ライフサイエンスコーパス: DNA content

1 ntiated by changes in mitochondrial mass and DNA content.

2 based on their greater than 6N (termed 6N+) DNA content.

3 n a parABI-deleted strain also increased the DNA content.

4 ithin the cell cycle based on its length and DNA content.

5 ermine nuclear size to a greater extent than DNA content.

6 rates per protein regardless of the cellular DNA content.

7 megakaryocytes and erythroblasts had normal DNA content.

8 chromatin compaction rather than changes in DNA content.

9 increases are not caused by a higher nuclear DNA content.

10 elements comprising roughly 11% of its total DNA content.

11 ndent manner, and resulted in cells with >4N DNA content.

12 ell density was determined by measurement of DNA content.

13 easily correlate to numbers of parasites or DNA content.

14 ic failure and accumulation of cells with 4n DNA content.

15 c release, nuclear fragmentation, and sub-G1 DNA content.

16 The primary endpoint was median %5-mC DNA content.

17 vity, cardiolipin content, and mitochondrial DNA content.

18 ve sequenced legume plastid genomes in novel DNA content.

19 to an accumulation of cells with a G(0)/G(1) DNA content.

20 nt the propagation of cells with an abnormal DNA content.

21 ct polymorphisms present at <1% of the total DNA content.

22 esults in cell filamentation, with polyploid DNA content.

23 growth conditions that alter cell volume and DNA content.

24 dramatic increase in megakaryocyte size and DNA content.

25 s that include heterochromatin or repetitive DNA content.

26 hable from those of WT but were deficient in DNA content.

27 ogenase, PGC1alpha, CoxII, and mitochondrial DNA content.

28 -EGF shedding --> EGFR --> ERK --> increased DNA content.

29 in ERK phosphorylation, HB-EGF shedding, and DNA content.

30 essed by DNA/wet weight of brain and protein/DNA content.

31 DNA flow cytometry was used to measure DNA content.

32 uo2 arrest in prometaphase of PMII with a 2C DNA content.

33 of mitotic cells with characteristic G(2)/M DNA content.

34 d an accumulation of mammalian cells with 4N DNA content.

35 hypertrophy before a change in cell size and DNA content.

36 L) assay and by flow cytometric analysis for DNA content.

37 analysis shows an extensive heterogeneity in DNA content.

38 , and resulted in cell-cycle arrest with 4 N DNA content.

39 ondrial metabolic activity and intracellular DNA content.

40 reak compared with those with larger nuclear DNA content.

41 lyploidy is defined as an increase in genome DNA content.

42 the proportion of cells with >4 C-value (C) DNA content.

43 ging properties of the cell such as size and DNA content.

44 ons in nuclear size occur without changes in DNA content.

45 hotgun sequencing reads) of their respective DNA content.

46 on both cellular DNA replication and nuclear DNA content.

47 e measured intensities essentially reflected DNA content.

48 s using flow cytometric analysis of cellular DNA content.

49 s, rather than a general response to altered DNA content.

50 tidylserine externalization, and hypodiploid DNA content.

51 (-70%) or overestimation (+160%) of species DNA contents.

52 structions of chromosome numbers and nuclear DNA contents.

53 -deficient horizontal cells display elevated DNA content (5N-34N) that varied continuously, suggestin

54 ls with an abnormal morphology and increased DNA content accumulated.

55 le the first provides information on nuclear DNA contents across land plants and some algal groups, t

56 orometric analysis of sub-G(0)-G(1) cellular DNA content after 24-h exposure.

57 but greater T cell receptor-excision circle DNA content after 48 weeks, despite similar virologic re

58 chondrial numbers per cell and mitochondrial DNA content, all of which increased after exposure to NO

59 ng a high proportion of cells with a haploid DNA content, an unprecedented state for trypanosomes.

60 interrogate larger cell populations by using DNA content analyses, a surprising result was obtained:

61 ay was verified using a molecular marker and DNA content analyses.

62 ase-pulse experiments with BrdU and EdU, and DNA content analysis indicate that uhrf1 mutant cells un

63 Detection of NH-MM DNA content and >/=1% PCs in S-phase were of independent

64 a quiescent G0 state, characterized by a 2N DNA content and a lower RNA content than G1 cells.

