ライフサイエンスコーパス: DNA adduct

1 and non-physiological barriers (for example, DNA adducts).

2 l II) stalled at a monofunctional pyriplatin-DNA adduct.

3 e is located to the 5' side of the cisplatin-DNA adduct.

4 oxyguanosine (N(2)-CEdG) as the major stable DNA adduct.

5 derstanding the human health consequences of DNA adducts.

6 nd repair, it is necessary to be able to map DNA adducts.

7 for the screening for both known and unknown DNA adducts.

8 in a manner distinct from that of cisplatin-DNA adducts.

9 e content, lipid peroxidation, and oxidative DNA adducts.

10 urther includes, among others, various bulky DNA adducts.

11 bles quantitative immunodetection of protein-DNA adducts.

12 by promoting accumulation of topoisomerase 1-DNA adducts.

13 of CP-TGGA compared to OX-TGGA and other Pt-DNA adducts.

14 dG residues in DNA to form aristolactam (AL)-DNA adducts.

15 toxicity vs. DNA of chemicals forming stable DNA adducts.

16 amino group of purine bases generating bulky DNA adducts.

17 ctive oxygen species and by the formation of DNA adducts.

18 UvrABC incisions of the bulky aminofluorene DNA adducts.

19 PC-RAD23B, failed to specifically bind to AL-DNA adducts.

20 sociated with the presence of detectable PAH-DNA adducts.

21 id reacts with DNA to form aristolactam (AL)-DNA adducts.

22 mainly responsible for removal of pyriplatin-DNA adducts.

23 ing algorithm can be used to detect putative DNA adducts.

24 ct to demonstrate the applicability to other DNA adducts.

25 dependent and sequence-specific formation of DNA adducts.

26 enal, which cause the formation of mutagenic DNA adducts.

27 n of persistent imidazole ring-opened AFB(1)-DNA adducts.

28 then can react with DNA to form carcinogenic DNA adducts.

29 ied DNA and, more frequently, when bypassing DNA adducts.

30 que DNA repair pathway that removes platinum-DNA adducts.

31 P450 enzymes in enzyme-DNA films to produce DNA adducts.

32 efficiency and also produce covalent pyrene-DNA adducts.

33 e of DNA-distorting damage such as cisplatin-DNA adducts.

34 tes to the accumulative pattern of cisplatin-DNA adducts.

35 e (N2-CEdG) is a major marker for AGE-linked DNA adducts.

36 o study the formation of endo- and exogenous DNA adducts.

37 , chromium stimulates the formation of B[a]P DNA adducts.

38 DNA-distorting lesions, including cisplatin-DNA adducts.

39 and can react with DNA in the films to form DNA adducts.

40 ull scan, was included for detecting unknown DNA adducts.

41 he development of technologies for detecting DNA adducts.

42 s influence the hPol eta-catalyzed bypass of DNA adducts.

43 revelation of the biological consequences of DNA adducts.

44 fter metabolic activation, with DNA to yield DNA adducts.

45 The DNA adduct 1,N(2)-etheno-2'-deoxyguanosine, with a large

46 pecific repair of lipid peroxidation-induced DNA adduct, 1, N(6)-ethenoadenine (epsilonA).

47 uniquely blocks excision repair of cisplatin-DNA adducts, 1,2-intrastrand cross-links, to potentiate

48 DNA templates modified with the carcinogenic DNA adducts, 2-aminofluoene (AF) or N-acetyl-2-aminofluo

49 cherichia coli AlkB dioxygenase of exocyclic DNA adducts 3,N(4)-ethenocytosine, 1,N(6)-ethenoadenine,

50 cts with DNA to form the aristolactam (AL-I)-DNA adduct 7-(deoxyadenosin-N(6)-yl) aristolactam I (dA-

51 to chemicals can result in the formation of DNA adducts, a molecular initiating event in genotoxin-i

52 , the mutagenic property of the primary AFB1-DNA adduct, AFB1-N7-Gua, in mammalian cells has not been

53 BaP forms covalent DNA adducts after metabolic activation and induces mutat

54 neo/neo) and Hus1(neo/Delta1) cells with the DNA adducting agent benzo(a)pyrene dihydrodriol epoxide

55 The preferential formation of AFB(1)-induced DNA adducts along the cII transgene was almost exclusive

56 PhIP-DNA adducts also were recovered quantitatively from form

57 The applications of mass spectrometry-based DNA adduct analysis for predicting the therapeutic outco

58 lopment of MS techniques on these fronts for DNA adduct analysis.

