ライフサイエンスコーパス: DNA demethylation

1 ed histone H3 Lys-27 trimethylation, and CpG-DNA demethylation).

2 e up-regulating Tet1 and Tet2, which promote DNA demethylation.

3 which is enriched in brain, and its ultimate DNA demethylation.

4 o 5-hydroxymethylcytosine (5 hmC) to mediate DNA demethylation.

5 ss in understanding the mechanism underlying DNA demethylation.

6 able, post-mitotic neurons exhibit extensive DNA demethylation.

7 epigenetic marks and likely intermediates in DNA demethylation.

8 ocation (TET) family members regulate active DNA demethylation.

9 estigations into the biological functions of DNA demethylation.

10 the DNA glycosylase ROS1, which facilitates DNA demethylation.

11 n the mechanism and function of TET-mediated DNA demethylation.

12 xylcytosine (5caC), thereby mediating active DNA demethylation.

13 genic pathways and inhibition of histone and DNA demethylation.

14 of mutations in IDM1, a regulator of active DNA demethylation.

15 by thymine DNA glycosylase (TDG), leading to DNA demethylation.

16 y of 5mC dioxygenases and an intermediate of DNA demethylation.

17 cision repair, transcription regulation, and DNA demethylation.

18 reprogramming, which includes comprehensive DNA demethylation.

19 enetic marks and potential intermediates for DNA demethylation.

20 evelopment and in PGCs at the time of global DNA demethylation.

21 d 5caC, connecting 5mC oxidation with active DNA demethylation.

22 ility led to genomic and methylated reporter DNA demethylation.

23 as been hypothesized to edit RNA and mediate DNA demethylation.

24 ethyltransferases and components involved in DNA demethylation.

25 lycosylase TDG, implicating 5mC oxidation in DNA demethylation.

26 oxyglutarate as an inhibitor of TET-mediated DNA demethylation.

27 y embryo, are resistant to vitamin-C-induced DNA demethylation.

28 ne has greatly advanced our understanding of DNA demethylation.

29 -ray cross-complementing group protein 1) in DNA demethylation.

30 by reexpression of miRNAs upon pharmacologic DNA demethylation.

31 The mammalian TET enzymes catalyze DNA demethylation.

32 yonic and germ cell development by mediating DNA demethylation.

33 o 5-hydroxymethylcytosine (5hmC) and promote DNA demethylation.

34 iad and Tet1, a gene known to be involved in DNA demethylation.

35 ripotent state, including X reactivation and DNA demethylation.

36 ion and because it may be an intermediate in DNA demethylation.

37 ate that could transiently be reactivated by DNA demethylation.

38 ica, suggesting its potential use in probing DNA demethylation.

39 oposed as a potential intermediate in active DNA demethylation.

40 ngator complex, to be important for paternal DNA demethylation.

41 ewly synthesized DNA was the likely cause of DNA demethylation.

42 insights into how TET and TDG mediate active DNA demethylation.

43 DG-abasic product dissociation during active DNA demethylation.

44 roxymethylcytosine (5hmC), which can lead to DNA demethylation.

45 ndard of care, mesna or nicotinamide-induced DNA demethylation.

46 d play a role in gene expression mediated by DNA demethylation.

47 een DNA methylation and ROS1-mediated active DNA demethylation.

48 itical roles in DNA base excision repair and DNA demethylation.

49 ession is partly maintained by TET2-mediated DNA demethylation.

50 s 5hmC, but also initiates active or passive DNA demethylation.

51 r oxidized methylcytosines, intermediates in DNA demethylation.

52 rate HBx induces EpCAM expression via active DNA demethylation.

53 es and meta-plasticity of neurons via active DNA demethylation.

54 maintaining genomic integrity and for active DNA demethylation, a central element of epigenetic regul

55 the central role of BER in mediating active DNA demethylation, a multistep process that erases the e

56 DNA demethylation, a process involving DNA repair, is cr

57 th promoters exhibited Th17 lineage-specific DNA demethylation, accompanied by demethylation of lysin

58 ative and high-resolution analysis of active DNA demethylation activity remains challenging.

