ライフサイエンスコーパス: DNA damage checkpoint

1 ing agents, even in mutants defective in the DNA damage checkpoint.

2 required for replisome assembly and for the DNA damage checkpoint.

3 ted repair before the execution of an intact DNA damage checkpoint.

4 poptotic response of the conserved pachytene DNA damage checkpoint.

5 int, but they are compromised for the G(2)/M DNA damage checkpoint.

6 o replication and subsequently arrest at the DNA damage checkpoint.

7 cell cycle because of the activation of the DNA damage checkpoint.

8 ) in the G(2) phase, thereby attenuating the DNA damage checkpoint.

9 n determines the activation threshold of the DNA damage checkpoint.

10 complex, but they maintain an intact S phase DNA damage checkpoint.

11 rmed recovery or when the cells adapt to the DNA damage checkpoint.

12 nase that is the effector molecule in the G2 DNA damage checkpoint.

13 cts in gamma-H2AX induction, or an abrogated DNA damage checkpoint.

14 hat miR-106b overrides a doxorubicin-induced DNA damage checkpoint.

15 ath, as cells are unable to recover from the DNA damage checkpoint.

16 breaks (DSBs), eukaryotic cells activate the DNA damage checkpoint.

17 lication fork collapse that activates the G2 DNA damage checkpoint.

18 auses a stable G2 arrest requiring an intact DNA damage checkpoint.

19 a well-established signal transducer in the DNA damage checkpoint.

20 hanisms to respond to DNA damage, termed the DNA damage checkpoint.

21 radiation due to increased activation of the DNA damage checkpoint.

22 teins that recapitulates key elements of the DNA damage checkpoint.

23 of origins of replication, and inhibits the DNA damage checkpoint.

24 distinguished from DNA breaks that activate DNA damage checkpoint.

25 etylation results in a defect in the S phase DNA damage checkpoint.

26 proteins were found to be controlled by the DNA damage checkpoint.

27 ances and also functions in the ATR-mediated DNA damage checkpoint.

28 gulation of the metabolic checkpoint and the DNA damage checkpoint.

29 egulated by cyclin-dependent kinases and the DNA damage checkpoint.

30 on nucleosome dynamics is independent of the DNA damage checkpoint.

31 l part of the MBF core, is the target of the DNA damage checkpoint.

32 BP1) dimer is essential for establishing the DNA damage checkpoint.

33 pindle checkpoint but instead depends on the DNA damage checkpoint.

34 ouble-strand breaks (DSBs) that activate the DNA-damage checkpoint.

35 o DNA lesions and subsequent activation of a DNA-damage checkpoint.

36 from DNA double-strand breaks that activate DNA damage checkpoints.

37 ging agents and play a role in activation of DNA damage checkpoints.

38 cade to facilitate repair by HR and regulate DNA damage checkpoints.

39 imulate DNA damage and to activate host cell DNA damage checkpoints.

40 ATR/Chk1 to promote efficient activation of DNA damage checkpoints.

41 ich are also important for the activation of DNA damage checkpoints.

42 DNA double-strand breaks (DSBs) to regulate DNA damage checkpoints.

43 s a central anti-tumorigenic function of the DNA damage checkpoints.

44 at requires interdependence with mediator of DNA damage checkpoint 1 (MDC1) and H2AFX.

45 n-induced gammaH2AX foci recruit mediator of DNA damage checkpoint 1 (MDC1) and p53 binding protein 1

46 sponse (DDR) proteins, including mediator of DNA damage checkpoint 1 (Mdc1) and p53 binding protein 1

47 d breaks and associates with the mediator of DNA damage checkpoint 1 (MDC1) and the ataxia telangiect

48 ce complex components (MCMs) and mediator of DNA damage checkpoint 1 (MDC1) expression.