59 number of interface contacts between the Pt-DNA adduct and HMGB1a.

60 AH exposure, resulting in both increased PAH-DNA adducts and altered DNA methylation.

61 cleotide excision repair mechanism to repair DNA adducts and are sensitive to alkylating agents.

62 These small molecules also act as DNA adducts and coordinate with their DNA hosts.

63 Immunohistochemistry of LPAM-DNA adducts and damage was performed as surrogates for L

64 significantly reduces formation of aflatoxin-DNA adducts and decreases size and number of aflatoxin-i

65 There were 170 cases fully evaluable for DNA adducts and ERCC1 mRNA expression.

66 (in a subset), and quantified benzo[a]pyrene-DNA adducts and genomic DNA methylation in cord blood DN

67 our research on the biological processing of DNA adducts and how this may impact the observed product

68 s corresponding to metabolites known to form DNA adducts and initiate lung cancer (2.35 A) or with tw

69 teins have been demonstrated to bind to CDDP-DNA adducts and initiate MMR protein-dependent cell deat

70 s involved in the recognition of these bulky DNA adducts and initiates the global genomic nucleotide

71 nly be formed through dissociation of duplex DNA adducts and not by direct interaction of PBDs with s

72 Proteins that discriminate between cisplatin-DNA adducts and oxaliplatin-DNA adducts are thought to b

73 escribe the first structure of levuglandinyl-DNA adducts and provide the tools with which to evaluate

74 eta is essential for processing AFB1-induced DNA adducts and that, in its absence, cells do not have

75 We mapped the formation of acrolein-induced DNA adducts and the kinetics of repair of the induced le

76 A1 are required for both the removal of Top2-DNA adducts and the subsequent resection of Top2-adducte

77 es between RC-DNA and cellular topoisomerase-DNA adducts and their known repair by tyrosyl-DNA-phosph

78 eptor (AR) ligand, is known to form covalent DNA adducts and to induce apoptosis potently in AR-posit

79 Using AL-DNA adducts and TP53 mutation spectra as biomarkers, we

80 To determine whether platinum-DNA adducts and/or mRNA expression of the excision nucle

81 t process that leads to formation of the PBD-DNA adduct, and have allowed the preference of 3a for IC

82 ates consistent with measured soil PAHs, PAH-DNA adducts, and CO readings.

83 pol delta L606K is impaired in the bypass of DNA adducts, and the homologous variant in mouse embryon

84 chniques for the quantitative measurement of DNA adducts, and the use of LC-MS along with molecular b

85 on mechanism by MXY, which leads to covalent-DNA adducts; and (iv) the redox properties of the adduct

86 DNA adducts are a measure of internal exposure to genoto

87 Etheno DNA adducts are a prevalent type of DNA damage caused by

88 For nuclear genomes, cisplatin-DNA adducts are enriched within promoters and regions ha

89 These PAH-DNA adducts are established markers of cancer risk.

90 rtain DNA primary or secondary structures or DNA adducts are known to cause transcriptional pausing a

91 Their DNA adducts are known to exist in an equilibrium between

92 cDPCP-DNA adducts are removed by the nucleotide excision repai

93 research has revealed that pyrimidopurinone DNA adducts are subject to enzymatic oxidation in vitro

94 etween cisplatin-DNA adducts and oxaliplatin-DNA adducts are thought to be responsible for the differ

95 racterization of reactions in which covalent DNA adducts are transient intermediates.

