ライフサイエンスコーパス: DMN

1 prominent node of the default mode network (DMN).

2 d constructed Disease Manifestation Network (DMN).

3 hically similar to the default mode network (DMN).

4 al connectivity in the default mode network (DMN).

5 the precuneus and the default-mode network (DMN).

6 he core regions of the default mode network (DMN).

7 onnectivity within the default mode network (DMN).

8 mans, are known as the default-mode network (DMN).

9 pposed to information integration across the DMN.

10 physiology and pathophysiology of the human DMN.

11 of T2DM on the biophysical integrity of the DMN.

12 between the anterior and posterior parts of DMN.

13 lore the functional connectivity (FC) of the DMN.

14 ontal cortex of the FPN and precuneus of the DMN.

15 MDD, abnormally taxes only sgPFC and not the DMN.

16 y has been reliably observed in nodes of the DMN.

17 text-dependent interplay between the CCN and DMN.

18 he evolutionarily preserved functions of the DMN.

19 ts in spatial attention activated the monkey DMN.

20 onarily preserved defining properties of the DMN.

21 d during shifts, largely overlapped with the DMN.

22 but in short-distance connections within the DMN.

23 transient connectivity between SN, CEN, and DMN.

24 of CCN regions, but not deactivation of the DMN; (2) variations in task-related, but not resting-sta

25 stributed network involving both the CCN and DMN; (3) functional segregation of core elements of thes

26 tence of the so-called default mode network (DMN)--a distributed functional brain system identified i

27 le-trial signature of (co)activations in the DMN, ACN, and neuromodulation, and accompanied by a decr

28 Crucially, we find increases in ongoing DMN activity after ripples, but not in other RSNs.

29 avior, are alone insufficient to account for DMN activity fluctuations.

30 fMRI could be informative to detect residual DMN activity for those patients that remain relatively s

31 However, increased spontaneous DMN activity has also been reliably associated with stab

32 As DMN activity has also been reported in nonhuman species,

33 In multiple contexts, increased spontaneous DMN activity has been associated with self-reported epis

34 Rs-fMRI indicated relatively preserved DMN activity in a small subset of VS/UWS patients, two o

35 However, recent evidence suggests greater DMN activity in an array of tasks, especially those that

36 laminergic transmission and a suppression of DMN activity in favor of externally-directed attentional

37 We found no evidence for increased DMN activity in the naturalistic compared to artificial

38 st whether simulated changes in FPCN/DAN and DMN activity produce similar effects, we demonstate that

39 The behavioral relevance of endogenous DMN activity remains elusive, despite an emerging litera

40 hat the cognitive processes that spontaneous DMN activity specifically reflects are only partially re

41 ing the quartile with largest head movement, DMN activity was decreased in VS/UWS compared to MCS, an

42 We investigated DMN activity with resting-state functional MRI (rs-fMRI)

43 activity and decreased default mode network (DMN) activity during the CRT compared with rest.

44 al organization of the Default Mode Network (DMN) - an important subnetwork within the brain associat

45 baseline functional connectivity within the DMN and baseline parasympathetic tone respectively, high

46 y and greater anticorrelation between SN and DMN and between SN and ECN compared with patients with u

47 associated with hypoconnectivity within the DMN and between the DMN and the frontoparietal network,

48 nctional connectivity within and between the DMN and CEN in 17 depressed patients, before and after a

49 patients was abnormally elevated within the DMN and diminished within the CEN, and connectivity betw

50 Our findings suggest that DMN and DMN-CEN connectivity differ in those at high vs

51 d stronger connectivity between areas of the DMN and EN during the creative task, and this difference

52 dentified that the topological properties in DMN and FPN are anti-correlated which comes, in part, fr

53 -cortical functional connectivity within the DMN and FPNs was preserved.

54 ations in the functional architecture of the DMN and HC may influence memory functions and possibly c

55 emonstrate that the PCC is vulnerable in the DMN and may shed light on the molecular neurobiology of

56 hese data implicate communication within the DMN and of the DMN with the descending modulatory system

57 ance, including impaired deactivation of the DMN and reduced activation of task-relevant regions.

