ライフサイエンスコーパス: DNA glycosylase

1 clease) and DNA repair enzymes (e.g., uracil-DNA glycosylase).

2 ranslational modification of the human MutYH DNA glycosylase.

3 effects were observed previously for thymine DNA glycosylase.

4 osphate and from genomic DNA by 8-oxoguanine-DNA glycosylase.

5 and into the active site of the 8-oxoguanine-DNA glycosylase.

6 adducts that can be removed by alkyladenine DNA glycosylase.

7 ue to inactivation of MUTYH, which encodes a DNA glycosylase.

8 utase (MnSOD) and mitochondrial 8-oxoguanine DNA glycosylase.

9 but instead depends, in part, on the thymine DNA glycosylase.

10 tic promiscuity, such as these two unrelated DNA glycosylases.

11 ine (G) are substrates for repair by various DNA glycosylases.

12 rent catalytic mechanism from those of other DNA glycosylases.

13 y a unique catalytic center in this class of DNA glycosylases.

14 nteractions in modulating the specificity of DNA glycosylases.

15 ich are repair intermediates of bifunctional DNA glycosylases.

16 ) base interrogation during lesion search by DNA glycosylases.

17 Human 8-oxoguanine-DNA glycosylase 1 (hOGG1) transgenic (TG) mice were prod

18 of DNA sliding is human 8-oxoguanine ((o)G) DNA glycosylase 1 (hOGG1), which repairs mutagenic (o)G

19 ere recently shown to stimulate 8-oxoguanine DNA glycosylase 1 (OGG1), an enzyme that removes oxidize

20 enzymes, the DNA glycosylases TDG and 8-oxoG DNA glycosylase 1 (OGG1), apurinic/apyrimidinic (AP) end

21 8-Oxoguanine-DNA glycosylase-1 (OGG1) is the primary enzyme for repai

22 more pronounced in the case of 8-oxoguanine-DNA-glycosylase-1 and nei-endonuclease-VIII-like.

23 of DNA damage repair molecules 8-oxoguanine-DNA-glycosylase-1, nei-endonuclease-VIII-like, X-ray-rep

24 eral host cellular proteins including uracil DNA glycosylase-2 (UNG2) and a cullin-RING E3 ubiquitin

25 erase 3alpha (TOP3alpha) and NEIL3 (Nei-like DNA glycosylase 3), as well as transcription and RNA reg

26 The major DNA glycosylase, 8-oxoguanine glycosylase (OGG1), is res

27 We examined the role of the viral uracil DNA glycosylase, a protein conserved among all herpesvir

28 ide cancer protection similar to that of the DNA glycosylase AAG.

29 e repair of deaminated purines, alkyladenine DNA glycosylase (AAG) and AP endonuclease (APE1).

30 oxyribosyl moiety of DNA, human alkyladenine DNA glycosylase (AAG) and Escherichia coli 3-methyladeni

31 Although the human alkyladenine DNA glycosylase (AAG) can specifically bind DNA containi

32 Human alkyladenine DNA glycosylase (AAG) employs nonspecific DNA binding in

33 In human alkyladenine DNA glycosylase (AAG), the enzyme that initiates base ex

34 The mouse alkyl adenine DNA glycosylase (AAG, also known as MPG) recognizes such

35 ng RONS-induced DNA damage; the alkyladenine DNA glycosylase (Aag/Mpg) excises several DNA base lesio

36 ve DNA demethylation mediated by the DEMETER DNA glycosylase accounts for all of the demethylation in

37 G/I, T/I, and A/I base pairs and a xanthine DNA glycosylase acting on all double-stranded and single

38 and A/U base pairs, but also a hypoxanthine DNA glycosylase acting on G/I, T/I, and A/I base pairs a

39 aired by the HCV core protein due to reduced DNA glycosylase activity for the excision of 8-oxo-2'-de

40 t a biochemical characterization of xanthine DNA glycosylase activity in MUG.

41 through the female lineage due to widespread DNA glycosylase activity in the male germline, and exten

42 /I > C/I, matching the trend of hypoxanthine DNA glycosylase activity observed in vitro.

43 domain of ROS1 is indispensable for the 5mC DNA glycosylase activity of ROS1.

44 f NEIL1 are catalytically inactive for their DNA glycosylase activity, these deficiencies may increas

45 superfamily studied thus far exhibit uracil-DNA glycosylase activity.

