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1 stability of the replisome once assembled on DNA.
2 erated by release of single-stranded product DNA.
3 organisms that lack large amounts of genomic DNA.
4 radical cations at defined positions within DNA.
5 s through specific hybridization with target DNA.
6 he binding and ATPase-driven unwinding of G4 DNA.
7 d as an intermediate in electron transfer in DNA.
8 One system (type I-F) targets DNA.
9 merization of Dnmt3a/Dnmt3L complexes on the DNA.
10 uld detect a minimum concentration of 0.4 fM DNA.
11 were assayed for the presence of phytoplasma DNA.
12 y solvent-exposed in the major groove of the DNA.
13 or a ribose 8oxoG (r8oxoG) site embedded in DNA.
14 F60, represses seedling growth by modulating DNA accessibility of hypocotyl cell size regulatory gene
15 GA motifs in the stem region of TGGAA repeat DNA act as hot spots to facilitate the transition betwee
19 excess cytosolic extrusion of mitochondrial DNA along with increased reactive oxygen species and red
20 ediated isothermal amplification (LAMP) is a DNA amplification approach characterized by high sensiti
24 DNA-binding domain that abrogates binding to DNA and leads to complete loss of canonical TH action.
25 gation to daughter nuclei by linking mitotic DNA and NPC segregation via the mitotic specific chromat
26 the interactions between negatively charged DNA and positively charged amino acid residues, the tran
27 oncentrates (VCs), containing bioinformative DNA and proteins, have been used to study viral diversit
28 h an emphasis on the enzymes that synthesize DNA and repair discontinuities on the lagging strand of
29 tion of clean DSBs by cleaving the 5' strand DNA approximately 10-20 nucleotides away from the ends.
30 y permits very efficient use of the template DNA as well as sequence reads, which are nearly all conf
34 n photoactivation, the conjugate cleaves the DNA backbone specifically near the mismatch site on a 27
38 ve in neutralizing negatively charged linker DNA because it has a reduced net charge, and in DNA bind
40 because it has a reduced net charge, and in DNA binding and protein-protein interactions because key
45 tingly, 5hmC colocalized with the methylated DNA binding protein MeCP2 and with the active chromatin
46 tation of Arg60 (R60Q) significantly reduced DNA binding, but retained a preference for the 5caC modi
47 R36W) or Arg35 (R35H/L) completely abolished DNA binding, mutation of Arg60 (R60Q) significantly redu
48 esidues in the C-terminal helix to engage in DNA binding, triggering a major reprogramming of gene ex
49 has been well studied for over a decade, the DNA-binding activities and the biological functions of t
50 rated knockin mice with a mutation in the TR DNA-binding domain that abrogates binding to DNA and lea
51 dapter-inducing interferon-beta (TRIF) and Z-DNA-binding protein 1 (ZBP1)/DNA-dependent activator of
52 Analysis of enriched transcription factor DNA-binding sites in the promoters of differentially exp
57 e when free in solution or with well matched DNA but exhibits a significant luminescence increase in
60 no acid residues, the translocation speed of DNA can be manipulated by deliberate charge decorations
61 sequences by proximity ligation, forming RNA-DNA chimeric sequences, which are converted to a sequenc
62 erials that target DNA gyrase by stabilizing DNA-cleavage complexes, but their clinical utility has b
63 l comparison of holo-ScNsrR with an apo-IscR-DNA complex shows that the [4Fe-4S] cluster stabilizes a
66 of DNA positioning on the nucleosome and the DNA conformation can provide key regulatory signals.
67 ion DNA probe used in the preparation of FCN-DNA conjugates, the amount of FCN-DNA dispensed on the c
68 estabilized Miz1-4(A86K) mutant bound to the DNA consensus with a 30-fold increase in affinity (100 n
79 modification coincides with the ATM-mediated DNA damage response that occurs on functional telomeres
81 y, radiation therapy and chemotherapy induce DNA damage to drive cells into apoptosis or senescence a
84 T1AM), on cell proliferation, cell death and DNA damage was studied in two ovarian cancer cell lines
85 promotes survival by suppressing endogenous DNA damage, and may control cell fate through the regula
91 tins) are unsaturated imines that are potent DNA damaging agents, thereby confirming an earlier mecha
92 were randomized to receive 4 mg of PENNVAX-G DNA delivered intramuscularly by Biojector or electropor
93 apeutics for additional infectious pathogens.DNA-delivered monoclonal antibodies (DMAbs) can be produ
95 5i), either alone or in combination with the DNA-demethylating agent 5-aza-2'-deoxycytidine (DAC).
