ライフサイエンスコーパス: DNA

1 is ~1,100 times shorter than the chromosomal DNA.

2 ns of telomeric sequences into non-telomeric DNA.

3 -7, in inactive double hexameric form around DNA.

4 th aberrant interphase replication of bridge DNA.

5 tion distinct from that of surrounding mouse DNA.

6 clear shape by directly associating with the DNA.

7 and reversible compaction of double-stranded DNA.

8 ding transcribing, replicating and repairing DNA.

9 s nuclease (Nuc)-mediated degradation of NET DNA.

10 er the dynamic features of DNA into the meta-DNA.

11 ities for colloidal crystal engineering with DNA.

12 lows for labeling of replicating or repaired DNA.

13 ging because of low bacterial and high human DNA abundances.

14 By regulating DNA access for transcription, replication, DNA repair, a

15 halan) activity, as measured by formation of DNA adducts.

16 One of these, Rv0060 (DNA ADP-ribosyl glycohydrolase, DarG(Mtb) ), functions a

17 nctions along with its cognate toxin Rv0059 (DNA ADP-ribosyl transferase, DarT(Mtb) ), to mediate rev

18 nsferase, DarT(Mtb) ), to mediate reversible DNA ADP-ribosylation (Jankevicius et al., 2016).

19 likely helps to position Bax1 at the forked DNA allowing the nuclease domain to incise one arm of th

20 clinical assays lack patient-matched control DNA and additional analysis is needed to distinguish som

21 DNA and cDNA 16S rRNA gene profiling demonstrated that t

22 w bronchoalveolar lavage fluid mitochondrial DNA and more severe disease.

23 reactive oxygen species (ROS), which oxidize DNA and other cellular components.

24 yme kinetic parameters of cellular and viral DNA and RNA polymerases with respect to cellular levels

25 event incorporation of N6-methyl-(d)ATP into DNA and RNA.

26 plasma viremia, reduced cell-associated SIV-DNA, and preserved Th17 homeostasis, including at pre-AR

27 Levels of anti-DNA antibodies can fluctuate widely, unlike those of ant

28 lations of nanofibers formed using analogous DNA approaches, gammaPNA structures appear to form bundl

29 tion in PCR-based diagnostics, high-affinity DNA aptamer generation, site-specific labeling of RNAs,

30 This is followed by a further injection of DNA as a competitor, either in a plasmid or in chromosom

31 highly motile ATL and ATL-UvrA complexes on DNA at the molecular level.

32 d off to the side of the catalytic Pol3-PCNA-DNA axis.

33 R17 and Q41 interacting exclusively with the DNA backbone.

34 Herein, we rationally design a DNA-based artificial molecular signaling system that use

35 e circulation by both mRNA-based and genomic DNA-based sequencing.

36 osensors (e.g. enzymatic, immunosensors, and DNA-based).

37 study unravels a role of endogenous oxidized DNA bases and APE1 in controlling the formation of highe

38 Cytosine DNA bases can be methylated by DNA methyltransferases an

39 we demonstrate that high-throughput in vitro DNA binding assays coupled with unbiased computational a

40 the allosteric mechanism of nickel-activated DNA binding by HpNikR is driven by conformational select

41 DNA binding correlates with nucleotide occupancy: five M

42 We show that the phosphorylation of the RNA-DNA binding protein fused in sarcoma (FUS) is higher in

43 gnition, some fundamental aspects of protein-DNA binding remain poorly understood(1,2).

44 cer and anti-obesity drugs by inhibiting its DNA-binding activities.

45 The Cys2His2 zinc finger is the most common DNA-binding domain expanding in metazoans since the fung

46 Here, we report a crystal structure of the DNA-binding domain of a model ASO-binding protein PC4, i

47 ee arsenic-coordinating cysteines within the DNA-binding domain, distal to the zinc-binding site.

48 Another motif, DPHK, is in the DNA-binding domain.

49 In vitro DNA-binding experiments and structural prediction show t

50 , enhanced phosphorylation (Ser73), and AP-1/DNA-binding in response to S. mansoni infection.

