ライフサイエンスコーパス: DMR

1 DMR detection is then carried out via a Wald test proced

2 DMRs located within intergenic regions were heavily enri

3 -0.0013; 95% CI: -0.0023, -0.0003, p = 0.01) DMR methylation, but primarily in females, (beta = -0.00

4 We validated 13/15 DMRs by targeted analysis of methylation.

5 macrophages emerged in VWAT along with 1520 DMRs (P < 0.0001), associated with 693 genes.

6 Rs of 648 genes were hypermethylated and 274 DMRs of 336 genes were hypomethylated in trained group c

7 Furthermore, a subset of 34 DMRs related to impaired oxidative stress, DNA repair, a

8 ribed in previous studies, in addition to 34 DMRs not previously reported.

9 We replicated 3/4 DMRs identified in our genome-wide screen in a different

10 We discovered that 440 DMRs of 648 genes were hypermethylated and 274 DMRs of 3

11 To examine biological themes, we selected 70 DMRs with false discovery rate of <0.1.

12 Using this approach we identified 77 DMRs, including nearly all those described in previous s

13 We identified 25,820 DMRs in islets from individuals with T2D.

14 anscription elongation factor AFF3 between a DMR and an enhancer.

15 These include a DMR at TUBGCP5 within the recurrent 15q11.2 microdeletio

16 ethylome and returning potentially novel age DMRs, in addition to replicating several loci implicated

17 protein-dependent intracellular calcium and DMR responses, but this receptor isoform remains functio

18 eriments in which accuracy of mC calling and DMR detection is evaluated on simulated data with variou

19 ustment for regional p-value combination and DMR annotation, we provide a method that may be applied

20 texts, read qualities, sequencing depths and DMR lengths, as well as on real data from a wide range o

21 both intracellular calcium mobilization and DMR responses in human embryonic kidney 293 cells, when

22 a new software package for detecting mCs and DMRs from bisulfite sequencing data.

23 We replicate the top DMP (RPS6KA2) and DMRs (VMP1, ITGB2 and TXK) in an independent cohort.

24 stricted ASM, and among them are 188 hap-ASM DMRs and 933 mQTLs located near GWAS signals for immune

25 ng sites were over-represented among hap-ASM DMRs and mQTLs, and analysis of the human data, suppleme

26 on changes, especially in non-CGI-associated DMRs.

27 ed ABBA to identify >1000 disease-associated DMRs.

28 ne marks were enriched in the T2D-associated DMRs.

29 ocal parental allelic histone acetylation at DMRs.

30 tion-free alleles from methylated alleles at DMRs in mouse embryo fibroblasts and embryos.

31 ethylation in peripheral blood leukocytes at DMRs of 22 human imprinted genes.

32 e define patterns of epigenetic variation at DMRs, identifying rare individuals with global gain or l

33 zed method for determining empirically based DMRs (eDMR) from high-throughput sequence data that is a

34 atments identified some associations between DMRs, genes and transposons.

35 ARK2, PID1, SLC2A2, and SOCS2, that had both DMRs and significant expression changes in T2D islets.

36 ic DMRs (t-DMRs) and cancer-specific DMRs (c-DMRs), and 5hmC is negatively correlated with methylatio

37 old, P < 10(-4)) and cancer-specific DMRs (C-DMRs; 3.6-fold, P < 10(-4)).

38 hypomethylated R-DMRs with hypermethylated C-DMRs and bivalent chromatin marks, and colocalization of

39 hypermethylated R-DMRs with hypomethylated C-DMRs and the absence of bivalent marks, suggesting two m

40 hted optimization algorithm eDMR for calling DMRs extends an established DMR R pipeline (methylKit) a

41 s, resulting in the discovery of 1966 common DMRs and 1754 rare DMRs.

42 In contrast, sperm-contributed DMRs are largely intergenic and become hypermethylated a

43 Altogether, BRCA1 and CRISP2 DMRs hold promise as novel blood surrogate markers for e

44 ntegrated network analysis, BRCA1 and CRISP2 DMRs were identified as most central disease-associated

45 Furthermore, our method can detect DMRs from a single pair of samples and can also incorpor

46 samples; and (iii) the capability to detect DMRs from a single pair of samples is demanded.

47 shows that ABBA has greater power to detect DMRs than existing methods, providing an accurate identi

48 l), a novel Bayesian framework for detecting DMRs from methylation array data.

