ライフサイエンスコーパス: DNA damage response

1 ation, promoted apoptosis, and augmented the DNA damage response.

2 survival of infected cells in response to a DNA damage response.

3 olves Rad3, a master kinase coordinating the DNA damage response.

4 relies on neither HBoV1 replication nor the DNA damage response.

5 L1, but also those required for the cellular DNA damage response.

6 tance of m(6)A in the ultraviolet-responsive DNA damage response.

7 ata identified a novel 53BP1-TIRR complex in DNA damage response.

8 oupling transcription with mRNA splicing and DNA damage response.

9 differentiation, and survival as well as the DNA damage response.

10 identified histone serine ADPr marks in the DNA damage response.

11 regulation of histone acetylation during the DNA damage response.

12 nduced by short telomeres, which trigger the DNA damage response.

13 , the function of the primary cilium and the DNA damage response.

14 e deposition of histone marks as part of the DNA damage response.

15 cruited to the site of DNA-DSBs via an early DNA damage response.

16 in preventing the L1 retrotransposon-induced DNA damage response.

17 cipates in programmed cell death in the UV-B DNA damage response.

18 y p53-dependent enhancer activity during the DNA damage response.

19 cancer subclass through a hormone dependent DNA damage response.

20 erved feature of the multifaceted eukaryotic DNA damage response.

21 reased level of Rad53p triggers an efficient DNA damage response.

22 ucial for coordinating an efficient cellular DNA damage response.

23 blish a pathway of autophagy specific to the DNA damage response.

24 gulator of ADP-ribosylation signaling in the DNA damage response.

25 dogenous triplex structures evoking a robust DNA damage response.

26 lated these abnormalities with dysfunctional DNA damage response.

27 P51 is the DUB for H2AK13,15ub and regulates DNA damage response.

28 echanism to repress spurious activation of a DNA damage response.

29 tudies to understand the role of this PPI in DNA damage response.

30 and elevated levels of H2AK15ub and impairs DNA damage response.

31 stablished roles in epigenetic regulation in DNA damage response.

32 n dependent on oxidative stress, rather than DNA damage response.

33 mplex relationship between autophagy and the DNA damage response.

34 B, deubiquitylates H2AK13,15ub and regulates DNA damage response.

35 f their previously characterized role in the DNA damage response.

36 we found that O-GlcNAcylation is induced by DNA damage response.

37 or DNA-damaging agents and inhibitors of the DNA damage response.

38 ducing replication stress and activating the DNA damage response.

39 hich is important for efficiently activating DNA damage response.

40 c replication are known to induce a cellular DNA damage response.

41 al event that mediates the first wave of the DNA damage response.

42 yeast, dNTP pools expand drastically during DNA damage response.

43 ng and histone deacetylation) complex in the DNA damage response.

44 to form the triple T complex that regulates DNA damage response.

45 ssion during B lymphocyte activation and the DNA damage response.

46 er mechanism how Plk1 antagonizes p53 during DNA damage response.

47 el roles for these and other proteins in the DNA damage response.

48 n the absence of p53 activity induced by the DNA damage response.

49 is essential for mitotic checkpoints and the DNA damage response.

50 tin modification plays a crucial role in the DNA damage response.

51 es in transcription, pre-mRNA processing and DNA damage response.

52 ylated H2A histone family member X)-mediated DNA-damage response.

53 late gene expression and participates in the DNA-damage response.

54 al kinase that orchestrates the multifaceted DNA-damage response.

55 carboplatin, does not kill cells through the DNA-damage response.

56 ity or diminishing its protein levels in the DNA-damage response.

57 limits cell-cycle progression by suppressing DNA damage responses.

58 Cs through G4 stabilization and promotion of DNA damage responses.

59 important for protecting infected cells from DNA damage responses.

60 we have explored how the centrosome controls DNA damage responses.

61 proteins participate in the same pathway of DNA damage responses.

62 DNA lesions (DNA-Pt) and trigger pleiotropic DNA damage responses.

63 with methylated histones and plays a role in DNA damage responses.