46 Here we report the crystal structures of the DNA glycosylase AlkA in complex with undamaged DNA.

47 Using the DNA glycosylase AlkD from Bacillus cereus, we crystallog

48 or quantitative measurements of 8-oxoguanine DNA glycosylase, alkyl-adenine DNA glycosylase, MutY DNA

49 tion of intercalation for human alkyladenine DNA glycosylase, an enzyme that initiates repair of alky

50 Uracils in DNA can be recognized by uracil DNA glycosylase and abasic endonuclease to produce singl

51 pyAXII) and demonstrated their DNA cleavage, DNA glycosylase and AP lyase activities in vitro at 37 d

52 the VACV D4 protein serves both as a uracil-DNA glycosylase and as an essential component required f

53 poson-based library construction with uracil DNA glycosylase and endonuclease VIII to specifically de

54 Recombinant DNG701 protein showed 5-meC DNA glycosylase and lyase activities in vitro.

55 product of 5hmC could be excised by thymine DNA glycosylase and MBD4 glycosylases regardless of cont

56 two additional uracil glycosylases, thymine-DNA glycosylase and SMUG1.

57 n to interact with the 8-oxoguanine (8-oxoG) DNA glycosylase and stimulate its enzymatic activities.

58 amages in opposing DNA strands with selected DNA glycosylases and human apurinic/apyrimidinic endonuc

59 Base excision repair (BER) is initiated by DNA glycosylases and is crucial in repairing RONS-induce

60 correlated with active DNA demethylation by DNA glycosylases and repressive targeting by the Polycom

61 vity of several enzymes [four BER-initiating DNA glycosylases and the downstream processing apurinic/

62 was paralleled by a compromised TDG (thymine DNA glycosylase) and TET1 (ten-eleven translocation prot

63 NA glycosylase, MutY DNA glycosylase, uracil DNA glycosylase, and APE1 activity.

64 d 5-HmdU, may be cleaved from DNA by thymine DNA glycosylase, and subsequent action of base-excision

65 7C and G241R was observed on a pre-assembled DNA glycosylase.AP-DNA complex as well.

66 Near the dyad, uracil DNA glycosylase/APE1 removes an outwardly oriented uraci

67 In contrast, DNA glycosylases, apurinic/aprymidinic endonuclease 1 an

68 DNA glycosylases are enzymes that perform the initial st

69 DNA glycosylases are important editing enzymes that prot

70 e in HD model R6/2 mice indicates that these DNA glycosylases are present in brain areas affected by

71 OS1/DEMETER family of 5-methylcytosine (5mC) DNA glycosylases are the first genetically characterized

72 rences between E. coli MUG and human thymine DNA glycosylase as well as that between the wild type MU

73 DNA glycosylase assays with purified enzymes indicated t

74 ost part, only allow for the analysis of one DNA glycosylase at a time.

75 oxidized bases, initiated by NEIL1 and other DNA glycosylases at the chromatin level remains unexplor

76 (house mouse) Neil3 (MmuNeil3) as an active DNA glycosylase both in vitro and in vivo.

77 Thymine DNA glycosylase can further remove 5fC and 5caC, connect

78 Also, the NEIL1 and NEIL3 DNA glycosylases can remove hydantoin lesions but none o

79 Levels of BER-initiating DNA glycosylases can vary between individuals, suggestin

80 have described both vertebrate and microbial DNA glycosylases capable of unhooking highly toxic inter

81 DNA glycosylases catalyze the first step of the base exc

82 In summary, CREB1 and DNA glycosylases compete for damaged CRE in vitro and in

83 results suggest that Fpg, and possibly other DNA glycosylases, convert part of the binding energy int

84 tion-associated genes in a Tet3- and thymine DNA glycosylase-dependent fashion in DRG neurons.

85 In this issue, Johnson et al. show that a DNA glycosylase derived from Chlorella virus and enginee

86 Why mammalian cells possess multiple DNA glycosylases (DGs) with overlapping substrate ranges

87 lf, the enzyme harbors a helix-hairpin-helix DNA glycosylase domain followed by a unique C-terminal d

88 encodes a large (1,812 amino acid residues) DNA glycosylase domain protein.

89 contains an N-terminal MBD and a C-terminal DNA glycosylase domain.

90 d process in all forms of life is the use of DNA glycosylase enzymes to excise rare damaged bases fro

91 amily 6 and designate it as the hypoxanthine-DNA glycosylase family.