49 tatistical method, DSS-single, for detecting DMRs from WGBS data without replicates.

50 We present DMRMark (DMR detection based on non-homogeneous hidden Markov mod

51 Least squares DNA methylation means at each DMR and birth weight were compared between infants of sm

52 eDMR for calling DMRs extends an established DMR R pipeline (methylKit) and provides a needed resourc

53 al aspects that we can improve over existing DMR detection (i) methylation statuses of nearby CpG sit

54 In contrast, very few DMRs distinguished regions of the cortex, limbic system

55 bles an accurate and scalable way of finding DMRs in high-throughput methylation sequencing experimen

56 terns of DNA methylation in regions flanking DMRs reveals a distinct subset of DMRs.

57 Few tools exist for DMR identification from this type of data, but there is

58 ol for mC calling, and a novel framework for DMR detection based on hidden Markov models (HMMs).

59 We propose a novel method for DMR identification that detects the region boundaries ac

60 ve been proposed for mC calling, methods for DMR detection have been largely limited.

61 ysis results reveals a strong enrichment for DMRs in T2D-susceptibility loci.

62 Furthermore, DMR assays under microfluidics allowed estimation of the

63 that AFF3 can specifically bind both gametic DMRs (gDMRs) and enhancers within imprinted loci in an a

64 blishment of methylation at maternal gametic DMRs.

65 There are a large number of germline DMRs that have not yet been associated with imprinting,

66 tween the <40 y group and the >/=40 y group (DMRs, 21% and 22%, respectively; P = 1).

67 e were no significant differences at the H19 DMR, infants born to smokers had higher methylation at t

68 ially methylated region upstream of H19 (H19-DMR), serving as the imprinting control region, determin

69 ion of the maternal but not the paternal H19-DMR reduces adult haematopoietic stem cell quiescence, a

70 Mechanistically, maternal-specific H19-DMR deletion leads to Igf2 upregulation and increased tr

71 Maternal-specific H19-DMR deletion results in activation of the Igf2-Igfr1 pat

72 inactivation of Igf1r partly rescues the H19-DMR deletion phenotype.

73 lving 4,106 genes could be potential new HCC DMR loci.

74 Each gene had high DMR methylation and lower expression, which were associa

75 Human DMRs were enriched for specific histone modifications an

76 on factor binding sites located within human DMRs, suggesting that alteration of regulatory motifs un

77 riod was associated with higher PLAGL1/HYMAI DMR methylation regardless of sex (beta = 0.0075; 95% CI

78 Hypermethylated DMRs were more likely to overlap with CpG islands and sh

79 Hypomethylated DMRs were more likely to be in regions associated with p

80 esent a novel program, metilene, to identify DMRs within whole-genome and targeted data with unrivale

81 ergenic differentially methylated region (IG-DMR) is required for expression of maternally expressed

82 The mechanism by which the IG-DMR functions is largely unknown.

83 rst non-coding RNA gene downstream of the IG-DMR.

84 genes and resulted in methylation of the IG-DMR.

85 sibly by maintaining active status of the IG-DMR.

86 has been suggested that the unmethylated IG-DMR acts as a positive regulator activating expression o

87 Our findings suggest that IGF2 DMR plasticity is an important mechanism by which in ute

88 o smokers had higher methylation at the IGF2 DMR than those born to never smokers or those who quit d

89 was mediated by DNA methylation at the IGF2 DMR.

90 19 different chromosomes, defining imprinted DMRs as sites where the maternal and paternal methylatio

91 me-wide approach to identify novel imprinted DMRs in the human placenta and investigated the dynamics

92 Forty-three known and 101 novel imprinted DMRs were identified in the human placenta by comparing

93 aberrant methylation levels of the imprinted DMRs or with changes in overall gene expression for the

94 investigated the dynamics of these imprinted DMRs during development in somatic and extraembryonic ti

95 No significant difference in DMRs was observed between the <40 y group and the >/=40

96 Inter-individual DMRs were readily detectable in these regions.

97 DMRs, Cdkn1c upstream region, and Inpp5f_v2 DMR and paternal allele-specific CTCF binding at the Peg

98 tionally, the ability to detect short length DMRs is necessary as biologically relevant signal may oc

99 Thus, many DMRs are broadly involved in tissue differentiation, epi

100 modifications were specific to the maternal DMR.