65 e maturation was verified by the increase in DNA content and adhesion to extracellular matrix protein

66 e (AD) neurons characterized by increases in DNA content and amyloid precursor protein (APP) gene cop

67 proliferating cells and display increases in DNA content and apoptosis, as well as mitotic spindle de

68 Myocytes show a diploid DNA content and carry, at most, two sex chromosomes.

69 lls results in dramatic increases in nuclear DNA content and cell and nucleolar size, whereas dMnt ov

70 Amphibian genomes differ greatly in DNA content and chromosome size, morphology, and number.

71 To more accurately estimate whole-genome DNA content and compare these estimates to newly assembl

72 and arrested cells have similar patterns of DNA content and cyclin expression, a large fraction of t

73 , and by combining it with detection of both DNA content and DNA replication, this method allows uneq

74 monstrated that there were increased triplex DNA content and double-stranded breaks in ChlR1-depleted

75 Mitochondrial DNA content and expression of genes involved in multiple

76 n the G(2)/M phase of the cell cycle with 2N DNA content and frequently contain only a single nucleus

77 brid cells that maintain a stable tetraploid DNA content and have morphology, growth rate, and antige

78 cts fundamental cellular properties, such as DNA content and intracellular localization.

79 rated that hYVH1 expression affects cellular DNA content and is a novel cell survival phosphatase pre

80 Further, DNA content and messenger RNA expression of osteogenic (

81 to examine the cell and nucleoid morphology, DNA content and metabolic activity.

82 ell cycle progression resulting in increased DNA content and multinucleation.

83 A diploid DNA content and only two chromosomes 12 were found in ne

84 mely variable and undergo dynamic changes in DNA content and organization.

85 We analyzed the DNA content and proliferation index of bone marrow plasm

86 o increases the proportion of cells with >4C DNA content and promotes repeat mutagenesis.

87 Here we demonstrate label-free prediction of DNA content and quantification of the mitotic cell cycle

88 as determined by flow cytometry analysis of DNA content and quantitation of the proportion of cells

89 were associated with decreased mitochondrial DNA content and reduced expression of mitochondria-encod

90 as also accompanied by reduced mitochondrial DNA content and reduced mitochondrial mRNA.

91 eration, reduced the number of cells with 4n DNA content and rescued expression of FoxM1 target genes

92 e bypassed so that the cell can increase its DNA content and size.

93 ed predominantly of myocytes with 2n diploid DNA content and that tetraploid and octaploid nuclei con

94 , short DNA fragment lengths, low endogenous DNA content and the potential for modern contamination.

95 w that isogenic, isotypic cells of identical DNA content and the same cell-cycle phase can still disp

96 rrangements that explain a rapid increase in DNA content and trigger breakage-fusion-bridge cycles.

97 low sorting of single nuclei on the basis of DNA content and whole-genome amplification (WGA); this i

98 melanoma cells is correlated with increased DNA content and, reciprocally, that the least reactive c

99 ts deletion gave rise to cells with aberrant DNA contents and increased volumes.

100 iochemical (collagen, glycosaminoglycan, and DNA content) and biomechanical (tensile and compressive)

101 sly measure the phagocytic index, macrophage DNA content, and 5-ethynyl-2'-deoxyuridine (EdU) incorpo

102 increase in exocrine pancreas size, protein/DNA content, and acinar proliferation were all blocked i

103 The arrested cells have a 4N DNA content, and addition of caffeine causes immediate e

104 d by increased annexin V staining, decreased DNA content, and appearance as assessed by transmission

105 ctivity, Mitotracker staining, mitochondrial DNA content, and cellular oxygen respiration.

106 ases mitochondrial biogenesis, mitochondrial DNA content, and glucose uptake in subcutaneous adipose

107 They also exhibit aberrations in morphology, DNA content, and growth characteristics compared with WT

108 viability, causes cell cycle arrest with 4N DNA content, and leads to apoptosis.

109 or absence of LPD, surface maker expression, DNA content, and microsatellite polymorphisms, 74 had di

110 sess mitochondrial morphology, mitochondrial DNA content, and mitochondrial enzyme activities.

