phagoc

115 (LPS) as ligands to interact with the human DC-SIGN.

116 In this study, stably transfected human DC-SIGN(+/-) Raji cell lines and monocyte-derived DCs (M

117 taining glycopolymers to interact with human DC-SIGN and the ability of these glycopolymers to inhibi

118 and can be restored by a knock-in with human DC-SIGN.

119 s response in detail, we generated humanized DC-SIGN mice (hDC-SIGN), and demonstrate that the anti-i

120 Using retagging, we identified DC-SIGN as a novel receptor involved in the initial reco

121 fects of costimulatory blockade and identify DC-SIGN(+) suppressive macrophages as crucial mediators

122 Importantly, DC-SIGN nanocluster dissolution exclusively compromised

123 ests how CRDs may be disposed differently in DC-SIGN compared with DC-SIGNR and in variant forms of D

124 C-terminal C-type CRDs, the neck domains in DC-SIGN and DC-SIGNR act as autonomous tetramerization d

125 s of the carbohydrate-recognition domains in DC-SIGN and DC-SIGNR result from variations in the seque

126 Further, LARG was observed to participate in DC-SIGN mediated internalization of HIV-1 in DCs.

127 Comparison of the binding sites in DC-SIGN and langerin, two other pathogen-binding recepto

128 used gene silencing to specifically inhibit DC-SIGN expression by DCs followed by allergen uptake st

129 Thus, approaches aiming to inhibit DC-SIGN, without blocking langerin, represent attractive

130 DC-specific ICAM-3 -: grabbing non integrin (DC-SIGN) and macrophage mannose receptor 1 (MMR-1).

131 to DC-specific ICAM3-grabbing non-integrin (DC-SIGN) and its related receptor, L-SIGN, were found.

132 r adhesion molecule-3 grabbing non-integrin (DC-SIGN) and mannose receptor, bound to FL surface immun

133 r adhesion molecule-3-grabbing non-integrin (DC-SIGN) on DCs as early as day 2 and continuing through

134 r adhesion molecule-3 grabbing non-integrin (DC-SIGN), after directly targeting the transcription fac

135 r adhesion molecule-3-Grabbing Non-integrin (DC-SIGN), CD123, neutrophil elastase, CD31, and carbonic

136 -cell-specific ICAM-3 grabbing non-integrin (DC-SIGN; also known as CD209).

137 Interestingly, DC-SIGN was found within the FL cell niche in situ.

138 by the internalization of P. gingivalis into DC-SIGN-rich intracellular compartments, and MoDCs secre

139 ore, we asked whether RSV infection involves DC-SIGN (CD209) or its isoform L-SIGN (CD299) (DC-SIGN/R

140 of the feline homologue to the human lectin DC-SIGN and show that it is a coreceptor for virulent st

141 tion domain (CRD) of the cell-surface lectin DC-SIGN (dendritic cell-specific intercellular adhesion

142 ty binding to the human transmembrane lectin DC-SIGN and act as inhibitors to prevent the binding of

143 G-I and Mda5 by activating the C-type lectin DC-SIGN and inducing signaling that prevents RLR dephosp

144 The C-type lectin DC-SIGN expressed on dendritic cells (DCs) facilitates c

145 en a human dendritic cell associated lectin (DC-SIGN) and the viral envelope glycoprotein gp120.

146 blocked viral binding to the C-type lectin, DC-SIGN.

147 eceptors CD81, SR-BI, and the C-type lectins DC-SIGN and L-SIGN.

148 rmore, CV-N competed with the C-type lectins DC-SIGN and mannose receptor for ligand binding and inhi

149 l, SARS-CoV is thought to use C-type lectins DC-SIGN and/or L-SIGN (collectively referred to as DC/L-

150 cell lines transduced to express full-length DC-SIGN but not in B-cell lines transduced to express DC

151 ld be involved in targeting or cross-linking DC-SIGN.

152 studies using Fc chimeras revealed that LRP, DC-SIGN, and mannose receptor can bind to FVIII; however

153 s in the healthy human brain through the MOG-DC-SIGN homeostatic regulatory axis, which is comprised

154 ular adhesion molecule-grabbing nonintegrin (DC-SIGN) (CD209) receptor, expressed by APCs, to be capt

155 ar adhesion molecule-3-grabbing nonintegrin (DC-SIGN) and heparan sulfate proteoglycan were implicate

156 ar adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and the macrophage galactose lectin, to glycopr

157 ion molecule 3 (ICAM3) grabbing nonintegrin (DC-SIGN) leads to a reduction in the expression of Toll-

158 hesion molecule type-3-grabbing nonintegrin (DC-SIGN) level in aged DCs.

