ライフサイエンスコーパス: DDT

1 DDT (1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane), a c

2 DDT enhanced both adipogenic and osteogenic differentiat

3 DDT was administered to C57BL/6J dams from gestational d

4 DDT-related and mirex/dechlorane-related compounds were

5 DDTs with demonstrated predictive accuracy for clinical

6 1-Dodecanethiol (1-DDT, 5 mM) was used as selective ligand for quantitative

7 ged since a bottleneck coincident with 1960s DDT spraying campaigns.

8 ntamination sources, such as extensive 1980s DDT usage in the former German Democratic Republic and i

9 Insecticide susceptibility to 4% DDT and 0.05% deltamethrin WHO-impregnated papers was de

10 ichlorodiphenyl)-2,2,2-trichloroethane (4,4'-DDT), 1,1-bis(4,4'-dichlorodiphenyl)-2,2-dichloroethene

11 double layer and a high ligand density (3.6 DDT molecules per nm(2)) are at the origin of the appare

12 Graphic: Pestroy, a DDT-laced coating marketed in 1946 by Sherwin-Williams R

13 There are 3 important questions that a DDT should answer with regard to antituberculosis drugs:

14 PBDEs (92.0%), chlordane (88.5%) and DDT (98.7%) were also detected frequently, although at l

15 reducing the 28-day DDT biouptake (66%) and DDT uptake into PE (>99%) compared to controls.

16 to 52,000 pg/m3 over the sampling area, and DDT, chlordane, and endosulfan concentrations were in th

17 istently over-expressed across carbamate and DDT resistant populations.

18 The composition of chlordane and DDT-related residues indicated recent emissions.

19 Elevated levels of dieldrin, chlordane- and DDT-related pesticides, polycyclic aromatic hydrocarbons

20 pled from walls using Bostik tape discs, and DDT concentrations [grams of active ingredient per squar

21 related significantly with GI, LASRC, DS and DDT.

22 spectively), with hexachlorocyclohexanes and DDT were identified in ginseng sources along with azoxys

23 erase/dopachrome isomerase activity (MIF and DDT genes).

24 PCBs, PBDEs, and DDT occur at significantly higher concentrations in fish

25 Uptake of HCHs, HCB, PCBs, and DDT plus metabolites was studied (log K(ow) 3.66 to 7.18

26 (carbaryl, cypermethrin, and permethrin) and DDT did not change over time in our study population.

27 In this insect, resistance to pyrethroid and DDT insecticides is strongly associated with the mutatio

28 utants (POPs), specifically PCBs, PBDEs, and DDTs, in the marine environment are well documented, how

29 We assessed DDT-treated MSCs for self-renewal, proliferation, and di

30 Extractability of sediment-associated DDT and chlordane by A. brasiliensis digestive fluids wa

31 ibers with dodecanethiol-coated AuNRs (AuNRs-DDT).

32 Upon the addition of AuNRs-DDT, P3HT-SH nanofibers were transformed into nanoribbon

33 trend toward a positive association between DDT and DDE exposure and odds of obesity.

34 indings suggest that the association between DDT exposure and hypertension may have its origins early

35 We identified 45 bioaccumulative DDT-related compounds of which the majority (80%) is not

36 performed to identify novel, bioaccumulative DDT-related compounds and to determine their abundance r

37 of interest were polychlorinated biphenyls, DDTs, chlordanes, dieldrin, and alpha- and gamma-hexachl

38 Both DDT and DDE increase amyloid precursor protein levels, p

39 ese ubiquitination events may be mediated by DDT-dependent E2/E3 ligases (e.g. RAD18 and SHPRH/HLTF).

40 bal use of the endocrine-disrupting chemical DDT has decreased, its persistence in the environment ha

41 cofol, a current use pesticide that contains DDT-related compounds.

42 product of the ubiquitous global contaminant DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane), ha

43 tify bioaccessibility of legacy contaminants DDT and PCBs in marine sediments from a Superfund site.

