ライフサイエンスコーパス: DESI

1 DESI also allowed the rapid detection of peroxide explos

2 DESI and LDI mass spectrometry (MS) from the nanoporous

3 DESI enabled the direct, rapid, native state interrogati

4 DESI imaging experiments, in which the spatial distribut

5 DESI imaging provided identification and distribution of

6 DESI-compatible dyes are used to produce spatially defin

7 DESI-MS enables rapid characterization of OA samples col

8 DESI-MS images showing the spatial distributions of part

9 DESI-MS imaging and IHC experiments confirmed that the s

10 DESI-MS imaging enabled clear visualization of fine papi

11 DESI-MS imaging is therefore possible for tumors for whi

12 DESI-MS imaging was carried out on 36 human glioma sampl

13 DESI-MS is an ambient ionization method in which a charg

14 DESI-MS offers unique advantages both for detailed chara

15 DESI-MS/MS imaging utilized selected reaction monitoring

16 DESI-MSI has the potential to be a diagnostic tool for p

17 DESI-MSI using an Orbitrap mass analyzer in full scan mo

18 ttributed to differences between the ESI and DESI ionization processes.

19 een ASAP, electrospray ionization (ESI), and DESI.

20 aine could be constructed using ToF-SIMS and DESI-MS, as the signals of methamphetamine and heroin we

21 Among other applications, DESI is used to identify and record spatial distribution

22 , that ambient ionization techniques such as DESI-MS and LESA-MS have great potential for species-spe

23 arious ovarian tissue types were analysed by DESI-MSI and co-registered with their corresponding haem

24 ts were subjected to peptidomics analysis by DESI-MS and LESA-MS.

25 ght the potential of direct swab analysis by DESI-MS for a wide range of clinical applications includ

26 tamoxifen and reserpine, during analysis by DESI-MS was studied.

27 good alternative for dried spot analysis by DESI-MS, improving stability of the signal and the LODs.

28 Confocal microscopy of areas analyzed by DESI allow droplet distribution, material utilization, a

29 surface can then subsequently be analyzed by DESI but also by many other techniques such as gas chrom

30 mounted on a rotating device and analyzed by DESI MS using an optimized protocol considering swab-inl

31 d the crude extract was directly analyzed by DESI-MS, with a total turnaround time of less than 10 mi

32 tomy specimens were examined and analyzed by DESI-MSI.

33 liomas into normal tissue can be detected by DESI-MS.

34 eir derivatives are successfully detected by DESI-MSI, with a strong correlation of the spatial produ

35 tions, the sequence coverages, determined by DESI-MS, were 100% for melittin, 100% for cytochrome c,

36 n, removed, rinsed, and analyzed directly by DESI-MS (MS/MS).

37 the largest protein successfully ionized by DESI to date.

38 rat brain, 23 of which were not observed by DESI alone.

39 e that the molecular information obtained by DESI-MSI/Lasso from pancreatic tissue samples has the po

40 protein were successfully detected online by DESI-MS.

41 tients, margins were found to be positive by DESI-MSI/Lasso, but negative by frozen section analysis.

42 Comparisons of the results recorded by DESI with those by LC-MS/MS show good agreement and are

43 lipid and metabolite MS profiles recorded by DESI-MS and explored using multivariate statistics allow

44 e directly analyzed from the sample spots by DESI-MS, using a commercial rotating sample platform.

45 his unique, label-free approach of combining DESI-MSI with the ability to turn specific genes on and

46 understanding of these is crucial to develop DESI as the robust and reliable technique required for s

47 eriments were performed including the direct DESI-MS/MS analysis of fruit peels and also of fruit/veg

48 ed electrochemical reactions suggest that EC/DESI-MS has good potential in bioanalysis.

49 equentially injected as a segmented flow for DESI ionization.

50 ltipass analysis is proposed as a method for DESI surface imaging.

51 le to optimize the instrument parameters for DESI led to an absolute intensity repeatability of bette

52 ASAP analysis or a charged solvent spray for DESI-like experiments.

53 molecular information obtained directly from DESI-MSI.