58 dividuals show increased connectivity in the DMN and salience when neocortical Tau levels are low, wh

59 ficantly associated with connectivity in the DMN and salience.

60 independent resting state data revealed that DMN and shift regions clustered conjointly, whereas regi

61 Core monkey DMN and shift-selective regions shared several functiona

62 ncreased functional connectivity between the DMN and subgenual prefrontal cortex (sgPFC)-connectivity

63 e default mode network (DMN) and between the DMN and the central executive network (CEN) in 111 indiv

64 ls, LOD patients showed decreased FC between DMN and the cingulo-opercular network (CON), as well as

65 associated with the decreased FC between the DMN and the CON, which probably resulted from the demyel

66 oconnectivity within the DMN and between the DMN and the frontoparietal network, but not with brain a

67 onnectivity within the default mode network (DMN) and between the DMN and the central executive netwo

68 ectivity in the dorsal default mode network (DMN) and executive control network (ECN).

69 ence suggests that the default-mode network (DMN) and fronto-pariatal network (FPN) play an important

70 in connections within default mode network (DMN) and in DMN interconnections with two task positive

71 The default mode network (DMN) and semantic network (SN) are two of the most exten

72 tworks, in particular, default mode network (DMN) and task-positive networks (TPNs), would co-occur w

73 en fluctuations in the default-mode network (DMN) and task-positive networks, we instead find evidenc

74 Es in two nodes of the default mode network (DMN) and two nodes in a lateral cortical network, reveal

75 actions between salience (SN), default mode (DMN), and central executive (CEN) networks-three brain s

76 salience network (SN), default-mode network (DMN), and frontoparietal task control network (FPTCN) wa

77 ecutive network (CEN), default mode network (DMN), and salience network (SN).

78 d in the thalamus, the Default Mode Network (DMN), and the bilateral Frontoparietal Networks (FPNs).

79 ectivity both within and between the CEN and DMN, and modulation of subgenual cingulate connectivity

80 neus and bilateral superior frontal gyrus of DMN, and right anterior insula of SN.

81 an demonstrating small-world properties, the DMN appears to be organized according to principles of a

82 e Network (SN) and the Default Mode Network (DMN) are thought to be important for cognitive control.

83 rontal-medial parietal default mode network (DMN)-are consistent findings in depression and potential

84 l-task positive" and "default-mode network" (DMN)] are responsive to increasing task difficulty.

85 lated deactivations in default mode network (DMN) areas.

86 cross the brain, (2) connectivity within the DMN as a function of age and intelligence quotient (IQ),

87 esults are compatible with the notion of the DMN as an intrinsically oriented system.

88 was observed within the midline core of the DMN, as well as in DMN connections with right lateralize

89 and adhesive molecules direct eve-dependent dMN axon guidance.

90 glian adhesion molecules to guide individual dMN axons.

91 range structural connections (such as in the DMN) between dogs and humans is likely to provide us wit

92 a functional neuroimaging paradigm in which DMN brain activation in a resting condition was contrast

93 creased engagement and responsiveness of the DMN but can perform a working memory task as well as hea

94 n-related subgenual hyperconnectivity in the DMN but did not alter connectivity in the CEN.

95 ith regions within the default mode network (DMN) but the IPS also showed connectivity with other bra

96 in key regions of the default mode network (DMN), but not the dorsal attention network.

97 the precuneus plays a core role not only in DMN, but also more broadly through its engagement under

98 ts suggest that, like the human DMN, the rat DMN can be partitioned into several subcomponents that m

99 ctivation of the human default mode network (DMN) can be measured with fMRI when subjects shift thoug

100 Our findings suggest that DMN and DMN-CEN connectivity differ in those at high vs low risk

101 Path analyses indicated that decreased DMN-CEN-negative connectivity mediated a relationship be

102 eased DMN connectivity, as well as decreased DMN-CEN-negative connectivity.