51 sequently suggests that the knowledge of the DNA-binding properties of the proteins is in itself not

52 TAR DNA-binding protein 43 (TDP-43) has emerged as a key pla

53 Insoluble, hyperubiquitylated TAR DNA-binding protein of 43 kDa (TDP-43) in the central ne

54 at small changes outside of highly conserved DNA-binding regions can lead to profound changes in prot

55 various DNA motifs are mediated by its flat DNA-binding surface, which is centered on a short loop s

56 e binding to the same consensus motif, their DNA-binding syntax is different, suggesting discriminato

57 Notably, the expression of the DNA-binding-deficient mutant of NuMA affects chromatin d

58 of nucleic acid detection for low-abundance DNA biomarkers.

59 are expected to pose a problem to efficient DNA bubble migration.

60 etics of recognition and repair of alkylated DNA by AlkB.

61 -toward the ultimate goal of forming RNA and DNA by polymerization.

62 Cellular DNA can be damaged by spontaneous hydrolysis, reactive o

63 rag force exerted by flow on a translocating DNA can be exploited to tune the kinetics of DNA translo

64 ole-genome bisulfite sequencing of cell free DNA (cfDNA) and of matched metastatic tumor biopsies fro

65 recombination intermediates may drive biased DNA cleavage.

66 mer competent for non-specific double-strand DNA cleavage.

67 ing at poly(ADP-ribose) polymerase 1 (PARP1)-DNA complexes trapped by PARP inhibitors, thereby promot

68 parameters that define the stability of p53/DNA complexes, and provide insight into the pathways by

69 titor, either in a plasmid or in chromosomal DNA, containing the same binding site but with a differe

70 with a Pyk2 kinase inhibitor increased viral DNA content in keratinocytes that maintain viral episome

71 on even when viral load exceeded 1 x 107 HSV DNA copies, and surges in granzyme B and IFN-gamma occur

72 l studies showed that Rad4, when tethered to DNA, could also open undamaged DNA, suggesting a 'kineti

73 to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment usin

74 lasma circulating tumor human papillomavirus DNA (ctHPVDNA) is a sensitive and specific biomarker of

75 esponse protein regulated in development and DNA damage 1 (REDD1) is necessary for the development of

76 unity, and in anticancer therapies involving DNA damage agents.

77 multiple factors, including cellular stress, DNA damage and immune surveillance.

78 protecting cells from replication-associated DNA damage and promoting cellular recovery.

79 ome ends from inappropriately activating the DNA damage and repair responses.

80 The measurement of UV-induced DNA damage as a dosimeter of exposure and predictor of s

81 etion of the Trp53 tumor suppressor or Chek2 DNA damage checkpoint kinase rescued Smc5 cKO neurodevel

82 letion of the conserved helicase PIF1 and/or DNA damage checkpoint-mediator RAD9.

83 ly, H. pylori-induced replication stress and DNA damage depend on the presence of co-transcriptional

84 reveal that excessive placental DNA damage in murine models for Cornelia de Lange syndro

85 The presence of DNA damage increases the frequency of pausing.

86 s in diverse biological processes, including DNA damage repair (Fanconi anemia), telomere maintenance

87 WS) and Bloom Syndrome (BS) are disorders of DNA damage repair caused by biallelic disruption of the

88 uring neurodevelopment, but it also mediates DNA damage repair essential to proliferating neural prog

89 ibition of an analog-sensitive CDK12 reduces DNA damage repair gene expression, but selective inhibit

90 tance (drug extrusion, drug degradation, and DNA damage repair) and using rate constants of these rea

91 PBRM1, BAP1 and SETD2), DNA methylation and DNA damage repair, all of which have been associated wit

92 n X-chromosome inactivation, imprinting, and DNA damage repair, and mutations in SMCHD1 can cause fac

93 protect 3D genome structure integrity during DNA damage repair.

94 l roles in base excision repair and ATR-Chk1 DNA damage response (DDR) pathways, it remains unknown h

95 Here, we investigate the impact of DNA damage response and repair on 3D genome folding usin

96 rent study, we report that inhibitors of the DNA damage response kinase ATR can significantly potenti

97 RF2 instead activate an attenuated telomeric DNA damage response that lacks accompanying telomere fus

98 SMC5/6 depletion triggers a CHEK2-p53 DNA damage response, as concomitant deletion of the Trp5

99 ggesting the modulation of transcription and DNA damage that may be mediated by the action of HDAC an

100 Chemotherapy and irradiation cause DNA damage to hematopoietic stem cells (HSCs), leading t

101 from IECs increases markers of inflammation, DNA damage, and cell proliferation and increases colorec

102 Shot loss leads to double-strand break (DSB) DNA damage, and the apoptotic response is exacerbated by

103 e mechanisms including the oxidative stress, DNA damage, lysosomal dysfunction, inflammatory cascade,

104 tiate a slow-cycling state following stress (DNA damage, targeted therapy, and aging).

