ライフサイエンスコーパス: DNA exonuclease

1 oth a 3' --> 5' DNA helicase and a 3' --> 5' DNA exonuclease.

2 uclease 1 (hExo1), a 5'-->3' double-stranded DNA exonuclease.

3 a cyclic AMPase; and RecJ, a single-stranded DNA exonuclease.

4 chiacoli RecQ helicase family, and a 3'-->5' DNA exonuclease.

5 as previously identified as a 3'-5'-directed DNA exonuclease.

6 of proteins constitute a novel class of RNA-DNA exonucleases.

7 by RecG DNA translocase and by single-strand DNA exonucleases.

8 ted that T4 RNase H, a 5'-3' exonuclease, T4 DNA exonuclease A (DexA) and the exonuclease activity of

9 encodes 3' --> 5' DNA helicase and 3' --> 5' DNA exonuclease activities, and is implicated in the mai

10 Both Pol delta and WRN encode 3' --> 5' DNA exonuclease activities.

11 sesses both 3'-->5' DNA helicase and 3'-->5' DNA exonuclease activities.

12 trinsic 3' --> 5' DNA helicase and 3' --> 5' DNA exonuclease activities.

13 However, TREX1 mutants competent for DNA exonuclease activity are also linked to AGS.

14 The 3' to 5' double-stranded DNA exonuclease activity associated with T5 DNA polymera

15 TREX1 constitutes the major 3'-->5' DNA exonuclease activity measured in mammalian cells.

16 pendent on the 5' --> 3' single-stranded (ss)DNA exonuclease activity of RecJ and the helicase activi

17 Here we report that APE1 has a DNA exonuclease activity on mismatched deoxyribonucleoti

18 enzyme not only displays 5'-3' double strand DNA exonuclease activity, but also shows an RNase H acti

19 enzyme exhibits an aberrant double-stranded DNA exonuclease activity, intrinsically producing a 3'-t

20 s at F266 and W280 of Ape1 increase 3' to 5' DNA exonuclease activity.

21 ciated ATPase activities, as well as 3'-->5' DNA exonuclease activity.

22 '->5' helicase activity and DNA2's 5'->3' ss-DNA exonuclease activity.

23 monstrate that WRN also exhibits an integral DNA exonuclease activity.

24 unknown function), Rnh (RNase H and 5' to 3' DNA exonuclease), alpha-gt (alpha-glucosyl transferase),

25 zyme of Escherichia coli is an ATP-dependent DNA exonuclease and a helicase.

26 The TREX1 gene encodes a potent DNA exonuclease, and mutations in TREX1 cause a spectrum

27 DNA exonucleases are critical for DNA replication, repai

28 tion study using t(14;18)-positive cell line DNA, exonuclease-based PCR detected fusion sequences at

29 changes the nature of RecBCD double-stranded DNA exonuclease by increasing the rate of digestion of t

30 Deficiency in the two major 3' single-strand DNA exonucleases, ExoI and ExoVII, stimulated hotspot mu

31 we have proposed for the other single-strand DNA exonucleases, exonuclease X may facilitate recombina

32 exhibits wild-type levels of double-stranded DNA exonuclease, helicase, and ATPase activity, its abil

33 en used to measure the degradation of DNA by DNA exonuclease I, providing data that would not be avai

34 Trex1 is the major 3' DNA exonuclease in mammalian cells, and mutations in the

35 Trex1, a major 3' DNA exonuclease in mammalian cells, has been thought to

36 the bacterium Escherichia coli there are 14 DNA exonucleases including exonucleases I-IX (including

37 s amino acid sequence similarity to other 3' DNA exonucleases, including ExoI.

38 3' repair exonuclease 1 (TREX1) is a known DNA exonuclease involved in autoimmune disorders and the

39 REX1, encoding the major mammalian 3' --> 5' DNA exonuclease, is the AGS1 gene, and AGS-causing mutat

40 9 g restriction fragments can be degraded by DNA exonucleases or ligated by T3 and T4 DNA ligases.

41 e repair exonuclease 1(TREX1), an endogenous DNA exonuclease, prevents immune activation by depleting

42 Additional analyses using a novel DNA exonuclease showed that the majority of the rAAV vec

43 The TREX1 protein is a dimeric 3' DNA exonuclease that degrades DNA to prevent inappropria

44 As ExoV, it is a potent double-stranded (ds)DNA exonuclease that destroys linear DNA produced by res

45 clease VII was first identified in 1974 as a DNA exonuclease that did not require any divalent cation

46 candidate is Exo1p, a 5'-3' double stranded DNA exonuclease that has previously been implicated in D

47 We show that the DNA exonuclease Trex1 is induced by radiation doses abov

48 overproduce type I IFNs owing to loss of the DNA exonuclease Trex1, inflammatory disease completely d

49 on is mediated by KSHV ORF37, a homolog of a DNA exonuclease widely present in other herpesviruses bu