54 gins delineated by the molecular images from DESI-MSI were consistent with those margins obtained fro

55 Quantifications from DESI-MSI revealed 0.2-1.2 ng of clozapine in individual

56 Further DESI-MS imaging of the flux of the contrast agent throug

57 Global DESI MSI models were able to distinguish adipose, stroma

58 n rate, allowing tissue polarimetry to guide DESI-MS analysis for rapid MS profiling or targeted MS i

59 surface under the DESI plume allows for high DESI solution flow rates without blurring the chemical i

60 sorption electrospray ionization MS imaging (DESI-MSI), specific changes in lipogenesis and specific

61 spray ionization mass spectrometric imaging (DESI-MSI), for 62 banked human cancerous and normal gast

62 ospray ionization mass spectrometry imaging (DESI MSI), both as a novel diagnostic tool and as a meth

63 ospray ionization mass spectrometry imaging (DESI-MSI) for identifying and differentiating tumor from

64 tion electrospray mass spectrometry imaging (DESI-MSI) generates spatially resolved metabolic profile

65 ospray ionization-mass spectrometry imaging (DESI-MSI) gives a new perspective on the important role

66 ospray ionization mass spectrometry imaging (DESI-MSI) on 54 banked human cancerous and normal prosta

67 ospray ionization mass spectrometry imaging (DESI-MSI) to provide an in situ lipidomic profile of gen

68 ospray ionization-mass spectrometry imaging (DESI-MSI) was applied to latent fingerprints to obtain n

69 ospray ionization mass spectrometry imaging (DESI-MSI) with the least absolute shrinkage and selectio

70 ospray ionization mass spectrometry imaging (DESI-MSI), statistical analysis, and conditional transge

71 ospray ionization-mass spectrometry imaging (DESI-MSI).

72 der to verify the reliability of the imprint-DESI-MS imaging data and evaluate the capability of tape

73 Using imprint-DESI-MS imaging we annotated the secondary metabolites r

74 In DESI-MSI, microdroplets strike the tissue sample, the re

75 ts indicate that the optimized conditions in DESI are a compromise between those conditions that are

76 an be used to study desorption mechanisms in DESI independently from ionization mechanisms.

77 d the limits of detection (LODs) observed in DESI-MS.

78 spray desorption mechanism that operates in DESI can be used as a general technique to collect solub

79 entrations sufficient for fungal inhibition; DESI-MS also indicated the presence of bromophycolides w

80 Intraoperative DESI-MS analysis of tissue smears, ex vivo, can be inser

81 Intraoperative DESI-MS measurements made at surgeon-defined positions e

82 ndation for implementation of intraoperative DESI-MS evaluation of tissue smears for rapid diagnosis.

83 Desorption electrospray ionization (DESI) allows the direct analysis of ordinary objects or

84 ing both desorption electrospray ionization (DESI) and easy ambient sonic-spray ionization (EASI) wit

85 is using desorption electrospray ionization (DESI) and laser desorption ionization (LDI).

86 ation of desorption electrospray ionization (DESI) and liquid-microjunction surface sampling probe (L

87 I) using desorption electrospray ionization (DESI) and matrix assisted laser desorption ionization (M

88 ities of desorption electrospray ionization (DESI) are examined using a rotating sample platform comb

89 Desorption electrospray ionization (DESI) coupled to high-resolution Orbitrap mass spectrome

90 Desorption electrospray ionization (DESI) directly analyzes soluble chemical components pres

91 such as desorption electrospray ionization (DESI) eliminate necessary sample preparation but suffer

92 Desorption electrospray ionization (DESI) has been used to confirm intact deposition of [Val

93 Desorption electrospray ionization (DESI) has emerged as a powerful technique for mass spect

94 Desorption electrospray ionization (DESI) is a powerful ambient ionization technique that ca

95 we used desorption electrospray ionization (DESI) mass spectrometry (MS) to image and chemically cha

96 ed using desorption electrospray ionization (DESI) mass spectrometry (MS) to obtain phospholipid mass

97 Desorption electrospray ionization (DESI) mass spectrometry is used for the rapid (<5 s), se

98 ion from desorption electrospray ionization (DESI) mass spectrometry, where the sampling time is on t

99 reactive desorption electrospray ionization (DESI) mass spectrometry.

100 coupling desorption electrospray ionization (DESI) MS with a waterwheel working electrode setup to sa

101 e, using desorption electrospray ionization (DESI) MS, we rapidly detect the tumor metabolite 2-hydro

102 using a desorption electrospray ionization (DESI) source coupled to a mass spectrometer.