44 oted AC sequestration by reducing the 28-day DDT biouptake (66%) and DDT uptake into PE (>99%) compar

45 dichlorodiphenyldichloroethylene (p,p'-DDE; DDT metabolite) accumulation by Glycine max L. (soybean)

46 In this study, DDTr (DDTr = DDT + DDD + DDE) relative bioavailability in historicall

47 on the uptake of weathered chlordane or DDx (DDT + metabolites) by Cucurbita pepo (zucchini), Zea may

48 Furthermore, defective DDT decreased the numbers of MPP-derived common lymphoid

49 me assessment (COA)--another type of defined DDT--is also discussed.

50 the xenobiotic dichlordiphenyltrichlorethan (DDT), by artificial selection or by transgenic expressio

51 Dichlorodiphenyltrichloroethane (DDT) was used extensively to control malaria, typhus, bo

52 cohort and dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) serum co

53 throids and dichlorodiphenyltrichloroethane (DDT) but fully susceptible to carbamates and organophosp

54 anochlorine dichlorodiphenyltrichloroethane (DDT), a known estrogen mimic and endocrine disruptor, ha

55 ts, such as dichlorodiphenyltrichloroethane (DDT) and polychlorinated biphenyls (PCBs), but has not b

56 chlordane, dichlorodiphenyltrichloroethane (DDT), malathion, and captan; others with notable but sli

57 containing dichlorodiphenyltrichloroethane (DDT) and chlordane.

58 For dichlorodiphenyltrichloroethane (DDT), we observed significant RTL shortening for lifetim

59 zene (HCB), dichlorodiphenyltrichloroethane (DDT), and dichlorodiphenyldichloroethylene (DDE) are per

60 s including dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) has been

61 , including dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenylethylene (DDE),

62 trations of dichlorodiphenyltrichloroethane (DDT) and PCBs show similar spatial distribution patterns

63 els of p,p'-dichlorodiphenyltrichloroethane (DDT), p,p'-dichlorodiphenyldichloroethylene (DDE) and fo

64 yls (PCBs), dichlorodiphenyltrichloroethane (DDT), dichlorodiphenyldichloroethylene (DDE), and hexach

65 e pesticide dichlorodiphenyltrichloroethane (DDT) and its metabolites in intermediate and deep ocean

66 e pesticide dichlorodiphenyltrichloroethane (DDT), were elevated in a small number of patients with A

67 Residual dichlorodiphenyltrichloroethane (DDT) was sampled from walls using Bostik tape discs, and

68 sistance to dichlorodiphenyltrichloroethane (DDT) in field-caught Anopheles gambiae sensu stricto hom

69 related to dichlorodiphenyltrichloroethane (DDT) were the most abundant.

70 pesticide (dichlorodiphenyltrichloroethane, DDT), which had been previously stored in vineyard soil,

71 including dichlorodiphenyltrichloroethylene (DDT, removed from the market in 1972), chlordane (1988),

72 wo different ligands [OAM and dodecanethiol (DDT), respectively] while keeping all other experimental

73 iodide and indium acetate) in dodecanethiol (DDT).

74 Our study proposes a dual DDT-receptor model and provides a structural background

75 t the early time points (6 h to 12 h) during DDT exposure.

76 The bulky trichloromethyl group of each DDT molecule fits snugly between four helices in the ben

77 ted with the decay in residual environmental DDT concentrations and growing human populations, but no

78 ,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT), and tris(2,3-dibromopropyl) phosphate (TDBPP), amo

79 1,1-trichloro-2,2-di(4-chlorophenyl)ethane (DDT) and its metabolites 1,1-dichloro-2,2-bis(4-chloroph

80 1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), the first organochlorine insecticide, and pyrethro

81 For DDT, a trend of decreasing net Arctic import will revers

82 DDT-contaminated sediment were assessed for DDT sediment-water flux, biouptake, and passive sampler

83 lowing the regulatory guidance documents for DDT qualification was developed, followed by individual

84 Thus, we sought to determine a role for DDT in renal cancer.

85 nt association with incident RA was seen for DDT (OR = 1.9; 95% CI: 0.97, 3.6).