96 an exogenous source of alphaKG restored the DNA demethylation cycle by promoting TDG function, TET1
99 ivation of MutLalpha endonuclease, PCNA- and DNA-dependent activation of MutLalpha ATPase, and MutLal
100 ta (TRIF) and Z-DNA-binding protein 1 (ZBP1)/DNA-dependent activator of IFN-regulatory factors (DAI)
102 confidence interval [CI], 6.3-21.9%) of HPV DNA detections in genital samples were attributable to v
103 ion of FCN-DNA conjugates, the amount of FCN-DNA dispensed on the conjugate pad and the dispensing cy
106 tively induced clustered DNA lesions (OCDL), DNA double-strand breaks (DSB), apoptosis, and the local
107 eiotic recombination, a subset of programmed DNA double-strand breaks (DSBs) are repaired as crossove
108 e disorders (eg, ataxia-telangiectasia), and DNA double-strand breaks are crucial to the modulation o
110 ny of the three major pathways known to mend DNA DSBs, namely homologous recombination (HR), nonhomol
111 leoprotein filament (NPF) on double-stranded DNA (dsDNA) that is capable of unwrapping the nucleosoma
115 bility to rewrite large stretches of genomic DNA enables the creation of new organisms with customize
116 ed via freeze drying and loaded with plasmid DNA encoding perlecan domain I and VEGF189 and analyzed
117 t that chitosan scaffolds containing plasmid DNA encoding VEGF189 and perlecan domain I have the pote
118 a, Vietnam and Cambodia and after successful DNA extraction fragment of the nuclear rhodopsin gene (R
119 ew class of site-specifically metal-modified DNA films was characterized by UV, circular dichroism (C
121 The local sequence-dependent features of DNA found in high-resolution structures introduce irregu
122 ge model, but we find no correlation between DNA fragmentation and sample age over the timespans anal
128 s (mainly methylglyoxal and glyoxal), called DNA glycation, is quantitatively as important as oxidati
129 d cytidine deaminase are processed by uracil-DNA glycosylase (UNG) and mismatch repair (MMR) pathways
131 re broad-spectrum antibacterials that target DNA gyrase by stabilizing DNA-cleavage complexes, but th
133 ds to the formation of a high density of PNA/DNA heteroduplexes on the electrode surface for the subs
134 okiol application also inhibited UVB-induced DNA hypermethylation and its elevation of the levels of
136 production stemmed from the accumulation of DNA in the cytoplasm of AT and Artemis-deficient cells.
137 s of PHF1 and MTF2 with bound CpG-containing DNAs in the presence of H3K36me3-containing histone pept
138 crophages were more potent in uptaking tumor DNA, increase of DNA sensing by blocking the interaction
141 ange were determined by spiking B. anthracis DNA into individual PCR mixtures and B. anthracis CFU in
144 demonstrate that the ability of Lon to bind DNA is determined by its ATPase domain, that this bindin
146 high-throughput sequencing technology, where DNA is sheared into smaller pieces, sequenced, and then
147 fic and it requires only 50 mug of leukocyte DNA isolated from 2-3 mL of blood to accurately quantify
149 c D2 mice manifested increased mitochondrial DNA lesions (8-oxoguanine) exclusively localized to glom
150 , we monitored oxidatively induced clustered DNA lesions (OCDL), DNA double-strand breaks (DSB), apop
151 first quantitative human genome-wide map of DNA lesions induced by ultraviolet (UV) radiation, the u
153 ional coupling of recombination steps at the DNA level with specific organizational features of meiot
155 ct measurements on single nucleotides within DNA macromolecules, we demonstrate that the distance ove
157 ration of interstrand cross-links in genomic DNA may contribute to aging, neurodegeneration, and canc
159 Our model, which estimates age based on DNA methylation at 329 unique CpG sites, has a median ab
164 in human populations, and the examination of DNA methylation is becoming increasingly common in psych
165 ensitive enough to detect changes in genomic DNA methylation levels as a function of growth phase in
167 tigation of these DMRs revealed differential DNA methylation localized to a 600 bp region in the prom
168 ther, these data suggest that differences in DNA methylation may partly explain the enantioselectivit
169 T-IH or during recovery from LT-IH prevented DNA methylation of AOE genes, normalized the expression
170 vestigated the impact of genome-wide cardiac DNA methylation on global gene expression in myocardial
172 ed longitudinal changes of genome-wide blood DNA methylation profiles in relation to the development
174 ed liver to have a pattern of acquisition of DNA methylation targeted to candidate enhancers active i
175 ssment of one epigenetic mark in particular, DNA methylation, in human populations, and the examinati
178 not associated with causative changes in the DNA methylome, which appears relatively impervious to dr
184 ontaining >/=105 copies herpes simplex virus DNA/ml collected a median of 5 months apart (IQR: 2-11 m
188 plast genome that is composed only of linear DNA molecules is unprecedented among eukaryotes, and hig
189 this gap, we analyzed ancient mitochondrial DNA (mtDNA) from Scythians of the North Pontic Region (N