59 We identify specific targets for DNA demethylation after nuclear transfer, such as germli

60 ation by coordinating efficient TDG-mediated DNA demethylation along with active transcription during

61 ely, our findings suggest that Tet2 promotes DNA demethylation and activation of cytokine gene expres

62 ing osteoblast differentiation as it impairs DNA demethylation and alters the recruitment of histone

63 views of 5hmC as a transient intermediate in DNA demethylation and as a modified DNA base with an ins

64 clues in a long elusive mechanism of active DNA demethylation and bolstered a fresh wave of studies

65 The link between inhibition of DNA demethylation and changes in expression is strong in

66 ensive epigenome resetting, including global DNA demethylation and chromatin reorganization.

67 FOXA1-dependent enhancers and mediates local DNA demethylation and concomitant histone 3 lysine 4 met

68 rimordial germ cells, but leads to defective DNA demethylation and decreased expression of a subset o

69 oxidase TET proteins play important roles in DNA demethylation and development.

70 ay serve as a direct link between epigenetic DNA demethylation and DNA repair in mammalian cells.

71 lycosylase activity, is essential for active DNA demethylation and embryonic development.

72 lase activity of TDG is essential for active DNA demethylation and for embryonic development.

73 ydroxymethylcytosine, which promotes passive DNA demethylation and functions as an intermediate in an

74 creased DNA methylation 2) as a regulator of DNA demethylation and gene silencing.

75 Our results indicate that DNA demethylation and histone acetylation are coordinate

76 romoters is accompanied by promoter-proximal DNA demethylation and histone marks associated with acti

77 ombinatorial cancer immunotherapy harnessing DNA demethylation and IFN-gamma response.

78 esults suggest that IDM2 functions in active DNA demethylation and in antisilencing by regulating IDM

79 A correlation between promoter DNA demethylation and injury-dependent gene induction wa

80 TDG functions in active DNA demethylation and is essential for embryonic develop

81 aKG to succinate ratio that promotes histone/DNA demethylation and maintains pluripotency.

82 ype of IDH mutant glioma was associated with DNA demethylation and poor outcome; a group of IDH-wild-

83 mesenchymal breast cancer cells resulted in DNA demethylation and reexpression of the genes identifi

84 ions of Tet3 and DNA replication in paternal DNA demethylation and reveals an unexpected contribution

85 advantage of its recently discovered role in DNA demethylation and selective recognition and repair o

86 al activity-induced, region-specific, active DNA demethylation and subsequent gene expression in the

87 ithout ascorbate (vitamin C), which promotes DNA demethylation and subsequently changes the sensitivi

88 e methyltransferase Dnmt1 induces widespread DNA demethylation and transcriptional activation of ERVs

89 ver, direct connections between TET-mediated DNA demethylation and transcriptional output are difficu

90 r progression, in part, through the specific DNA demethylation and upregulation of epidermal growth f

91 anistically, peripheral nerve injury induces DNA demethylation and upregulation of multiple regenerat

92 Mechanistically, XCR requires both DNA demethylation and Xist silencing, ensuring that only

93 We focus on DNA methylation, DNA demethylation, and common histone tail modifications

94 eports linking AID and related deaminases to DNA demethylation, and describes the many important ques

95 ne (5hmC), providing an active mechanism for DNA demethylation, and it may also provide its own regul

96 contribute to adaptive and innate immunity, DNA demethylation, and the modification of cellular mRNA

97 Global DNA demethylation appears to be a shared attribute of re

98 Thus, tissue-specific DNA demethylation appears to be necessary for proper som

99 ine (5mC)) and their removal by TET-mediated DNA demethylation are critical for setting up pluripoten

100 Tet proteins and DNA demethylation are key regulators of embryonic stem c

101 , but the mechanisms of regulation of active DNA demethylation are not well understood.

102 n vitro PGC (iPGC) formation and genome-wide DNA demethylation are unaffected by the absence of Tet1

103 Smad proteins promote locus-specific active DNA demethylation as part of the transforming growth fac

104 Modulation of histone and DNA demethylation, as well as HIF-1alpha stability, medi

105 e oxidized methylcytosines, intermediates in DNA demethylation, as well as new epigenetic marks.

106 rease in the level of 5hmC with accompanying DNA demethylation at a subset of CGIs.