96 data support that N(2)-CEdG, a minor-groove DNA adduct arising from MG, is an important endogenous s

97 However, the utility of a single DNA adduct as a biomarker in risk assessment is debatabl

98 However, the employment of DNA adducts as biomarkers in human studies is often rest

99 h form the same monofunctional-intercalative DNA adducts as the parent compounds, as demonstrated in

100 tabolites, estrogen conjugates, and estrogen-DNA adducts as well as exogenous steroid derivatives.

101 rmation rate measurements of major and minor DNA adducts as well as the metabolites themselves in <5

102 s well suited for processing other localized DNA adducts as well.

103 Control cells repaired 78% of platinum-DNA adducts at 12 h, compared with 33% repair in cells p

104 is specifically required for the removal of DNA adducts at sites of DNA breaks.

105 cation-dependent removal of Topo-isomerase I-DNA adducts at the step of strand cleavage, leading to s

106 lts in covalent methyltransferase-DNA (MTase-DNA) adducts at cytosine methylation sites.

107 Second, targeted detection of anticipated DNA adducts based on the reactivity of the DNA alkylatin

108 ues can serve as biospecimens for carcinogen DNA adduct biomarker research.

109 Because cisplatin-DNA adducts block RNA polymerase II unless removed by tr

110 that Y-family DNA polymerases tolerate large DNA adducts, but a substantial decrease in catalytic eff

111 says have been used for the analysis of many DNA adducts, but problems are frequently encountered in

112 a efficiently replicates past a minor groove DNA adduct by positioning the adducted base in the syn c

113 oindels are 'scars' from the bypass of large DNA adducts by a translesional polymerase, e.g. the 'Tar

114 ecent studies have demonstrated that various DNA adducts can be detected in human tissues and fluids

115 The DNA adducts can be used as biomarkers for studies of AA

116 Interstrand cross-linked (ICL) dG-MC-dG-DNA adducts can prevent strand separation.

117 This new theme in PAH DE-DNA adduct conformation differs from (1) the classical i

118 dent increase in 8-hydroxy-2'-deoxyguanosine DNA adducts consistent with cumulative ROS damage.

119 measures relative rates of DNA oxidation and DNA adduct damage.

120 a-OHPdG) is an endogenously formed mutagenic DNA adduct derived from lipid peroxidation.

121 In vivo, the predominant DNA adduct derived from metabolically activated benzo[a]

122 N(2)-yl)-1-aminopyrene (dG(1,8)), one of the DNA adducts derived from 1-NP, can be bypassed by Sulfol

123 We established a method to measure DNA adducts derived from 16 ubiquitous genotoxicants and

124 DNA adducts derived from AA-I and AA-II have been isolat

125 DNA adducts derived from carcinogenic polycyclic aromati

126 e used to simultaneously screen for multiple DNA adducts derived from different classes of carcinogen

127 NA adducts from archived tissue by measuring DNA adducts derived from four other classes of human car

128 ligned 10S (+)-trans-anti-B[a]P-N(2)-dG (G*) DNA adduct, derived from the environmental carcinogen be

129 Wide-SIM/MS(2) successfully detected DNA adducts, derived from chemicals in the diet and trad

130 he relative stability of single-stranded PBD/DNA adducts despite a complete loss of minor groove stru

131 igarette smoking increases oxidative damage, DNA adducts, DNA strand breaks, chromosomal aberrations,

132 is432Arg forms an observable and unique Tdp1-DNA adduct during catalysis.

133 of the toxic and mutagenic properties of the DNA adduct EA have been limited to in vitro experiments

134 ) and Csb(-/-) mice fail to remove cisplatin-DNA adducts efficiently in vitro; and unlike Xpc(-/-) mi

135 ication forks initially encountering a bulky DNA adduct exhibit a dual nature of stalling: a checkpoi

136 first quantitative analysis of DEB specific DNA adducts following low ppm and subppm exposure to BD.

137 tion of a covalent phosphoramidate histidine-DNA adduct for cell-to-cell transfer.