190 This was tested using a major mitochondrial DNA (mtDNA) survey and sequencing of two nuclear markers
193 d lead to fast and automated purification of DNA nanostructures of various shapes and sizes, which wo
197 e set of OL maturation genes and reduces the DNA occupancy of YY1, a transcription factor required fo
198 ost common non-standard nucleotides found in DNA of eukaryotic cells, with over 100 million rNMPs tra
201 ased diagnostic (CRISPR-Dx), providing rapid DNA or RNA detection with attomolar sensitivity and sing
203 ts demonstrate the potential synergy between DNA origami technology and colloidal science, in which t
211 owing infection with Listeria monocytogenes, DNA-PKcs-deficient murine macrophages produce reduced le
212 ditionally, Cu(II) chelated PyED outcompetes DNA polymerase I to successfully inhibit template strand
215 ning buffers, the concentration of detection DNA probe used in the preparation of FCN-DNA conjugates,
216 pad and the dispensing cycles of the capture DNA probes on the test-zone), the biosensor could detect
219 assay, based on random amplified polymorphic DNA (RAPD) analysis was developed for its efficient and
221 junction (HJ) is a hallmark intermediate in DNA recombination and must be processed by dissolution (
225 ts, we used somatic variants in hypermutable DNA regions to reconstruct high-confidence phylogenetic
226 lysis revealed pathways including apoptosis, DNA repair and early estrogen response that were differe
229 an apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expre
234 e is concomitant with defective ATM-mediated DNA repair signaling and accumulation of protein-linked
237 erdependent coupled oscillators and identify DNA replication as a critical process in the circadian m
239 ction between TopBP1 and Treslin and promote DNA replication despite the presence of a Cdk2 inhibitor
240 biogenesis and composition of the eukaryotic DNA replication fork, with an emphasis on the enzymes th
245 of both RECQL5 and WRN severely compromises DNA replication, accumulates genomic instability and ult
246 meiosis share many processes, including the DNA replication, chromosome condensation and precisely r
247 teins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases
249 ragment in complex with its cognate promoter DNA, revealing the molecular details of promoter recogni
251 utilizes RNA-functionalized AuNPs which form DNA-RNA heteroduplex structures through specific hybridi
252 d microcapillary into a lower ionic strength DNA sample reservoir induces spontaneous DNA migration a
253 re potent in uptaking tumor DNA, increase of DNA sensing by blocking the interaction of SIRPalpha wit
256 del without fitting parameters, with genomic DNA sequence being the only input, we further validate t
260 of G-quadruplexes formed by, e.g., telomeric DNA sequences, but are also interesting targets for supr
261 into the study of human genetic disease when DNA sequencing alone is not sufficient to reveal the und
262 ociated with somatic variations, advances in DNA sequencing indicate that cell-specific variants affe
264 We demonstrate that targeted next-generation DNA sequencing reactions and in situ point mutation dete
265 With the development of new high-throughput DNA sequencing technologies and decreasing costs, large
267 duction, with high-throughput 18 S ribosomal DNA sequencing to elucidate the relationship between euk
268 s in estuarine and marine environments using DNA-SIP and to characterise marine isoprene-degrading ba
269 gher levels of circulating mitochondrial (mt)DNA, soluble thrombomodulin (sCD141) and ICAM-1, reflect
272 an average ratio of 29.2% by targeting both DNA strands simultaneously with an over 98.6% coverage.
273 owerful weapons in the fight against foreign DNA, such as phages and plasmids, as well as a revolutio
274 ductase (MTHFR) gene, an enzyme essential in DNA synthesis and methylation, have been associated with
275 ctivity is required to activate compensatory DNA synthesis during mitosis and to resolve mitotic inte
279 A oligomer was synthesized in a conventional DNA synthesizer, containing neutral nucleotides with a m
280 se of nuclear factor kappa B (NFkappaB) from DNA target sites in a process we have termed molecular s
282 cific single-molecule analysis of replicated DNA technique, we found that depletion of FANCM dramatic
284 la pertussis Ptl systems support conjugative DNA transfer in E. coli and trigger P. aeruginosa T6SS k
288 ect ligand binding as blocking events during DNA unzipping, allowing determination of ligand selectiv
293 levels of dG-gx-dC and dG-gx-dA in leukocyte DNA were 1.94 +/- 1.20 and 2.10 +/- 1.77 in 10(8) normal
296 red to female MNX mice having FVB/NJ nuclear DNA with either FVB/NJ, C57BL/6J, or BALB/cJ mtDNA.
297 create NGS libraries from as little as 20 pg DNA with PCR error correcting capabilities, and capture
298 table labeling and monitoring of HIV genomic DNA within infected cells during cytoplasmic transit, nu
299 ing chip and the unpaired fragment of target DNA works as a trigger to initiate the nonlinear HCR, fo
300 nt-based methods, we show that the resulting DNA-wrapped carbon nanotubes can be further sorted to pr
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