64 of the Protein Regulated in Development and DNA Damage Response 1 (REDD1) in diabetes-induced retina

65 related protein regulated in development and DNA damage responses 1 (REDD1) is significantly overexpr

66 We also investigated the contribution of the DNA damage response, a pathway activated by HCMV and imp

67 DNA damage, replicative stress activates the DNA damage response, a signaling cascade allowing cell c

68 that is suppressed by the activation of the DNA damage response and a G1/S-phase growth arrest.

69 of NMD is tolerated, loss of hUPF1 induces a DNA damage response and cell cycle arrest.

70 uggest a novel USP10-MSH2 pathway regulating DNA damage response and DNA mismatch repair.

71 zymes is an important factor in the cellular DNA damage response and has gained much attention for it

72 Ura7 both resulted in the activation of the DNA damage response and imbalanced dNTP pools.

73 is an important step for its function in the DNA damage response and in DNA repair.

74 localize to telomeres but fail to repress a DNA damage response and inappropriate repair by A-NHEJ.

75 ng CDT1/ORC1, p21/p27, and PHLPP1 to trigger DNA damage response and induce growth arrest at the G2/M

76 t contributes to transcriptional regulation, DNA damage response and limits heterochromatin spreading

77 py-number alterations (CNAs) associated with DNA damage response and modulation of DNA editing/repair

78 NEK1 is essential for the ionizing radiation DNA damage response and priming of the ATR kinase and of

79 nerating novel mechanistic inhibitors of the DNA damage response and repair (DDR) pathways by focusin

80 The alterations affected pathways regulating DNA damage response and repair, transcription and chroma

81 t are involved in chromatin modification and DNA damage response and repair.

82 that the cell cycle critically regulates the DNA damage response and survival of intestinal stem cell

83 ly-SUMO-mediated cellular processes, such as DNA damage responses and cell cycle progression.

84 gle-stranded telomere DNA to prevent illicit DNA damage responses and to enhance telomerase-mediated

85 r ataxias, indicating an association between DNA damage-response and repair pathways and the age at o

86 d by phosphorylation of p53, activation of a DNA-damage response and cell cycle arrest in G1 phase, f

87 KK family, plays a critical role in the cell DNA-damage response and is an attractive anticancer drug

88 ated upon genotoxic stress and regulates the DNA-damage response and telomere repair.

89 lleviated RSV-induced replication stress and DNA damage response, and consequently attenuating cellul

90 ration, dedifferentiation, activation of the DNA damage response, and gene signatures of aggressive H

91 d CDK4/6 blockade on cell-cycle progression, DNA damage response, and immune-modulation and may provi

92 processes including nutrient sensing and the DNA damage response, and implicated Vts1 in de novo gene

93 ochondria integrity maintain, cell cycle and DNA damage response, and ion transportation.

94 (6)A modification in the ultraviolet-induced DNA damage response, and our findings collectively suppo

95 ogene expression levels, retained functional DNA damage responses, and acquired chromatin changes tha

96 osis, chromosome organization, regulation of DNA damage responses, and cell cycle.

97 g DSB repair, which led to DSB accumulation, DNA damage responses, and early replication arrest in HG

98 ly demonstrate that Pml NBs are critical for DNA damage responses, and suggest that Pml NB disruption

99 dified chemotherapy approaches targeting the DNA damage response, angiogenesis inhibitors, immune che

100 is involved in major cellular events such as DNA damage response, apoptosis and p53-mediated growth-a

101 ange resection factors and activation of the DNA damage response are also diminished.

102 DNA damage responses are partially regulated by the ubiq

103 tations in ATM kinase, a master regulator of DNA damage responses, are found in many cancers, but the

104 e results highlight cIAP2 as a player in the DNA damage response as a posttranscriptional regulator o

105 a-telangiectasia mutated (ATM) regulates the DNA damage response as well as DNA double-strand break r

106 is directly involved in the transcriptional DNA damage response as well as in the cell death pathway

107 ce, a condition associated with an activated DNA damage response, as p19(Arf)-/- MEFs do not senesce

108 rmore, XAB2 mediates specific aspects of the DNA damage response associated with end resection profic

109 o single-stranded telomeric DNA, eliciting a DNA damage response at telomeres that promote inappropri

110 arrest due to activation of the p53-mediated DNA damage response at the neonatal stage, which reduces

