ライフサイエンスコーパス: DNA deletion

1 h element was sufficient to inhibit specific DNA deletion.

2 ear to be responsible for gene silencing and DNA deletion.

3 30-nt small RNAs known to be associated with DNA deletion.

4 on the location and length of the telomeric DNA deletion.

5 ate of DNA influx is balanced by the rate of DNA deletion.

6 parently because of its high rate of genomic DNA deletion.

7 d on the frequency of a single mitochondrial DNA deletion.

8 nce basis for misalignment in the process of DNA deletion.

9 e-site mutations and in the patient with the DNA deletion.

10 luding site-specific chromosome breakage and DNA deletion.

11 xygen species, transmembrane instability, or DNA deletions.

12 legia associated with multiple mitochondrial DNA deletions.

13 s sequences resulting in a high frequency of DNA deletions.

14 vels and, as a genetic instability endpoint, DNA deletions.

15 guanosine, gamma-H2AX foci, micronuclei, and DNA deletions.

16 II) significantly increased the frequency of DNA deletions.

17 ank two-thirds of the reported mitochondrial DNA deletions.

18 able of detecting submicroscopic chromosomal DNA deletions.

19 cient mice display an increased frequency of DNA deletions.

20 stant sites of microhomology, creating large DNA deletions.

21 -targeting vectors to generate large genomic DNA deletions.

22 ht patients (67%) had a single mitochondrial DNA deletion, 12 (10%) had a point mutation of mitochond

23 ower in patients with a single mitochondrial DNA deletion (2%) as compared to those with a point muta

24 To generate DNA deletions, a tandem array of class IIS restriction e

25 any age-dependent increases in mitochondrial DNA deletions also detected by the long polymerase chain

26 Using DNA deletion analysis of the 5'-flanking region of promo

27 DNA deletion analysis of the fis promoter (fis P) region

28 n by nuclear run-on transcription assays and DNA deletion analysis of transfected SCD1-chloramphenico

29 ry chain defects, secondary to mitochondrial DNA deletion and depletion, are likely to be responsible

30 These results indicated that DNA deletion and recombination had occurred in either ci

31 Moreover, the D6 sequence showed evidence of DNA deletion and substitution in this region relative to

32 nd IV due to clonally-expanded mitochondrial DNA deletions and a significant reduction in mitochondri

33 The results show that mitochondrial DNA deletions and cytochrome c oxidase-deficient cones a

34 efects and single, large-scale mitochondrial DNA deletions and is less frequently associated with poi

35 DNA deletions and other genome rearrangements are involv

36 l, progressive accumulation of mitochondrial DNA deletions and point mutations accompanied by increas

37 Mitochondrial DNA deletions and point mutations accumulate in an age-d

38 uric acid-reactive substances, mitochondrial DNA deletions, and renal expression of fibrogenic genes,

39 P1, CCNJ, CHST2/7, CLEC12A/B, and PTPRM; ERG DNA deletions; and 4-year relapse-free survival of 94.7%

40 Mitochondrial DNA deletions are prominent in human genetic disorders,

41 use microcytic anemia, whereas mitochondrial DNA deletions are responsible for Pearsons syndrome with

42 ve stress and genetic instability, including DNA deletions, are involved in carcinogenesis.

43 DNA deletion assays may be sensitive indicators for carc

44 ay a role in the generation of mitochondrial DNA deletions associated with a number of human patholog

45 es by causing chromosomal translocations and DNA deletions at cancer genes.

46 within 20 base pairs) to known mitochondrial DNA deletion breakpoints.

47 inding in patients with single mitochondrial DNA deletions but that it is highly predictive of an und

48 The frequency of DNA deletions by homologous recombination at the pink-ey

49 arbons in genotoxicity assays that score for DNA deletions by intrachromosomal recombination in vivo

50 Inherent disorders of mitochondria such as DNA deletions cause major disruption of metabolism and c

51 lation of peripheral T cells enriched in the DNA deletion circles created by alphabeta and gammadelta

52 RAG-2, bind and cleave the cRSS to generate DNA deletion circles during the V(H) replacement process

53 ectomy resulted in the gradual loss of these DNA deletion circles in all of the peripheral lymphoid t

54 dase-deficient fibers revealed mitochondrial DNA deletions, consistent with damage from oxidative str

55 romoter-intron reporter assays using various DNA deletion constructs indicated that several HIF-1 bin

56 large-scale genomic rearrangements, such as DNA deletions, duplications, and translocations.