138 s, NO-aspirin 2 inhibited [3H]benzo[a]pyrene-DNA adduct formation and DNA damage elicited by TCDD or

139 base for dichloromethane genotoxicity (i.e., DNA adduct formation and gene mutations in target tissue

140 exposures to aflatoxin (AFB1) and subsequent DNA adduct formation being a significant driver.

141 xogenous FA causes only a modest increase in DNA adduct formation compared with the amount of adducts

142 The method can be applied to compare AA-DNA adduct formation in cells and tissues.

143 ar uptake, aqueous reactivity, and extent of DNA adduct formation in the A2780 ovarian carcinoma cell

144 with which to evaluate the potential for LG-DNA adduct formation in vivo.

145 does not induce p53R2, suggesting that DNMT/DNA adduct formation is the molecular trigger for p53R2

146 Experimental evidence suggests that PAH-DNA adduct formation may preferentially target methylate

147 n for 11beta, which supplements conventional DNA adduct formation to promote cancer cell death.

148 ytotoxicity, cDDP cellular accumulation, and DNA adduct formation was compared in the CLDN3- and CLDN

149 brane potential and terminating in oxidative DNA adduct formation, DNA strand breakage, and cell deat

150 Despite DNA adduct formation, localized fork stalling was abroga

151 abricated to measure reactive metabolite and DNA-adduct formation rates relevant to genotoxicity scre

152 hydroperoxide was responsible for endogenous DNA-adduct formation.

153 may be the case with ethano-adenine (EA), a DNA adduct formed by an important anticancer drug, BCNU,

154 8-Halogenated guanine (haloG), a major DNA adduct formed by reactive halogen species during inf

155 inobiphenyl (dG-C8-ABP), the predominant ABP-DNA adduct formed in bladder cells and tissues, was mark

156 s genome integrity by hydrolyzing 5'-tyrosyl DNA adducts formed by abortive topoisomerase II (Top2) c

157 The DNA adducts formed by the 1-NP metabolites stall replica

158 ance by catalyzing the replicative bypass of DNA adducts formed by the widely used chemotherapeutic a

159 known nucleotide composition and analysis of DNA adducts formed from chemically diverse AAs in vitro.

160 re exceptionally bulky, structurally diverse DNA adducts formed in cells upon exposure to endogenous

161 the efficacy of our method for retrieval of DNA adducts from archived tissue by measuring DNA adduct

162 latin, consistent with shielding of platinum-DNA adducts from excision repair.

163 Preferential repair of bulky DNA adducts from the transcribed genes via nucleotide ex

164 ite the chemically different nature of their DNA adducts, further supporting a role for monofunctiona

165 is the most common method for biomonitoring DNA adducts, generally targeting single exposures and me

166 However, the genomic pattern of cisplatin-DNA adducts has remained unknown owing to the lack of a

167 However, no exogenous formaldehyde-induced DNA adducts have been detected in animals after inhalati

168 Specifically, aristolactam-DNA adducts have been found in renal tissues and urothel

169 These DNA adducts have been shown to block DNA replication by

170 rcinogens derived from cooked meats, such as DNA adducts, have not been identified in human samples t

171 t increase in the 4-oxo-2(E)-nonenal-derived DNA-adduct, heptanone-etheno-2'-deoxyguanosine (Hepsilon

172 , the chemical constitution of the retrieved DNA adducts hint at a direct link with an increase in NO

173 at a site-specific monofunctional pyriplatin-DNA adduct in the active site.

174 NA helicases are inhibited by bulky covalent DNA adducts in a strand-specific manner.

175 It can be used to detect topoisomerase 1-DNA adducts in as little as 60 ng of DNA, corresponding

176 unknown PR104A-induced mono and cross-linked DNA adducts in biological samples.