111 eplication defects that result in persistent DNA damage responses at telomeres, leading to the engage

112 regulation, including DNA synthesis (NPAT), DNA damage response (ATM), mitosis (PMF1, CENPN and MAD1

113 of a single-strand annealing protein [DdrB (DNA damage response B)] in complex with a partially anne

114 Further, we reveal different DNA damage responses between neonatal and adult neural s

115 now known to play key roles not only in the DNA damage response but also in regulating numerous mole

116 Ube2w does not have an essential role in the DNA damage response, but is deleterious in the absence o

117 arrest specific cell cycle phases nor elicit DNA damage response, but rather induce an irreversible,

118 1 also participates in gene silencing during DNA damage response, but the precise downstream function

119 pluripotent stem cells also display a robust DNA damage response, but the stability of their genome i

120 tenuated drug-induced activation of cellular DNA damage response by evading G2/M arrest in cancer cel

121 ere, we investigate roles of nuclear PPIs in DNA damage response by sequestering specific PPIs with t

122 c-1 interactions with the following genes in DNA damage response: C34F6.1, him-3 (ortholog of HORMAD1

123 DNA damage response can trigger tumor suppressor p53 act

124 To position NONO in the DNA-damage response cascade, we analysed the loading ont

125 ponents of the apical MRE11/RAD50/NBS1 (MRN) DNA damage response complex.

126 The function of numerous DNA damage response components is fine-tuned by posttran

127 Collectively referred to as the DNA damage response, conserved pathways ensure proper DN

128 mon translatome identified components of the DNA damage response, consistent with a role for the tran

129 Genes that have roles in the DNA damage response could underpin a common DNA repeat-b

130 ere, we show that the complete disruption of DNA damage response (DDR) adaptor proteins in ETI cells

131 xpression results in sustained activation of DNA damage response (DDR) after platinum treatment.

132 meres, PHF11 was enriched as cells mounted a DNA damage response (DDR) against exposed chromosome end

133 eptibility genes encode proteins involved in DNA damage response (DDR) and are characterized by rare

134 Open chromatin structure is important for DNA damage response (DDR) and DNA repair.

135 ew the genome-protective role of the mitotic DNA damage response (DDR) and evidence suggesting that i

136 ed regeneration coincides with activation of DNA damage response (DDR) and impaired ability to differ

137 In mouse HSCs, Pot1a knockdown increases DNA damage response (DDR) and inhibits self-renewal.

138 hrough resection activates the ATR-dependent DNA damage response (DDR) and is required for DSB repair

139 t, they also exhibited a uniquely attenuated DNA damage response (DDR) and muted DNA repair.

140 complex syndromes that include a compromised DNA damage response (DDR) and prominent nervous system p

141 The function of many factors involved in DNA damage response (DDR) and the cell cycle depends on

142 x-subunit protein complex that represses the DNA damage response (DDR) at chromosome ends.

143 t mitotic arrest induces a caspase-dependent DNA damage response (DDR) at telomeres in non-apoptotic

144 Autophagy plays a central role in the DNA damage response (DDR) by controlling the levels of v

145 The mitotic kinase Plk1 contributes to the DNA damage response (DDR) by targeting multiple factors

146 n response to this replication blockade, the DNA damage response (DDR) cell signalling network is act

147 together PTTG and PBF significantly modulate DNA damage response (DDR) genes, including p53 target ge

148 We recently linked Gene 33 to the DNA damage response (DDR) induced by hexavalent chromium

149 anipulation of host chromatin.IMPORTANCE The DNA damage response (DDR) is a cellular network that is

150 The DNA damage response (DDR) is a set of cellular events th

151 ature of the adenovirus genome, the cellular DNA damage response (DDR) is considered a barrier to suc

152 KSHV replication, we have determined that a DNA damage response (DDR) is directed to viral genomes b

153 SIGNIFICANCE STATEMENT: The DNA damage response (DDR) is essential for prevention of

154 Here we show that these agents activate the DNA damage response (DDR) kinases ATM and DNA-PKcs throu

155 The DNA damage response (DDR) orchestrates a network of cell

156 H3K36me3 localizes components of the DNA damage response (DDR) pathway and SETD2 mutation imp

157 USP7) in the regulation of the p53-dependent DNA damage response (DDR) pathway is well established.

158 to ionizing radiation (IR), cells activate a DNA damage response (DDR) pathway to re-program gene exp