107 reveals a role for Tet proteins in not only DNA demethylation at enhancers but also regulating the 2

108 function as a cancer therapy via histone and DNA demethylation at genes involved in differentiation a

109 ogonia also displayed developmentally linked DNA demethylation at meiotic genes and also at certain m

110 beta-globin locus was coincident with global DNA demethylation at most genomic elements.

111 nner and coordinates histone acetylation and DNA demethylation at SEs.

112 enge [i.e., forced swimming (FS)] results in DNA demethylation at specific CpG (5'-cytosine-phosphate

113 We found that localized DNA demethylation at the H19 imprinting control region (

114 xp3 in regulatory T cells (Tregs) depends on DNA demethylation at the Treg-specific demethylated regi

115 ll, the companion cell of the egg, undergoes DNA demethylation before fertilization, but the targetin

116 dilution both contribute to global paternal DNA demethylation, but demethylation of the maternal gen

117 RNF4 does not promote DNA demethylation, but mediates the ubiquitination of Me

118 lly controlled by DNA methylation and active DNA demethylation, but the mechanisms of regulation of a

119 that TET2, a cellular enzyme that initiates DNA demethylation by converting 5-methylcytosine (5mC) i

120 on of TET2, a cellular enzyme that initiates DNA demethylation by converting 5-methylcytosine (5mC) i

121 utarate-dependent enzymes (Tet1/2/3) promote DNA demethylation by converting 5-methylcytosine to 5-hy

122 sion-suppressor miRNAs by inhibiting genomic DNA demethylation by direct targeting of TET1, thereby l

123 allelic expression is correlated with active DNA demethylation by DNA glycosylases and repressive tar

124 effect is likely the result of both passive DNA demethylation by DNMTi and active conversion of 5-me

125 MBD4 is also implicated in active DNA demethylation by initiating base excision repair of

126 e Tet 5-methylcytosine dioxygenases catalyze DNA demethylation by producing 5-hydroxymethylcytosine a

127 17 and BLIMP1, drives comprehensive germline DNA demethylation by repressing DNA methylation pathways

128 2 were previously shown to facilitate active DNA demethylation by the 5-methylcytosine DNA glycosylas

129 ailing both passive and active mechanisms of DNA demethylation by the ten-eleven translocation (TET)

130 pon miR-494 overexpression, whereas enforced DNA demethylation can abolish the repression.

131 Here, we present a summary of how DNA demethylation can be initiated directly, utilizing t

132 Hence, DNA demethylation can occur globally during somatic cell

133 MT targeting protein, UHRF1, can augment the DNA demethylation capacities of existing DNA methylation

134 tes at key transitioning steps of the active DNA demethylation cascade and reveals a regulatory role

135 Our results show that active DNA demethylation combats the activity of RNA-directed D

136 an exogenous source of alphaKG restored the DNA demethylation cycle by promoting TDG function, TET1

137 Restoring the epimetabolic control of DNA demethylation cycle promises beneficial effects on c

138 pathway represents a replication-independent DNA demethylation cycle.

139 expression through a mechanism regulated by DNA demethylation-dependent nuclear hormone receptor rec

140 In Arabidopsis, active DNA demethylation depends on the function of the ROS1 su

141 Derepression coincided with DNA demethylation, dissociation of polycomb proteins, an

142 f Oct4, a master gene that undergoes dynamic DNA demethylation during cellular reprogramming.

143 SNORD116 cluster may protect the PWS-IC from DNA demethylation during early development.

144 l processes, including the genome-wide/local DNA demethylation during early embryogenesis, cell diffe

145 hypomethylation, which were recapitulated by DNA demethylation during in vitro directed differentiati

146 small non-coding RNA mediated regulation on DNA demethylation dynamics and the differential expressi

147 ome of cells that have emerged from a global DNA demethylation event.

148 ryos does not fully recapitulate the natural DNA demethylation events occurring at fertilization, res

149 two oxidized 5mC bases indicative of active DNA demethylation events.

150 n important regulatory role of Tet-dependent DNA demethylation for the maintenance of DNA methylation

151 y, suggesting a requirement for Tet-mediated DNA demethylation for the proper regulation of gene expr

152 D and streptozotocin mice eliciting, in HFD, DNA demethylation, glucose uptake, and insulin response.

153 Although global DNA demethylation has been observed after treatment, it

154 DNA demethylation has been primarily studied in the cont

155 Therefore, bypassing stage-specific DNA demethylation has significant consequences for proge

156 ered epigenetic mark produced through active DNA demethylation, has not been previously investigated

157 ocessing oxidized 5mC derivatives to achieve DNA demethylation have emerged.