177 MGMT homeostasis and DNA repair of alkylated DNA adducts in cells.

178 s and accurate measurements of the levels of DNA adducts in cellular and tissue DNA constitute the fi

179 Studies showed that levels of ethylated DNA adducts in certain tissues and urine are higher in s

180 Finally, we detected both DNA adducts in colon tissue of a mouse orally treated wi

181 that a broad spectrum of combustion-related DNA adducts in cord blood was associated with attention

182 TDP1 removes covalent 3'DNA adducts in DNA single-strand break repair.

183 Top2a-DNA adducts in human cells, and gyrase-DNA adducts in Escherichia coli.

184 s of binding of PARP-1 to different platinum-DNA adducts in greater detail, biotinylated DNA probes c

185 ts the interpretation that formation of AFB1-DNA adducts in hepatocytes seeds a population of mutatio

186 ed RADAR assay can detect Top1-DNA and Top2a-DNA adducts in human cells, and gyrase-DNA adducts in Es

187 potentially carcinogenic N(2)-deoxyguanosine DNA adducts in human cells.

188 antification of glyoxal-derived cross-linked DNA adducts in human leukocyte DNA and their association

189 used for the simultaneous analysis of the 16 DNA adducts in human lung biopsy specimens.

190 here are no previous reports of formaldehyde-DNA adducts in humans.

191 019 causes interstrand cross-links and bulky DNA adducts in mammalian cell lines.

192 rescence-based assay for the detection of AA-DNA adducts in multiple samples.

193 ns between a DNA polymerase and carcinogenic DNA adducts in real-time by single-molecule fluorescence

194 m (after metabolic activation) pro-mutagenic DNA adducts in renal tissue.

195 this neuropathy correlates with formation of DNA adducts in sensory neurons, growing evidence suggest

196 Second, we demonstrated both DNA adducts in target cells (Salmonella typhimurium TA10

197 cally inhibits repair of the major cisplatin-DNA adducts in TGCT cells by using the human TGCT excisi

198 chemicals, by simultaneously detecting their DNA adducts in the genome; some of which may induce canc

199 Several anticancer agents that form DNA adducts in the minor groove interfere with DNA repli

200 Immunodotblot determination of DNA adducts in the overall genome of AFB(1)-exposed cell

201 we identified dA-aristolactam (AL) and dG-AL DNA adducts in the renal cortex of patients with EN but

202 and G, to form premutagenic cyclic covalent DNA adducts in vitro and in vivo.

203 od crops (e.g., broccoli and cabbage), forms DNA adducts in vitro and is mutagenic to bacterial and m

204 sible for the generation of the HepsilondGuo DNA-adduct in CESS cells.

205 n was associated with increased formation of DNA adducts, increased apoptosis, and intracellular sign

206 To identify the mechanisms by which bulky DNA adducts induce damage signaling, we developed an in

207 ide-based DNMT inhibitors that form covalent DNA adducts induce p53R2 expression.

208 e genome for 8-oxoguanine, a major mutagenic DNA adduct induced by reactive oxygen species, and catal

209 loped to investigate anticipated and unknown DNA adducts induced by DNA alkylating agents in biologic

210 s mismatched nucleotides but also recognizes DNA adducts induced by DNA-damaging agents, and triggers

211 cted to be a powerful tool for screening for DNA adducts induced by endogenous or exogenous exposures

212 ed the processing of topoisomerase II (Top2)-DNA adducts induced by treatment with the chemotherapeut

213 The transient enzyme/DNA adduct is mediated by a phosphodiester bond between

214 Monitoring urinary levels of DNA adducts is one approach to assess genomic exposure t

215 ), which covalently bind to DNA to form drug-DNA adducts, is linked to their recognition by repair pr

216 a positive correlation was observed between DNA adduct levels and cell sensitivity to AF.

