ライフサイエンスコーパス: DEHP

1 DEHP concentrations in ECMO patients were greater in the

2 DEHP concentrations were the highest of the phthalates m

3 DEHP is in fact a plastic contaminant always presents on

4 DEHP leached from circuit A at 0.32 +/- 0.12 microgram/

5 DEHP leaches from ECMO circuits, with potential exposure

6 DEHP-induced elevations in serum testosterone and E2 lev

7 The most important findings are (1) DEHP steady-state concentrations increased greatly with

8 In protocol 2, DEHP was undetected in the control patients.

9 PCA identified a DEHP component and a non-DEHP component.

10 As yet, little is known about DEHP effects in utero on fetal Leydig cells (FLC).

11 All DEHP plasma concentrations were measured by gas chromato

12 d ratios were found across gestation for all DEHP [di(2-ethylhexyl) phthalate] metabolites.

13 jor phthalate diesters (DiBP, DnBP, BBzP and DEHP) monitoring in food items has been developed and va

14 %, 12.0% and 14.1%, for DiBP, DnBP, BBzP and DEHP, respectively.

15 During the bonne chauffe, DBP and DEHP accumulated in the secondes more than in the brandy

16 The concentration of DBP and DEHP in hot-water samples from plastic bags were found i

17 ion of highly hydrophobic compounds, DBP and DEHP.

18 ective cohorts report that gestational BBzP, DEHP, di-butyl phthalate (DBP), and di-ethyl phthalate (

19 r regression models and associations between DEHP metabolites and clinical outcomes using logistic re

20 significantly positive correlations between DEHP daily intake and urinary 5OH-MEHP, 5oxo-MEHP, and 5

21 After corrections for method blank DEHP, co-eluting compounds, and unidentified carbon, the

22 ee model radiolabeled molecules, namely BPA, DEHP and 4n-NP.

23 ry glycine, which inactivates Kupffer cells, DEHP did not increase radical signals.

24 showed almost no leaching from the circuit; DEHP concentrations decreased at a rate of 0.2 +/- 0.04

25 as induced in male rats by a diet containing DEHP and clofibrate for 3-60 days.

26 Safety Improvement Act of 2008, may decrease DEHP exposure, but additional work characterizing the na

27 tances (PFASs), metabolites of diethylhexyl (DEHP) and diisononyl (DiNP) phthalates, PCB-153, and p,p

28 -weight (HMW), and di-2-ethylhexylphthalate (DEHP) metabolites, controlling for sex, television watch

29 ctive, comparative clinical study evaluating DEHP plasma concentrations in ECMO vs. non-ECMO patients

30 The authors examined DEHP exposure in relation to the timing of labor in a pr

31 nancy, or early pregnancy loss, and in fact, DEHP [di(2-ethylhexyl) phthalate] metabolites {MEOHP [mo

32 and synthetic musks in the gas phase and for DEHP, DiBP, DBP, and DINP in the airborne particles.

33 f the particle-gas partition coefficient for DEHP.

34 Daily plasma concentrations for DEHP were collected until 3 days after decannulation fro

35 thyl phthalate (DMP) to 0.673 mug/kg/day for DEHP.

36 75-500 ng/mL for DBP and 150-1000 ng/mL for DEHP.

37 Relationships with OHdG were significant for DEHP metabolites as well as mono-n-butyl phthalate (MBP)

38 The estimated DI values for DEHP in 39 individuals were above the U.S. Environmental

39 zed urine samples from eight adults for four DEHP metabolites [mono(2-ethylhexyl) phthalate, mono(2-e

40 and occupational and clinical exposures from DEHP-plasticized medical devices, e.g., blood bags, hemo

41 Furthermore, DEHP given with [(13)C(2)]dimethyl sulfoxide produced a

42 8-11% of children less than 2 years old had DEHP exposure estimates exceeding cancer benchmarks.

43 identifies a novel pathway modulating human DEHP toxicity with potential clinical implications for a

44 The discovery that CAR2 is an ultimate human DEHP receptor identifies a novel pathway modulating huma

45 Importantly, DEHP increased oxidant production in wild-type but not i

46 viously unknown mitochondrial dysfunction in DEHP-induced testicular toxicity and highlight the impor

47 y partially mimicked the effects observed in DEHP-treated cells.

48 ical pregnancy and live birth for individual DEHP metabolites.

49 Intriguingly, DEHP appeared to inhibit DNA replication as evidenced by

50 4% in rats receiving 10, 100, and 750 mg/kg DEHP, respectively.

51 control after exposures to 100 and 750 mg/kg DEHP, respectively.