49 We show that mediator of DNA damage checkpoint 1 (MDC1), a binding partner of pho

50 ion together with recruitment of mediator of DNA damage checkpoint 1 (MDC1), and the Mre11-Rad50-Nbs1

51 phorylated H2AX (gammaH2AX), and mediator of DNA damage checkpoint 1 (MDC1), as well as components of

52 DNA damage factors such as NBS1, mediator of DNA damage checkpoint 1 (MDC1), RNF8, 53BP1, and BRCA1.

53 (H2AX, also known as H2AFX)- and mediator of DNA damage checkpoint 1 (MDC1)-dependent events.

54 lcNAcylation of histone H2AX and mediator of DNA damage checkpoint 1 (MDC1).

55 and blocks recruitment of MDC1 (mediator of DNA damage checkpoint 1) and 53BP1 (p53 binding protein

56 ited by gamma-H2AX and by MDC-1 (mediator of DNA damage checkpoint 1), which binds to gamma-H2AX in c

57 n of phosphorylated histone 2AX, mediator of DNA-damage checkpoint 1, and p53 binding protein 1, at D

58 e-strand breaks (DSBs) and activation of the DNA damage checkpoint [2-7].

59 nt transformation by enabling cells to evade DNA damage checkpoints activated by oncogenic stimuli.

60 ation, cyclin E was upregulated resulting in DNA damage checkpoint activation and apoptosis.

61 HR is error-prone in this context because of DNA damage checkpoint activation and base pair lesions a

62 These data demonstrate that L1CAM augments DNA damage checkpoint activation and radioresistance of

63 for the recruitment of factors critical for DNA damage checkpoint activation and repair by homologou

64 rgeting L1CAM by RNA interference attenuated DNA damage checkpoint activation and repair, and sensiti

65 tions, we found that H3K14ac is critical for DNA damage checkpoint activation by directly regulating

66 nucleoprotein aggregates form in response to DNA damage checkpoint activation in egg chambers of fema

67 early passage primary MEFs is antagonized by DNA damage checkpoint activation, consistent with nuclea

68 Resection, the generation of ssDNA, affects DNA damage checkpoint activation, DNA repair pathway cho

69 knockdown is independent of p53 activation, DNA damage checkpoint activation, or changes in the AKT

70 ly regulates RAD53 transcription to suppress DNA damage checkpoint activation.

71 that result from Chk-2 (checkpoint kinase-2) DNA damage checkpoint activation.

72 eedback loop to limit ssDNA accumulation and DNA damage checkpoint activation.

73 ctly dependent on ATM-, but not ATR-mediated DNA damage checkpoint activation.

74 The metabolic conversion of ANI-7 induces DNA damage, checkpoint activation, S-phase cell cycle ar

75 the hTERT-RPE1 clones displayed evidence of DNA-damage checkpoint activation.

76 ted acetylation of the ATM kinase, promoting DNA-damage-checkpoint activation and cell survival.

77 4 was required for rapid inactivation of the DNA damage checkpoint after DSB repair.

78 nover of Mre11 at DNA ends, shutting off the DNA damage checkpoint and allowing cell cycle progressio

79 (GSCs) display a preferential activation of DNA damage checkpoint and are relatively resistant to ra

80 NUDT15 ablation potentiated induction of the DNA damage checkpoint and cancer cell death by 6-thiogua

81 nd break (DSB) is sufficient to activate the DNA damage checkpoint and cause Saccharomyces cells to a

82 upon ART-27 depletion include regulators of DNA damage checkpoint and cell cycle progression, sugges

83 RNR3 gene is dependent on activation of the DNA damage checkpoint and chromatin remodelling by SWI/S

84 signaling abrogates the activation of the G2 DNA damage checkpoint and confers specific sensitization

85 1 mutants were associated with activation of DNA damage checkpoint and depletion of dNTP concentratio

86 sDNA that is essential for activation of the DNA damage checkpoint and DNA repair by homologous recom

87 -2 are involved in the maintenance of a G2/M DNA damage checkpoint and DNA repair mediated by the non

88 f DNA damage by concurrently attenuating the DNA damage checkpoint and DNA repair, resulting in polyp

89 eactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.

90 h that late activation of Notch triggers the DNA damage checkpoint and G2/M interphase arrest.