101 3 is maternally expressed, the paternal Meg3 DMR was methylated, and activating histone modifications

102 e goal of this study was to analyze the Meg3 DMR during imprinting establishment and maintenance for

103 l histone modifications detected at the Meg3 DMR of ES cells were biallelic.

104 Maternally methylated DMRs, that usually overlap with promoters exhibited high

105 ele-specific bias than paternally methylated DMRs that reside in intergenic regions.

106 group comparisons, MethylAction detects more DMRs with strong differential methylation measurements c

107 es of neonatal keratinocytes share many more DMRs with adult breast luminal and myoepithelial cells t

108 maternally inherited deletion of the Nesp55 DMR (DeltaNesp55(m)) replicate these Gnas epigenetic abn

109 aused by the maternal deletion of the Nesp55 DMR result from biallelic XLalphas expression.

110 rinted expression associated with nine novel DMRs.

111 re cancer-specific, including numerous novel DMRs.

112 Seventy-two novel DMRs showed a pattern consistent with placental-specific

113 From these, we identified a network of DMR-associated genes involved in glutamatergic synaptic

114 ct locations of DMRs and better agreement of DMRs with gene expression and DNase I hypersensitivity.

115 there is little evidence for association of DMRs with genes that show quantitative differences in ge

116 nal statistical test allows the detection of DMRs in large methylation experiments with multiple grou

117 method classifies both the directionality of DMRs and their genome-wide distribution, and we have obs

118 c islets, and to investigate the function of DMRs in islet biology.

119 1 knockout mice revealed hypermethylation of DMRs of imprinted genes in sperm, which can be traced ba

120 ods, providing an accurate identification of DMRs in the large majority of simulated cases.

121 s insights into the origin and influences of DMRs in a crop species with a complex genome organizatio

122 he sequence specificity of DMRs, location of DMRs relative to genes and transposons, and patterns of

123 imates of mC levels, more exact locations of DMRs and better agreement of DMRs with gene expression a

124 lines provides evidence that the majority of DMRs are heritable.

125 cows, and mice contains differing numbers of DMRs, but the PEG3-CpG island is the only DMR that is co

126 ful in selecting the most robust patterns of DMRs.

127 racterization of the sequence specificity of DMRs, location of DMRs relative to genes and transposons

128 s flanking DMRs reveals a distinct subset of DMRs.

129 of DMRs, but the PEG3-CpG island is the only DMR that is conserved among these three species.

130 ed GPR120L receptors, no specific calcium or DMR responses were observed in cells transfected with th

131 Unlike existing methods, our DMR detection is achieved without predefined boundaries

132 To demonstrate further the utility of our DMR set, we use it to classify unknown samples and ident

133 Several of our DMRs are at genes with potential relevance for age-relat

134 P-DMRs located in INSR and CPT1A have enhancer activity in

135 ociated differentially methylated regions (P-DMRs) is lacking in humans.

136 on and further exploratory analysis of six P-DMRs highlight the critical role of gestational timing.

137 We show that P-DMRs preferentially occur at regulatory regions, are cha

138 restingly, differential methylation of the P-DMRs extends along pathways related to growth and metabo

139 al allele-specific CTCF binding at the Peg13 DMR.

140 sociated with a significant decrease in PEG3 DMR methylation (beta = -0.0014; 95% CI: -0.0023, -0.000

141 Taken together, deletion of the Peg3-DMR caused global changes in the imprinting and transcri

142 of the Peg3 domain, confirming that the Peg3-DMR is an ICR for this imprinted domain.

143 blocker profiling showed that the pinacidil DMR is due to the activation of SUR2/Kir6.2 KATP channel

144 , FAM92A1, MIR155HG, and VWA8) with promoter DMRs and expression associated with overall survival (OS

145 Genes with promoter DMRs and expression levels significantly associated with

146 (DMRs) in the reprogrammed cells (denoted R-DMRs) were significantly enriched in tissue-specific (T-

147 rks, and colocalization of hypermethylated R-DMRs with hypomethylated C-DMRs and the absence of bival

148 observed colocalization of hypomethylated R-DMRs with hypermethylated C-DMRs and bivalent chromatin

149 cells are derived from fibroblasts, their R-DMRs can distinguish between normal brain, liver and spl

150 e applied to a variety of datasets for rapid DMR analysis.

151 discovery of 1966 common DMRs and 1754 rare DMRs.