103 tography supported the findings of decreased DMN-CEN-negative connectivity.

104 The DMN-CON FC and the FA, RD of the fiber tracts were both

105 n the midline core of the DMN, as well as in DMN connections with right lateralized prefrontal region

106 ssion is associated with inflexibly elevated DMN connections.

107 omprehensively understanding the dynamics of DMN connectivity across brain states in individuals with

108 DMN connectivity also correlated with several symptom me

109 otient (IQ), and (3) the association between DMN connectivity and empathic accuracy.

110 ant group difference in the relation between DMN connectivity and empathic accuracy.

111 Patients with FO had higher within-DMN connectivity and greater anticorrelation between SN

112 The objective of this study was to examine DMN connectivity in children/adolescents with ASD.

113 the right precentral gyrus and decreases in DMN connectivity in the right inferior frontal gyrus and

114 amilial risk for depression showed increased DMN connectivity, as well as decreased DMN-CEN-negative

115 ted an atypical connectivity profile lacking DMN connectivity, with increased dorsal anterior cingula

116 ssociated with reduced default mode network (DMN) connectivity.

117 The existence of DMN correlates in other species, such as mice, challenge

118 of topological patterns between the FPN and DMN could predict conscious state more effectively than

119 Moreover, DMN coupling strength predicted memory of narrative segm

120 s showed significantly reduced modulation of DMN deactivation by task difficulty, despite their succe

121 Controls showed expected modulation of DMN deactivation with increasing task difficulty.

122 search the patterns of Default Mode Network (DMN) deactivation in Obsessive Compulsive Disorder (OCD)

123 nt/transmission processes primarily mediated DMN disconnectivity.

124 The DMN distribution reduces to the multinomial distribution

125 ethod increases the feasibility of using the DMN distribution to model many high-throughput problems

126 The Dirichlet-multinomial (DMN) distribution is a fundamental model for multicatego

127 er mindfulness meditation training increases DMN-dlPFC rsFC and whether these rsFC alterations prospe

128 x during encoding and 2) deactivation of the DMN during recognition in type 2 diabetic patients, desp

129 nt connectivity of the default mode network (DMN) during resting state.

130 multilevel fMRI characterization of CCN and DMN dynamics, measured during performance of a cognitive

131 In addition to affecting DMN dynamics, these atypicalities may also impact social

132 We, and others, have also found DMN dysfunction in chronic pain populations.

133 er there were differences in three networks: DMN, ECN and anterior salience network connectivity, as

134 23) with individuals shown to have decreased DMN engagement (chronic pain patients, n = 28).

135 ts had difficulties with the deactivation of DMN even when the non-rest condition includes the presen

136 tional connectivity across most parts of the DMN, except for the HC network for which age-related ele

137 However, conventional DMN fabrication methods have several drawbacks.

138 hat will be faced in large-scale fill-finish DMN fabrication processes and demonstrating superior the

139 Our results relate endogenous DMN fluctuations to hippocampal ripples, thereby linking

140 where we observe a dramatic increase in the DMN fMRI signal following ripples, but not following oth

141 creased or "negative" [default-mode network (DMN)] fMRI responses during task performance are dynamic

142 e courses sampled from independently defined DMN foci showed significant shift selectivity during the

143 atter tracts within the SN predicts abnormal DMN function.

144 ly, we examined between-group differences in DMN functional connectivity and its relationship to depr

145 with DM1 showed strong associations between DMN functional connectivity and schizotypal-paranoid tra

146 reamline tractography, and correlations with DMN functional connectivity were determined.

147 The ECN and DMN had regions (middle temporal gyrus and bilateral mid

148 ty (FC) of the brain's default mode network (DMN) has been identified within the context of mood diso

149 The default mode network (DMN) has been shown to increase its activity during the

150 The default mode network (DMN) has been suggested to support a variety of self-ref

151 The default mode network (DMN) has been traditionally assumed to hinder behavioral

152 rformed by the brain's default-mode network (DMN) has prompted interest in examining the role of the

153 Regions of the default mode network (DMN) have been frequently identified as "cortical hubs"

154 The brain's default mode network (DMN), having a high rate of basal energy metabolism, is

155 However, the exact form of DMN-HC alterations in aging and concomitant memory defic

156 ing from early visual cortex (lowest) to the DMN (highest).