91 This sustains the DNA damage checkpoint and is suppressed by Rad53 phospho

92 control the activity of cyclin A at the G(1) DNA damage checkpoint and may thereby prevent S-phase en

93 protein complex that impacts mammalian G2/M DNA damage checkpoint and NHEJ.

94 t1 stabilization, which in turn triggers the DNA damage checkpoint and p53-dependent apoptosis.

95 UmuD is implicated in a primitive DNA damage checkpoint and prevents DNA polymerase IV-dep

96 DNA damage checkpoint and recombinational repair are bot

97 o its loading mechanism and association with DNA damage checkpoint and repair enzymes.

98 omplex at DSBs occurs independently of known DNA damage checkpoint and repair proteins.

99 Mec1-Ddc2 (ATR-ATRIP) controls the DNA damage checkpoint and shows differential cell-cycle

100 cells that fail to launch a robust G2 phase DNA damage checkpoint and that this renders them sensiti

101 In budding yeast, both the DNA damage checkpoint and the spindle assembly checkpoin

102 otein kinase Rad53 is a key regulator of the DNA damage checkpoint and uses its two FHA domains to in

103 responses including cell cycle progression, DNA damage checkpoints and apoptosis.

104 e helicase displayed increased activation of DNA damage checkpoints and genomic instability.

105 protect telomeres against activation of the DNA damage checkpoints and recombinational repair.

106 as an essential factor for the initiation of DNA damage checkpoints and the maintenance of genomic st

107 uses chronic activation of the ATM-dependent DNA-damage checkpoint and accumulation of a discrete sin

108 mRNA turnover through the activation of the DNA-damage checkpoint and the Aft1/Aft2-controlled iron

109 ability to recruit telomerase, activates the DNA damage checkpoint, and loses heterochromatin at telo

110 and rid mutant viability is dependent on the DNA damage checkpoint, and surprisingly Mrc1, a protein

111 tor p21, which promotes cell-cycle arrest at DNA damage checkpoints, and Gadd45 and p53R2, with pivot

112 accumulated oxidative DNA damage, activated DNA damage checkpoints, and showed G1-phase arrest at at

113 specific DSBs, fail to properly activate the DNA-damage checkpoint, and show genetic interactions wit

114 tabilization of Claspin, an activator of the DNA-damage checkpoint, and Wee1, an inhibitor of cell-cy

115 dk activities and excess failure of the G2/M DNA damage checkpoint appear to fuel increased ploidy ab

116 Although DNA damage checkpoints are broadly activated in response

117 in DSB repair and the deoxyribonucleic acid (DNA) damage checkpoint are unclear.

118 Fun30 is required to allow the adaptation of DNA damage checkpoint-arrested cells with an unrepaired

119 G2/M DNA damage checkpoint, ATM signaling, mitochondrial dysf

120 of Obfc2b does not affect the initiation of DNA damage checkpoints, Atm activation, or the maintenan

121 This process is regulated by the DNA damage checkpoint, because RFWD3 is phosphorylated b

122 that the requirements for recovery from the DNA damage checkpoint become more stringent with increas

123 not only on Mec1 and other components of the DNA damage checkpoint but also on the presence of the ce

124 lethality that is dependent on the upstream DNA damage checkpoint but independent of the downstream

125 ive process resulting from activation of the DNA damage checkpoint by an ATR-regulated pathway, which

126 ether with UmuC, plays a role in a primitive DNA damage checkpoint by decreasing the rate of DNA synt

127 Here we review how impaired DNA-repair or DNA-damage checkpoints can lead to genetic instability a

128 aries of spindle-class females, an activated DNA damage checkpoint causes inefficient Grk translation

129 cells compromised in DNA repair pathways or DNA damage checkpoints, cells reliant on homologous reco

130 response to DNA damage, two branches of the DNA damage checkpoint, Chk1 and Rad53, are activated in