217 net accumulation of platinum (Pt) and the Pt-DNA adduct levels were reduced in CLDN3KD and CLDN4KD ce

218 ould significantly advance studies regarding DNA adduct levels, which are extremely difficult to dete

219 In mammalian cells, bulky DNA adducts located in the template but not the coding s

220 of the deoxyribose (dR) from the protonated DNA adducts ([M + H - 116]+) in the MS/MS scan mode trig

221 and quantification of both known and unknown DNA adducts, mass spectrometry (MS) is deemed to be the

222 If not repaired, DNA adducts may compromise cellular functions by blockin

223 to retrospectively analyze FFPE tissues for DNA adducts may provide clues to the origin of human can

224 For example, protein-DNA adducts must be removed to allow repair by either no

225 ss spectrometry to quantify the formaldehyde-DNA adduct N(6)-hydroxymethyldeoxyadenosine (N(6)-HOMe-d

226 dA in a DNA duplex, the prototype arylamine-DNA adduct [N-(2'-deoxyguanosin-yl)-7-fluoro-2-aminofluo

227 slesion DNA synthesis past the pro-mutagenic DNA adduct O(6)-benzylguanine (O(6)-BnG).

228 nucleotide has been demonstrated for a model DNA adduct O(6)-benzylguanine by a DNA polymerase.

229 ly higher concentrations of the NOC-specific DNA adduct O(6)-carboxy-methylguanine when pork underwen

230 Indeed, the toxic and mutagenic DNA adduct O(6)-carboxymethylguanine (O(6)-CMG) is frequ

231 Among the ethylated DNA adducts, O(2)-ethylthymidine (O(2)-edT) and O(4)-eth

232 ication of this method to the synthesis of a DNA adduct of a complex natural product.

233 The DNA adduct of PhIP, N-(deoxyguanosin-8-yl)-PhIP (dG-C8-P

234 However, the DNA adducts of 1 are removed from repair systems with lo

235 Recently, our laboratory reported that DNA adducts of aristolochic acid, a carcinogenic compone

236 We report here that DNA adducts of aristolochic acids (AAs) can be measured

237 In this study, DNA adducts of biological relevance, O(6)-methylguanine

238 S) was employed to simultaneously screen for DNA adducts of environmental, dietary, and endogenous ge

239 ve nano-LC-Orbitrap MS (n) method to measure DNA adducts of several carcinogens originating from well

240 an hepatocytes treated with 4-ABP, and three DNA adducts of the cooked-meat carcinogen 2-amino-3,8-di

241 Five DNA adducts of the tobacco carcinogen 4-aminobiphenyl (4

242 results indicate that structurally different DNA adducts of these platinum complexes exhibit a differ

243 e duplexes containing kappaB site damaged by DNA adducts of three platinum complexes.

244 ll DNA from tobacco smokers was screened for DNA adducts of various classes of carcinogens in tobacco

245 cular epidemiologic studies, measurements of DNA adducts often are precluded by the unavailability of

246 Cells defective in repairing (6-4) Py:Py DNA adducts or processing DNA crosslinks are extremely s

247 dihydro-2'-deoxyguanosine (oxoG) is a common DNA adduct produced by the oxidation of DNA by reactive

248 major mutagenic, carcinogenic and cytotoxic DNA adduct produced by various endogenous and exogenous

249 ne (N(2),3-epsilonG) is one of the exocyclic DNA adducts produced by endogenous processes (e.g. lipid

250 reactive oxygen species or recognize damaged DNA adducts promote infection, suggesting that H. pylori

251 To our knowledge, this is the most sensitive DNA adduct quantitation method yet reported, exceeding t

252 This new 'RADAR' (rapid approach to DNA adduct recovery) assay accelerates processing time 4

253 DNA adducts reflect the internal exposure to genotoxican

254 Platinum-DNA adduct repair was assessed by atomic absorbance spec

255 , and that Gli1 strongly influences platinum-DNA adduct repair, and cellular sensitivity to cisplatin

256 DNA adducts represent internal dosimeters to measure exp

257 s tested and optimized using a mixture of 18 DNA adducts representing a range of biologically relevan

258 Replicative bypass of cisplatin DNA adducts requires the cooperative actions of at least

259 These advancements in the technology of DNA adduct retrieval from FFPE tissue clear the way for

260 rized herein as a basis for potential future DNA adduct sequencing technologies.

