ライフサイエンスコーパス: DFSP

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1 DFSP incidence was similar for sun-exposed and covered s

2 Our data shows that: 1) DFSP has a distinctive gene expression profile; 2) array

3 nrecognized association between ADA-SCID and DFSP with unique features, such as multicentricity and o

4 d Relevance: Age at diagnosis, male sex, and DFSP tumor size appear to be important prognostic factor

5 The characteristic DFSP-associated translocation, t(17;22)(q22;q13), was id

6 sign, Setting, and Participants: We examined DFSP using data for 3686 patients with histologically co

7 RECENT FINDINGS: DFSP carries a translocation of chromosomes 17 and 22 le

8 ervation should prompt regular screening for DFSP in patients with ADA-SCID.

9 s the target of our current drug therapy for DFSP, imatinib, a tyrosine kinase inhibitor that interfe

10 d PDGF beta, respectively, were amplified in DFSP.

11 and characterized DNA copy number changes in DFSP by array-based comparative genomic hybridization (a

12 for patients with unresectable or metastatic DFSP, associated with response rates approaching 50%.

13 for treatment of unresectable or metastatic DFSP.

14 The nine DFSPs were readily distinguished from 27 other diverse s

15 ients with histologically confirmed cases of DFSP diagnosed between 1972 and 2012 from the 18 US regi

16 Results: There were 3686 cases of DFSP examined.

17 Although the natural course of DFSP in the setting of ADA-SCID is unknown, this observa

18 he characteristic gene expression profile of DFSP and characterized DNA copy number changes in DFSP b

19 formalin-fixed, paraffin-embedded samples of DFSP were analyzed by array CGH (four cases) and DNA mic

20 Dermatofibrosarcoma protuberans (DFSP) is a rare malignant skin tumor associated with a c

21 OF REVIEW: Dermatofibrosarcoma protuberans (DFSP) is a rare mesenchymal neoplasm arising in the derm

22 Dermatofibrosarcoma protuberans (DFSP) is an aggressive spindle cell neoplasm.

23 reatment of dermatofibrosarcoma protuberans (DFSP) is wide resection, namely, margins > or = 3 cm bey

24 a (MCC) and dermatofibrosarcoma protuberans (DFSP).

25 tients with dermatofibrosarcoma protuberans (DFSP).

26 Genes characteristically expressed in the DFSPs included PDGF beta and its receptor, PDGFRB, APOD,

27 bserved an unexpected high incidence of this DFSP in children affected with adenosine deaminase-defic

28 The outcome of treatment of 18 patients with DFSP by radiation alone (n = 3) and radiation and surger

29 odality on overall survival of patients with DFSP.

30 ve option in the management of patients with DFSP.

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