86 The halving times for DDTs, chlordanes, and dieldrin are 8.7 +/- 0.4 years for

87 Four DDTs were identified as having a track record to answer

88 r to regulate other DDT pathways, error-free DDT mechanisms are employed by H2Bub1-deficient cells as

89 on and activated carbon to reduce risks from DDT-contaminated sediment were assessed for DDT sediment

90 Functionally, DDT and MIF demonstrate a significant overlap in control

91 or some compounds in the studied area, e.g., DDT in the western part of Germany and dieldrin.

92 All samples had detectable levels of HCB, DDT, and DDE, with median levels of 0.087 ng/g serum for

93 However, DDT inhibition consistently displayed more severe effect

94 Together, our findings identify DDT as a functionally redundant but more potent cytokine

95 In DDT IRS households, women who reported taking more than

96 her, our results suggest a role of IGF-1R in DDT.

97 oding RNAs to be differentially expressed in DDT-treated MSCs compared with controls cells.

98 g was performed to assess gene expression in DDT-treated MSCs.

99 Expression of factors in DDT-treated cells was similar to that in estrogen-treate

100 only one isoform (MDR49B) was implicated in DDT resistance.

101 Rad18 is a central E3 ubiquitin ligase in DDT, which exists in a monoubiquitinated (Rad18*Ub) and

102 ential role of MDR49, an ABC transporter, in DDT resistance, however, to date the details of how MDR4

103 Median levels of DDT and DDE among women in DDT IRS households were 2.6 (IQR: 1.1-6.6) and 8.5 (IQR:

104 Although both interventions increased DDT resistance, neither increased lifespan.

105 The contact insecticide DDT has been reappraised as a safe, life-saving compound

106 versial, but animal studies directly linking DDT to risk are lacking.

107 e.g., covering water and food) had 40% lower DDT levels (95% CI: -63, -0.3%) than women who took fewe

108 ard, rather than a public tap, had 73% lower DDT (95% CI: -83, -57%) and 61% lower DDE (95% CI: -74,

109 Mapping DDT binding sites is necessary for understanding mechani

110 high correlation and that, mechanistically, DDT is a novel hypoxia-inducible gene and direct target

111 sehold with a low likelihood of DDT use (non-DDT IRS household, n = 106), IRS village in household wi

112 racy of the HFS-TB, or any other nonclinical DDT such as an animal model, has yet to be robustly eval

113 and Lambda-cyhalothrin) pyrethroids but not DDT.

114 89.3 +/- 1.8% of DDT, 63.2 +/- 1.9% of DDD, and 50.9 +/- 1.6% of DDE were

115 , to evaluate sensitivity to amelioration of DDT-associated hypertension by ACE inhibition.

116 ulations that would allow reduced amounts of DDT, thereby minimizing environmental impact.

117 ations, plays a role in the early aspects of DDT resistance in 91-R.

118 The association of DDT (dichlorodiphenyltrichloroethane) with breast cancer

119 to inhibit MIF signaling may fail because of DDT compensation.

120 pound-specific carbon isotope composition of DDT and its metabolites, and the microbial community in

121 The mean residual concentration of DDT post-IRS was 0.37 g ai/m(2); 84.9% of walls were und

122 We examined concentrations of DDT (p,p - and o,p -) and its metabolite p,p -DDE (dichl

123 ciations of maternal serum concentrations of DDT and DDE during pregnancy with body mass index, obesi

124 Similar concentrations of DDT and DDEs were found in the surface water, while the

125 transformed maternal serum concentrations of DDT, PBDE congeners 28 and 183, and paternal serum conce

126 Levels of HCB and congeners of DDT and DDE were measured in serum collected during the

127 ays (p = 0.04), but not for lifetime days of DDT use (p = 0.08).