52 c-Kit ligand (KITL) were induced by 10 mg/kg DEHP.

53 e than one sample may be necessary for MBzP, DEHP, and BPA.

54 In the N-of-1 trials, mean DEHP removal rates range from 95.9% (SD = 0.1%) to 97.0%

55 The measured DEHP partition coefficient to ammonium sulfate particles

56 Twenty percent of the modeled DEHP exposure occurred between 2200 hours and 0500 hours

57 washing with soap-and-water removes 80% more DEHP than handwashing with water alone, and may be a cos

58 PCA identified a DEHP component and a non-DEHP component.

59 Interactions between sex and non-DEHP component association with outcomes were statistica

60 In boys, higher maternal non-DEHP, but not DEHP, component scores were associated wit

61 Contrary to hypotheses, prenatal non-DEHP phthalate exposures were associated with lower BMI

62 In boys, higher maternal non-DEHP, but not DEHP, component scores were associated with lower BMI z-

63 alue of 2.5-fold 2 h after administration of DEHP, before peroxisomal oxidases were induced.

64 This amount of DEHP extrapolates in the ECMO patient to a potential exp

65 home from 23 to 35 degrees C, the amount of DEHP in the gas- and particle-phase combined is predicte

66 ol to determine the surface concentration of DEHP.

67 Testicular concentrations of DEHP and PCB153 perturbed sperm viability, motility and

68 n urine and by determining concentrations of DEHP in exposure media (e.g., air, food, dust).

69 Although significant concentrations of DEHP leach from the nonheparin-bonded circuits over time

70 mated associations between concentrations of DEHP metabolites and gestational age at delivery using l

71 Urinary concentrations of DEHP metabolites were inversely associated with oocyte y

72 The gas-phase concentrations of DEHP versus time were measured at air flow rate of 450 m

73 The content of DEHP in VF was measured at about 15% (w/w) using pressur

74 error method to determine times and doses of DEHP that resulted in a best fit of predicted and observ

75 DEHP toxicity we investigated the effect of DEHP on DNA replication.

76 We assessed the effect of DEHP on gene expression using microarray analysis.

77 The present study investigated effects of DEHP on FLC function.

78 e provided approximately 250 mug extracts of DEHP with carbon purity ranging from 92.5 +/- 1.2% (n =

79 first report of the contemporary fraction of DEHP isolated from market butter in the U.S.

80 The adsorption isotherm of DEHP on the stainless steel chamber surfaces was explici

81 and one was found containing 453.67 ng/mL of DEHP.

82 e typical mouse, rat, and marmoset models of DEHP toxicity cannot accurately profile potential human

83 sion rate and to measure the partitioning of DEHP onto airborne particles.

84 The strong partitioning of DEHP onto the stainless steel surface was found to follo

85 adjustment, women at the 75th percentile of DEHP metabolite concentrations had a 2-day-longer mean l

86 Various concentrations (1-100 ppm) of DEHP in deionized MilliQ water were tested using the fun

87 than 1%, whereas the migration quotients of DEHP were higher than 2.0%.

88 esults demonstrate that the emission rate of DEHP is substantially enhanced in the presence of partic

89 t it takes several weeks for the sorption of DEHP onto the stainless steel surface to reach equilibri

90 e (DEHP) and could be an important source of DEHP in homes.

91 (95% CI): 1.19 (1.06, 1.35) for molar sum of DEHP metabolites and 1.22 (1.01, 1.47) for BPA] at media

92 The numbers of Leydig cells in the testis of DEHP-treated rats were 40-60% higher than in control rat

93 Furthermore, the toxicity of DEHP led to respiratory chain defects and attenuation of

94 xposure by back calculating intakes based on DEHP metabolite concentrations in urine and by determini

95 0.03-0.20 mug mL(-1), respectively, but only DEHP was found in clear chicken soup samples in the rang

96 associations were not significant for HMW or DEHP metabolites, and results did not change substantial

97 s female rats received vehicle (corn oil) or DEHP at 10, 100, or 750 mg/kg by oral gavage from gestat

98 ree samples were measured for four oxidative DEHP metabolites, mono-(2-ethyl-5-hydroxyhexyl) phthalat

99 to 245 mug/m(3), the total (gas + particle) DEHP concentrations increased by a factor of 3 to 8; und

100 the idea that interactions between gas-phase DEHP and soiled surfaces have been reduced to interactio

101 model prediction and the observed gas-phase DEHP chamber concentrations.