158 fforts, the factors responsible for paternal DNA demethylation have not been identified.

159 o memory formation, the regulation of active DNA demethylation (i.e., cytosine-5 demethylation) has o

160 We sought to investigate the role of DNA demethylation in activating inflammasome genes durin

161 precursor protein cleaving enzyme 1 (bace-1) DNA demethylation in AD-vulnerable brain regions.

162 Weng et al. (2017) reveal a role for active DNA demethylation in allowing axon regeneration to occur

163 nd functions at several stages during active DNA demethylation in Arabidopsis.

164 cancer cells can be partially reactivated by DNA demethylation in cells disrupted for the DNA methylt

165 TDG could potentially be useful for studying DNA demethylation in cells.

166 ate (alphaKG) in the epimetabolic control of DNA demethylation in CMSCs.

167 length TET1 (TET1-FL) induces massive global DNA demethylation in differentiated cells.

168 SCs recapitulated the process of genome-wide DNA demethylation in embryonic PGCs, including significa

169 Evidence that AID promotes DNA demethylation in epigenetic reprogramming phenomena,

170 plicate base excision repair for genome-wide DNA demethylation in germ cells and early embryos.

171 none exposure leads to active and functional DNA demethylation in HEK293 cells in a mechanism involvi

172 Global DNA demethylation in humans is a fundamental process tha

173 o 5-hydroxymethylcytosines (5hmCs), promotes DNA demethylation in mammalian cells through a process t

174 ew, we discuss the mechanism and function of DNA demethylation in mammalian genomes, focusing particu

175 Active DNA demethylation in mammals involves oxidation of 5-met

176 Active DNA demethylation in mammals involves TET-mediated itera

177 lopment and suggest a two-step mechanism for DNA demethylation in mammals, whereby 5-methylcytosine a

178 and thus provide a possible means for active DNA demethylation in mammals.

179 d oxidation-deamination mechanism for active DNA demethylation in mammals.

180 consistent with its potential role in active DNA demethylation in memory.

181 The cellular function of active DNA demethylation in neurons, however, remains largely u

182 nctional consequence of abrogating two-stage DNA demethylation in PGCs was precocious germline differ

183 e regulatory elements that escape systematic DNA demethylation in PGCs, providing a potential mechani

184 Active DNA demethylation in plants is mediated by a family of D

185 est a requirement for Tet- and 5hmC-mediated DNA demethylation in proper regulation of gene expressio

186 recently been shown to have a role in active DNA demethylation in reprogramming toward pluripotency a

187 The importance of DNA demethylation in SLE was confirmed through twin stud

188 Finally, novel mechanisms contributing to DNA demethylation in SLE were discovered.

189 ent accelerator of global and locus-specific DNA demethylation in somatic and pluripotent stem cells.

190 Treg numbers were detected via DNA demethylation in the FOXP3 TSDR.

191 TET1 (TET1) has been shown to promote active DNA demethylation in the nervous system.

192 Maternal obesity induces DNA demethylation in the promoter of zinc finger protein

193 ized the expression of genes associated with DNA demethylation in the uninjured and injured retina.

194 echanisms and critical functional players of DNA demethylation in this process remain largely unexplo

195 lcytosine in these regions implicated active DNA demethylation in this process.

196 vels of TET enzyme, which is responsible for DNA demethylation in UVB-exposed skin.

197 thermore, the biological functions of active DNA demethylation in various biological contexts have al

198 , our results support a revised model of PGC DNA demethylation in which the first phase of comprehens

199 c DNA methylation, and downstream targets of DNA demethylation, in incubation of cocaine craving.

200 45-beta (Gadd45-beta), a molecular player of DNA demethylation, in the mouse frontal cortex and hippo

201 nd that inhibition of DNA replication blocks DNA demethylation independently from Tet3 function and t

202 before fertilization also impaired paternal DNA demethylation, indicating that the SAM radical domai

203 ranscription is significantly upregulated by DNA demethylation induced by 5-aza-2'-deoxycytidine plus

204 In ESCs with DNA demethylation induced by acute deletion of Dnmt1, we

205 We further establish that DNA demethylation induced by XPC expression in somatic c

206 lants exhibit a reduced capacity to complete DNA demethylation initiated by ROS1.