57 sion of the RNA hairpin also causes targeted DNA deletion during conjugation, although at low efficie

58 Ab isotype is mediated by a recombinational DNA deletion event and must be robustly upregulated duri

59 Approximately 6000 specific DNA deletion events occur during development of the soma

60 cient cells (rho(-)) harboring mitochondrial DNA deletion exhibit dependency on glycolysis, increased

61 The multiple mitochondrial DNA deletions found in skeletal muscle revealed a mitoch

62 nts in the Cx40 promoter region, a series of DNA deletion fragments flanking exon I was prepared, sub

63 Many cancers harbor homozygous DNA deletions (HDs).

64 l phage resistance mechanism via chromosomal DNA deletion in P. aeruginosa.

65 Recent molecular studies on DNA deletion in Tetrahymena have revealed two interestin

66 ference (RNAi) has been linked to programmed DNA deletion in the ciliate Tetrahymena thermophila.

67 ro can induce the formation of mitochondrial DNA deletions in a PCR detection assay.

68 most common cause of multiple mitochondrial DNA deletions in adults, following POLG [polymerase (DNA

69 of oxidative DNA damage and the frequency of DNA deletions in Atm-deficient (AT-mutated) mice.

70 OH deoxyguanosine level and the frequency of DNA deletions in Atm-deficient mice.

71 orf2 or RRM2B, or had multiple mitochondrial DNA deletions in muscle without an identified nuclear ge

72 leven patients showed multiple mitochondrial DNA deletions in skeletal muscle and 67% showed ragged r

73 ither with or without multiple mitochondrial DNA deletions in skeletal muscle.

74 he question of the spectrum of mitochondrial DNA deletions in skin and whether this can be used as an

75 was a significant increase in the number of DNA deletions in the embryo as evidenced by spotted offs

76 -deficient fibres and multiple mitochondrial DNA deletions in the majority of patients harbouring OPA

77 e-negative fibres and multiple mitochondrial DNA deletions in the muscle of patients with s-IBM have

78 the nutritional supplement Cr(III) increase DNA deletions in vitro and in vivo, when ingested via dr

79 tochondrial protein carbonyls, mitochondrial DNA deletions, increased autophagy and signaling for mit

80 ion, we have introduced an identical genomic DNA deletion into the murine CLN3 homologue (Cln3) to cr

81 creased mitochondrial defects, mitochondrial DNA deletion levels, and susceptibility to such dysfunct

82 s microsatellite) primer pairs and a plastid DNA deletion marker that distinguishes most lowland Chil

83 This high rate of DNA deletion may explain the compact nature of the nemat

84 chromium(III) chloride on the frequencies of DNA deletions measured with the deletion assay in Saccha

85 Large mitochondrial (mt) DNA deletion mutations (4.4-9.7 kb) were detected in all

86 ndrial abnormalities contained mitochondrial DNA deletion mutations as revealed by laser capture micr

87 We hypothesized that mitochondrial DNA deletion mutations contribute to the fiber atrophy a

88 causal role for age-associated mitochondrial DNA deletion mutations in sarcopenia.

89 Site-specific DNA deletion occurs at thousands of sites within the gen

90 When there was no homology with the donor DNA, deletions of up to 5 kb involving direct repeats th

91 ngly activate transcription when targeted to DNA; deletion of this domain generates an allele that ex

92 s to the formation of multiple mitochondrial DNA deletions over time, similar to aging and Parkinson'

93 DNA deletion patients with atypical symptoms have been a

94 lasma apolipoprotein (apo) A-I can be due to DNA deletions, rearrangements, or nonsense or frameshift

95 basement membrane thickening, mitochondrial DNA deletions, reduction of nerve conduction velocities

96 -/-) mice displayed an elevated frequency of DNA deletions, resulting from HR at the endogenous p(un)

97 ion technique to determine the mitochondrial DNA deletion spectrum of almost the entire mitochondrial

98 eased DNA ligase IIIalpha and a reduction in DNA deletions, suggesting that FLT3 signaling regulates

99 led that Cr(III) is a more potent inducer of DNA deletions than Cr(VI) once Cr(III) is absorbed.

100 mal stripe (NCS) mutants carry mitochondrial DNA deletions that affect subunits of respiratory comple

101 This interference with DNA deletion usually is manifested as a cytoplasmic domi

102 ntrast, in Fancg(-/-) mice, the frequency of DNA deletions was decreased.

103 ients with single, large-scale mitochondrial DNA deletions we demonstrate that a variety of outcome m

104 Multiple mitochondrial DNA deletions were seen by long polymerase chain reactio

105 Multiple mitochondrial DNA deletions were universally present in patients who u

106 legia associated with multiple mitochondrial DNA deletions, whereas recessive SLC25A4 mutations cause