102 and 2 +/- 1 m, respectively), (3) gas-phase DEHP concentration in equilibrium with the vinyl floorin

103 were pretreated with diethylhexyl phthalate (DEHP) and butyl benzyl phthalate (BBP), and were stimula

104 , bisphenol A (BPA), diethylhexyl phthalate (DEHP) and mineral oil hydrocarbons (MOHs), are evaluated

105 ECs, including diethylhexyl phthalate (DEHP) and polychlorinated bisphenol 153 (PCB153), were d

106 dhood exposure to di-2-ethylhexyl phthalate (DEHP) and butylbenzyl phthalate (BBzP) may increase the

107 he metabolites of di-2-ethylhexyl phthalate (DEHP) and dibutyl phthalate (DBP), in addition to monobe

108 The emission of di-2-ethylhexyl phthalate (DEHP) from vinyl flooring (VF) was measured in specially

109 halate (BBzP) and di-2-ethylhexyl phthalate (DEHP) in residential indoor environments and the influen

110 tric means of the di-2-ethylhexyl phthalate (DEHP) metabolites mono-(2-ethyl)-hexyl phthalate (MEHP)

111 coefficient K of di-2-ethylhexyl phthalate (DEHP) on typical impervious surfaces including aluminum,

112 s, metabolites of di-2-ethylhexyl phthalate (DEHP) were associated with increased IL-6 and IL-10 but

113 (DCHP) to 74% for di-2-ethylhexyl phthalate (DEHP).

114 r metabolites of di(2-ethylhexyl) phthalate (DEHP) [percent difference (%Delta)=-2.83 to -2.16].

115 Rats were given di(2-ethylhexyl) phthalate (DEHP) acutely.

116 Di(2-ethylhexyl) phthalate (DEHP) and butyl benzyl phthalate (BBzP) were the dominan

117 contained > 10% bis(2-ethylhexyl) phthalate (DEHP) and could be an important source of DEHP in homes.

118 lates, including di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP), have been shown to

119 ate (MnBP)], and di(2-ethylhexyl) phthalate (DEHP) are being replaced by substitutes including other

120 late (BBzP), and di(2-ethylhexyl) phthalate (DEHP) based on NAS recommendations, and included diethyl

121 ](+) ion of the bis(2-ethylhexyl) phthalate (DEHP) for performing the exact mass measurements of the

122 Emissions of di-(2-ethylhexyl) phthalate (DEHP) from one type of polyvinylchloride (PVC) flooring

123 Exposures to di-(2-ethylhexyl) phthalate (DEHP) have been shown to be associated with decreased ad

124 alate (DBP) and di-2-(ethylhexyl) phthalate (DEHP) in packaged food prior to analysis by gas chromato

125 alate (DBP) and di-(2-ethylhexyl) phthalate (DEHP) in soft drinks.

126 Di-(2-ethylhexyl) phthalate (DEHP) is a plasticizer used in consumer and medical prod

127 n industry, and di-(2-ethylhexyl) phthalate (DEHP) is the most abundant phthalate in the environment.

128 t phthalates, 4 di-(2-ethylhexyl) phthalate (DEHP) metabolites (Sigma4DEHP) and mono-benzyl phthalate

129 ), compared with di(2-ethylhexyl) phthalate (DEHP) metabolites.

130 ectivity for the di(2-ethylhexyl) phthalate (DEHP) molecule.

131 stillate, while bis(2-ethylhexyl) phthalate (DEHP) only partially, and diisononyl phthalate (DINP) ac

132 e metabolites of di(2-ethylhexyl) phthalate (DEHP)) and Sigma14phthalates (sum of 14 urinary phthalat

133 rally produced bis (2-ethylhexyl) phthalate (DEHP), a ubiquitous plasticizer known to contaminate pac

134 metabolites of di-(2-ethylhexyl) phthalate (DEHP), and BPA.

135 hthalate (DnBP), di(2-ethylhexyl) phthalate (DEHP), and diethyl phthalate (DEP).

136 mon plasticizer, di(2-ethylhexyl) phthalate (DEHP), as a highly potent and uniquely selective agonist

137 essment covering di(2-ethylhexyl) phthalate (DEHP), di-n-butyl phthalate (DnBP), di-isobutyl phthalat

138 f six phthalates-di(2-ethylhexyl) phthalate (DEHP), di-n-octyl-, di-iso-butyl-, di-n-butyl-, butylben

139 henol A (BPA), bis (2-ethylhexyl) phthalate (DEHP), nonylphenol monoethoxylate (NMP) and nonylphenol

140 a metabolite of di(2-ethylhexyl) phthalate (DEHP), the percent of the total effect mediated by 8-iso

141 Di(2-ethylhexyl) phthalate (DEHP), used primarily as a plasticizer for polyvinyl chl

142 he results from di-(2-ethylhexyl) phthalate (DEHP)-treated HepG2 cells revealed that the minimal VLCA

143 , filled with a bis(2-ethylhexyl) phthalate (DEHP).