111 component cardiolipin, of the mitochondrial DNA content, and of the mitochondrial DNA replication an

112 mors, flow-sorting genomic subpopulations by DNA content, and profiling genomes using comparative gen

113 cells (binding of 31 antibodies, viability, DNA content, and relative cell size).

114 onse, exhibited an increase in mitochondrial DNA content, and required oxidative phosphorylation to m

115 cellular volume, even with the same absolute DNA content, and so must compensate for differences in D

116 tochondrial enzyme activities, mitochondrial DNA content, and the number and size of mitochondria.

117 f photosynthetic pigments and polyphosphate, DNA content, and the rate of translation.

118 y (approximately 9 kb/gene) and lower repeat DNA content (approximately 13.1%) in Brachypodium when c

119 features of transporter activity as well as DNA content are determinants of SP/NSP identity.

120 d or polytene cells, which have more than 2C DNA content, are widespread throughout nature and presen

121 Cells with abnormal DNA content arose in the population, and replication was

122 Embryos with DNA contents around this value show intermediate cell cy

123 hac1Delta spore clones contain a diploid DNA content as determined by fluorescence-activated cell

124 es of endoreduplication, with some attaining DNA contents as high as 96C and 192C.

125 idy (state of abnormal chromosome number and DNA content) at the next mitosis since extra centrosomes

126 mmediately arrested cells at a status of 4 N DNA content, B19V-infected 4 N cells still incorporated

127 Genes can be mutated by altering DNA content (base changes) or DNA length (insertions or

128 DNA content based flow sorting of tumor cells followed b

129 We applied DNA content-based flow sorting to identify and isolate t

130 death, such as an increase in cells with 4N DNA content before the appearance of cells with <2N DNA

131 uncover substantial differences in regional DNA content between inbred strains of mice.

132 Its outputs permit estimation of DNA content between mapped loci and help to create an in

133 DCV)" characterized by an increased range of DNA content both in cell populations and within single c

134 requires the precise duplication of cellular DNA content but also of membranes and organelles.

135 that myofiber transcription is responsive to DNA content but uncoupled from cell size during hypertro

136 o morphology, major structural proteins, and DNA content but were noninfectious.

137 in embryos increased postnatal day 10 brain DNA content by 28%, suggesting a role for IGF-1 in brain

138 The detection of changes in nuclear DNA content by correlating color recovery of H2B::mEosFP

139 ovel method to measure the relative telomere DNA content by dot blot analysis.

140 Analysis of their DNA content by flow cytometry, as well as chromosome cou

141 aging of individual cells by measuring their DNA content by fluorescence microscopy.

142 ring of endocycles results in higher nuclear DNA content (C value) that in some cases has been correl

143 ls and that an increase in human-specific L1 DNA content can be detected in the brains of normal cont

144 s in vitro by annexin V staining, subdiploid DNA content, caspase activation, and loss of mitochondri

145 VDase) activity and by measuring nucleosomal DNA content (cell death ELISA).

146 tively understanding the relationships among DNA content, cell size, and gene expression variability

147 f the host plant, had deoxyribonucleic acid (DNA) contents, cellular sizes and survival rates similar

148 duplication events that fundamentally alter DNA content, chromosome number, and gene dosage.

149 of data representing cellular doubling time, DNA content, chromosome number, metacentric chromosome f

150 d-NudC-infected PC-3 cells have a G2/M-phase DNA content compared to about 16-19% in Ad-Luciferase (A

151 ta1 scaffolds exhibited a trend of increased DNA content compared with unstimulated EPC scaffolds.

152 ncreased number of centrosomes and increased DNA content, compared to Tsc1(+/+) cells.

153 G1/S boundary were slower to reach full G2/M DNA content, consistent with a delay in S phase.

154 Flow cytometry revealed an increased 4N DNA content, consistent with a G2 arrest.

155 rofile whereby a majority of cells have a 4N DNA content, consistent with the onset of G2 arrest.

156 This variation in DNA content correlates with effective population size, s

157 ed the ability to proliferate with increased DNA content despite the presence of functional p53.

