ライフサイエンスコーパス: DDE

1 DDE is similar to phenobarbital (PB) in that both compou

2 DDE was recently found to inhibit binding of androgen to

3 to 7 y of age (PCB: beta = 1.23, P = 0.003; DDE: beta = 1.11, P = 0.008).

4 rmal-weight mothers (beta = 1.25, P = 0.04); DDE was associated with increased WC only in girls with

5 g x kg(-1) [PCB], 24.0 and 3.1 mug x kg(-1) [DDE], 8.5 and 1.0 mug x kg(-1) [PBDE], respectively), bu

6 loro-2,2-bis(p-chlorophenyl)ethane] and 4,4'-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene], from

7 '-dichlorodiphenyl)-2,2-dichloroethene (4,4'-DDE), hexachlorobenzene (HCB), pentachlorophenol (PCP)).

8 ) in the surface water was dominated by 4,4'-DDE.

9 in the non-intensive group (57.4% to 40.6%; DDE 10.0 pp, 95% CI -1.3 to 21.4, p = 0.072).

10 almon (mug x m(-2); R(2) = 0.76 [PCB], 0.64 [DDE], 0.64 [PBDE]) than by land development/agriculture,

11 d pesticides (comprised of approximately 95% DDE) (plasma), sum polychlorinated biphenyls (PCBs) (pla

12 rst example of genomic island formation by a DDE type transposon.

13 ation between polypeptides, one containing a DDE motif and one that does not.

14 Recently, a DDE triad of carboxylate residues essential for catalysi

15 lts provide the first strong evidence that a DDE/D active site can hydrolyze DNA strands of opposite

16 udy of maternal and infant serum PCB-153 and DDE concentrations and responses to infant tuberculosis

17 6-month infant concentrations of PCB-153 and DDE were strongly associated with lower 6-month BCG-spec

18 65, 95% confidence interval: 0.36, 1.18) and DDE (fecundability odds ratio for DDE > or = 60 microg/l

19 sure to PCBs (polychlorinated biphenyls) and DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene] reduc

20 the abiotic transformation of DDT, DDD, and DDE (collectively referred to as DDX) require both sulfi

21 Median levels of DDT and DDE among women in DDT IRS households were 2.6 (IQR: 1.1

22 Median levels of DDT and DDE among women in unsprayed villages were 0.3 [interqua

23 iations between prenatal exposure to DDT and DDE and several measures of obesity at 9 years of age in

24 amined the effects of maternal serum DDT and DDE concentrations on preterm birth, small-for-gestation

25 boys, 10-fold increases in prenatal DDT and DDE concentrations were associated with increased odds o

26 of maternal serum concentrations of DDT and DDE during pregnancy with body mass index, obesity, wais

27 t positive relation between in utero DDT and DDE exposure and obesity status of 7-year-old children.

28 oward a positive association between DDT and DDE exposure and odds of obesity.

29 We examined the relation of in utero DDT and DDE exposure to child obesity at 7 years of age.

30 Both DDT and DDE increase amyloid precursor protein levels, providing

31 The predictors of DDT and DDE plasma levels identified in the present study may in

32 um concentrations of p,p' isomers of DDT and DDE were above the limit of detection (LOD) in >/=98% of

33 Levels of HCB and congeners of DDT and DDE were measured in serum collected during the follicul

34 used organochlorine pesticides like DDT and DDE.

35 association of serum levels of HCB, DDT, and DDE with implantation failure, chemical pregnancy, and s

36 mples had detectable levels of HCB, DDT, and DDE, with median levels of 0.087 ng/g serum for HCB, 1.1

37 of DDT (dichlorodiphenyltrichloroethane) and DDE (dichlorodiphenyldichloroethylene) levels among resi

38 Dental assessments for ECC and DDE (enamel hypoplasia, demarcated and diffuse opacities

39 infants, we report the incidence of ECC and DDE at 8 and 18-20 mos of corrected age.

40 plasma levels (in micrograms per liter) and DDE (in micrograms per liter) to identify predictors for

41 investigated the association between PCB and DDE exposure and time to pregnancy by using serum levels

42 ts suggest that prenatal exposure to PCB and DDE may play a role for subsequent obesity development.