128 s revealed a strong cell intrinsic defect of DDT-deficient HSCs in reconstituting lethally irradiated

129 Since the discovery of DDT in the late 1960s, most studies on TLS in eukaryotes

130 Here, using computational docking of DDT into the Kv1.2-based mosquito sodium channel model,

131 The protective effect of DDT required activation of the metabolic stress enzyme A

132 ration of ICI 182,780 blocked the effects of DDT.

133 In addition, a prediction equation of DDT concentrations in soils based on stepwise multiple r

134 We further assessed the influence of DDT exposure on the expression of mRNAs that regulate BP

135 Accordingly, although dual inhibition of DDT and MIF demonstrated additive effects in vitro, DDT

136 Serum concentrations of p,p' isomers of DDT and DDE were above the limit of detection (LOD) in >

137 Median levels of DDT and DDE among women in DDT IRS households were 2.6 (

138 Median levels of DDT and DDE among women in unsprayed villages were 0.3 [

139 llage in household with a high likelihood of DDT use (DDT IRS household, n = 100).

140 illage in household with a low likelihood of DDT use (non-DDT IRS household, n = 106), IRS village in

141 ts contribute to the majority of the load of DDT-related contaminants in these sentinels of ocean hea

142 Three modes of DDT have been documented: translesion synthesis (TLS), t

143 2006, calls for the complete phasing out of DDT as soon as practical, with limited use in the interi

144 Few studies have examined predictors of DDT (dichlorodiphenyltrichloroethane) and DDE (dichlorod

145 The predictors of DDT and DDE plasma levels identified in the present stud

146 that H2Bub is required for the regulation of DDT after genome duplication.

147 To investigate the role of DDT in maintaining hematopoietic stem cells (HSCs) and p

148 These findings indicate a critical role of DDT in maintaining HSCs and progenitor cells, and in pre

149 ata indicate that cardiomyocyte secretion of DDT has important autocrine/paracrine effects during isc

150 However, the sources of DDT in eastern China are mainly from historic applicatio

151 n the ecosystem, indoor residual spraying of DDT is still recommended for malaria control in Africa.

152 luencing the migration and transformation of DDT isomers and their metabolites in soils.

153 we found that the abiotic transformation of DDT, DDD, and DDE (collectively referred to as DDX) requ

154 e of Indian sand flies, the continued use of DDT in this IRS program is questionable.

155 Although the use of DDT is banned in most of the world due to its detrimenta

156 However, the use of DDT to control vector-borne diseases continues in develo

157 trations exhibited aqueous concentrations of DDTs and PCBs that exceeded Ambient Water Quality Criter

158 For instance, the elevated concentrations of DDTs in the Barents and Atlantic sectors of the Arctic O

159 Higher concentrations of DDTs were found in the European part of the Arctic Ocean

160 tlantic current as a significant conveyor of DDTs.

161 our understanding of the large-scale fate of DDTs in the Arctic.

162 Due to the adverse impact of DDTs on ecosystems and humans, a full fate assessment de

163 Here, the distribution and inventories of DDTs in water of the Arctic shelf seas and the interior

164 the migration and transformation pathways of DDTs in Chinese arable soils, which will allow data-base

165 nd an alternative splicing event in MDR49 on DDT-resistance in 91-R, as compared to the DDT susceptib

166 ile H2Bub1 does not appear to regulate other DDT pathways, error-free DDT mechanisms are employed by

167 ed with increased odds (OR) of obesity [o,p -DDT adjusted (adj-) OR = 1.17, 95% CI: 0.75, 1.82; p,p -

168 cells using either estradiol (E(2)) or o,p -DDT to identify distinct cellular gene expression respon

169 We included 270 children with o,p -DDT, p,p -DDT, and p,p -DDE concentrations measured in m

170 A 10-fold increase in o,p -DDT, p,p -DDT, or p,p -DDE, was nonsignificantly associa

171 d (adj-) OR = 1.17, 95% CI: 0.75, 1.82; p,p -DDT adj-OR = 1.19, 95% CI: 0.81, 1.74; p,p -DDE adj-OR =

172 These associations between p,p -DDT and hypertension were robust to adjustment for indep

173 Prenatal p,p -DDT exposure was associated with hypertension [adjusted

174 .2, 5.3 for middle and high tertiles of p,p -DDT relative to the lowest tertile, respectively].