158 increased number of cells with more than 4N DNA content, detected in the absence of p53, suggesting

159 DNA content distribution histograms showed S-phase block

160 mutants exit macronuclear S with a wild-type DNA content, division of the amitotic macronucleus is bo

161 nts to show that a 16-fold change in nuclear DNA content does not influence the relative size of the

162 The DNA content, epitope 846, COL2(IX), and the denaturation

163 d that the arrest of cells with a particular DNA content equivalent to that in cells in the G1 phase

164 ents and quantitative PCR (qPCR) of telomere DNA content, expressed as the ratio of telomeric product

165 ing, fluorescence in situ hybridization, and DNA content flow cytometry.

166 uces the accumulation of cells with > or =4N DNA content, followed by cell death.

167 arrest, a medium hypomorph arrested with 4N DNA content, followed later by apoptosis, and a strong P

168 ncreatic mass were paralleled by protein and DNA content following camostat feeding and rapamycin adm

169 ting (disassembly) of NCs to expose their RC DNA content for conversion to CCC DNA.

170 of endoreplication, and blt mutants uncouple DNA content from morphogenesis in mutants with increased

171 train becomes predominantly unbudded with 1N DNA content (G1 arrest), whereas gcr1delta cln1delta cln

172 d results in the endoreduplication (cellular DNA content >4N) of MCF-7 and MDA MB-231 cells.

173 Finally, changes in repetitive DNA content, guanine-cytosine isochore structure, and nu

174 Telomere length/DNA content has been measured in epidemiological/clinica

175 absence of detectable increases in cellular DNA content however, it has been difficult to directly d

176 t, and arrested in a G(1)-like state with 4N DNA content in a p53-dependent manner.

177 Analysis of repeat DNA content in BESs revealed that approximately 15.42% o

178 tosine (%-5hmC) and 5-methylcytosine (%-5mC) DNA content in blood collected at birth (n=306), early c

179 sed device is sufficient to measure cellular DNA content in both fixed and living tumor cells.

180 cle cells, which attain an inappropriate 32C DNA content in both Rbf1 and Dp mutants but not in E2f2

181 ulted in the accumulation of abnormally high DNA content in cells over time (hyperploid).

182 The DNA content in cells sorted by fluorescent tissue-specif

183 progenitor cell proliferation and a reduced DNA content in endoreduplicating trophoblast giant cells

184 link in coordinating cell shape and nuclear DNA content in endoreplicated Arabidopsis trichomes.

185 th regard to measurements of telomere length/DNA content in epidemiological/clinical circumstances.

186 idium homodimer-2) to detect both lipoid and DNA content in individual particles.

187 ization and estimation of changes in nuclear-DNA content in live cells during their development has n

188 hosphorylation, and longer term increases in DNA content in mesangial cells.

189 s were utilized to demonstrate that aberrant DNA content in RB-deficient cells occurs concomitantly w

190 Myofibers increase size and DNA content in response to a hypertrophic stimulus, thus

191 cells, FANCJ-null (FA-J) cells accumulate 4N DNA content in response to DNA interstrand crosslinks (I

192 To scan for gene and repeat DNA content in the libraries, end-sequencing was perform

193 Whole-genome duplication (WGD) doubles the DNA content in the nucleus and leads to polyploidy.

194 ed by Western blot comparison with the viral DNA content in the tumors.

195 umber of cells is lower than normal, and the DNA content in these cells is significantly increased.

196 have focused on measurements of the relative DNA content in tumor cells compared to normal cells and

197 omes with similar methylation and repetitive DNA content, including those from crops and mammals.

198 On average, DNA content increased by approximately 250 megabases, of

199 evidenced by accumulation of cells with 4 n DNA content, increased mitotic index, separated centroso

200 lei displayed large variability with average DNA content increases of ~8% over non-diseased controls

201 ith flow cytometric determination of nuclear DNA content indicated near perfect agreement between the

202 leads to the accumulation of cells that have DNA content intermediate to 2N and 4N in proliferating t

203 disassembly (uncoating) to deliver their RC DNA content into the host cell nucleus for conversion to

204 potential (DeltaPsi(m) loss) in relation to DNA content is also demonstrated.

205 e cell cycle even in 2-cell embryos when the DNA content is increased.