105 enhances DNA end-labeling, and protects from DNA damage, ultimately blocking the proneoplastic effect

106 MDM2 autoubiquitination and degradation upon DNA damage, whereas S429A substitution protects MDM2 fro

107 ed another mechanism wherein 5-AzadC induced DNA damage, which then resulted in enhanced occupancy of

108 report that L1 activity triggers FOA through DNA damage-driven apoptosis and the complement system of

109 ication arrest, allowing replication despite DNA damage.

110 mportant hub for processing various types of DNA damage.

111 metabolism or other perturbations that cause DNA damage.

112 reaks (DSB) are the most deleterious type of DNA damage.

113 se mitochondrial function trigger release of DNA damaging reactive oxygen species.

114 In this DNA demethylated context, either deletion of the CTCF bi

115 of Dppa3 facilitated the emergence of global DNA demethylation in mammals.

116 s a resource to facilitate future studies of DNA demethylation in pathogenesis and the development of

117 stage of human NK cell development in which DNA demethylation takes place to allow for active transc

118 ed by CGAS or STING knockdown, mitochondrial DNA depletion or mitochondrial outer membrane permeabili

119 tegy for achieving a sensitive biosensor for DNA detection and diagnostic applications.

120 posed sensor was successfully applied in HBV DNA detection in sera from patients without any amplific

121 This perspective will highlight DNA double-strand break (DSB) repair pathways in human c

122 To repair a DNA double-strand break by homologous recombination, 5'-

123 DNA double-strand breaks (DSB) are the most deleterious

124 lusively occupies the strong double-stranded DNA (dsDNA)-binding surface on cGAS and sterically preve

125 to be endoergic in aqueous solution and the DNA duplexes but slightly exoergic in the polymerase, wi

126 A ring-shaped helicase unwinds DNA during chromosome replication in all organisms.

127 validation experiments employed mycobacteria DNA, either extracted or intracellular.

128 DNA-encoded small molecule libraries (DELs) have enabled

129 fe of Nkx3.1 reduces proliferation, enhances DNA end-labeling, and protects from DNA damage, ultimate

130 , and other enzymes that modify incompatible DNA ends to allow their ligation.

131 Interestingly, DNA flanking the RNA-5' side of R-loops is not intrinsic

132 RSE) is characterized by the capture of long DNA fragments (15-20 kb) by magnetic beads, after enzyma

133 vs. 11/20 aqueous samples along with shorter DNA fragments.

134 Moreover, analysis of DNA from 79 subjects showed sequence variations in the l

135 e barrier to ensure safeguarding of germline DNA from environmental insults.

136 h synthetic DNA templates and validated with DNA from two breast cancer cell-lines and two patient tu

137 Our data show that endogenous DNA gap repair in E coli supports efficient multiplex si

138 rotein PC4, in complex with a full PS 2'-OMe DNA gapmer ASO.

139 e a coiled-coil heterodimer pair with unique DNA handles in order to link DNA origami nanostructures

140 Compared to double stranded DNA, PX DNA has dramatically enhanced (sometimes >1000 fold) res

141 ies on ISG15 functional interaction with the DNA helicase RECQ1, which promotes restart of stalled re

142 e licensed by the loading of the replicative DNA helicase, Mcm2-7, in inactive double hexameric form

143 ed by biallelic disruption of the WRN or BLM DNA helicases respectively.

144 reveals they bind to and randomly diffuse on DNA, however, in the presence of UV-induced DNA lesions

145 nd on the presence of co-transcriptional RNA/DNA hybrids (R-loops) that form in infected cells during

146 posi's sarcoma-associated herpesvirus (KSHV) DNA in blood and increased antibody titres may indicate

147 A large region of fission yeast DNA inserted into a mouse chromosome was previously obse

148 These results define the repair pathways of DNA interstrand crosslinks caused by an endogenous and a

149 required for packaging of newly synthetized DNA into nucleosomes during the S phase when their expre

150 The organization of genomic DNA into nucleosomes profoundly affects all DNA-related

151 owered motors during assembly to translocate DNA into procapsid shells.