175 -DDE, dichlorodiphenyltrichloroethane (p,p -DDT), dieldrin, heptachlor epoxide, HCB, trans-nonachlor

176 We included 270 children with o,p -DDT, p,p -DDT, and p,p -DDE concentrations measured in maternal se

177 A 10-fold increase in o,p -DDT, p,p -DDT, or p,p -DDE, was nonsignificantly associated with i

178 ol-induced PEPCK gene expression, while o,p'-DDT and methoxychlor inhibited cortisol-stimulated Arg a

179 The inverse dependence of o,p'-DDT and p,p'-DDE on temperature evidences the transforma

180 The EFs and delta(13)C of o,p'-DDT in soils from western China show smaller deviations

181 ds of becoming overweight or obese (for o,p'-DDT, adjusted odds ratio (OR) = 2.5, 95% confidence inte

182 umulation was found for the chiral OCPs o,p'-DDT, cis- and trans-chlordane, nonachlor MC6 and oxychlo

183 -cyhalothrin, cypermethrin, resmethrin, o,p'-DDT, p,p'-DDT, methoxychlor, ethiofencarb, and tolylflua

184 lambda-cyhalothrin, resmethrin, 3-PBA, o,p'-DDT, p,p'-DDT, p,p'-DDE, methoxychlor- and tolylfluanid-

185 sitive associations between exposure to p,p'-DDT and increased adiposity in rodents.

186 We classified p,p'-DDT and p,p'-DDE as "presumed" to be obesogenic for huma

187 ehold wet mopping significantly reduced p,p'-DDT and p,p'-DDE exposure.

188 Median (interquartile range) p,p'-DDT and p,p'-DDE serum concentrations for VHEMBE cohort

189 r malaria control had 5-7 times higher p,p'-DDT and p,p'-DDE serum concentrations than those who nev

190 potential reduction in population-level p,p'-DDT and p,p'-DDE serum concentrations under five hypothe

191 more volatile PCB congeners and TC, CC, p,p'-DDT and p,p'-DDE than the respective PARTs, while they a

192 ausibility of the obesogenic effects of p,p'-DDT and p,p'-DDE.

193 g access to water significantly reduced p,p'-DDT exposure and increasing the frequency of household w

194 confidence interval (CI): 1.0, 6.3; for p,p'-DDT, adjusted OR = 2.1, 95% CI: 1.0, 4.5; and for p,p'-D

195 in, cypermethrin, resmethrin, o,p'-DDT, p,p'-DDT, methoxychlor, ethiofencarb, and tolylfluanid showed

196 Concentrations of p,p'-DDT, p,p'-DDE and beta-HCH were not associated with diab

197 els for the lifetime bioaccumulation of p,p'-DDT, p,p'-DDE, and p,p'-DDD in harbor porpoises.

198 halothrin, resmethrin, 3-PBA, o,p'-DDT, p,p'-DDT, p,p'-DDE, methoxychlor- and tolylfluanid-reduced co

199 Typically, models performed better for p,p'-DDT/E than PBDE congeners.

200 ature evidences the transformation of parent DDT to its metabolites.

201 Our results show levels of PBBs, DDT, and HBB in tree bark collected within 10 km of the

202 hesized ACs and biochars to sorb PAHs, PCBs, DDTs, inorganic Hg, and MeHg at environmentally relevant

203 Perinatal DDT exposure induces hypertension and cardiac hypertroph

204 verses the hypertension induced by perinatal DDT exposure.

205 We hypothesized that perinatal DDT exposure causes hypertension in adult mice.

206 ajor metabolite of the chlorinated pesticide DDT.

207 Elevated levels of the pesticide DDT (dichlorodiphenyltrichloroethane) have been positive

208 persistent pollutants such as the pesticide DDT and its metabolite p,p'-DDE.

209 ssociation between exposure to the pesticide DDT and its metabolites and obesity to develop hazard id

210 d whether prenatal exposure to the pesticide DDT increases risk of adult hypertension.