206 In each dot, the DNA content is measured by a DNA stain (Dx) and the telo

207 asured by a DNA stain (Dx) and the telomeric DNA content is measured with a telomeric probe (T).

208 k of correlation between guard cell size and DNA content, lack of arabinans in cell walls, and perpet

209 NA, which showed mitotic progression with 4N DNA content leading to mitotic catastrophe after abrogat

210 ty of detectable transcripts, an increase in DNA content led to a proportional increase in mRNA.

211 ors resulted in accumulation of MKs with low DNA content levels and significant reduction of higher p

212 known ploidy status either by karyotyping or DNA content measurement using flow cytometry.

213 DNA content measurement, real-time polymerase chain reac

214 a, NRF-1, Tfam and CytC genes, mitochondrial DNA content, mitochondrial activity and mitochondrial me

215 ism measures the ratio of cellular volume to DNA content, most likely through sequestration of a tran

216 ; instead, the twofold overall difference in DNA content must reflect locally operating forces betwee

217 sation achieved can be judged by the uniform DNA content, narrow size distribution, synchronous divis

218 ontrast to the twofold overall difference in DNA content, no disparity in size was observed for this

219 ycle pause in Drosophila is about 70% of the DNA content normally present at cycle 14.

220 The typical increase in myofiber DNA content observed at the later stage of hypertrophy w

221 ed next generation sequencing to analyze the DNA content of ALT telomeres.

222 homes, which are single cells with a nuclear DNA content of approximately 16C to 32C.

223 rise to ventral cord neurons with an average DNA content of approximately 2.5 n.

224 The DNA content of dnaE mutants increased about eightfold in

225 chromosome rearrangements to manipulate the DNA content of embryos, we determined that the threshold

226 d reduced by half the mean C-value and total DNA content of endosperm nuclei.

227 n, that constitute a large percentage of the DNA content of eukaryotic genomes.

228 The DNA content of eukaryotic nuclei (C-value) varies approx

229 e same method is effective in predicting the DNA content of fission yeast, it is likely to have a bro

230 was present between H(f), and the repetitive DNA content of five eukaryotic genomes previously determ

231 The DNA content of mature endosperm increased 43% upon RBR1

232 The DNA content of mature stalk cells suggests that they als

233 Unexpectedly, the DNA content of methylglyoxal-derived imidazopurinone and

234 To determine how the DNA content of one nucleus is communicated to the other,

235 xpression of DN-HSF1 dramatically alters the DNA content of PC-3 cells (derived from p53 null prostat

236 asured by [3H]thymidine incorporation and by DNA content of the cultures.

237 Analysis of the DNA content of the mutant neurons indicates that defecti

238 eightfold in 4 h at 40 degrees C, as did the DNA content of the suppressed strains.

239 vesicle cytokine responses, whereas the CpG DNA content of vesicles did not.

240 on phenotype of seqA mutants and reduced the DNA content of wild-type strains; virtually identical ef

241 Hybrids with DNA contents of approximately 2n, 3n, and 4n were observ

242 d pancreatic mass, independent of changes in DNA content or cell proliferation in mice.

243 pertrophic remodeling, altered cardiomyocyte DNA content or nucleation, or enhanced phosphorylation o

244 Large cells are produced by increasing DNA content or ploidy, a developmental strategy employed

245 GLP-1R agonists did not increase pancreatic DNA content or the number of Ki67(+) cells in the exocri

246 Although blt mutants have normal trichome DNA content, overexpression of BLT results in an additio

247 GAA treatment significantly reduces genomic DNA content (P < 0.0001) and creates an increased potent

248 Established biomarkers (abnormal DNA content, p53, and cyclin A expression) and new bioma

249 aining of isolated plastids to determine the DNA content per plastid for seedlings grown in the dark

250 Thus, the DNA content per plastid is not constant but varies durin

251 the DNA paralleled a progressive decrease in DNA content per plastid.

252 Cellular DNA content profiles obtained by flow cytometry and quan

253 DNA content profiling of dcd1Delta cells differs from an

254 smooth muscle cell (CASMC) number, cellular DNA content, protein synthesis, and PCNA staining.