159 ve DNA damage and activation of the ATR-Chk1 DNA damage response (DDR) pathway via ill-defined mechan

160 and BCLAF1 in the regulation of the cellular DNA damage response (DDR) pathway, a key pathway involve

161 ression is associated with activation of the DNA damage response (DDR) pathway, as evidenced by eleva

162 an S-phase checkpoint that acts through the DNA damage response (DDR) pathway, involving the Cds1 ki

163 irectly participate in the regulation of the DNA damage response (DDR) pathway, we challenged Plk1-ov

164 that encodes a critical apical kinase of the DNA damage response (DDR) pathway.

165 its known functions, to date, pertain to the DNA damage response (DDR) pathway.

166 ctions at the cross-roads of three different DNA damage response (DDR) pathways involved in protectin

167 of the Spindle Assembly Checkpoint (SAC) and DNA Damage Response (DDR) pathways.

168 The DNA damage response (DDR) plays a pivotal role in mainta

169 Whether intranuclear inclusions containing DNA damage response (DDR) proteins are causally linked t

170 on-exclusive markers, including constitutive DNA damage response (DDR) signaling, senescence-associat

171 ent of the Fanconi anemia-related pathway of DNA damage response (DDR) signaling.

172 DSBs trigger the DNA damage response (DDR) that directs a cell to repair

173 Mammalian cells have evolved a common DNA damage response (DDR) that sustains cellular functio

174 FA signaling is crucial in the DNA damage response (DDR) to mediate the repair of damag

175 rylation cascade integrates signals from the DNA damage response (DDR) towards PGC-1beta-dependent mi

176 s of mice (MVM) induces a sustained cellular DNA damage response (DDR) which the virus exploits to pr

177 s of mice (MVM) induces a sustained cellular DNA damage response (DDR) which the virus then exploits

178 E-ALI) cultures, HBoV1 infection initiates a DNA damage response (DDR), activating all three phosphat

179 te procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflamm

180 o apoptosis or senescence as outcomes of the DNA damage response (DDR).

181 old protein CCDC98 (Abraxas) and facilitates DNA damage response (DDR).

182 ch play key roles in regulating the cellular DNA damage response (DDR).

183 generates small noncoding RNA to mediate the DNA damage response (DDR).

184 oped a coordinated signalling network called DNA damage response (DDR).

185 he acute-phase response, metabolism, and the DNA damage response (DDR).

186 e, and in the cytosol/nucleus as part of the DNA damage response (DDR).

187 double-strand break sites (DSBs) during the DNA damage response (DDR).

188 O binding induces a lesion that triggers the DNA damage response (DDR).

189 foci, suggesting similar activation of early DNA damage response (DDR).

190 ol for real-time single-cell analysis of the DNA damage response (DDR).

191 t are potently activated during the cellular DNA damage response (DDR).

192 vents beta-cell apoptosis by attenuating the DNA damage response (DDR).

193 l RNAs (diRNA) play an important role in the DNA damage response (DDR).

194 stress response pathways collectively termed DNA damage response (DDR).

195 ymphocytes and that targeted manipulation of DNA damage-response (DDR) signaling pathways would allow

196 Mice lacking genes involving in the DNA-damage response (DDR) are often tumor prone owing to

197 ted this approach by targeting genes for the DNA-damage response (DDR) proteins MDC1, 53BP1, RIF1 and

198 ZNF423 participates in the DNA-damage response (DDR), raising questions regarding i

199 the breast epithelium unleashes a torrent of DNA damage responses (DDRs) at the telomeres, culminatin

200 ly and has been implicated in the control of DNA damage responses (DDRs) through its interactions wit

201 kDa (Sam68) as a novel signaling molecule in DNA damage responses (DDRs).

202 Conserved DNA-damage responses (DDRs) sense genome damage and prev

203 A system of DNA repair, called the DNA damage response, detects and repairs damaged DNA and

204 number of de novo genetic alterations due to DNA damage response during reprogramming.