157 posterior cingulate cortex (PCC), a central DMN hub region, was selectively compromised in T2DM, whe

158 he major determinant of dorsal motor neuron (dMN) identity in Drosophila.

159 egions involved in the default mode network (DMN), implicated in divergent thinking and generating no

160 attention centered on midline regions of the DMN in both MEG and fMRI, boosting confidence in a possi

161 re dynamic interactions between SN, CEN, and DMN in children, characterized by higher mean lifetimes

162 of cortex and indicate that the role of the DMN in cognition might arise from its position at one ex

163 ulate, a key region closely aligned with the DMN in depression.

164 al workspace framework, which implicates the DMN in global information integration for conscious proc

165 tion, as they suggest a central role for the DMN in higher cognitive processing.

166 This might explain a breakdown of the DMN in many neurological diseases characterized by decli

167 unctional connectivity between sgPFC and the DMN in MDD represents an integration of the self-referen

168 ompted interest in examining the role of the DMN in MDD.

169 ropsychiatric disorders, partitioning of the DMN in nonhuman species, which has previously not been r

170 hanges in functional connectivity within the DMN in patients and controls.

171 te predominantly within certain parts of the DMN in preclinical AD and already then affect brain conn

172 etal WM networks and deactivated the typical DMN in response to increasing task demands.

173 However, genetic control over the DMN in schizophrenia (SZ) and psychotic bipolar disorder

174 Recent evidence, however, implicates the DMN in self-referential and memory-based processing.

175 We show the presence of a potential DMN in the mouse brain both structurally and functionall

176 x (PCC) regions of the default mode network (DMN) in dogs.

177 ibution similar to the default mode network (DMN) in humans, consistent with earlier findings in youn

178 ss of fit (GOF) of the default mode network (DMN) in the drug group and decreased GOF in the placebo

179 T2DM, whereas the other nodal regions of the DMN, including the medial prefrontal cortex, lateral inf

180 This shows that coupling between the rAI and DMN increases with cognitive control and that damage wit

181 ons within default mode network (DMN) and in DMN interconnections with two task positive networks (TP

182 I data, modularity analyses fractionated the DMN into an anterior and a posterior subsystem, which we

183 e FNE was found in the default-mode network (DMN) involved with spontaneous internal thoughts during

184 range of higher-order paradigms that report DMN involvement.

185 Furthermore, the DMN is activated as a sentinel, monitoring the environme

186 The DMN is activated during monitoring the external world fo

187 To investigate whether a responsive DMN is required for successful cognitive performance, we

188 If a responsive DMN is required for successful performance, patients hav

189 Rs-fMRI of the DMN is sensitive to clinical severity.

190 The default mode network (DMN) is a commonly observed resting-state network (RSN)

191 The default mode network (DMN) is a complex dynamic network that is critical for u

192 eactivation within the default mode network (DMN) is common in individuals with primary affective dis

193 The default mode network (DMN) is critical in this study, given the insight it pro

194 The brain's default mode network (DMN) is highly active during wakeful rest when people ar

195 The brain's default mode network (DMN) is highly heritable and is compromised in a variety

196 The default-mode network (DMN) is known to be dysfunctional, although correlation

197 The momentary configurations of DMN ISFC were highly replicable across groups.

198 The implications for the variability in the DMN, its cognitive coherence, and interpretation of rest

199 Consistent task-related deactivation of the "DMN-like" dominant metabolic RSN was observed in healthy

200 Unfortunately, numerical computation of the DMN log-likelihood function by conventional methods resu

201 Time-course comparisons of DMN loss in longitudinal resting metabolic scans from PD

202 Given more recent evidence of DMN maturation throughout adolescence, our findings sugg

203 Alterations in DMN may be associated with less efficient cognitive proc

204 These findings suggest that a responsive DMN may not be required for successful cognitive perform

205 gs suggest that the changing topology of the DMN may play an important role in characterizing brain s

