ライフサイエンスコーパス: DMSA

1 DMSA scans were obtained by both pinhole and SPECT techn

2 etallic ligand-protected cluster, Ag(4)Ni(2)(DMSA)(4) (DMSA = meso-2,3-dimercaptosuccinic acid) was s

3 gand-protected cluster, Ag(4)Ni(2)(DMSA)(4) (DMSA = meso-2,3-dimercaptosuccinic acid) was synthesized

4 nization (ESI) mass spectrometry to be Ag(7)(DMSA)(4), where DMSA represents meso-2,3-dimercaptosucci

5 99mTc-DMSA late static planar imaging or SPECT is being used f

6 99mTc-DMSA SPECT, spiral CT, and MR imaging appear to be equal

7 njection of a cortical fixation agent, 99mTc-DMSA or 99mTc-GH, and requires effective immobilization

8 enal length measurements determined by 99mTc-DMSA SPECT into management algorithms.

9 enal length measurements determined by 99mTc-DMSA SPECT is similar to that reported previously using

10 ior image quality in the evaluation of 99mTc-DMSA renal SPECT data, with the potential for markedly r

11 obtained 2-3 hours after injection of 99mTc-DMSA.

12 Fifty sequential pediatric patient 99mTc-DMSA SPECT studies of 98 kidneys were retrospectively an

13 d a literature review, we suggest that 99mTc-DMSA scintigraphy be performed early when evaluating gir

14 1-16 y; mean age, 5.4 y) who underwent 99mTc-DMSA SPECT were measured independently by 2 observers.

15 case, such a kidney was detected with 99mTc-DMSA scintigraphy but not by intravenous pyelography.

16 able 99mTc-labelled dimercaptosuccinic acid (DMSA) assay and contrast cystography.

17 lutions of meso-2,3-dimercaptosuccinic acid (DMSA) at increasing concentration (0.025, 0.050, and 0.1

18 (DMPS) or meso-2,3-dimercaptosuccinic acid (DMSA) caused a significant reduction (P < 0.0001) in the

19 imaging with 99mTc-dimercaptosuccinic acid (DMSA) has become the imaging test of choice for the diag

20 ter delivery, and a dimercaptosuccinic acid (DMSA) radioisotope scan at 3 months was done on those wi

21 renograms, (99m)Tc-dimercaptosuccinic acid (DMSA) renal cortical scans, (99m)Tc-based hepatobiliary

22 Quantitative 99mTc-dimercaptosuccinic acid (DMSA) renal uptake was studied in unilateral reflux-rela

23 f lack of uptake on dimercaptosuccinic acid (DMSA) scans (P < 0.01).

24 had early and late dimercaptosuccinic acid (DMSA) scans to detect acquired focal defects, and their

25 phy, technetium 99m-dimercaptosuccinic acid (DMSA) scintigraphy, contrast material-enhanced computed

26 obtained with 99mTc-dimercaptosuccinic acid (DMSA) SPECT.

27 ad, tibia lead, and dimercaptosuccinic acid (DMSA)-chelatable lead and measures of neurobehavioral an

28 pared with those of dimercaptosuccinic acid (DMSA).

29 ation with meso-2,3-dimercaptosuccinic acid (DMSA).

30 chelating agent 2,3-dimercaptosuccinic acid (DMSA, succimer).

31 ramme data, we describe change in VBLL after DMSA treatment courses in a cohort of 1,156 children </=

32 ound showed no correlation with VUR, and all DMSA scans but one were normal.

33 re considered, MAG3-F(0) was as sensitive as DMSA.

34 footprinting and DNA mobility shift assays (DMSA) using rat liver nuclear extracts identify a number

35 In most patients with fixed defects on both DMSA and MAG3-F(0), follow-up studies showed no resoluti

36 ient decrease in C/EBP alpha, as measured by DMSA, and an increase in beta 2 AR mRNA levels and rate

37 and compared with the results of concurrent DMSA studies.