159 c cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN) necessary for human immunodeficiency virus, typ

160 ar adhesion molecule-3-grabbing nonintegrin (DC-SIGN) on microglia and DCs.

161 on molecule-3 (ICAM-3)-grabbing nonintegrin (DC-SIGN) with respect to retrovirus binding.

162 c cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN), and TLR4 because ActApo-induced up-regulation

163 c cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN), mannose-binding lectin, and heparan sulfate, e

164 ar adhesion molecule-3-grabbing nonintegrin (DC-SIGN), which could in turn trigger delayed but long-l

165 ar adhesion molecule-3-grabbing nonintegrin (DC-SIGN).

166 ar adhesion molecule-3-grabbing nonintegrin (DC-SIGN).

167 ar adhesion molecule 3-grabbing nonintegrin (DC-SIGN).

168 ar adhesion molecule-3-grabbing nonintegrin (DC-SIGN)/CD23, are increased.

169 c cell-specific ICAM-3-grabbing nonintegrin (DC-SIGN, CD209), Dectin-1, Toll-like receptors (TLRs), c

170 hat ES targets DC-specific ICAM nonintegrin (DC-SIGN) to survive in myeloid DCs for which outer membr

171 This novel DC-SIGN-T(H)2 pathway initiated by an endogenous ligand,

172 stimulatory blockade favored accumulation of DC-SIGN-expressing macrophages that inhibited CD8(+) T c

173 urther confirmed by its specific blocking of DC-SIGN engagement with the Ebola virus glycoprotein.

174 prehensive report on the characterization of DC-SIGN-binding proteins in common allergenic foods such

175 Deletion of DC-SIGN-expressing macrophages in vivo, interfering with

176 ther investigate the lateral distribution of DC-SIGN.

177 ayers displaying the extracellular domain of DC-SIGN and a neoglycolipid bearing an oligosaccharide l

178 In the work reported here, neck domains of DC-SIGN and DC-SIGNR expressed in isolation are shown to

179 ET treatment results in downregulation of DC-SIGN, a marker of immature DCs, and upregulation of D

180 ersely correlated with surface expression of DC-SIGN (DC-specific intercellular adhesion molecule-3-g

181 th HHV-8 resulted in increased expression of DC-SIGN and a decrease in the expression of CD20 and maj

182 rate that cocaine induces over expression of DC-SIGN and significantly enhances virus transfer from D

183 Thus, the expression of DC-SIGN is essential for productive HHV-8 infection of a

184 in on LC but downregulated the expression of DC-SIGN on iDDC, as we previously reported for MDDC.

185 This profile is enhanced by expression of DC-SIGN on MoDCs and minor mfa-1 fimbriae on P. gingival

186 The relative expression of DC-SIGN, GLUT-1, HSPGs, and NRP-1 first was examined on

187 s of CD209e (DC-SIGNR4), a murine homolog of DC-SIGN, were increased in the lungs of HDM-challenged V

188 In addition, differences in the lengths of DC-SIGN and DC-SIGNR extracellular domains with equivale

189 eas immature DC, expressing higher levels of DC-SIGN and similar FcgammaRIIa levels, did not undergo

190 Location of DC-SIGN in FL tissue revealed high levels in sinusoidlik

191 luence the nanoscale lateral organization of DC-SIGN but restrict the mobility of the receptor to dis

192 he absence of Ca(2+) and by preincubation of DC-SIGN with mannan, suggesting that C1q binds to DC-SIG

193 thrin, thereby increasing the probability of DC-SIGN-clathrin interactions beyond random encountering

194 Consequently, the role of DC-SIGN and other HTLV-1 attachment factors was analyzed

195 However, the precise role of DC-SIGN in food allergy pathogenesis is not yet understo

196 The surprising stability of DC-SIGN microdomains may reflect structural features tha

197 hus, HIV sequestration by and stimulation of DC-SIGN helps HIV evade immune responses and spread to c

198 ains to Raji cells and MoDCs is dependent on DC-SIGN, whereas the double fimbriae mutant strain does

199 n) sites in gp120 that contribute to optimal DC-SIGN binding.

200 Blocking of MMR-1 or DC-SIGN with neutralizing Abs partially inhibits this ef

201 derived inflammatory DCs such as CD14 and/or DC-SIGN, E-Cadherin, and/or CX3CR1.

202 pressing the interleukin-3 receptor CD123 or DC-SIGN.

203 versatility in entry routes (FcgammaRIIa or DC-SIGN) in mature DC broadens target options and sugges

204 s on the C-type lectin receptor, langerin or DC-SIGN, involved in gp120 interaction.