103 d with a desorption electrospray ionization (DESI) source.

104 CI), and desorption electrospray ionization (DESI) sources.

105 Ambient desorption electrospray ionization (DESI) technique is uniquely suited for such imaging expe

106 nducting desorption electrospray ionization (DESI) using a commercially available ion source.

107 Desorption electrospray ionization (DESI) was utilized to monitor the presence of targeted c

108 used for desorption electrospray ionization (DESI) were optimized to achieve biocompatibility for cli

109 ESI) and desorption electrospray ionization (DESI), hyphenated with miniaturized high-field asymmetri

110 (DART), desorption electrospray ionization (DESI), or low-temperature plasma (LTP), the desorption o

111 method, desorption electrospray ionization (DESI), which is coupled to a linear ion trap mass spectr

112 ns using desorption electrospray ionization (DESI)-MS revealed phospholipid-derived signals that diff

113 ues like desorption electrospray ionization (DESI).

114 ation by desorption electrospray ionization (DESI).

115 tions of desorption electrospray ionization (DESI, polarity range limited) and direct analysis in rea

116 Desorption ES ionization (DESI) MS has however transformed the study of tissue sur

117 new in-line LS DESI MS system, in angled LS DESI MS, and in electrospray ionization (ESI) MS, which

118 sity was higher in in-line than in angled LS DESI MS.

119 S containing electrolytes was simplest by LS DESI MS.

120 In online electrochemistry (EC)/LS DESI MS, when 0 V was applied to the EC cell Tyr ion sig

121 Ion signals in a new in-line LS DESI MS system, in angled LS DESI MS, and in electrospra

122 solution flow rates was tested in in-line LS DESI MS.

123 desorption ionization mass spectrometry (LS DESI MS), supplied continuously through a LS interface s

124 ual (observation) of the operation of the LS DESI MS system showed a thick spray plume generated by t

125 All of the measured DESI mass spectra (in both positive and negative ion mod

126 The measured DESI mass spectral lipid fingerprints were then analyzed

127 Nano-DESI enables rapid screening of different classes of com

128 Nano-DESI is a new ambient pressure ionization technique that

129 nt of the spatial resolution offered by nano-DESI imaging combined with high detection efficiency wil

130 s and metabolites in tissue sections by nano-DESI imaging.

131 Furthermore, nano-DESI enables the efficient detection of chemically labil

132 y ionization mass spectrometry imaging (nano-DESI MSI) was used to characterize the molecular speciat

133 of 22 endogenous PC species observed in nano-DESI MSI.

134 ominantly observed as sodium adducts in nano-DESI spectra indicating that addition of sodium to the s

135 In nano-DESI, analyte is desorbed into a solvent bridge formed b

136 ray desorption electrospray ionization (nano-DESI) and direct infusion electrospray ionization (ESI)

137 ray desorption electrospray ionization (nano-DESI) combined with high-resolution mass spectrometry (H

138 ray desorption electrospray ionization (nano-DESI) combined with high-resolution mass spectrometry wa

139 ray desorption electrospray ionization (nano-DESI) combined with high-resolution mass spectrometry wa

140 ray desorption electrospray ionization (nano-DESI) combined with tandem mass spectrometry (MS/MS), hi

141 ray desorption electrospray ionization (nano-DESI) is an ambient MSI technique where a solvent is use

142 ray desorption electrospray ionization (nano-DESI) was developed by integrating a shear-force probe w

143 using nanospray desorption ionization (nano-DESI).

144 ray desorption electrospray ionization (nano-DESI).

145 ray desorption electrospray ionization, nano-DESI, is a new ambient technique that enables spatially

146 The constant-distance mode nano-DESI MSI enabled imaging of many metabolites, including

147 Based on this effort, constant-mode nano-DESI MSI proved to be ideally suited for imaging biologi

148 e experiments indicate the potential of nano-DESI for ambient imaging with a spatial resolution of be

149 We demonstrate the utility of nano-DESI imaging for sensitive detection of the drug in tiss

150 nds in the ionization process, reactive nano-DESI analysis enables quantification of individual compo

151 ed as the working solvents for reactive nano-DESI analysis.

152 unds to examine the utility of reactive nano-DESI for the analysis of complex organic mixtures.