207 Active DNA demethylation involves stepwise oxidation of mC to 5

208 suggest a new potential mechanism for active DNA demethylation, involving TDG excision of Tet-produce

209 To assess if PD-1 promoter DNA demethylation is impacted by prolonged stimulation d

210 Hydroxymethylation and subsequent DNA demethylation is more complex and involves additiona

211 This study provides evidence that DNA demethylation is part of a plant-induced immune resp

212 implicated in hydroxymethylation and active DNA demethylation, is a key regulator of EBV latency typ

213 ical model, which accurately predicts global DNA demethylation kinetics.

214 from Tet3 function and that Tet3 facilitates DNA demethylation largely by coupling with DNA replicati

215 Emerging evidence suggests that active DNA demethylation machinery plays important epigenetic r

216 g (WGBS) analysis revealed that Tet-mediated DNA demethylation mainly occurs at distally located enha

217 To begin investigating whether DNA demethylation may contribute to retina regeneration,

218 Our study raises the possibility that DNA demethylation may occur through Tet-catalyzed oxidat

219 ina and optic nerve regeneration and suggest DNA demethylation may underlie the reprogramming of cell

220 inding sequence, supporting that this active DNA demethylation mechanism functions during oncogenic t

221 s could play a role in an alternative active DNA demethylation mechanism via deformylation of fdC or

222 We also show that DDB2 regulates active DNA demethylation mediated by REPRESSOR OF SILENCING 1 (

223 anied by decreased nucleosome enrichment and DNA demethylation mediated by SWI/SNF- and Tet1/Tet2-con

224 Here, we show that active DNA demethylation mediated by the DEMETER DNA glycosylas

225 lved antisilencing mechanisms such as active DNA demethylation mediated by the REPRESSOR OF SILENCING

226 onstrate a new role for Elongator in somatic DNA demethylation/methylation and suggest a function for

227 Our results reveal that DNA demethylation modulates enhancer activity, and its d

228 recovered as second-site suppressors of the DNA demethylation mutant ros1-1.

229 inery that is responsible for the HG-induced DNA demethylation observed.

230 In PGCs, global and locus-specific DNA demethylation occur in sequential stages, with an in

231 Potent dose-related DNA demethylation occurred on the daily x 5 regimen, rea

232 DG, but the mechanism by which TDG-dependent DNA demethylation occurs in a rapid and site-specific ma

233 Global DNA demethylation occurs in the early embryo and the ger

234 erall hypomethylated state and site specific DNA demethylation of enhancer elements within the proxim

235 Here we report widespread DNA demethylation of enhancers during the phylotypic per

236 a and interleukin-2 to activate Tet-mediated DNA demethylation of Foxp3 to promote immune tolerance.

237 onse to maternal genome dosage imbalance and DNA demethylation of male gametes.

238 This is followed by DNA demethylation of many gene promoters and upregulatio

239 Specific DNA demethylation of regulatory sequences can result in

240 ring development is accompanied by extensive DNA demethylation of specific sites that vary between ce

241 Downregulation is caused by DNA demethylation of the gene bodies and restoration of

242 of human colorectal tumors exhibit aberrant DNA demethylation of the GM-CSF promoter and overexpress

243 DNA demethylation of the trophoblast like cell lines BeW

244 A strong dependence of 5-azacytidine-induced DNA demethylation on hENT1 activity was also confirmed b

245 hes the embryo, exhibits extensive localized DNA demethylation on maternally inherited chromosomes.

246 A methyltransferase expression, resulting in DNA demethylation, overexpression of immune genes, and a

247 However, an active DNA demethylation pathway is initiated during late seed

248 nducible, beta (GADD45b) protein-coordinated DNA demethylation pathway, utilizing cytidine deaminases

249 n a Tet (ten eleven translocation)-initiated DNA demethylation pathway.

250 as an initiating step of mitosis-independent DNA demethylation pathways and has not yet been observed

251 ther the histone and DNA methylation nor the DNA demethylation pathways known to regulate some other

252 igation, as they are likely intermediates in DNA demethylation pathways.