131 The DNA damage checkpoint clamp (the 9-1-1 complex) has been

132 The yeast DNA damage checkpoint clamp Ddc1-Mec3-Rad17 (human Rad9-

133 loader, replication factor C (RFC), and the DNA damage checkpoint clamp loader, Rad24-RFC, using two

134 ork progression is reduced in the absence of DNA damage checkpoint components and nonhomologous end-j

135 to oncogenic transformation, and hyperactive DNA damage checkpoints, consistent with upregulated leve

136 ration down-regulation was associated with a DNA damage checkpoint consisting of p53, p21, and endoth

137 The DNA damage checkpoint, consisting of an evolutionarily c

138 ary microcephaly, plays an important role in DNA damage checkpoint control and mitotic entry.

139 ctivity of HPV-16 E7 involves attenuation of DNA damage checkpoint control by accelerating the proteo

140 Here we show that the CHK2 (CHEK2)-dependent DNA damage checkpoint culls not only recombination-defec

141 ved signal transduction cascade known as the DNA damage checkpoint (DDC).

142 st in cell-cycle progression enforced by the DNA-damage checkpoint (DDC) signalling pathway positivel

143 Despite the underlying DNA damage checkpoint defects, increased DNA damage sign

144 avior of cells after they have experienced a DNA damage checkpoint delay is poorly characterized.

145 ion, we define a role for MRN in the S-phase DNA damage checkpoint-dependent slowing of replication t

146 in various cellular processes including the DNA damage checkpoint, DNA repair, and transcription.

147 nd Mrc1 experience chronic activation of the DNA damage checkpoint during chromosome replication and

148 Such pathways, along with DNA-damage checkpoints, ensure that either the damage is

149 acterized genes, including mRNA splicing and DNA damage checkpoint factors.

150 3 postreplication repair complex, downstream DNA-damage checkpoint factors (Rad53, Chk1, and Dun1), o

151 l viability that was associated with S-phase DNA damage checkpoint failure.

152 r have been known to be downregulated by the DNA damage checkpoint for many years.

153 uire homologous recombination repair and the DNA damage checkpoint for viability.

154 Aberrant regulation of DNA damage checkpoint function leads to genome instabili

155 We found that Dss1p and Rae1p have a DNA damage checkpoint function, and upon treatment with

156 on fork metabolism, are required for S-phase DNA damage checkpoint function.

157 Rad17 in either activation or termination of DNA damage checkpoint function.

158 caused by disruption of either MEC1 or RAD53 DNA damage checkpoint genes, as well as the lethality se

159 itates this phenotype because it can repress DNA damage checkpoint genes.

160 s (CAFs), Asf1 and CAF-1, in turning off the DNA damage checkpoint in budding yeast.

161 f primate lentiviruses, arrests cells at the DNA damage checkpoint in G2 phase of the cell cycle, but

162 Finally, we suggest escaping this DNA damage checkpoint in maternal ageing may be one of t

163 cells display a significant defect in G(2)/M DNA damage checkpoint in response to ionizing radiation

164 Previous work on the DNA damage checkpoint in Saccharomyces cerevisiae has sh

165 n Rad4(TopBP1) facilitates activation of the DNA damage checkpoint in Schizosaccharomyces pombe by ph

166 V treatment, and the noted abrogation of the DNA damage checkpoint in the MTA1-depleted cells may be,

167 ohesin is also required for the integrity of DNA damage checkpoints in somatic cells, where cohesin l

168 ion initiation can lead to activation of the DNA damage checkpoint independent of the intra-S phase c

169 In one example, a pathway-based screen for DNA damage checkpoint inhibitors identified a compound,

170 The G2 DNA damage checkpoint inhibits Cdc2 and mitotic entry th

171 urbed conditions and the DNA replication and DNA damage checkpoints into a single transcriptional com

172 However, it remains unclear how the DNA damage checkpoint is activated by oxidative stress a

173 This lack of an efficient DNA damage checkpoint is because oocytes fail to effecti

174 minent when a DSB is slowly repaired and the DNA damage checkpoint is fully activated.