153 Our results indicate that reactive nano-DESI is a valuable approach for examining the presence o

154 tonitrile/toluene is used as a solvent, nano-DESI generates electrospray-like spectra.

155 ctrospray ionization mass spectrometry (nano-DESI/HRMS), and ultrahigh resolution and mass accuracy 2

156 The results demonstrate that nano-DESI analysis efficiently ionizes petroleum constituents

157 system enables robust operation of the nano-DESI imaging source over many hours by precisely control

158 between two capillaries comprising the nano-DESI probe and the solid analyte for controlled desorpti

159 formed by scanning the sample under the nano-DESI probe at 10 mum/s, while higher-energy collision-in

160 ntegrating a shear-force probe with the nano-DESI probe.

161 the distance between the sample and the nano-DESI probe.

162 holine (PC) standards were added to the nano-DESI solvent for simultaneous imaging and quantification

163 ically labeled standard is added to the nano-DESI solvent to compensate for matrix effects and ion su

164 Doping the nano-DESI solvent with carefully selected standards enables o

165 The nano-DESI technique possesses distinct advantages of technica

166 Stable signals achieved using nano-DESI make it possible to obtain high-quality HR-MS data

167 plexes we report the development of a native DESI platform.

168 Overall therefore we introduce this native DESI platform with the potential for high-throughput lig

169 alysts has been well-studied, the ability of DESI to intercept intermediates formed in the first few

170 edge, this study is the first application of DESI-MSI to the study of complex and porous mineral surf

171 easured intact, indicating the capability of DESI for preserving weak noncovalent interactions.

172 nseen samples demonstrates the capability of DESI-MSI to characterise ovarian samples and to overcome

173 sample pretreatment, and the hyphenation of DESI with the miniaturized FAIMS enhanced the relative a

174 One hurdle to implementation of DESI-MS intraoperatively is the need for tissue freezing

175 issue smears by comparison with a library of DESI mass spectra of pathologically determined tissue ty

176 dom to choose a favorable ionization mode of DESI or traditional electrolysis solvent systems, and th

177 As a result of the direct sampling nature of DESI, several useful features of such a coupling have be

178 eractions, and illustrating the potential of DESI-MS in understanding chemically-mediated biological

179 ples significantly extends the mass range of DESI-MS, allowing the analysis of high-mass proteins suc

180 wer limit on both the temporal resolution of DESI and the maximum achievable sampling rate.

181 ults obtained demonstrate the sensitivity of DESI as they meet the stringent European Union pesticide

182 technique with the specificity and speed of DESI-MS and MS/MS.

183 Synchronization of DESI (sDESI) with the ion injection period (IT)of low-du

184 Generally, synchronization of DESI with IT improves performance and expands the range

185 Our results show that synchronization of DESI with the IT of an LTQ Orbitrap-XL mass spectrometer

186 The clinical translation of DESI-MS into a universal label-free imaging technique th

187 Combined use of DESI and LDI offer greater peptide coverage than either

188 d agreement and are favorable for the use of DESI imaging in drug and metabolite detection directly f

189 long-term benefits to patients of the use of DESI-MSI for surgical margin evaluation is also needed t

190 These results corroborate the utility of DESI-MS in assessing surgical margins for maximal safe t

191 , liquid sample DESI, an extended version of DESI used for analysis of liquid samples, was shown to h

192 achieved with an accuracy of 98.2% based on DESI MSI data (PPV 0.96, NVP 1, specificity 0.96, sensit

193 Reactive DESI-MS imaging in positive ion mode of rat brain and ze

194 Use of reactive DESI in the imaging mode allowed 2D spatial distribution

195 of free cholesterol in serum using reactive DESI was demonstrated using cholesterol-d7 as internal s

196 fish tissues were investigated with reactive DESI-MS in which the dictation forms a stable bond with

197 detected in positive ion mode with reactive DESI-MS with enhanced signal intensity.

198 This type of "reactive" DESI methodology can provide rapid information on bindin

199 High-resolution DESI-MS analysis demonstrated that chemical aging result

200 Liquid sample DESI allows the direct formation of intact protein-ligan

201 Liquid sample DESI of hydrophobic peptide gramicidin D suggests that t

202 method for ligand screening by liquid sample DESI was demonstrated, in which different ligands were s

203 bin) desorbed from solution by liquid sample DESI were measured intact, indicating the capability of

204 In this study, liquid sample DESI, an extended version of DESI used for analysis of l

205 investigate the application of liquid sample DESI-MS to probe protein-ligand interactions.