43 ed BMI (beta = 2.07, P = 0.007), and PCB and DDE were associated with an increased change in BMI from

44 PCB and DDE were measured in maternal serum and breast milk, and

45 l cycle functioning associated with PCBs and DDE, and increased odds of spontaneous abortion associat

46 sed historically to toxic levels of PCBs and DDE; however, acute effects on tern egg development have

47 of sequence similarity between piggyBac and DDE family of recombinases.

48 racterize network heterogeneity than WSE and DDE.

49 Similar concentrations of DDT and DDEs were found in the surface water, while the relative

50 wever, egg concentrations of PCBs as well as DDE (1,1-bis(p-chlorophenyl)-2,2-dichloroethene), the de

51 m was to investigate the association between DDE exposure and preterm birth.

52 dea that induction of hepatic 3A1 and 2B1 by DDE is mediated through the activation of CAR and PXR.

53 the induction of hepatic CYP 3A1 and 2B1 by DDE was correlated with CAR and PXR activity.

54 al activities were significantly enhanced by DDE.

55 A class of enzymes called DDE recombinases utilize conserved D and E residues to c

56 acilitating both functions, is the so-called DDE motif.

57 ibed models as it ensures that the catalytic DDE motif makes correct, monodentate interactions with t

58 MooV recombinases do not contain a conserved DDE motif, which defines the retroviral integrase/transp

59 se superfamily whose hallmark is a conserved DDE motif.

60 ons revealed the importance of the conserved DDE motif and a W residue.

61 recombinases share a structurally conserved 'DDE' catalytic domain, comparisons among the limited set

62 In this study, DDTr (DDTr = DDT + DDD + DDE) relative bioavailability in historically contaminat

63 iments on the organochlorine pesticides DDT, DDE, DDD, and chlordane in well-mixed slurries support t

64 icant associations were observed between DDT/DDE and IVF outcomes or between HCB and chemical pregnan

65 veral intervention approaches may reduce DDT/DDE exposure in pregnant women living in IRS communities

66 (DDT), and dichlorodiphenyldichloroethylene (DDE) are persistent chlorinated pesticides with endocrin

67 (DDT) and dichlorodiphenyldichloroethylene (DDE) has been hypothesized to increase risk of obesity l

68 (DDT) and dichlorodiphenyldichloroethylene (DDE) serum concentrations measured in VHEMBE mothers whe

69 ane (DDT), dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) concentrations were me

70 esticides [dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB) and mirex] with diabetes.

71 (100 muL), dichlorodiphenyldichloroethylene (DDE) and BDE-153 were the only analytes with detection f

72 nonachlor, dichlorodiphenyldichloroethylene (DDE), polychlorinated biphenyls (PCBs), and dioxins and

73 levels of dichlorodiphenyldichloroethylene (DDE), the metabolite of the pesticide dichlorodiphenyltr

74 DDT), p,p'-dichlorodiphenyldichloroethylene (DDE) and four polybrominated diphenyl ether (PBDE) conge

75 ) and p,p'-dichlorodiphenyldichloroethylene (DDE) and subsequent obesity at 5 and 7 y of age.

76 olite p,p'-dichlorodiphenyldichloroethylene (DDE) are associated with negative reproductive outcomes

77 and its metabolite dichlorodiphenylethylene (DDE), has been hypothesized to increase the risk of obes

78 and p,p'-dichlorodiphenyl dichloroethylene (DDE) are associated with thyroid function during pregnan

79 c ethnicity, but not with corresponding dust-DDE concentrations.

80 ctive version containing the mutation EA326 (DDE mutant), the predominant reaction product is a linea

81 studies of developmental defects of enamel (DDE) and early childhood caries (ECC) in very low birthw

82 Although degree distribution entropy (DDE), SD structure entropy (SDSE), Wu structure entropy

83 lly meaningful delay differential equations (DDEs) into functional mapping, a statistical model desig

84 Difference-in-differences estimates (DDEs) of impact were calculated, adjusting for clusterin

85 ,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) pesticide levels (< or =1-32 ppb) are associated wi

86 ,1-Dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), a persistent environmental contaminant, is a metab

87 ,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), an antiandrogen.