205 ctin domains of the mannose receptor (MR) or DC-SIGN bind mannosylated Igs in vitro and bind to FL ce

206 iated knockdown of LRP, mannose receptor, or DC-SIGN expression in monocyte-derived dendritic cells d

207 y bind to the dendritic cell-surface protein DC-SIGN.

208 k regions, and receptor diffusion to provide DC-SIGN with the exquisite ability to dock pathogens at

209 A human orthologue of SIGN-R1, DC-SIGN, displays a similar binding specificity to SIGN-

210 f the dendritic cell glycan-binding receptor DC-SIGN and the closely related endothelial cell recepto

211 Targeting of myeloid-dendritic cell receptor DC-SIGN by numerous chronic infectious agents, including

212 The dendritic cell receptor DC-SIGN mediates pathogen recognition by binding to glyc

213 cell contact and the dendritic cell receptor DC-SIGN.

214 fimbria, targets the C-type lectin receptor DC-SIGN for invasion and persistence within human monocy

215 cells expressing the C-type lectin receptor DC-SIGN, persisted at sites of HSV-2 reactivation for mo

216 12 and PGT123, or the C-type lectin receptor DC-SIGN.

217 port that SAP but not CRP binds the receptor DC-SIGN (SIGN-R1) to affect the innate immune system, an

218 mains (CRDs) in the glycan-binding receptors DC-SIGN (dendritic-cell-specific intercellular adhesion

219 tivalent interactions of HIV/Ebola receptors DC-SIGN and DC-SIGNR (collectively termed as DC-SIGN/R)

220 gens and on mammalian cells by the receptors DC-SIGN (CD209) and DC-SIGNR (L-SIGN, CD299) is dependen

221 However, soluble recombinant DC-SIGN was shown to inhibit the binding between SP-D an

222 Indeed, removal of fucose on myelin reduced DC-SIGN-dependent homeostatic control, and resulted in i

223 Finally, we show that, by reducing DC-SIGN in the cellular membrane, miR-155 is involved in

224 through a similar pathway to IVIG, requiring DC-SIGN, STAT6 signaling, and FcgammaRIIB.

225 y stimulation of IL-33 production that seems DC-SIGN independent.

226 an H. pylori carriers exhibited a semimature DC-SIGN(+)HLA-DR(hi)CD80(lo)CD86(lo) phenotype.

227 Several DC-SIGN-binding proteins show reactivity in serum IgE im

228 1-grabbing nonintegrin; CD209) and DC-SIGNR (DC-SIGN-related receptor, also known as L-SIGN and vario

229 Intriguingly, our data showed that silencing DC-SIGN on DCs promotes a Th2 phenotype in DC/T cell co-

230 Mechanistically, that simultaneous DC-SIGN engagement by fucosylated ligands and TLR4 signa

231 In this study, DC-SIGN dynamics in microdomains were explored with seve

232 uced interleukin-4 production and subsequent DC-SIGN expression in this cell population.

233 Thus, MV subverts DC-SIGN to control RLR activation and escape antiviral r

234 Infection of T1H6-DC-SIGN cells with HHV-8 induces expression of beta-gala

235 infective dose (TCID50) assay using the T1H6-DC-SIGN cell line.

236 mutant molecule with K270W and a C-terminal DC-SIGN CRD subdomain transmitted HIV-1.

237 immune system differently from CRP, and that DC-SIGN is a target for antifibrotics.

238 ingle particle tracking, we demonstrate that DC-SIGN intrinsic nanoclustering strictly depends on its

239 Fluorescence imaging indicated that DC-SIGN microdomains may contain other C-type lectins an

240 Blink indicates that DC-SIGN, another CTL (CD206), and influenza hemagglutini

241 Although it is known that DC-SIGN organizes in nanoclusters at the surface of DCs,

242 We estimate, as a lower limit, that DC-SIGN and HA nanodomains contain on average two tetram

243 the QD surface mannose valency reveals that DC-SIGN binds more efficiently to densely packed mannosi

244 In the present study, we show that DC-SIGN, a C-type lectin expressed on DCs, binds directl

245 We have recently shown that DC-SIGN, a C-type lectin first identified on dendritic c

246 These data suggest that DC-SIGN structural elements distinct from the oligosacch

247 receptors on DCs and strongly suggests that DC-SIGN plays a critical role in HTLV-1 binding, transmi

248 conferred to L-SIGN chimeras containing the DC-SIGN CRD.