206 charge can be integrated with liquid sample DESI-MS, without interfering with the formation of prote

207 membrane surfaces, demonstrated by specific DESI MS signatures.

208 n electrospray ionization mass spectrometry (DESI MS) measurements has been conducted with the involv

209 n electrospray ionization mass spectrometry (DESI MS) was assessed for pharmaceutical forensic purpos

210 n electrospray ionization mass spectrometry (DESI MS), where ion formation occurs in ambient conditio

211 n electrospray ionization mass spectrometry (DESI MS)-based molecular analysis and imprint imaging us

212 n electrospray ionization mass spectrometry (DESI-MS) analysis.

213 n electrospray ionization mass spectrometry (DESI-MS) and its applications in investigating various e

214 n electrospray ionization mass spectrometry (DESI-MS) and liquid extraction surface analysis mass spe

215 n electrospray ionization mass spectrometry (DESI-MS) and nanoDESI-MS.

216 ined with high-resolution mass spectrometry (DESI-MS) for detailed chemical characterization and stud

217 n electrospray ionization mass spectrometry (DESI-MS) for the purpose of analyzing drugs from raw uri

218 n electrospray ionization-mass spectrometry (DESI-MS) has advantages for rapid sample analysis with l

219 n electrospray ionization mass spectrometry (DESI-MS) has demonstrated potential for intraoperative t

220 n electrospray ionization mass spectrometry (DESI-MS) imaging revealed that surface-associated bromop

221 n Electrospray Ionization Mass Spectrometry (DESI-MS) imaging validated with statistical analysis and

222 n electrospray ionization mass spectrometry (DESI-MS) imaging was applied to analyze the lipid profil

223 n electrospray ionization-mass spectrometry (DESI-MS) imaging, multivariate statistical analysis, and

224 n electrospray ionization mass spectrometry (DESI-MS) imaging.

225 n electrospray ionization mass spectrometry (DESI-MS) in combination with online reaction monitoring.

226 n electrospray ionization-mass spectrometry (DESI-MS) is able to measure large proteins and noncovale

227 n electrospray ionization mass spectrometry (DESI-MS) is applied to study common lithium ion battery

228 n electrospray ionization mass spectrometry (DESI-MS) is assessed, as the sprayer is thought to be a

229 n electrospray ionization mass spectrometry (DESI-MS) is quite challenging.

230 n electrospray ionization-mass spectrometry (DESI-MS) is used to characterize tissue smears by compar

231 n electrospray ionization mass spectrometry (DESI-MS) revealed several key intermediates in the propo

232 n electrospray ionization mass spectrometry (DESI-MS) to image and chemically characterize the lipid

233 n electrospray ionization mass spectrometry (DESI-MS) was demonstrated.

234 n electrospray ionization mass spectrometry (DESI-MS) was used in an imaging mode to interrogate the

235 n electrospray ionization mass spectrometry (DESI-MS) was used in this study for the profiling and im

236 n electrospray ionization mass spectrometry (DESI-MS) was used.

237 n electrospray ionization mass spectrometry (DESI-MS) with a stable dication on biological tissues.

238 n electrospray ionization-mass spectrometry (DESI-MS), abundant ions are sometimes observed that appe

239 n electrospray ionization mass spectrometry (DESI-MS), but such techniques have been almost exclusive

240 n electrospray ionization mass spectrometry (DESI-MS), the type of surface in addition to low gas and

241 n electrospray ionization mass spectrometry (DESI-MS).

242 n electrospray ionization mass spectrometry (DESI-MS).

243 rospray ionization tandem mass spectrometry (DESI-MS/MS) and whole-body autoradiography (WBA) were us

244 al exposure to drugs screened using the SPME DESI-MS/MS method showed good agreement with the convent

245 The performance of the SPME DESI-MS/MS method was evaluated by preparing calibration

246 /MS also showed good agreement with the SPME DESI-MS/MS method.

247 h with unique capabilities, including spray (DESI-like)-only, MICI-only, and DEMI (multimode), and ca

248 nhanced TM-DESI-MS when compared to standard DESI-MS.