152 is by comparing the distant metastasis rate (DMR) on initial (18)F-FDG PET/CT in a group of breast ca

153 Whole cell dynamic mass redistribution (DMR) assays enabled by label-free optical biosensor were

154 free whole cell dynamic mass redistribution (DMR) assays under persistent and duration-controlled sti

155 obilization and dynamic mass redistribution (DMR) assays, together with quantitative imaging measurem

156 Dynamic mass redistribution (DMR) profiling resulted in a pharmacological activity ma

157 tically similar dynamic mass redistribution (DMR) signals in A431, A549, HT29 and HepG2C3A, but not i

158 referred to as dynamic mass redistribution (DMR).

159 the NESP55 differentially methylated region (DMR) (delNESP55/ASdel3-4(m), delNAS(m)) from the GNAS lo

160 o the Gtl2 differentially methylated region (DMR) on the unmethylated maternal allele.

161 y the Meg3 differentially methylated region (DMR), but the mechanism by which this DMR acts is unknow

162 e upstream differentially methylated region (DMR), which also included the site motifs for the enhanc

163 ion at the differentially methylated region (DMR)-0.

164 y the Peg3-differentially methylated region (DMR).

165 Multiple differentially methylated regions (DMR) could be identified in atherosclerosis patients, re

166 ed 50 differentially DNA methylated regions (DMR) in gene promoters.

167 nreported differentially methylated regions (DMR): one in the promoter region of mouse Zim3 and anoth

168 ed 197 differential DNA methylation regions (DMR) in gene promoters, termed epimutations.

169 for differentially methylated gene regions (DMRs) using a methylated DNA immunoprecipitation on chip

170 germline differentially methylated regions (DMRs) and 23 previously unknown DMRs, with some occurrin

171 5 hap-ASM differentially methylated regions (DMRs) and 3,082 strong methylation quantitative trait lo

172 ificantly differentially methylated regions (DMRs) and 963 differentially methylated genes (DMGs) wer

173 that differentially DNA-methylated regions (DMRs) and enhancers are two major classes of cis-element

174 tional 11 differentially methylated regions (DMRs) and found that, in general, H3K79me3 was associate

175 D-related differentially methylated regions (DMRs) and replicate the top signals in 42 unrelated T2D

176 ues, 2481 differentially methylated regions (DMRs) are cancer-specific, including numerous novel DMRs

177 ependent, differentially methylated regions (DMRs) are identical to the DMRs recently identified in u

178 Differentially methylated regions (DMRs) are stable epigenetic features within or in proxim

179 nreported differentially methylated regions (DMRs) associated primarily with genomic imprinting or DN

180 fied 1027 differentially methylated regions (DMRs) associated with parental THC exposure in F1 adults

181 dentified differentially methylated regions (DMRs) associated with prognostic mutations in older (>/=

182 -specific differentially methylated regions (DMRs) between any two genotypes.

183 to detect differentially methylated regions (DMRs) between paired samples.

184 g control differentially methylated regions (DMRs) established in the germline.

185 to detect differentially methylated regions (DMRs) from whole-genome bisulfite sequencing (WGBS).

186 Of 811 differentially methylated regions (DMRs) identified in ACF, 537 (66%) were hypermethylated

187 ith known differentially methylated regions (DMRs) in colon tumors.

188 identify differentially methylated regions (DMRs) in diabetic islets, and to investigate the functio

189 Differentially methylated regions (DMRs) in each methylation context showed very distinct m

190 ndreds of differentially methylated regions (DMRs) in humans compared to non-human primates and estim

191 K46 at 11 differentially methylated regions (DMRs) in reciprocal mouse crosses using multiplex chroma

192 The differentially methylated regions (DMRs) in the reprogrammed cells (denoted R-DMRs) were si

193 in known Differentially Methylated Regions (DMRs) including reprogramming specific DMRs and cancer s

194 identify differentially methylated regions (DMRs) instead of DMPs.

195 ection of differentially methylated regions (DMRs) is a necessary prerequisite for characterizing dif

196 ection of differentially methylated regions (DMRs) is enthralling for many disease studies.