175 tinct mechanism of how an ATR-Chk1-dependent DNA damage checkpoint is mediated by APE2 in the oxidati

176 udding yeast (Saccharomyces cerevisiae), the DNA damage checkpoint is regulated by a signaling cascad

177 E7 maintains proliferation despite activated DNA damage checkpoints is incompletely understood.

178 Thus, SAC, much like the DNA damage checkpoint, is essential for genome stability

179 point kinase 1 (Chk1), a component of the G2 DNA damage checkpoint, is important in the resistance of

180 caused by mutations in the gene encoding the DNA damage checkpoint kinase ATM, is characterized by mu

181 blocks the serine 345 phosphorylation of the DNA damage checkpoint kinase Chk1 by Rad3 (ATR) at broke

182 sensitive to single-agent inhibition of the DNA damage checkpoint kinase Chk1, leading us to examine

183 The DNA damage checkpoint kinase Mec1(ATR) is critical for m

184 e tumour cells to clinical inhibitors of the DNA damage checkpoint kinase, ATR, both in vitro and in

185 nto nuclear foci and activation of the Rad53 DNA damage checkpoint kinase, indicating that the toxici

186 tumor suppressor genes Egr1 and JunB and the DNA damage checkpoint kinase, polo-like kinase 2 (Plk2)

187 nuclei from syncytial blastoderm embryos via DNA damage checkpoint kinase-mediated retention of speci

188 ere, we show that, in the absence of induced DNA damage, checkpoint kinase-1 (CHK1), an enzyme essent

189 nds the existing knowledge of the targets of DNA damage checkpoint kinases and provides insights into

190 esponse to DNA damage is orchestrated by the DNA damage checkpoint kinases ATAXIA TELANGIECTASIA MUTA

191 ntify in vivo kinase substrates of the yeast DNA damage checkpoint kinases Mec1, Tel1, and Rad53 (ort

192 In normal cells, p53 is activated by DNA damage checkpoint kinases to simultaneously control

193 These phosphorylations were dependent on the DNA damage checkpoint kinases, Mec1/Tel1 and Rad53.

194 s (CDK), Dbf4-dependent kinase (DDK) and the DNA damage checkpoint kinases.

195 the core component of NHEJ, partnering with DNA-damage checkpoint kinases ataxia telangiectasia muta

196 The results suggest that defects in DNA damage checkpoints may be recognized in melanomas th

197 strains with deletions of both ISC1 and the DNA damage checkpoint mediator gene RAD9 display reduced

198 In the S-phase DNA damage checkpoint, MRN acts both in activation of ch

199 Novel targeted therapies against the DNA damage checkpoint or stem-cell maintenance pathways

200 Recently, strategies aimed at targeting DNA damage checkpoints or DNA repair processes have demo

201 in GGR are not achieved by either activating DNA damage checkpoints or regulating the expression of t

202 We propose that the DNA damage checkpoint pathway coordinates resection and

203 We find the DNA damage checkpoint pathway facilitates HR, in part, b

204 The DNA damage checkpoint pathway governs how cells regulate

205 nuclear extensions, whereas inactivating the DNA damage checkpoint pathway in a DNA repair mutant red

206 Here we identify roles for the DNA damage checkpoint pathway in facilitating homologous

207 The DNA damage checkpoint pathway is activated in response t

208 her MTA1 also participates in the UV-induced DNA damage checkpoint pathway remains unknown.

209 To determine whether reduced activity in the DNA damage checkpoint pathway would cooperate with MMR d

210 As a central component of the DNA damage checkpoint pathway, the conserved protein kin

211 plex functions as a mediator in the ATR-Chk1 DNA damage checkpoint pathway.

212 participates in the UV-induced ATR-mediated DNA damage checkpoint pathway.

213 Delta cells and relieves the reliance on the DNA damage checkpoint pathway.

214 The Chk2-mediated deoxyribonucleic acid (DNA) damage checkpoint pathway is important for mitochon

215 DNA damage checkpoint pathways operate to prevent cell-c

216 ication fork protection, and DNA replication/DNA damage checkpoint pathways.