88 ,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (DDE), are often detected in soils and sediments containi

89 ,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), the main metabolite of the pesticide 1,1,1-trichlo

90 und class detected in the blubber, following DDE, and TCPMOH loads were greater than DDT.

91 , was observed in the liver tissue following DDE and PB treatment.

92 5% confidence interval (CI): 0.73, 2.23) for DDE and 0.94 (95% CI: 0.50, 1.78) for DDT.

93 odds ratio was 0.75 (95% CI: 0.44, 1.26) for DDE and 0.69 (95% CI: 0.73, 1.27) for DDT; none of the s

94 -248], and 388 ng/g lipid (IQR: 115-847) for DDE.

95 een PE and SPME estimated concentrations for DDE was high (R(2) = 0.95).

96 were similar in magnitude and precision for DDE.

97 1.18) and DDE (fecundability odds ratio for DDE > or = 60 microg/liter = 0.65, 95% confidence interv

98 eported practicing EBF in the previous 24 h (DDE 36.2 percentage points [pp], 95% CI 21.0-51.5, p < 0

99 ely 40% of breeding-age coastal condors have DDE levels associated with eggshell thinning in other av

100 exception of penta- and hexachlorobiphenyls, DDE and mirex.

101 ng mesenteric visceral AT (vAT) of HF and HF/DDE groups revealed a decrease in expression of nervous

102 If DDE has important antiandrogenic action in humans, it ma

103 including domesticated MULE and IS1595-like DDE transposases.

104 open reading frames, including an IS30-like DDE transposase in place of a Tyr/Ser recombinase and ho

105 cides, no loss occurred for aldrin, lindane, DDE or DDD, whereas losses exceeding 80% were found for

106 exposure category (PCBs < 1.24 microg/liter, DDE < 14 microg/liter), time to pregnancy increased for

107 lower DDT (95% CI: -83, -57%) and 61% lower DDE (95% CI: -74, -40%) levels.

108 les to examine the relation between maternal DDE levels during pregnancy and adjusted odds of cryptor

109 The median maternal DDE concentration was 25 mg/L (range 3-178)-several fold

110 The metabolite, DDE (1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene), has

111 , 63.2 +/- 1.9% of DDD, and 50.9 +/- 1.6% of DDE were degraded by sulfide (5 mM) in the presence of g

112 hanistic plausibility for the association of DDE exposure with AD.

113 excluding preterm births, the association of DDE with small-for-gestational-age remained.

114 Median serum concentrations of DDE were 43 mug/liter (interquartile range: 32-57; range

115 al Arctic Ocean increasing concentrations of DDE with depth were observed in the Makarov and Amundsen

116 le may be more susceptible to the effects of DDE.

117 stations were used to calculate the flux of DDE, DDD, DDMU, and selected PCB congeners from sediment

118 nited States has a detectable serum level of DDE.

119 were highly correlated with brain levels of DDE (rho = 0.95).

120 entifying people who have elevated levels of DDE and carry an APOE epsilon4 allele may lead to early

121 Levels of DDE were 3.8-fold higher in the serum of those with AD (

122 Serum levels of DDE were highly correlated with brain levels of DDE (rho

123 Serum levels of DDE were measured in 79 control and 86 AD cases.

124 gy for target joining used by the members of DDE superfamily of transposases and retroviral integrase

125 The highest tertile of DDE levels was associated with an odds ratio of 4.18 for

126 Examination scores in the highest tertile of DDE were -1.753 points lower in the subpopulation carryi

127 ce water, while the relative contribution of DDEs increased with depth, demonstrating a transformatio

128 titution of DDN(610) with either DDD(610) or DDE(610) significantly reduced in vivo functions of Metn

129 Neither substrate is cleaved by the DDD or DDE mutant, under the conditions where wild-type Metnase

130 We next tested whether the DDD or DDE mutants cleave single-strand extensions and flaps in

131 osure of human neuroblastoma cells to DDT or DDE increased levels of amyloid precursor protein.

132 No associations were observed between PCB or DDE and BMI in 5-y-old girls.

133 l, evidence of an association between PCB or DDE exposure and time to pregnancy was weak and inconclu

134 significant adverse associations of PCBs or DDE with WRAML indices.