152 meta-DNA to transfer the dynamic features of DNA into the meta-DNA.

153 The nucleolytic resection of DSB-adjacent DNA is a key step in meiotic DSB repair, but this proces

154 The enzymatic synthesis of DNA is a promising alternative, but thus far has not bee

155 lex that differ based on whether target site DNA is annealed or dynamic.

156 longevity and enormous information density, DNA is considered a promising data storage medium.

157 ative DNA polymerase to variously structured DNA is sufficient to predict the complex genomic behavio

158 RNA genome is converted into double-stranded DNA, is that it is slow and non-processive.

159 The primary endpoint was total HIV DNA isolated from peripheral blood CD4(+) T-cells at wee

160 independent of the nucleic acid type (RNA or DNA), its strandedness (single or double), and its seque

161 on recognition by ATL and directly visualize DNA lesion search by highly motile ATL and ATL-UvrA comp

162 DNA, however, in the presence of UV-induced DNA lesions these complexes stall.

163 in cell-associated DNA load, intact proviral DNA levels, and in inducible SIV reservoir in lymph node

164 ce the effective depth of synthesized vector DNA libraries, thereby raising the discovery cost of nov

165 es, there was a reduction in cell-associated DNA load, intact proviral DNA levels, and in inducible S

166 of Cd and smoking exposures with human blood DNA methylation (DNAm) profiles.

167 elling (for example, PBRM1, BAP1 and SETD2), DNA methylation and DNA damage repair, all of which have

168 tation information, with new developments in DNA methylation classification.

169 Human DNA methylation data have been used to develop biomarker

170 s similar Dnmt3b isoforms facilitate de novo DNA methylation during embryonic development and in soma

171 ubles the number of published syndromes with DNA methylation episignatures and, most significantly, o

172 mber of studies have reported that bacterial DNA methylation has important functions beyond the roles

173 s of maternal SMCHD1 does not alter germline DNA methylation imprints pre-implantation or later in ge

174 Increased DNA methylation in Ppargc1a promoter had a fetal origin;

175 nally, exposed fish exhibited differences in DNA methylation in selected genes, across all three gene

176 DNA methylation is a major silencing mechanism of transp

177 neurotrophic factor (BDNF) and total percent DNA methylation of Th and Bdnf genes in the frontal cort

178 Our analyses indicate that DNA methylation patterns associated with the susceptible

179 Local levels of DNA methylation result from opposing enzymatic activitie

180 human cohort data have revealed differential DNA methylation signatures in proxy tissues that are ass

181 Our study links DNA methylation to disease endpoints via intermediate pr

182 We discuss this phenomenon and propose that DNA methylation turnover might facilitate key lineage de

183 argc1a promoter had a fetal origin; elevated DNA methylation was also detected in neonatal BAT and br

184 onchoscopy to collect epithelial cells whose DNA methylation was measured using the Illumina 450 K pl

185 atin remodeler-associated modifications, and DNA methylation) that contribute to relapse to cocaine,

186 asures of mRNA expression, miRNA expression, DNA methylation, and histone acetylation from ASD and co

187 s reveal that histone modifications, but not DNA methylation, underlie exon-specific transcription of

188 histone post-translational modifications and DNA methylation.

189 fering RNAs (siRNAs) that guide RNA-directed DNA methylation.

190 -T cells displayed altered expression of the DNA methyltransferase 1 (DNMT1) isoform.

191 Cytosine DNA bases can be methylated by DNA methyltransferases and subsequently oxidized by TET

192 more frequently in isolates with defects in DNA mismatch repair that confer an elevated mutation rat

193 icantly contribute to genetic instability in DNA mismatch repair-defective human tumors.

194 zymes responsible for regulating protein and DNA modifications are targets of current cancer therapie

195 t mediates stable binding to a non-canonical DNA motif.

196 The binding of Fpr to various DNA motifs are mediated by its flat DNA-binding surface,

197 tant pedigree computation, and mitochondrial DNA (mtDNA) copy number inference.

198 Furthermore, 2'F modifications of DNA NANPs significantly enhances RIG-I mediated producti

199 As DNA nicking by MutLgamma depends on its co-factors, the

200 G4) is a noncanonical secondary structure of DNA or RNA which can enhance or repress gene expression,

201 air with unique DNA handles in order to link DNA origami nanostructures bearing complementary strands

202 enzymatic method to clean up and reconfigure DNA-origami structures.