144 sphenol-A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and dibutyl phthalate (DBP) at two different doses

145 Di(2-ethylhexyl)phthalate (DEHP) and diisononyl phthalate (DINP) were the most abun

146 urinary oxidative di(2-ethylhexyl)phthalate (DEHP) metabolites, our proxy for exposure to DEHP-tainte

147 al efficiency of di-(2-ethylhexyl)phthalate (DEHP) on hands by handwashing with soap-and-water versus

148 ned the effect of di(2-ethylhexyl)phthalate (DEHP) on the metabolic profile of cardiomyocytes because

149 ome proliferators di(2-ethylhexyl)phthalate (DEHP), clofibrate, and 4-chloro-6-(2,3 xylidino)-2-pyrim

150 Di-(2-ethylhexyl)-phthalate (DEHP) is a ubiquitously used endocrine disruptor.There i

151 sure emissions of di-2-ethylhexyl-phthalate (DEHP) from vinyl flooring, with ammonium sulfate particl

152 ldren 4-9 years of age, though high prenatal DEHP exposure may be associated with lower fat mass in c

153 bon, the mean fraction of naturally produced DEHP in butter was determined to be 0.16 +/- 0.12 (n = 5

154 rface is close to the vapor pressure of pure DEHP, and (4) with an increase of temperature in a home

155 By feeding male rats DEHP for 2 weeks, rat spermatogenesis became disrupted,

156 average daily mean and median reconstructed DEHP doses were 10.9 and 5.0 microg/kg-day, respectively

157 ic exposures to low environmentally relevant DEHP levels on testicular function.

158 In two three-day N-of-1 trials, residual DEHP was measured in a single female adult who washed ex

159 In Ukrainian children, the PC3 score (DEHP) was positively associated with current wheeze (adj

160 In adjusted models, MEHP, MECPP, and Sigma DEHP metabolites were associated with significantly incr

161 (2-ethyl-5-oxohexyl) phthalate, MECPP, Sigma DEHP, MBP, and mono-(3-carboxypropyl) phthalate metaboli

162 s a result of the introduction of only small DEHP plasticizer molecules.

163 The particles rapidly sorb DEHP from the gas phase, allowing more to be emitted fro

164 resonance spectrum, providing evidence that DEHP stimulates (*)OH radical formation in vivo.

165 We found that DEHP contributed most to summation operatorandrogen-disr

166 n vitro, consistent with the hypothesis that DEHP induced FLC aggregation.

167 repeated measures analysis, we reported that DEHP metabolites and BPA were significantly associated w

168 and mammalian two-hybrid assays reveal that DEHP activates CAR2 at low nanomolar concentrations, res

169 Data suggest that DEHP exposure results in metabolic remodeling of cardiom

170 These data suggest that DEHP may interfere with signaling related to the timing

171 The DEHP-particle sorption equilibration time was demonstrat

172 er time, our in vivo studies showed that the DEHP plasma concentrations were less than the previously

173 Fast food may be a source of exposure to DEHP and DiNP.

174 -term complications from chronic exposure to DEHP have not been determined.

175 ne disruptor.There is widespread exposure to DEHP in the general population which has raised substant

176 Daily human exposure to DEHP in the U.S. is significant, and occupational and cl

177 Exposure to DEHP led to up-regulation of genes associated with fatty

178 DEHP) metabolites, our proxy for exposure to DEHP-tainted foodstuffs in children </=10 years, during

179 n together, indicate that fetal exposures to DEHP have effects on FLC number, distribution, and most

180 hed the minimal VLCAD promoter's response to DEHP treatment.

181 up-regulate VLCAD expression in response to DEHP treatment.

182 es appeared to be particularly vulnerable to DEHP toxicity we investigated the effect of DEHP on DNA

183 In conclusion, urinary DEHP metabolites decreased progressively in children aft

184 (PVC) flooring with approximately 13% (w/w) DEHP as plasticizer were measured in the Field and Labor

185 ing increased risk of allergic diseases with DEHP and BBzP exposure.

186 alibrated on a single person self-dosed with DEHP in conjunction with the eight participants' data, w

187 eonatal rat cardiomyocytes were treated with DEHP at a concentration and duration comparable to clini