38 A new drug, DMSA (meso 2,3-dimercaptosuccinic acid) has been approve

39 Of the 30 early DMSA scans (within 2 weeks of function), one child with

40 sociations between clinical events and focal DMSA lesions appearing in grafts were measured.

41 dysfunction and fixed focal defects and, for DMSA, focal defects without parenchymal loss.

42 from 20 mCi MAG3 were lower than those from DMSA (6 mCi) or GH (20 mCi).

43 al uptake persisted, but the elevated global DMSA accumulation seen for group C (with irreversible im

44 al abnormalities in APN as was the 3- to 4-h DMSA routine procedure.

45 heir mutual interdependence for detection in DMSA, and 4) inhibition of expression of HMG proteins by

46 differential uptake resulted from increased DMSA accumulation (absolute % dose uptake) by the nondis

47 Courses of DMSA of 19 or 28 d duration administered to children wit

48 Impact of DMSA was calculated as end-course VBLL as a percentage o

49 0.673-0.789, P < 0.01) for the prediction of DMSA defects.

50 so raises questions about the sensitivity of DMSA, considering that only a small percentage of patien

51 ry to the renal tubule that alters uptake of DMSA.

52 e the renal function and are readily seen on DMSA, but not ultrasound scans.

53 eurobehavioral performance than was tibia or DMSA-chelatable lead, mainly in the domains of executive

54 Oral DMSA was a pharmacodynamically effective chelating agent

55 acers, e.g. (67)Ga-citrate and (99m)Tc-penta-DMSA.

56 elonephritis is slightly better than pinhole DMSA scan, the overall accuracy of these two imaging tec

57 (99m)Tc-DMSA is filtered bound to alpha1-microglobulin and accum

58 Renal accumulation of (99m)Tc-DMSA is thus critically dependent on megalin/cubilin rec

59 jected intravenously with 0.5 MBq of (99m)Tc-DMSA or (99m)Tc-mercaptoacetyltriglycine (MAG3).

60 /cubilin-mediated endocytosis of the (99m)Tc-DMSA protein complex.

61 ta for 1062 kidneys, with a positive (99m)Tc-DMSA scan prevalence of 36%.

62 ta for 537 children, with a positive (99m)Tc-DMSA scan prevalence of 59% overall, and seven studies w

63 n UTI who had undergone both MCU and (99m)Tc-DMSA scintigraphy, and which also reported both positive

64 eficient mice an increased amount of (99m)Tc-DMSA was excreted in an approximately 27-kDa form, which

65 No renal accumulation of (99m)Tc-DMSA was identified in scintigrams of megalin/cubilin-de

66 abnormalities and relative uptake of (99m)Tc-DMSA were recorded.

67 )Tc-labeled dimercaptosuccinic acid ((99m)Tc-DMSA) accumulates in the kidney cortex and is widely use

68 99m-labeled dimercaptosuccinic acid ((99m)Tc-DMSA) renal scintigraphy in 2 cases of preemptive LKT de

69 )Technetium-dimercaptosuccinic acid ((99m)Tc-DMSA) scintigraphy.

70 The size and identity of (99m)Tc-DMSA-bound proteins in urine were analyzed by fractionat

71 increase in the urinary excretion of (99m)Tc-DMSA.

72 responsible for the renal uptake of (99m)Tc-DMSA.

73 ptake; however, DMPS was more effective than DMSA (P < 0.001).

74 Evidence exists that DMSA is effective in lowering the blood lead concentrati

75 The sensitivity of the DMSA scan for detection of affected kidneys was 92% for

76 t of pyelonephritis were correlated with the DMSA images and renal pathology.

77 ass spectrometry to be Ag(7)(DMSA)(4), where DMSA represents meso-2,3-dimercaptosuccinic acid.

78 nous blood lead level (VBLL) associated with DMSA treatment in the largest cohort of children </= 5 y

79 Associations with DMSA-chelatable lead were similar to those for blood lea

80 ower specificity for MAG3-F(0) compared with DMSA (86%); this finding needs further study, because it

81 Compared with DMSA and when both regional dysfunction and focal defect

82 However, comparisons with DMSA indicated certain disadvantages of MAG3 SPECT.