261 g pregnancy as well as by the measurement of DNA adducts specific to benzo[a]pyrene (BaP), a represen

262 t with nucleobases to give carboxymethylated DNA adducts such as N3-carboxymethylthymidine (N3-CMdT)

263 he main pathway used for the repair of bulky DNA adducts such as those caused by UV light exposure an

264 lein reacts with DNA bases forming exocyclic DNA adducts, such as gamma-hydroxy-1,N(2)-propano-2'-deo

265 esterase I (Tdp1) catalyzes the repair of 3'-DNA adducts, such as the 3'-phosphotyrosyl linkage of DN

266 mokers in levels of a leukocyte formaldehyde-DNA adduct, suggesting a potentially important and previ

267 merases are more efficient at bypass of many DNA adducts than replicative polymerases.

268 thylguanine (O(6)-MeG) is a highly mutagenic DNA adduct that forms in human genomic DNA upon reaction

269 is then degraded on DNA, yielding a peptide-DNA adduct that is bypassed by CMG.

270 urfuryl-deoxyguanosine (fdG) is carcinogenic DNA adduct that originates from furfuryl alcohol.

271 minofluorene (NA-AAF), which generates bulky DNA adducts that block RNA polymerase movement.

272 h a stable A.T base pair to create alkylated DNA adducts that can be removed by alkyladenine DNA glyc

273 ncodes an enzyme that hydrolyzes 5'-tyrosine-DNA adducts that mimic abortive Top2cc.

274 NA polymerases are unable to synthesize past DNA adducts that result from diverse chemicals, reactive

275 This method is based on the RADAR assay for DNA adducts that we previously developed, but incorporat

276 to create vectors containing a site-specific DNA adduct, the mutagenic potential was determined in pr

277 Binary Cr-DNA adducts, the most abundant form of Cr-DNA damage, we

278 : a nucleophilic His (His(nuc)) that attacks DNA adducts to form a covalent 3'-phosphohistidyl interm

279 the polycyclic aromatic hydrocarbon-derived DNA adducts (+)-trans-anti-B[a]P-N(6)-dA, which is subje

280 The study of DNA adduct types and levels in human tissue therefore of

281 he DNA adductome; the levels of 22 different DNA adduct types significantly increased upon the consum

282 to occluded DNA ends by removing Ku or other DNA adducts via an Mre11-dependent nucleolytic reaction.

283 ase D superfamily that hydrolyzes 3'-phospho-DNA adducts via two conserved catalytic histidines-one a

284 s and a replicating plasmid bearing a single DNA adduct was developed.

285 ial nucleotide opposite an O(6)-alkylguanine DNA adduct was verified using a novel 2',3'-dideoxy deri

286 o studies demonstrating the formation of MMC-DNA adducts, we chose to investigate alternative nucleic

287 d3-related (ATR) is also stimulated by bulky DNA adducts, we conclude that a common biochemical mecha

288 Potential predictors of BPDE-DNA adducts were evaluated by stratification and multiva

289 (deoxyguanosin-8-yl)-AalphaC (dG-C8-AalphaC) DNA adducts were formed in hepatocytes.

290 The induced acrolein-DNA adducts were moderately resistant to DNA repair.

291 AL-DNA adducts were present in the renal cortex of 83% of p

292 chemicals to DNA results in the formation of DNA adducts which are reflective of exposure of the huma

293 multaneous mass spectrometric analyses of 16 DNA adducts, which can be easily extended by adducts for

294 lymerases discriminate between CP- and OX-GG DNA adducts, which could partly account for differences

295 l cellular defense system against carcinogen-DNA adducts, which, if not repaired, can initiate cancer

296 Quantification of oxidative DNA adducts with (32)P-postlabeling also revealed genoty

297 method, we measured the levels of the three DNA adducts with the use of 10 mug of DNA isolated from

298 binding protein domain HMGB1a binds to CP-GG DNA adducts with up to 53-fold greater affinity than to

299 ts for the possible interactions of platinum DNA adducts with zinc finger proteins, the complexes [Pt

300 ective, we focus on the analysis of multiple DNA adducts within a sample with the emphasis on untarge