197 ified 167 differentially methylated regions (DMRs) of DNA at baseline that distinguished responders f

198 on in the differentially methylated regions (DMRs) of Peg3 and Gnas imprinted domains, which are know

199 important differentially methylated regions (DMRs) of the genome that are altered during development

200 addition, differentially methylated regions (DMRs) often contain single nucleotide polymorphisms asso

201 -specific differentially methylated regions (DMRs) often overlap tissue-specific distal cis-regulator

202 ssociated differentially methylated regions (DMRs) passed Bonferroni correction (P-value < 1.15 x 10(

203 on at two differentially methylated regions (DMRs) regulating Insulin-like Growth Factor 2 (IGF2) and

204 cation of differentially methylated regions (DMRs) revealed that DMRs mostly cosegregated with the ge

205 everaging differentially methylated regions (DMRs) specific to cell type, identified from DNAm measur

206 ulated by differentially methylated regions (DMRs) that are established in the germline and maintaine

207 alter the differentially methylated regions (DMRs) that control the monoallelic expression of imprint

208 gnificant differentially methylated regions (DMRs) using a bump hunting approach and a permutation-ba

209 ion at 12 differentially methylated regions (DMRs) was analyzed in cord blood samples from 58 offspri

210 secondary differentially methylated regions (DMRs) were identified by an overlapping pattern of H3K4

211 Differentially methylated regions (DMRs) were identified in the 5'-end regulatory regions,

212 to reveal differentially methylated regions (DMRs) with context-specific functional correlations.

213 ontaining differentially methylated regions (DMRs) with negative correlation between their expression

214 ection of differentially methylated regions (DMRs) with small effect size is a necessary feature of t

215 level of differentially methylated regions (DMRs), and bootstrapping determines false discovery rate

216 d 2485 CG differentially methylated regions (DMRs), both of which show patterns of divergence compare

217 n several differentially methylated regions (DMRs), including Xist, Nespas and Peg3, which all become

218 and their differentially methylated regions (DMRs), whereas broad local enrichment of H3K27me3 (BLOC)

219 Ps) and 5 differentially methylated regions (DMRs), which we study in detail using whole genome bisul

220 ue set of differentially methylated regions (DMRs)--including many CpG island promoters--that are mai

221 er 16 000 differentially methylated regions (DMRs).

222 entifying differentially methylated regions (DMRs).

223 discover differentially methylated regions (DMRs).

224 l allele of differential methylated regions (DMRs).

225 based on differentially methylated regions (DMRs).

226 esence of differentially methylated regions (DMRs).

227 ied 2,130 differentially methylated regions (DMRs; <5% false discovery rate), of which 738 are associ

228 tional or degenerative mitral regurgitation (DMR) at high surgical risk.

229 or severe degenerative mitral regurgitation (DMR).

230 eam that retrospectively evaluated high-risk DMR patients enrolled in the EVEREST (Endovascular Valve

231 A total of 141 high-risk DMR patients were consecutively enrolled; 127 of these p

232 A prohibitive-risk DMR cohort was identified by a multidisciplinary heart t

233 tral valve repair (TMVR) in prohibitive-risk DMR patients have not been previously reported.

234 Hypomethylated SE-DMRs are in proximity to genes with SE relevant function

235 ify SE differentially methylated regions (SE-DMRs).

236 Therefore, our selected DMRs can serve as a starting point to guide new, more ef

237 l regurgitation (MR) in patients with severe DMR at prohibitive surgical risk undergoing TMVR.

238 eg3-CpG island was the only area that showed DMR status.

239 eQTLs where a methylation change at a single DMR is associated with transcriptional changes in a subs

240 fic chromatin marks at the Peg13 and Slc38a4 DMRs, Cdkn1c upstream region, and Inpp5f_v2 DMR and pate

241 A novel cancer-specific DMR in the WFDC2 promoter showed frequent methylation in

242 rogramming specific DMRs and cancer specific DMRs, while the rest (10,315) involving 4,106 genes coul

243 e-specific DMRs (t-DMRs) and cancer-specific DMRs (c-DMRs), and 5hmC is negatively correlated with me

244 s; 2.6-fold, P < 10(-4)) and cancer-specific DMRs (C-DMRs; 3.6-fold, P < 10(-4)).

245 ions (DMRs) including reprogramming specific DMRs and cancer specific DMRs, while the rest (10,315) i

246 fy thousands of developmental stage-specific DMRs (dsDMRs) across zebrafish developmental stages.