211 experiments on the organochlorine pesticides DDT, DDE, DDD, and chlordane in well-mixed slurries supp

212 Prenatal DDT exposure is associated with elevated blood pressure

213 e rates for the association between prenatal DDT exposures and hypertension treated with medication i

214 e, among boys, 10-fold increases in prenatal DDT and DDE concentrations were associated with increase

215 stance in Vallee du Kou (VK) to pyrethroids, DDT and dieldrin, moderate level for carbamates and full

216 of knockdown resistance (kdr) to pyrethroids/DDT resistance observed in Anopheles funestus across Afr

217 showing strong correlation with pyrethroids/DDT and dieldrin resistance.

218 t several intervention approaches may reduce DDT/DDE exposure in pregnant women living in IRS communi

219 AC treatment was effective in reducing DDT and chlordane concentration in polyethylene (PE) sam

220 mitted to both agencies, pursuing regulatory DDT endorsement.

221 360, 91.3%) of pre-IRS samples had residual DDT concentrations of <0.1 g ai/m(2).

222 olyubiquitin chain by Ubc13-Mms2/Rad5 routes DDT to the template switching pathway.

223 ntibody-dependent neutralization of secreted DDT exacerbated both ischemia-induced cardiac contractil

224 timated daily intakes of gamma-HCH and Sigma-DDT (3.35 and 1.22mug/kg bw/day) through consumption of

225 biodynamic model were developed to simulate DDT flux and biouptake, respectively, and models confirm

226 We generated cardiomyocyte-specific DDT knockout mice (Myh6-Cre Ddtfl/fl), which demonstrate

227 r abundance relative to the commonly studied DDT-related compounds.

228 hers has described D-dopachrome tautomerase (DDT) as a functional homologue of MIF with a similar gen

229 D-dopachrome tautomerase (DDT) is an enzyme that lacks physiologic substrates in m

230 es of these compounds, we analyzed technical DDT, the primary source of historical contamination in t

231 ainly from historic application of technical DDTs and dicofol.

232 wing DDE, and TCPMOH loads were greater than DDT.

233 We find that DDT expression mirrors MIF expression in ccRCC tumor sec

234 Here, we observed that DDT is highly expressed in murine cardiomyocytes and sec

235 Our results suggest that DDT and DDD are transformed by surface intermediates for

236 e II/III domain interface and suggested that DDT binds within PyR1.

237 at in estrogen-treated MSCs, suggesting that DDT may function via the estrogen receptor (ER)-mediated

238 Accumulating evidence suggests that DDT exposure has long-term adverse effects on developmen

239 The DDT pathways, which involve translesion synthesis and te

240 of racemic/standard compound, indicating the DDT residues there mainly result from atmospheric transp

241 Here, we investigated the role of the DDT in the locomotor development of zebrafish larvae.

242 Given the poor quality of the DDT-based IRS, ready availability of pyrethroids, and su

243 f clean sediment (0.5 cm) did not reduce the DDT flux when bioturbation was present, while a thin (0.

244 cm) AC cap was still capable of reducing the DDT flux by 94%.

245 n DDT-resistance in 91-R, as compared to the DDT susceptible strain 91-C.

246 at the dopaminergic otpb population, via the DDT, is responsible for spinal D(4)R signaling to mediat

247 ize the surface of CIS NCs obtained with the DDT method.

248 n of experimental quantitative output in the DDTs that correlates with sterilizing effect in humans.

249 The role of the DDTs used for evaluating the efficacy of antituberculosi

250 Regulatory endorsement of these DDTs is critical for drug developers, as it promotes con

251 Dysregulation of this DDT pathway in human cells leads to increased mutation r

252 dicators such as DS, dough development time (DDT), LASRC and gluten index (GI) were positively relate

253 An alternative to DDT, giving year-round transmission control in sub-Sahar

254 Exposure of human neuroblastoma cells to DDT or DDE increased levels of amyloid precursor protein

255 MSCs exposed to DDT demonstrated profound alterations in self-renewal, p

256 Adult mice perinatally exposed to DDT exhibited chronically increased systolic BP, increas

257 MSCs exposed to DDT formed fewer colonies, suggesting a reduction in sel

258 man mesenchymal stem cells (MSCs) exposed to DDT were used to evaluate the impact on stem cell biolog

259 hypertension in mice perinatally exposed to DDT.