135 t in response to its estrogenic isomer, o,p -DDE [1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)

136 Exposure to a 2:1 ratio of p,p -DDE:o,p -DDE did not result in the younger latency observed with

137 o,p -DDE had similar results, but only at </= 10 months of ag

138 DT (p,p - and o,p -) and its metabolite p,p -DDE (dichlorodiphenyldichloroethylene) in prenatal serum

139 < 0.001), betaHCH (trend p = 0.01), and p,p -DDE (p trend = 0.04).

140 inducing potential of the antiandrogen, p,p -DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene], the

141 -DDT adj-OR = 1.19, 95% CI: 0.81, 1.74; p,p -DDE adj-OR = 1.22, 95% CI: 0.72, 2.06].

142 Age-14 p,p -DDE and PCB concentrations were both associated with sig

143 in females; and between 17% and 29% for p,p -DDE and PCB congeners 138, 156, 157, 167, 170, 172, and

144 slands health studies were analyzed for p,p -DDE and PCBs 118, 138, 153, and 180 and adjusted for tot

145 ns between cord blood concentrations of p,p -DDE and PCBs and sperm disomy in adulthood were not cons

146 oup (n = 40) and were also analyzed for p,p -DDE and PCBs.

147 No associations were observed between p,p -DDE and Tanner stage 5 for genitalia growth or TV >/= 20

148 Adult p,p -DDE and total PCB serum concentrations were both associa

149 0 children with o,p -DDT, p,p -DDT, and p,p -DDE concentrations measured in maternal serum during pre

150 to determine whether early exposure to p,p -DDE correspondingly predisposes women to early-onset bre

151 p,p -DDE exposure at concentrations relevant to human exposur

152 oys with higher serum HCB, betaHCH, and p,p -DDE had significantly lower mean [95% confidence interva

153 p,p -DDE implants significantly accelerated mammary tumor ons

154 Lipid-adjusted levels of p,p -DDE in mammary adipose tissue and serum in young mice we

155 tinues to affect tumor onset even after p,p -DDE levels have declined.

156 rmine whether developmental exposure to p,p -DDE stored in adipose tissue surrounding the cancer-pron

157 In addition, the highest quintile of p,p -DDE was associated with a significantly lower mean (95%

158 Only the highest quartile of serum p,p -DDE was associated with later pubic hair maturation.

159 delivery, Elvax 40P pellets containing p,p -DDE were implanted into the mammary fat pads of prepuber

160 compared mammary tumor development with p,p -DDE with development in response to its estrogenic isome

161 re to dichlorodiphenyldichloroethylene (p,p -DDE) and polychlorinated biphenyl (PCB) pollutants.

162 cally dichlorodiphenyldicholorethylene (p,p -DDE) and polychlorinated biphenyls (PCBs), and sperm ane

163 p,p -dichlorodiphenyldichloroethylene (p,p -DDE) concentrations were 159 ng/g lipid, 168 ng/g lipid,

164 chloro-2,2-bis(p-chlorophenyl)ethylene (p,p -DDE), polychlorinated biphenyls (PCBs), and hexachlorobe

165 4,4 -dichlorodiphenyldichloroethylene (p,p -DDE)] were studied.

166 d p,p-dichlorodiphenyldichloroethylene (p,p -DDE)] with age at attainment of sexual maturity among bo

167 beta-hexachlorocyclohexane (beta-HCH), p,p -DDE, dichlorodiphenyltrichloroethane (p,p -DDT), dieldri

168 fold increase in o,p -DDT, p,p -DDT, or p,p -DDE, was nonsignificantly associated with increased odds

169 increases in risk of ID were found with p,p -DDE.

170 for total DDT, and 1.04 ng/g serum for p,p -DDE.

171 Exposure to a 2:1 ratio of p,p -DDE:o,p -DDE did not result in the younger latency obser

172 pregnancy increased 16% per 10 microg/L p,p'-DDE (6-27).