217 eak (DSB) repair, meiotic recombination, and DNA damage checkpoint pathways.

218 eplication upon Emi1 depletion activates the DNA damage checkpoint pathways.

219 Although the DNA damage checkpoint PI3-kinases ATM and ATR localize t

220 The DNA damage checkpoint plays a crucial role in maintainin

221 Pds1p stabilization by the spindle or DNA damage checkpoints prevents sister-chromatid separat

222 IIalpha mutant activated the ATM/R-dependent DNA damage checkpoint, probably due to reduced catalytic

223 , where it plays a key role in advancing the DNA damage checkpoint process.

224 es a docking site to recruit the mediator of DNA damage checkpoint protein 1 (MDC1) and DNA repair pr

225 Mediator of DNA damage checkpoint protein 1 (MDC1) is an early and k

226 des interact with phosphorylated mediator of DNA damage checkpoint protein 1 (phospho-MDC1) or E3 ubi

227 cycle checkpoint proteins MDC1 (mediator of DNA damage checkpoint protein 1) and BRCA1 (breast cance

228 it the DDR factors because MDC1 (mediator of DNA damage checkpoint protein 1), which normally binds t

229 dies have found that TRF2 interacts with the DNA damage checkpoint protein Chk2.

230 ablished that Cdc2 kinase phosphorylates the DNA damage checkpoint protein Crb2(53BP1) in mitosis, th

231 The DNA damage checkpoint protein Hus1 associates with Rad9

232 53BP1, first identified as a DNA damage checkpoint protein, and BRCA1, a well-known b

233 onstrate that by fusing AtCRY2 to the TopBP1 DNA damage checkpoint protein, light-induced AtCRY2 PBs

234 Mediator of DNA Damage Checkpoint protein, MDC1, and H2AX are chroma

235 , XPA, XPC, TFIIH, XPG, and XPF-ERCC1), core DNA damage checkpoint proteins (ATR-ATRIP, TopBP1, RPA),

236 Here, we find that within minutes of DNA damage checkpoint proteins are assembled at the kine

237 n promotes DSB processing and recruitment of DNA damage checkpoint proteins, thus implicating cohesin

238 for binding by homologous recombination and DNA damage checkpoint proteins.

239 In response to DNA damage, checkpoint proteins halt cell cycle progress

240 The requirement for specific DNA-damage checkpoint proteins suggests roles in recruit

241 The molecular pathways linking DNA-damage checkpoint proteins to cell-cycle progression

242 ed PLK1 at threonine 210, a prerequisite for DNA damage checkpoint recovery, remained detectable foll

243 and its degradation plays a critical role in DNA damage checkpoint recovery.

244 t progress has advanced our understanding of DNA damage checkpoint regulations, little is known as to

245 how chromatin remodeling complexes regulate DNA damage checkpoints remain unclear.

246 Activation of DNA damage checkpoints requires the rapid accumulation o

247 DNA damage cause a metabolic checkpoint and DNA damage checkpoint, respectively.

248 n, aberrant replication, and activation of a DNA damage checkpoint response (DDR), rendering therapeu

249 biquitin-ligase CRL4 controls cell cycle and DNA damage checkpoint response and ensures genomic integ

250 s the signal that activates the ATR-mediated DNA damage checkpoint response and that the signal is en

251 The DNA damage checkpoint response delays cell cycle progres

252 -mimetic agent to analyze the basic steps of DNA damage checkpoint response in a biochemically define

253 iRNAs genetically interact with genes in the DNA damage checkpoint response pathway and in the insuli

254 t of undamaged plasmid or sperm DNA allows a DNA damage checkpoint response to be activated.

255 ivates signaling through the Chk1 arm of the DNA damage checkpoint response via recruitment and stimu

256 However, no deficiencies in DNA damage checkpoint response were detected in Cdc14b m

257 cleotide damage repair, mismatch repair, and DNA damage checkpoint response, but its function in DNA

258 ecause many activated oncoproteins trigger a DNA damage checkpoint response, which serves as a barrie

259 ell-cycle regulation is also observed in the DNA damage checkpoint response.