206 nt deactivation in two anterior nodes of the DMN (medial frontal and superior frontal) in the non-res

207 connectivity of the two primary nodes of the DMN: medial prefrontal cortex and posterior cingulate co

208 the balance of activity in the FPCN/DAN and DMN might control global metastability, providing a mech

209 Therefore, a responsive DMN might not be needed for successful cognitive perform

210 er methods (including salient regions in the DMN) might not exert such broad influence.

211 synaptogenesis that significantly influenced DMN modulation in psychoses.

212 tered alone has no effect on gastric-NST or -DMN neuron responsiveness, or on gastric motility.

213 neurons and activates dorsal motor nucleus (DMN) neurons involved in the gastric accommodation refle

214 tivity and structural connectivity among the DMN nodal regions are compromised in T2DM.

215 ional connectivity were observed between the DMN node pair, but not in the distinct lateral cortical

216 lace area showed NF activation closer to the DMN node.

217 ateral posterior cingulate and left parietal DMN nodes in DM1 patients compared with controls.

218 wed a typical pattern of connectivity across DMN nodes, as previously reported in depressed patients

219 vity between the DLPFC and medial prefrontal DMN nodes.

220 r dynamic topological reconfiguration of the DMN occurs across different brain states, and whether th

221 onnectivity within the default mode network (DMN) of the brain while participants listened to sounds

222 Immunization using low dose TIV-loaded DMN patches induced significantly higher antibody respon

223 alent inactivated influenza vaccine (TIV) in DMN patches is fully stable for greater than 6months at

224 Dissolvable microneedle (DMN) patches for immunization have multiple benefits, in

225 tudies to date have examined emotion-related DMN pathology in adolescent depression.

226 as observed within the default-mode network (DMN) post-treatment.

227 Anticorrelation of SN-DMN predicted outcomes with higher accuracy than fluid-a

228 ation into the neurobiological mechanisms of DMN processing in preclinical models of both normal and

229 connections within the default mode network (DMN; prominent during introspective thought) and connect

230 Does the default mode network (DMN) reconfigure to encode information about the changin

231 ced negative fMRI response (deactivation) of DMN regions (posterior cingulate/precuneus, medial prefr

232 th memory performance [4, 5]-particularly in DMN regions [6-8].

233 These DMN regions exhibit the greatest geodesic distance along

234 e changes in cognitive context would recruit DMN regions in female and male nonhuman primates.

235 sity and the functional connectivity between DMN regions, and provides anatomical evidence to support

236 ventrolateral prefrontal cortex, but not of DMN regions, correlated with task accuracy.

237 een the posterior cingulate cortex (PCC) and DMN regions, depending on the region, but also showed st

238 tients exhibited enhanced mPFC FC with other DMN regions, including the posterior cingulate cortex (P

239 , deactivation or functional connectivity of DMN regions, or some combination of both.

240 tive shifting in primates generally recruits DMN regions.

241 t also showed stronger connectivity with non-DMN regions.

242 in external-task-positive regions but not in DMN regions.

243 e networks, we instead find evidence for two DMN-related iCAPs consisting the posterior cingulate cor

244 prominently including many areas outside the DMN, relative to both young adults (Y) and aged rats wit

245 onstrate a comprehensive functional role for DMN remains relatively scarce, the global workspace fram

246 eversed effects (decreased ECN and increased DMN, respectively).

247 cessful performance, patients having reduced DMN responsiveness should show worsened performance; if

248 editation may increase default mode network (DMN) resting-state functional connectivity (rsFC) with r

249 help redefine our understanding of the exact DMN role in human cognition.