203 design as an approach for generating useful DNA parts.

204 Tyrosyl-DNA phosphodiesterase 2 (TDP2) reverses Topoisomerase 2

205 Deletion of DNA-PK or PTEN, or inhibition of DNA-PK sensitized recov

206 Deletion of DNA-PK or PTEN, or inhibition of DNA-PK sensitized recovering BLBCs to AZD1775 by abrogat

207 AZD1775 induced phosphorylation of DNA-PK, protecting cells from replication-associated DNA

208 clease domain mutations in the gene encoding DNA polymerase epsilon (POLE) have incredibly high mutat

209 Interestingly, human DNA polymerase eta (poleta) proficiently incorporates dG

210 how that the response of a model replicative DNA polymerase to variously structured DNA is sufficient

211 y challenging the notion that lagging-strand DNA polymerases frequently dissociate from replisomes du

212 ntial to be highly mutagenic because it uses DNA polymerases, nucleases, and other enzymes that modif

213 Analysis of the DNA polymorphisms revealed that 2347 nonsynonymous SNPs

214 Background DNA prevented any diagnosis in cases analyzed without mi

215 This work shows that V1V2 scaffold DNA priming immunization provides a method to focus immu

216 ged with transposon ends and U-shaped target DNA prior to integration (the target capture complex) an

217 diesterase 2 (TDP2) reverses Topoisomerase 2 DNA-protein crosslinks (TOP2-DPCs) in a direct-reversal

218 Compared to double stranded DNA, PX DNA has dramatically enhanced (sometimes >1000 f

219 acent RuvC nuclease and propagates up to the DNA recognition lobe in full-length CRISPR-Cas9.

220 factor X, or MAX for short, to bind certain DNA recognition motifs in gene promoters that regulate g

221 functions to moderately enhance class-switch DNA recombination (CSR), while decreasing at higher dose

222 DNA into nucleosomes profoundly affects all DNA-related processes in eukaryotes.

223 e 1 (PARP-1) is a nuclear enzyme involved in DNA repair and transcription regulation, among other pro

224 NAD(+) levels also affect DNA repair capacity as NAD(+) is a substrate for PARP-en

225 cellular NAD(+) content and NAD(+)-dependent DNA repair capacity.

226 ak (DSB) repair pathways in human cells, how DNA repair failures can lead to human disease, and how P

227 DNA repair GAs are relatively frequent in GBC and associ

228 Direct DNA repair gene GAs were identified in 109 patients (14.

229 on treatments that target RNA processing and DNA repair pathways simultaneously as effective cancer t

230 gradation process involved in transcription, DNA repair, and cell division.

231 g DNA access for transcription, replication, DNA repair, and epigenetic modification, chromatin forms

232 omatid cohesion, chromosome segregation, and DNA repair.

233 asis, affects ATP production, and attenuates DNA repair.

234 tion, activating antioxidants, and enhancing DNA repair.

235 chanistically, 6-4PPs, but not CPDs, impeded DNA replication across the genome as revealed by microfl

236 ription of the MCM6 gene that is involved in DNA replication by directly binding to specific motifs w

237 duplicate only once in coordination with the DNA replication cycle and have an important role in segr

238 frequently dissociate from replisomes during DNA replication in vivo.

239 nism essential for replisome assembly during DNA replication initiation that is vulnerable to inhibit

240 -subunit origin recognition complex (ORC), a DNA replication initiator, defines the localization of t

241 ription-coupled homologous recombination and DNA replication restart.

242 , we explore the transcriptional profile and DNA replication timing (RT) under mild replication stres

243 However, SP-2509 does inhibit viral DNA replication, late gene expression, and virus product

244 t pathways controlled by (pp)pGpp, including DNA replication, transcription, nucleotide synthesis, ri

245 of endonucleases throughout the biosphere in DNA restriction, repair, and homing.

246 ree different gRNAs targeting HEK293 genomic DNA, resulting in a set of 55 high-confidence gRNA cleav

247 rements of full length p53 tetramers binding DNA reveal the parameters that define the stability of p

248 temperatures have measurable differences in DNA, RNA and protein composition that allow OGT predicti

249 ce as input to predict binding of protein to DNA, RNA, and other proteins.