260 um essential set of factors for ATR-mediated DNA damage checkpoint response.

261 te origins become active despite an elevated DNA damage-checkpoint response.

262 l32, and Rad5) and in the early steps of the DNA-damage checkpoint response (Rad17, Mec3, Ddc1, Mec1,

263 unction for IKK and NF-kappaB modulating the DNA-damage checkpoint response, allowing the cell to int

264 d protein that coordinates activation of the DNA-damage-checkpoint response by coupling binding of th

265 Chk1 is a key regulator of DNA damage checkpoint responses and genome stability in

266 ed damage through preferential activation of DNA damage checkpoint responses and increased capacity f

267 st that the HPV-16 E7 oncoprotein alleviates DNA damage checkpoint responses and promotes mitotic ent

268 Here, we show that L1CAM (CD171) regulates DNA damage checkpoint responses and radiosensitivity of

269 of cyclin D1b was not sufficient to abrogate DNA damage checkpoint responses, it did efficiently over

270 that L1CAM signals through NBS1 to regulate DNA damage checkpoint responses.

271 ect DNA repair processes, but does influence DNA damage checkpoint responses.

272 NBS1 (MRN), thereby repressing ATM-dependent DNA damage checkpoint responses.

273 us to dissect MRN's ATM-independent S-phase DNA damage checkpoint roles from its role in ATM activat

274 tails that are essential for the assembly of DNA damage checkpoint signaling and DNA repair protein c

275 rrant replication intermediates to attenuate DNA damage checkpoint signaling and prevent pathological

276 critical feature of the human ATR-initiated DNA damage checkpoint signaling has not been demonstrate

277 dephosphorylation of Rad53 when the upstream DNA damage checkpoint signaling is turned off.

278 ents form bulky lesions on DNA that activate DNA damage checkpoint signaling pathways in human cells.

279 Chk1 is widely known as a DNA damage checkpoint signaling protein.

280 In fission yeast, DNA damage checkpoint signaling requires Rad3, the homol

281 asia mutated and Rad3-related (Atr)-mediated DNA damage checkpoint signaling, including activation of

282 nates the processing and repair of DSBs with DNA damage checkpoint signalling, preserving genome inte

283 In response to DNA damage, checkpoint signalling protects genome integr

284 protein kinase is an important transducer of DNA damage checkpoint signals, and its mutation contribu

285 Here we show that the conserved DNA damage checkpoint sliding clamp (the 9-1-1 complex)

286 The S-phase DNA damage checkpoint slows the rate of DNA synthesis in

287 which is required for the activation of the DNA damage checkpoint, suggesting that this checkpoint p

288 ex to damaged DNA, leading to both premature DNA damage checkpoint termination and inhibition of DNA

289 aryotic genome integrity is maintained via a DNA damage checkpoint that recognizes DNA damage and hal

290 protein kinase that is a key mediator of the DNA damage checkpoint that responds to DNA double-strand

291 on unbroken chromosomes, suggesting that the DNA damage checkpoint through Eco1 provides genome-wide

292 owed that p53 plays a central role in G1 and DNA damage checkpoints, thus contributing to genomic sta

293 lar processes that include activation of the DNA damage checkpoint, transient cell cycle arrest, DNA

294 al that loss of miRNA biogenesis activates a DNA damage checkpoint, up-regulates p19(Arf)-p53 signali

295 It seems that DNA damage checkpoints were not reactivated in cells tha

296 breaks (DSBs), eukaryotic cells activate the DNA damage checkpoint, which is orchestrated by the PI3

297 ion was associated with activation of a G2/M DNA damage checkpoint, which prevented activation of the

298 In Saccharomyces cerevisiae, the DNA damage checkpoint, which responds to lesions such as

299 uble-strand breaks (DSBs), and activation of DNA damage checkpoints, which in primary human cells lea

300 DNA repair and DNA damage checkpoints work in concert to help maintain