260 nd associations between prenatal exposure to DDT and DDE and several measures of obesity at 9 years o

261 data demonstrate that perinatal exposure to DDT causes hypertension and cardiac hypertrophy in adult

262 gambiae sensu stricto to survive exposure to DDT.

263 Development of resistance to DDT and pyrethroids is a serious global obstacle for man

264 Sand flies were highly resistant to DDT but susceptible to deltamethrin.

265 expression only CM1 and CM7 are resistant to DDT, and the other two strains (CM2 and AM3), like the f

266 on infectious blood were more susceptible to DDT than mosquitoes that fed on noninfectious blood duri

267 four Accord-free strains, are susceptible to DDT.

268 DNA damage tolerance (DDT) enables bypassing of DNA lesions during replication

269 main regulator of the DNA damage tolerance (DDT) pathway.

270 bypass is mediated by DNA damage tolerance (DDT) pathways and homologous recombination (HR).

271 age may be overcome by DNA damage tolerance (DDT) pathways that bypass such obstacles, postponing rep

272 e often bypassed using DNA damage tolerance (DDT) pathways to avoid prolonged fork stalling and allow

273 proceed via one of two DNA damage tolerance (DDT) pathways, allowing replicative DNA synthesis to res

274 is due to an aberrant DNA Damage Tolerance (DDT) response upon fork stalling.

275 The first nonclinical drug development tool (DDT) advanced by the Critical Path to TB Drug Regimens (

276 riments, represents a drug development tool (DDT) with the potential for use to develop tuberculosis

277 Several nonclinical drug-development tools (DDTs) have been used for antituberculosis drug developme

278 er and develop novel drug development tools (DDTs), such as biomarkers.

279 g/g serum for HCB, 1.12 ng/g serum for total DDT, and 1.04 ng/g serum for p,p -DDE.

280 The geographically total DDT concentrations are higher in eastern than western Ch

281 es the dopaminergic diencephalospinal tract (DDT).

282 tivariable models of natural log-transformed DDT plasma levels (in micrograms per liter) and DDE (in

283 ven the lack of a gold-standard tuberculosis DDT, the forecasting accuracy of a completely unreliable

284 to sodium channel model, we predict that two DDT molecules can bind simultaneously within PyR1 and Py

285 , we used Pcna(K164R/K164R) mice as a unique DDT-defective mouse model.

286 positions and revealed 10 previously unknown DDT-sensing residues within PyR1 and PyR2.

287 re, we show that anthropogenic chemical use (DDT; dichlorodiphenyltrichloroethane) and increasing urb

288 household with a high likelihood of DDT use (DDT IRS household, n = 100).

289 gnificant positive relation between in utero DDT and DDE exposure and obesity status of 7-year-old ch

290 We examined the relation of in utero DDT and DDE exposure to child obesity at 7 years of age.

291 MIF demonstrated additive effects in vitro, DDT plays a dominant role in tumor growth in vivo.

292 for formal quantitative analyses of how well DDTs forecast clinical outcomes.

293 Among households where DDT is likely to be used for IRS, education regarding ho

294 However, whether DDT binds to both pyrethroid receptor sites remains unkn

295 Here, we identify a mechanism by which DDT alters cellular signaling and gene expression, indep

296 elanogaster has been intensely selected with DDT over six decades.

297 porting to have lived in a home sprayed with DDT for malaria control had 5-7 times higher p,p'-DDT a

298 levels among residents in homes sprayed with DDT for malaria control with the aim of identifying expo

299 those who never lived in a home sprayed with DDT.

300 Furthermore, treatment with DDT protected isolated hearts against injury and contrac