249 Under static DESI-FAIMS conditions selected for transmission of doubl

250 In this study, DESI-MS and tandem mass spectrometry experiments (MS/MS)

251 Our results suggest DESI-MS as a powerful approach for rapid serous ovarian

252 These results demonstrate that DESI MSI may be a valuable tool in the improved diagnosi

253 Our work demonstrates that DESI-MS technology has the potential to identify the his

254 s from 10 surgical resection cases show that DESI-MS allows detection of glioma and estimation of hig

255 These results show that DESI-MS provides intact molecular information on battery

256 s a proof-of-principle example, we show that DESI-MSI allows interrogation of the molecular products

257 This study clearly shows that DESI-based electrochemical MS is capable of capturing el

258 The results suggest that DESI-MSI imaging of fingerprints with GDBT analysis migh

259 The results obtained suggest that DESI-MSI/Lasso may be valuable for routine intraoperativ

260 The DESI response was linear over 3 orders of magnitude for

261 The DESI-MS approach described here provided a practical and

262 use of pure water and compressed air as the DESI spray solution and nebulizing gas, respectively, sh

263 ple and the thin solvent film created by the DESI spray, resulting in more effective dissolution of t

264 Doping the DESI spray solvent with supercharging reagents resulted

265 Lasso), we analyzed all metabolites from the DESI-MS data and identified parsimonious sets of metabol

266 As in IMS, the DESI-MS experiments analyze material that starts in the

267 etyl-aspartic acid, was also observed in the DESI mass spectra, and these data further assisted in di

268 each of the explosives were observed in the DESI mass spectrum.

269 he residence time of the sample spots in the DESI plume, and thus the sampling rate.

270 g reagent betaine aldehyde directly into the DESI solvent spray, leading to in situ chemical derivati

271 ally, considerations for optimization of the DESI-MS process are described in order to increase the p

272 Comparison of the DESI-MS/MS signal for propranolol and the radioactivity

273 emical species is determined by scanning the DESI probe across an entire sample surface, revealed tha

274 ntinuously moving the sample relative to the DESI sprayer and the inlet of the mass spectrometer.

275 The rapid movement of the surface under the DESI plume allows for high DESI solution flow rates with

276 u (IV) intermediate is not observed when the DESI spray solution is sparged with Ar gas, indicating t

277 e images are in excellent agreement with the DESI images obtained from the selected ions and also the

278 Unidirectional surface scanning with the DESI source was found suitable to determine both the loc

279 ting all of the target compounds; therefore, DESI MSI, a complementary mass spectrometry imaging tech

280 This DESI-MSI approach is generally applicable to a wide rang

281 Gadoteridol+K](+) adduct as revealed through DESI-MS complements the in vivo MRI results.

282 nalytical performance of surface enhanced TM-DESI-MS when compared to standard DESI-MS.

283 mode desorption electrospray ionization (TM-DESI) coupled to an ion trap mass spectrometer capable o

284 mode desorption electrospray ionization (TM-DESI).

285 These results indicate that TM-DESI/ion trap technology could be a powerful on-site too

286 ces, and experimental conditions amenable to DESI-MSI, especially for analytes that are weakly attach

287 ferred to flat hard surfaces, was coupled to DESI-MS and applied for the first time to fungal cocultu

288 dergoing surgical resections were subject to DESI MSI.

289 tic digestion and comparative analysis using DESI-MS and LESA-MS using tandem electrospray MS.

290 antimalarial formulations was obtained using DESI MS that was performed in the imaging mode, which en

291 of this study show the feasibility of using DESI-MS/MS to obtain useful chemical images of a drug in

292 reductive elimination was also probed using DESI-MS.

293 pranolol images of the tissue sections using DESI-MS/MS were obtained at surface scan rates of 0.1, 0

294 t analysis of adjacent tissue sections using DESI-MSI is also reported.

295 y ESI and directly from steel surfaces using DESI ambient ionization at levels >/=0.0004% w/w (4 ppm)

296 With DESI MS, we identify isocitrate dehydrogenase 1-mutant t

297 alysis and greater sensitivity compared with DESI-MS.

298 ty, and rate of consumption of material with DESI.

299 Imaging tissue sections with DESI MS shows that the 2-HG signal overlaps with areas o

300 In this work, DESI DM-MSI experiments on biological tissue samples suc