173 ficant dependence of HCB (r(2) = 0.83), p,p'-DDE (r(2) = 0.60), and PCBs (r(2) = 0.36-0.47) concentra

174 p,p'-DDE -treatment exacerbated several of the metabolic synd

175 ective associations between exposure to p,p'-DDE and adiposity assessed by body mass index (BMI) z-sc

176 r compounds with longer half-lives like p,p'-DDE and BDE-153.

177 Concentrations of p,p'-DDT, p,p'-DDE and beta-HCH were not associated with diabetes or pr

178 sitive associations between exposure to p,p'-DDE and BMI z-score (beta=0.13 BMI z-score (95% CI: 0.01

179 Nonetheless, concentrations of p,p'-DDE and chlordanes were higher than New York State Ambie

180 higher in the subarctic colony, whereas p,p'-DDE and HCB concentrations tended to be higher in high a

181 ds, they experienced higher exposure of p,p'-DDE and HCB over the incubation period than birds inhabi

182 crease in circulating concentrations of p,p'-DDE and HCB; the effect size being within the same order

183 break-up, highly lipophlic OCs, such as p,p'-DDE and PCB 153, were higher during years of early ice c

184 PCB153 and p,p'-DDE antagonized pbPPARG, although their predicted recept

185 We classified p,p'-DDT and p,p'-DDE as "presumed" to be obesogenic for humans, based on

186 significant for some PCB congeners and p,p'-DDE at the most marine sampling location (Terneuzen, L1)

187 owth, plants were watered with the same p,p'-DDE containing solutions.

188 The root and total plant p,p'-DDE content of all three species was significantly incre

189 Ag decreased the p,p'-DDE content of G. max tissues by up to 40%, with NP expo

190 Fullerenes increased the shoot p,p'-DDE content of zucchini by 29%; contaminant levels in so

191 ',5,5'-hexachlorobiphenyl (PCB-153) and p,p'-DDE did not change consistently with age.

192 We conclude that p,p'-DDE does not merely accumulate in fat, but may contribut

193 Thus, it is hypothesized that p,p'-DDE exposure could aggravate the harm of an obesogenic c

194 ping significantly reduced p,p'-DDT and p,p'-DDE exposure.

195 Our results suggest that p,p'-DDE impairs vAT normal function and effectively decrease

196 We measured p,p'-DDT and p,p'-DDE in preserved maternal serum samples drawn 1-3 days a

197 easing IRRs for increasing quartiles of p,p'-DDE in XX, XY, and total sex-chromosome disomy, and a si

198 Total shoot p,p'-DDE levels in non-Ag exposed G. max and C. pepo were 500

199 Total shoot p,p'-DDE levels in nonfullerene exposed tomato, soybean, and

200 Our findings suggest that exposure to p,p'-DDE may be associated with increased rates of XX, XY, an

201 ate that the antiandrogenic activity of p,p'-DDE may mitigate harmful androgen effects on the ovary d

202 The inverse dependence of o,p'-DDT and p,p'-DDE on temperature evidences the transformation of paren

203 rs and PAHs and the presence of HCB and p,p'-DDE rather than heavier compounds, suggesting the import

204 dian (interquartile range) p,p'-DDT and p,p'-DDE serum concentrations for VHEMBE cohort participants

205 trol had 5-7 times higher p,p'-DDT and p,p'-DDE serum concentrations than those who never lived in a

206 uction in population-level p,p'-DDT and p,p'-DDE serum concentrations under five hypothetical interve

207 PCB congeners and TC, CC, p,p'-DDT and p,p'-DDE than the respective PARTs, while they are similar to

208 plant type, significantly decreased the p,p'-DDE uptake.

209 or example, a 10-ng/g increase in serum p,p'-DDE was associated with a 0.05-log(E(1)C) decrease (p =

210 118, 138, 153, and 180 (SigmaPCB4)] and p,p'-DDE were 0.19 (0.01-2.59) and 0.31 (0-14.93) ng/g serum,

211 ions for non-dioxin-like PCBs, HCB, and p,p'-DDE were 2.68 (1.06-6.81), 2.63 (1.07, 6.46), and 2.87 (

212 40 mL solution containing 100 ng/mL of p,p'-DDE with 0 or 100 mg/L humic acid.