250 We tested for alterations in DMN rsFC using a posterior cingulate cortex seed-based a

251 Mechanistic support for the DMN's role in memory consolidation might come from inves

252 association networks [default-mode network (DMN), salience network (SAL), dorsal attention network,

253 tention network (DAN), default-mode network (DMN), salience network (SN), and executive control netwo

254 Moreover, the FPCN and DMN showed significantly elevated coupling with each oth

255 th increased behavioral variability, highest DMN signal levels were best explained by intense mind-wa

256 self-referential processing supported by the DMN.SIGNIFICANCE STATEMENT Modularity, an index of the d

257 modulation was seen within and between these DMN subcomponents using a neurocognitive aging model.

258 stent within known DMN subsystems and across DMN subregions.

259 ionships were highly consistent within known DMN subsystems and across DMN subregions.

260 anatomical evidence to support the detected DMN subsystems.

261 ute magnitude of this effect was greater for DMN, suggesting a heightened specialization for resting-

262 associated with impaired deactivation of the DMN, suggesting that acute hyperglycemia contributes to

263 ith disrupted functional connectivity in the DMN, suggesting that common mechanisms may underlie stru

264 reased activity in the default mode network (DMN), suppressed activity within the anti-correlated (ta

265 However, DMN thalamo-cortical functional connectivity was disrupt

266 eduction in cerebral blood flow and restored DMN thalamo-cortical functional connectivity.

267 refrontal cortex (mPFC) is a key node of the DMN that is anatomically connected with the descending p

268 C to isolate correlation patterns within the DMN that were locked to the processing of each narrative

269 , these results suggest that, like the human DMN, the rat DMN can be partitioned into several subcomp

270 l measures to assess the contribution of the DMN to global functional connectivity dynamics in 22 hea

271 of salient external stimuli and signals the DMN to reduce its activity when attention is externally

272 We found that DMN topology changes over time and those different patte

273 e investigated both nodal and global dynamic DMN-topology metrics across different brain states.

274 ention dysfunction in ADHD emphasize altered DMN-TPN interactions.

275 our a priori hypothesis, we observed reduced DMN-TPN segregation co-occurring with structural abnorma

276 insula (rAI), a key node of the SN, and the DMN transiently increased during stopping.

277 network (FPCN) and the default mode network (DMN), two networks that do not strongly interact with on

278 structural changes of default mode network (DMN) underlying the cognitive impairment in Late-onset d

279 enous fluctuations in specific RSNs-like the DMN-unitarily.

280 After identifying DMN using a group-level independent-component analysis o

281 We directly compared the SN and DMN using a large (n = 69) distortion-corrected function

282 e sought to identify constituents of the rat DMN using resting-state functional MRI (rs-fMRI) and dif

283 High pretrial activity within the DMN was associated with a greater increase in shift tria

284 no significant connection of SN with CEN and DMN was found in PTSD patients.

285 tand the temporally changing topology of the DMN, we investigated both nodal and global dynamic DMN-t

286 activity and functional coupling within the DMN when listening to naturalistic sounds.

287 etworks, including the default mode network (DMN), which contains a set of cortical regions that inte

288 on associated with the default mode network (DMN), which is more active during rest than under active

289 thin the resting state default mode network (DMN), which may signal heightened risk for cognitive dec

290 tagonistic system--the default-mode network (DMN)--which typically deactivates during performance of

291 recuneus) and global connectivity within the DMN, which are associated with better performance.

292 ly distinct interactions between the FPN and DMN, which may mediate conscious state.

293 meditation training functionally couples the DMN with a region known to be important in top-down exec

294 ncreased RD of these fiber tracts connecting DMN with CON were found in LOD patient.

295 We combined DMN with mimMiner, which was a widely used phenotype dat

296 self-referential processes supported by the DMN with the affectively laden, behavioral withdrawal pr

297 Examining the DMN with the cGERGM, we show that, rather than demonstra

298 cate communication within the DMN and of the DMN with the descending modulatory system as a mechanism

299 thesized by conjugating diaminomaleonitrile (DMN) with benzothiazole unit, and characterized by singl

300 demanding cognitive shifts could recruit the DMN, yet it is unknown whether this holds for nonhuman s