249 onfirmed that the minor fimbria contains the DC-SIGN-targeting carbohydrates fucose (1.35 nmol/mg), m

250 We identified Trp-258 in the DC-SIGN CRD to be essential for HIV-1 transmission.

251 himeras demonstrated that replacement of the DC-SIGN carbohydrate-recognition domain (CRD) with that

252 no competition against known ligands of the DC-SIGN CRD.

253 Most of the DC-SIGN ligands studied previously are mannose- or fucos

254 and reduced transcriptional activity of the DC-SIGN promoter, which is likely to be the basis for it

255 for the complete extracellular region of the DC-SIGN tetramer was similar for all antibody glycoforms

256 SF1-dependent development, or preventing the DC-SIGN signaling pathway abrogated tolerance.

257 y reduce neutrophil influx via targeting the DC-SIGN murine homolog SIGN-related 1.

258 ay contain other C-type lectins and that the DC-SIGN cytoplasmic region is not required for microdoma

259 DC differentiation and function through the DC-SIGN-mediated induction of cell-signaling pathways.

260 rotein capable of selectively binding to the DC-SIGN protein.

261 ocyte-derived dendritic cells (MDDC) through DC-SIGN, resulting in nonproductive infection.

262 nner leaflet lipids are able to move through DC-SIGN microdomains.

263 Antibodies to DC-SIGN, a c-type lectin selectively expressed by macrop

264 ctivation of human DCs by LPS via binding to DC-SIGN and MMR-1, leading to attenuated TLR signaling.

265 of gp120 also exhibited decreased binding to DC-SIGN in the context of native envelope spikes on a vi

266 MV binding to DC-SIGN leads to activation of the kinase Raf-1, which i

267 Binding to DC-SIGN on MoDCs is followed by the internalization of P

268 id (aa) 196 and E1 aa 139 mediate binding to DC-SIGN, which supports the results of a previous report

269 action, were not required for C1q binding to DC-SIGN.

270 ts, chickpea, and corn, showed no binding to DC-SIGN.

271 GN with mannan, suggesting that C1q binds to DC-SIGN at its principal Ca(2+)-binding pocket, which ha

272 Mannosylated scFv also bound to DC-SIGN on the surface of dendritic cells.

273 m as neither recombinant Fc nor sFc bound to DC-SIGN.

274 C1q and the globular portion of C1q bound to DC-SIGN.

275 as confirmed by binding of soluble BTN2A1 to DC-SIGN-transfectants and its inhibition by a specific A

276 tion confers broader binding capabilities to DC-SIGN.

277 stability of DC-SIGNR tetramers compared to DC-SIGN.

278 herapy does not involve binding of IgG Fc to DC-SIGN and that alternative cell-surface lectins are re

279 d the binding of highly sialylated IgG Fc to DC-SIGN-expressing myeloid cells.

280 ferentially deliver the PSCA antigen gene to DC-SIGN-expressing 293T cells and bone marrow-derived DC

281 the binding of HIV envelope protein gp120 to DC-SIGN at nanomolar concentrations.

282 he entry of HHV-8 into B cells is related to DC-SIGN-mediated endocytosis.

283 er full-length nor cytoplasmically truncated DC-SIGN in microdomains appreciably exchanged with like

284 complex to high mannose, these vectors used DC-SIGN as their receptor.

285 control monoclonal antibody or delivered via DC-SIGN, another lectin receptor.

286 ficant mobility within microdomains, whereas DC-SIGN does not.

287 In summary, while DC-SIGN can bind to a flexible combination of N-glycans

288 y revealed that C1q and gC1qR associate with DC-SIGN on blood DC precursors and immature DCs.

289 and was significantly reduced in cells with DC-SIGN knockdown.

290 est that allergens are able to interact with DC-SIGN and induce tumor necrosis factor-alpha expressio

291 whether our targeting vectors interact with DC-SIGN, which traps many types of viruses and gene ther

292 ound that these vectors do not interact with DC-SIGN.

293 non-IgE-binding proteins that interact with DC-SIGN; these proteins may be important for regulating

294 her fucosylation and better interaction with DC-SIGN [DC-specific intercellular adhesion molecule-3 (

295 The interactions with DC-SIGN demonstrated the significance of alpha(1-6)manna

296 study that Y. pestis directly interacts with DC-SIGN and invades both DCs and alveolar macrophages.

297 We conclude that ES interacts with DC-SIGN to subvert the host immune responses by disarmin

298 The interaction of MOG with DC-SIGN in the context of simultaneous TLR4 activation r

299 that, rather than being densely packed with DC-SIGN proteins, an elemental substructure exists.

300 ell in response to select microbes, yielding DC-SIGN(+) cells with critical functions of DCs.