213 p,p'-dichlorodiphenyl dichloroethylene (p,p'-DDE) and attention and impulse control using a Continuou

214 ) and dichlorodiphenyldichloroethylene (p,p'-DDE) exposures with sperm sex-chromosome disomy.

215 p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) have been measured in surplus serum collected in 20

216 chloro-2,2-bis(p-chlorophenyl)ethylene (p,p'-DDE) is a metabolite of the insecticide 2,2-bis(p-chloro

217 p,p'-dichlorodiphenyl dichloroethylene (p,p'-DDE) levels and behaviors associated with attention defi

218 , and dichlorodiphenyldichloroethylene (p,p'-DDE) were quantified in archived maternal serum drawn in

219 rment for condors from exposure to DDE (p,p'-DDE), a major metabolite of the chlorinated pesticide DD

220 loro-2,2-bis (p-chlorophenyl) ethylene (p,p'-DDE), and hexachlorobenzene (HCB) were measured twice ea

221 p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE), are bioaccumulated in the adipose tissue (AT) and

222 95% CI: 0.01, 0.25) per log increase of p,p'-DDE).

223 bis[4-chlorophenyl]-1,1-dichloroethene (p,p'-DDE).

224 rved values for hydrophobic pollutants (p,p'-DDE).

225 ted OR = 2.1, 95% CI: 1.0, 4.5; and for p,p'-DDE, adjusted OR = 1.97, 95% CI: 0.94, 4.13).

226 th r(2) of 0.22-0.52 for PCBs, 0.42 for p,p'-DDE, and 0.44-0.72 for the more volatile PAHs.

227 Banned pesticides such as HCB and p,p'-DDE, and other legacy and ongoing pollutants such as PCB

228 e lifetime bioaccumulation of p,p'-DDT, p,p'-DDE, and p,p'-DDD in harbor porpoises.

229 tions of certain POPs (trans-nonachlor, p,p'-DDE, and several PCBs) in their milk than primiparous fe

230 n concentrations in vegetation of PCBs, p,p'-DDE, and the more volatile PAHs with lipid content were

231 Increased concentrations of p,p'-DDE, HCB, beta-HCH, dicofol, and PCBs (congeners -138, -

232 egacy organochlorine pesticides such as p,p'-DDE, lindane, and hexachlorobenzene were found in higher

233 resmethrin, 3-PBA, o,p'-DDT, p,p'-DDT, p,p'-DDE, methoxychlor- and tolylfluanid-reduced cortisol-sti

234 2-bis(p-chlorophenyl)ethane metabolite, p,p'-DDE, was not significantly associated with NHL in most a

235 ighest observed concentrations were for p,p'-DDE, with 2200 and 990 pg/L deduced from PE and SPME, re

236 d in the past, 1100 ng cm(-2) y(-1) for p,p'-DDE.

237 ed area: 240 to 260 ng cm(-2) y(-1) for p,p'-DDE.

238 d with solution containing 100 ng/mL of p,p'-DDE.

239 as the pesticide DDT and its metabolite p,p'-DDE.

240 l ether (PBDE) congeners 47 and 99, and p,p'-DDE.

241 ecially of persistent compounds such as p,p'-DDE.

242 Weaker associations were found for p,p'-DDE.

243 concentrations of 57 PCB congeners and p,p'-DDE.

244 the CRS-T at higher levels of PCBs and p,p'-DDE.

245 1.06, 2.92) and a similar relation for p,p'-DDE.

246 the obesogenic effects of p,p'-DDT and p,p'-DDE.

247 sononyl (DiNP) phthalates, PCB-153, and p,p'-DDE.

248 re on dichlorodiphenyldichloroethylene (p,p'-DDE; DDT metabolite) accumulation by Glycine max L. (soy

249 on of dichlorodiphenyldichloroethylene (p,p'-DDE; DDT metabolite) by Cucurbita pepo L. (zucchini), Gl

250 Cord serum PCB, DDE (dichlorodiphenyldichloroethylene), and maternal per

251 There was also evidence of PCB-DDE additivity, where exposure to both compounds reduced

252 We quantified PCBs, DDE, and PBDEs in resident fishes from 13 Great Lakes tr

253 Plasma DDE levels were not associated with a higher frequency o

254 nces in response to the skin tests by plasma DDE levels.