205 , induce DNA breaks and orientation-specific DNA damage responses during conflicts with replication f

206 on entails the activation of p53 through the DNA damage-response enzymes, ATM and ATR, and requires t

207 work identifies a critical chromatin-binding DNA damage response factor, ZMYM3, which modulates BRCA1

208 Chromatin connects DNA damage response factors to sites of damaged DNA to p

209 One such response can include DNA damage response factors, which can promote an arrest

210 takes advantage of signaling pathways in the DNA damage response for efficient genome amplification i

211 mportant role in regulating the ATM mediated DNA damage response, for epithelial cell survival/self-r

212 lar senescence, as evidenced by a persistent DNA damage response (gammaH2AX and 53BP1) and the expres

213 ontain hepatocytes with a notable persistent DNA damage response (gammaH2AX, 53BP1) due to chronic in

214 FANCM is a DNA-damage response gene whose heterozygous mutations pr

215 Furthermore, the expression of 10 DNA damage response genes was downregulated in cells tre

216 he regulatory pathways implicated in the HSC DNA damage response have not been fully elucidated.

217 DNA damage responses have evolved to sense and react to

218 SSB1 and SSB2 are crucial regulators of the DNA damage response; however, their overlapping roles du

219 een Pol epsilon and the main elements of the DNA damage response in Arabidopsis (Arabidopsis thaliana

220 age in vitro and significantly decreased the DNA damage response in gnotobiotic Il10(-/-) mice.

221 ivo fate analysis of HFSCs revealed that the DNA damage response in HFSCs causes proteolysis of type

222 This is the first study to detect an acute DNA damage response in operators performing fluoroscopic

223 senescence may result from chronic, low-dose DNA damage responses in which p19(Arf) has a specific ro

224 omeric overhang of telomeres, elicits potent DNA-damage responses in melanoma cells; however, its mec

225 le-strand breaks (DSBs) activate a canonical DNA damage response, including highly conserved cell cyc

226 damage, severe hypoxia (<0.1% O2) induces a DNA damage response, including the activation of p53 and

227 We sought to study DNA damage and DNA damage responses induced by house dust mite (HDM) in

228 unctional role of ATM kinase, which controls DNA damage responses involving several hundreds of prote

229 The DNA damage response is an essential process for the surv

230 In vertebrate cells, the DNA damage response is controlled by three related kinas

231 1 has been established well as a mediator in DNA damage response, its function in mitosis is not clea

232 Loss-of-function mutations in the DNA damage response kinase ATM are common in lung adenoc

233 The DNA damage response kinase ATM is frequently mutated in

234 recurrent functional mutations of the master DNA damage response kinase ATM, which has been shown to

235 ts we find the response does not require the DNA damage response kinases ATM or ATR.

236 While mTOR is known to be involved in the DNA damage response, little is actually known regarding

237 the G4 fold in vitro and in cells, induces a DNA damage response localized to telomeres, inhibits PAR

238 mplex that protects chromosome ends from the DNA damage response machinery.

239 th a strong induction of the p53 pathway and DNA damage response, manifesting as gamma-H2A.X positivi

240 the DNA damage/repair marker, gamma-H2AX and DNA damage response marker, phosphorylated ataxia telang

241 ing that the role of p19(Arf) in the chronic DNA damage response may be partially p53-independent.

242 long these lines, we have tested whether the DNA damage response mediated by the Ataxia Telangiectasi

243 Consistent with the role of cyclin D1 in DNA damage response, ML364 also caused a decrease in hom

244 The expression of the DNA damage response molecule gamma-H2AX was significantl

245 ranslation of DNA replication, survival, and DNA damage response mRNAs.

246 and 53BP1 foci, two factors involved in the DNA damage response network, in cells treated with small

247 s to hypothesize that protein VII may affect DNA damage responses on the cellular genome.

248 orylation of Mdm2 regulates the p53-mediated DNA damage response or p53 tumor suppression in vivo.