255 concentration-dependent increase in cellular DNA content, protein synthesis, cell number, and prolife

256 ted for all 10 sorghum chromosomes and their DNA content quantified.

257 S phase nuclei, flow-sorted on the basis of DNA content, replicative labeling was widely distributed

258 DNase I to dissolve NETs, which have a high DNA content, restored perfusion in the kidney and heart

259 d enlarged epidermal cells with an increased DNA content resulting from additional endocycles.

260 o a comparable level but the reduced overall DNA content results in significantly higher viability of

261 Knockdown of SIRT1 increases cellular abasic DNA content, sensitizing cells to death induced by genot

262 ometric analysis of DNA strand breaks versus DNA content showed that apoptosis induced by PEITC-NAC o

263 Flow cytometric analysis of DNA content showed that JNJ-7706621 delayed progression

264 Measurement of nuclear DNA contents showed that PL cells were haploid relative

265 ucleolin in relation to cell cycle position (DNA content) showed expression during G1-S and persisten

266 tent before the appearance of cells with <2N DNA content, suggesting a mixed response.

267 e-sensitive mutant of dpb2 arrests with a 1C DNA content, suggesting that Dpb2 is required for initia

268 cancer cells also have greater-than-diploid DNA content, suggesting that polyploidy is a common prec

269 Nutlin-3a for 24 hours accumulated 2N and 4N DNA content, suggestive of G(1) and G(2) phase cell cycl

270 specimens containing potentially less target DNA content than specimens from symptomatic males.

271 repair and the maintenance of mitochondrial DNA content, the regulation and function of RRM2B in sen

272 patchy cell cycle behavior due to threshold DNA contents, the expression of these genes correlates t

273 ecies, provide information about euchromatic DNA content, they cannot give an accurate estimate of ge

274 th intact checkpoint function arrest with 4N DNA content, those with compromised checkpoint function

275 e is for the cell to amplify its chromosomal DNA content through endoreduplication cycles.

276 DNA yield: depletion of the human genomic (g)DNA content through hybridization with human gDNA baits,

277 Yet, cells fail to increase their DNA content to 4N as revealed by FACS analysis, probably

278 ell types become polyploid, increasing their DNA content to attain a large cell size.

279 s play crucial roles in equal segregation of DNA content to daughter cells, coordination of growth an

280 Cdc25B also causes cells with an S phase DNA content to enter mitosis prematurely in a p53-indepe

281 ic DNA and allows progressive delineation of DNA content to within a few hundred base pairs of a geno

282 orted into S-phase fractions on the basis of DNA content using flow cytometry.

283 al cortex brain cells were found to display "DNA content variation (DCV)" characterized by an increas

284 HIV DNA content was 15-fold higher in CD25(+) FoxP3(+) memor

285 e-sequence-positive SMCs, the average unique DNA content was approximately 6.5 Mb (range 0.3-22.2 Mb)

286 ells with an anomalous size distribution and DNA content was found in this population.

287 tage of EU-positive myonuclei; however, when DNA content was held constant by preventing myonuclear a

288 re determined by Western blot, mitochondrial DNA content was measured by real-time PCR, and mitochond

289 a significant increase in cell viability and DNA content were observed in PKCdelta knockdown McA cell

290 llular assays demonstrated increased triplex DNA content when RPA is transiently repressed, suggestin

291 ted in accumulation of cells with 4N or more DNA content, whereas coadministration of vorinostat mark

292 odazole, RB-proficient cells arrest with 4 n DNA content, whereas RB-deficient cells bypass the mitot

293 hain vibrations originating from protein and DNA contents, whereas the second was predominantly the g

294 wever, this study primarily measured the HIV DNA content, which also includes defective proviruses th

295 suggest that organisms with high repetitive DNA content, which include humans, could use similar dev

296 es detect CN changes relative to the overall DNA content, which is often not diploid in cancer.

297 ence intensity is proportional to the cell's DNA content, which varies in a predictable fashion durin

298 ested EPCs at a cell cycle status with a 4 N DNA content, which was previously claimed to be "G2/M ar

299 cyclin/p53(-/-) tumors showed a near-diploid DNA content with no aberrant centrosome numbers.

300 cell shapes, but the mechanism coordinating DNA content with shape and size remains obscure.