250 alpha-1 antitrypsin concentrations.Methods: DNA samples from 1,693 non-Hispanic white individuals, 3

251 e-boronic acid (An-BA) probe to a biomimetic DNA scaffold and consequently, to use the unique photoph

252 is based on standardized recombinase-driven DNA scaffolds expressing different genes according to th

253 in controlling the formation of higher-order DNA secondary structures to regulate transcription beyon

254 d thus activates the TMEM173/STING-dependent DNA sensor pathway, which results in macrophage infiltra

255 These days, enormous amounts of DNA sequence and other omics data are generated.

256 t a rate approximately 25 times greater than DNA sequence changes and typically have short half-lives

257 us sequencing reads, an additional 8.9 Mb of DNA sequence was mappable, variant calling achieved a hi

258 analysis was conducted using six chloroplast DNA sequences from leaf material from across the BI and

259 its efficiency for the introduction of large DNA sequences in zygotes is low.

260 ide unprecedented insight into how different DNA sequences select distinct compositions and configura

261 that transcription factors bind to specific DNA sequences using a combination of base readout and sh

262 structures of nucleosomes containing native DNA sequences.

263 ng the way to cost-effective single-molecule DNA sequencing, capable of handling widely varying GC-bi

264 A 2D DNA sheet could be modularized into connected parts (e.g

265 abolished and p53 binds initially to cognate DNA sites as a dimer.

266 cDmc1 results from its lower single-stranded DNA (ssDNA) affinity, compared to that of ScRad51.

267 that potentially binds with single-stranded DNA (ssDNA) in a manner similar to human PC4, the protot

268 sequence as the relaxosome, which nicks the DNA strand destined for transfer and couples the nicked

269 tructures, which makes accessing the encased DNA strands difficult, or chemical modification, such as

270 k by homologous recombination, 5'-terminated DNA strands must first be resected to reveal 3'-overhang

271 ented by the presence or absence of distinct DNA strands, called molecular bits (molbits).

272 dification, such as covalent crosslinking of DNA strands.

273 4) structures are four-stranded noncanonical DNA structures enriched at telomeres and oncogenes' prom

274 ed at nucleotide 991, creating an additional DNA substrate for the unessential but highly conserved A

275 A, we observe transient interactions between DNA substrates and the Rad50 coiled coils.

276 Engineered DNA substrates that stabilize a reaction intermediate by

277 n tethered to DNA, could also open undamaged DNA, suggesting a 'kinetic gating' mechanism whereby les

278 ides a way to study the effect of defects on DNA supercoiling and the dynamics of supercoiling in mol

279 Cs) are generally characterized by excellent DNA surveillance and repair, resulting in one of the low

280 The Pif1-dependent stimulation of DNA synthesis across strong protein barriers may be bene

281 We perform a comprehensive analysis of DNA synthesis at all STR permutations and interrogate th

282 pendent cohesin removal is needed to restart DNA synthesis at stalled forks and promote survival foll

283 nucleotide was in the first coding position, DNA synthesis fidelity was similar to that observed with

284 with the natural A, T, G and C bases during DNA synthesis, which allows for labeling of replicating

285 d by the idiosyncratic needs of the encoding DNA tag relegating DEL compatible chemistry to dilute aq

286 mes are implicated in the control of diverse DNA-templated processes including gene expression.

287 The assay was developed with synthetic DNA templates and validated with DNA from two breast can

288 rchical strand-displacement reaction on meta-DNA to transfer the dynamic features of DNA into the met

289 ics of biological and physical systems, from DNA to turbulent plasmas, as well as in climbing, weavin

290 he initiating steps of conjugative transfer, DNA transfer and replication (Dtr) proteins assemble at

291 DNA can be exploited to tune the kinetics of DNA translocation.

292 Cryo-EM reveals that DNAs transported into E-S/E-K compartments are 'clamped'

293 sformed between two conformations with a few DNA "trigger" strands.

294 division, FtsK translocates double-stranded DNA until both dif recombination sites are placed at mid

295 everse-transcribing and single-stranded (ss) DNA viruses.

296 DNA was extracted and sequenced.

297 ions between the globular domains of M/R and DNA, we observe transient interactions between DNA subst

298 el-miR-71-5p and bma-lin-4, and O-150 repeat DNA were assessed.

299 ion (unlooping) rates (kloop and kunloop) of DNA with sticky ends over three helical periods (100-130

300 nanonucleases, able to cleave pBR322 plasmid DNA with the highest efficiency reported so far for cata