253 ess of TET-5hmC pathways and reveal critical DNA demethylation patterns.

254 rocess where regulatory components mediating DNA demethylation play a leading role.

255 ROS1-mediated DNA demethylation plays a critical role in the regulatio

256 Here, we show that TET2-mediated DNA demethylation plays a primary role in the de novo es

257 cellular tumor suppressor involved in active DNA demethylation, plays a central role in regulating th

258 ses Tet1 and Tet2 in the initial genome-wide DNA demethylation process has not been examined directly

259 Our biochemical understanding of the DNA demethylation process has prompted new investigation

260 s and indicate that TET/TDG-dependent active DNA demethylation process occurs extensively in the mamm

261 nd functions as an intermediate in an active DNA demethylation process.

262 methylation, hydroxymethylation, and active DNA demethylation provide a framework for the identifica

263 dogenous gene loci and validate programmable DNA demethylation reagents with potential utility for re

264 have been characterized, the mechanisms for DNA demethylation remain poorly understood.

265 ocation (TET) family of dioxygenase-mediated DNA demethylation requires new methods to quantitatively

266 DNA demethylation restricts multiplication and vascular

267 methylated ros1 mutant, which is affected in DNA demethylation, revealed that their opposite resistan

268 neurological disorders are also resistant to DNA demethylation, revealing potential for transgenerati

269 In DNA demethylation, TDG excises 5-formylcytosine (fC) and

270 Essential for DNA demethylation, TDG excises 5-formylcytosine and 5-ca

271 ed patients with CAPS undergo more efficient DNA demethylation than those of healthy subjects.

272 embryogenesis, including initial genome-wide DNA demethylation that establishes the germline epigenet

273 TET enzymes catalyse DNA demethylation through 5-methylcytosine oxidation.

274 pecies are reported to have a role in active DNA demethylation through 5mC oxidation and DNA repair,

275 translocation (TET) proteins are involved in DNA demethylation through iteratively oxidizing 5-methyl

276 teins are the key enzymes involved in active DNA demethylation through stepwise oxidation of 5mC.

277 oxidize 5-methylcytosine to initiate active DNA demethylation through the base-excision repair (BER)

278 silence somatic gene expression and dynamic DNA demethylation to activate pluripotency gene transcri

279 ution methylome analysis reveals progressive DNA demethylation to basal levels in week 5-7 in vivo hP

280 enetic barrier that can be removed by active DNA demethylation to permit axon regeneration in the adu

281 equential epigenetic changes and genome-wide DNA demethylation to reset the epigenome for totipotency

282 t may be exploited to facilitate therapeutic DNA demethylation to reverse kidney fibrosis.

283 ew methods for the genomic mapping of active DNA demethylation using limited numbers of cells or sing

284 To understand mammalian active DNA demethylation, various methods have been developed t

285 nases have also been proposed to function in DNA demethylation via deamination of either 5-methylcyto

286 main protein 4 (MBD4)--is involved in active DNA demethylation via the base excision repair pathway.

287 NA glycosylase (TDG) is implicated in active DNA demethylation via the base excision repair pathway.

288 The mechanism is NaCl-induced DNA demethylation via the recruitment of the hydroxytran

289 SFN enhances active DNA demethylation viaTet1andTet2and promotes preosteobla

290 Global and gene-specific DNA demethylation was achieved in peripheral blood monon

291 genase 2 (TET2) and nuclear factor kappaB to DNA demethylation was tested by using chromatin immunopr

292 The effect of DNA demethylation was transient, and prolonged exposure

293 antisense pancRNAs caused sequence-specific DNA demethylation, whereas a decrease of expression indu

294 and ten-eleven translocation (Tet)-dependent DNA demethylation, which contribute to the regulation of

295 This process is underpinned by genome-wide DNA demethylation, which may occur through several overl

296 dependent repair of DNA lesions arising from DNA demethylation, which prevents zygotes carrying unrep

297 e expression profiling after pharmacological DNA demethylation with functional screening to identify

298 is resource to monitor the outcome of global DNA demethylation with reversion of primed PSCs to the n

299 ut7 in murine CD4(+) T cells correlates with DNA demethylation within a minimal promoter in skin/infl

300 In conclusion, we show that DNA demethylation within the fut7 gene controls selectin