247 gnificantly enriched in both tissue-specific DMRs (t-DMRs) and cancer-specific DMRs (c-DMRs), and 5hm

248 ised methods for use when cell-type specific DMRs are not available, allowing scientists to estimate

249 The sperm DMR provide potential epigenetic biomarkers for transgen

250 T-DMR-associated genes were enriched for developmental gen

251 ively spliced genes were associated with a T-DMR.

252 tly enriched in both tissue-specific DMRs (t-DMRs) and cancer-specific DMRs (c-DMRs), and 5hmC is neg

253 el DNA sequences motifs overrepresented in T-DMRs were identified as being associated with positive a

254 pecific differentially methylated regions (T-DMRs) were preferentially located in exons and introns.

255 significantly enriched in tissue-specific (T-DMRs; 2.6-fold, P < 10(-4)) and cancer-specific DMRs (C-

256 y conservation analysis suggest that these T-DMRs are likely to be biologically relevant.

257 This study demonstrates that DMR assays can be used to elucidate the functional conse

258 Results showed that DMR assays under different conditions differentiated the

259 re, gene ontology analysis demonstrated that DMRs associated with promoters were enriched for genes i

260 ted genetic variation provided evidence that DMRs can occur without local sequence variation, but the

261 ally methylated regions (DMRs) revealed that DMRs mostly cosegregated with the genotype from which th

262 The DMR was not significantly higher in younger breast cance

263 G PET/CT examinations were reviewed, and the DMR was recorded for each clinical stage subgroup (stage

264 , where Meg3 is biallelically expressed, the DMR showed variable DNA methylation, with biallelic meth

265 otide polymorphisms found within or near the DMR.

266 cytosine guanine dinucleotide status of the DMR correlated with expression of the miRNAs following a

267 The majority of the DMR genes in the CHH context were transcriptionally down

268 Pathway deconvolution revealed that the DMR of epinephrine is originated mostly from the remodel

269 The DMRs identified in this study represent suggestive evide

270 The DMRs in patients not selected for age were 8% for stage

271 how that AG-haESCs carrying deletions in the DMRs (differentially DNA methylated regions) controlling

272 -specific DNA methylation differences in the DMRs of PEG3, IGF2/H19, and PLAGL1/HYMAI in adulthood.

273 n, reducing methylation levels at two of the DMRs analyzed, IGF2R in girls and GTL2-2 in boys.

274 ele-specific DNA methylation patterns of the DMRs of Peg3, Zim2 and Zim3 were not affected in the mic

275 Many of the DMRs that are significantly associated with local geneti

276 sociation scan found that nearly half of the DMRs with common variation are significantly associated

277 thylated regions (DMRs) are identical to the DMRs recently identified in uniparental ESCs.

278 These DMR provide potential epigenetic biomarkers for transgen

279 These DMRs cover loci with known islet function, e.g., PDX1, T

280 These DMRs fell predominantly within introns, exons, and inter

281 These DMRs were primarily localized to nonpromoter regions and

282 , Rex1 may function as a protector for these DMRs against DNA methylation.

283 esis did not cause any major change in these DMRs although the same YY1 KD caused hypermethylation in

284 same YY1 KD caused hypermethylation in these DMRs among a subset of aged mice.

285 Interestingly, these DMRs overlapped with 1,145 known tumor suppressor genes.

286 a substantial number of genes; four of these DMRs are near transcription factors (castor zinc finger

287 More than half of these DMRs have cell type-restricted ASM, and among them are 1

288 Investigation of these DMRs revealed differential DNA methylation localized to

289 The methylation level for each of these DMRs was also assayed in 31 additional maize or teosinte

290 Strikingly, these DMRs exhibited polymorphic imprinted methylation between

291 egion (DMR), but the mechanism by which this DMR acts is unknown.

292 Among genes implicated by the top DMRs were protocadherins, homeobox genes, MAPKs and ryan

293 A number of these transgenerational DMR form a unique direct connection gene network and hav

294 TS-DMRs were significantly enriched near genes involved in

295 A large proportion of TS-DMRs were located near genes that are differentially exp

296 ecific differentially methylated regions (TS-DMRs) observed at intragenic CpG islands and low CG dens

297 We discovered a unique DMR at the 5'-end of FAM50B at 6p25.2.

298 ted regions (DMRs) and 23 previously unknown DMRs, with some occurring at microRNA genes.

299 In subjects with DMR, all MV annular geometry-defining values were not si

300 ences in gene expression are associated with DMRs, and there is little evidence for association of DM