255 than 7.6 ppb, individuals with higher plasma DDE levels had lowered mitogen-induced lymphoproliferati

256 The mean plasma DDE concentration for coastal condors was 500 +/- 670 (s

257 specimens were analyzed for levels of plasma DDE (a metabolite of 1,1,1-trichloro-2,2-bis(p-chlorophe

258 onclude that relatively low levels of plasma DDE are associated with statistically significant change

259 DDT congeners and their breakdown products (DDE, DDD, DDMU, and DDNU) and 43 PCB congeners using GC-

260 nge of organisms, we identified the putative DDE/D triad for all superfamilies.

261 9, 131, and 675 ng, respectively; total root DDE content for the three plants was 402, 5970, and 5830

262 ere 500 and 970 ng, respectively; total root DDE content was 13,700 and 20,300 ng, respectively.

263 Serum DDE levels, AD diagnosis, severity of AD measured by the

264 boys whose mother's recovery-adjusted serum DDE level was less than 21.4 microg/liter, boys with mat

265 Elevated serum DDE levels are associated with an increased risk for AD

266 dily with increasing concentrations of serum DDE (ORs=1, 1.5, 1.6, 2.5, 3.1; trend p<0.0001).

267 In this population, the range of serum DDE levels was large (0.8-398 microg/liter).

268 ase repeatedly utilizes the same active site DDE residues to cleave and join a single DNA strand at e

269 The Rag1 active site DDE triad clearly plays a catalytic role in both cleavag

270 Bulk and NP Ag at 500 mg/L suppressed DDE uptake by C. pepo by 21-29%, although Ag exposure at

271 These data suggest that DDE exposure would promote, but not cause, mammary tumor

272 The DDE-like motif is crucial for its DNA cleavage action as

273 arately from its role in V(D)J cleavage, the DDE motif of the RAG1/2 active site is specifically requ

274 karyotic family of mariner/Tc1 elements, the DDE motif was considered absent in other classes of euka

275 l intasome/transpososome structures from the DDE(D) recombinase superfamily have been reported, the m

276 born between 1959 and 1966 and measured the DDE concentration in their mothers' serum samples stored

277 The three amino acids of the DDE motif (Asp-97, Asp-188, and Glu-326), which are cons

278 is, single mutations at each position of the DDE motif were constructed.

279 that piggyBac transposase is a member of the DDE superfamily of recombinases, an unanticipated result

280 AG-1 subunit contributes the residues of the DDE triad to the recombinase active site, cleavage of in

281 This catalytic triad resembles the DDE motif often associated with transposase and retrovir

282 e of active-site metal binding residues (the DDE motif), suggesting that active-site amino acids in R

283 The results show that the DDE triad is contributed to a single recombinase active

284 nc site is located in close proximity to the DDE active site.

285 Analogous to the DDE and DEDD catalytic motifs of transposases and RuvC,

286 ved amino acid residues or motifs within the DDE/D domain that together form a "signature string" tha

287 The DDEs model the ability of circadian rhythm to generate a

288 tive impairment for condors from exposure to DDE (p,p'-DDE), a major metabolite of the chlorinated pe

289 In animal experiments, in utero exposure to DDE decreases anogenital distance in male offspring.

290 ine the hypothesis that in utero exposure to DDE decreases anogenital distance in newborn human males

291 le Sprague-Dawley rats following exposure to DDE.

292 found no evidence that exposure in utero to DDE was related to reduced androgen action as reflected

293 omain containing an acidic amino acid triad (DDE or DDD) that catalyzes the "cut and paste" transposi

294 u serves as a model system for understanding DDE transposases and integrases.

295 When DDE levels were categorized as 1 or less, more than 1 to

296 birth cohort study begun in 1959-1966, when DDE levels were much higher than they are at present.

297 nd dust were positively associated; whereas, DDE concentrations in blood were positively associated w

298 tion between sulfide and black carbon, while DDE degradation involves reductive dechlorination.

299 odds of spontaneous abortion associated with DDE, suggest that these compounds could affect fertility

300 t was less suggestive of an association with DDE.