249 d cyclin-dependent kinase 1 (CDK1) activity, DNA damage responses, or unscheduled DNA synthesis but t

250 hways that control cell proliferation (ERK), DNA-damage responses (p53), and innate immune and stress

251 Activation of this DNA damage response pathway also occurred upon antigen-s

252 nced G2 cell cycle arrest with activation of DNA damage response pathway and increased apoptosis was

253 Huwe1's critical role as a modulator of the DNA damage response pathway in the earliest steps of spe

254 induced AICD, as a result of activating the DNA damage response pathway through ATM-mediated Ser15 p

255 gene-induced stress pathway) but not via the DNA damage response pathway.

256 as fludarabine, which act primarily via the DNA damage response pathway.

257 BW7alpha, an E3 ligase that functions in the DNA damage response pathway.

258 er and from eliciting erroneous induction of DNA damage response pathways.

259 ts partners, notably those implicated in the DNA-damage response, preferentially localized to and act

260 ass III deacetylase SIRT1; activation of the DNA damage response prevents SIRT1 deacetylation of TopB

261 variation lies in genes that are part of the DNA damage response, previously suggested to be importan

262 Injury-induced ATM mediated DNA damage response, pro-survival genes, stem cell marke

263 cancer subclass through a hormone-dependent DNA damage response.Prostate cancer is a heterogeneous d

264 ation was associated with an accumulation of DNA damage response protein gammaH2AX, impaired downstre

265 The role of the DNA damage response protein kinase ataxia telangiectasia

266 acting protein 1 (Rint1) associates with the DNA damage response protein Rad50 during the transition

267 We report that deficiency of 53BP1, a DNA damage-response protein, caused age-dependent overpr

268 regions were enriched for pro-coagulant and DNA damage response proteins.

269 targeting and modulating of the activity of DNA damage response proteins.

270 conserved sites disrupt its deacetylation of DNA-damage response proteins by impairing SIRT2 catalyti

271 The genetic evidence implicates a DNA damage response-related pathway in modulating the pa

272 However, the role of CTCF in DNA damage response remains elusive.

273 -specific small non-coding RNAs, also termed DNA damage response RNAs (DDRNAs), have been shown to pl

274 zed the effect of H. pylori infection on the DNA damage response sensor, ATM, in gastric epithelial c

275 protein expression of key modulators of the DNA damage response.Sequestering mRNA in cytoplasmic str

276 vealed a reliance of SS tumor cells upon the DNA damage response serine/threonine protein kinase ATR.

277 Additionally, we show increased DNA damage response signaling in fibroblasts from affect

278 Analyses of various DNA damage response signaling pathways demonstrated that

279 antiviral factor IRF1 but not on downstream DNA damage response signaling.

280 tant roles in transcriptional regulation and DNA damage response signaling.

281 used endoplasmic reticulum stress, activated DNA-damage-response signaling, and ultimately induced ap

282 has been attributed to its canonical role in DNA damage response signalling following replication for

283 cant overexpression of genes involved in the DNA damage response, specifically in SCLC.

284 gulate multiple cellular functions including DNA damage response, telomere maintenance, and Notch sig

285 ata identifies a new target for manipulating DNA damage response that could impact the development of

286 re to ultraviolet light leads to a cell-wide DNA damage response that includes a global reduction in

287 modification coincides with the ATM-mediated DNA damage response that occurs on functional telomeres

288 layed onset (days), in contrast to the acute DNA-damage responses that occur in minutes to hours.

289 and p-ATM expression, and further triggered DNA damage response through activation of ATM-p53-p21 an

290 ng enzyme that has been reported to regulate DNA-damage responses through its N-terminal region in a

291 Viruses often interfere with the DNA damage response to better replicate in their hosts.

292 thus identifies TRAIP as a component of the DNA damage response to replication-blocking DNA lesions.

293 aluate whether NONO could be involved in the DNA-damage response to UV radiations.

294 NA-mRNA interaction networks involved in the DNA damage response, validating them through the identif

295 ese results suggest that CTCF participate in DNA damage response via poly(ADP-ribosylation).

296 The transcription-related DNA damage response was analyzed on a genome-wide scale

297 Reducing MYC during the DNA damage response was important for cell-fate regulati

298 despread intron retention and markers of the DNA damage response were also observed with SMN depletio

299 BRCA1 is an important mediator of the DNA damage response, which promotes homologous recombina

300 hort telomeres must avoid recognition by the DNA damage response while promoting telomerase recruitme