92 DNA glycosylases for oxidized bases carry both a glycosy

93 dification sites was developed that utilizes DNA glycosylases found in the base excision repair pathw

94 Endonuclease III (Nth), formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) are me

95 Formamidopyrimidine-DNA glycosylase (Fpg) excises 8-oxoguanine (oxoG) from D

96 A glycosylase (UDG) and formamido-pyrimidine-DNA glycosylase (FPG), 3'-5' exonucleases, and enzymes w

97 e, by the repair enzyme, formamidopyrimidine-DNA glycosylase (Fpg), likely involves multiple gates.

98 revealed introduction of formamidopyrimidine-DNA glycosylase (Fpg)-sensitive oxidative DNA lesions su

99 xamined the consequences of compromising the DNA glycosylases (Fpg and MutY) and endonucleases (Smx a

100 The family 4 uracil-DNA glycosylase from the hyperthermophilic organism Arch

101 Unlike uracil-DNA glycosylases from diverse sources, where the C termi

102 DEMETER (DME), a DNA glycosylase functioning in the base-excision DNA rep

103 antitative PCRs (qPCRs) targeting the uracil DNA glycosylase gene (udg) or the 23S rRNA gene are desc

104 atory circuit centered on a 5-methylcytosine DNA glycosylase gene is required for long-term epigeneti

105 hat targeted inactivation of the mouse Smug1 DNA glycosylase gene is sufficient to ablate nearly all

106 combined with inactivation of the Ung uracil-DNA glycosylase gene leads to a loss of nearly all detec

107 Their processing by the OGG1 and MUTYH DNA glycosylases generates closely spaced incisions on o

108 Human alkyladenine DNA glycosylase (hAAG) excises alkylated purines, hypoxa

109 Three DNA glycosylases have been identified in mammals that ar

110 Human N-methylpurine DNA glycosylase (hMPG) initiates base excision repair of

111 We have determined that the DNA glycosylase hNTH1, apurinic endonuclease (APE), and

112 the structure of a human 8-oxoguanine (oxoG) DNA glycosylase, hOGG1, in which a normal guanine from D

113 Human DNA glycosylase, hOGG1, is known to perform DNA repair b

114 The MutY DNA glycosylase homologue (MutYH) recognizes A:8-oxo-G m

115 equence, all three analogs can be cleaved by DNA glycosylases; however, glycosylase activity is block

116 leobase excision activities of human thymine DNA glycosylase (hTDG) toward duplex DNA substrates harb

117 ssay to study damage search by human thymine DNA glycosylase (hTDG), which initiates BER of mutagenic

118 DNA repair enzymes such as human uracil-DNA glycosylase (hUNG) perform the initial step in the b

119 Human uracil DNA glycosylase (hUNG) plays a central role in DNA repai

120 kbone in sliding and hopping by human uracil DNA glycosylase (hUNG), which is an exemplar that effici

121 ell line that had no detectable human uracil DNA glycosylase (hUNG2) activity, establishing that hUNG

122 ed the probability that nuclear human uracil DNA glycosylase (hUNG2) excised two uracil lesions space

123 abasic site recognition, the rate of uracil-DNA glycosylase hydrolysis of the N-glycosidic bond, con

124 responses, whereas a lack of other Nei-like DNA glycosylases (i.e., NEIL1 and NEIL2) had no signific

125 e (AAG) and Escherichia coli 3-methyladenine DNA glycosylase II (AlkA) bind tightly to their abasic D

126 3-Methyladenine DNA glycosylase II (AlkA) is an enzyme that cleaves a wi

127 The Escherichia coli 3-methyladenine DNA glycosylase II protein (AlkA) recognizes a broad ran

128 This study provides the first structure of a DNA glycosylase in complex with an inhibitory base lesio

129 domain (MBD) family, MBD4 serves as a potent DNA glycosylase in DNA mismatch repair specifically targ

130 regulatory mechanism for the essential MutYH DNA glycosylase in human cells.

131 glycosylase (Fpg) are two of the predominant DNA glycosylases in Escherichia coli that remove oxidati

132 dues are removed from DNA by specific uracil-DNA glycosylases in the base excision repair pathway.

133 Here we identify a new class of DNA glycosylases in the UDG superfamily that lacks UDG a

134 Instead, these enzymes act as hypoxanthine-DNA glycosylases in vitro and in vivo.

135 breaks caused by base excision from ssDNA by DNA glycosylases, including Nei-like (NEIL) 1, would gen

136 Knockdown of thymine DNA glycosylase increased 5caC in genome, affected cell

137 Though expression of the 12 known human DNA glycosylases individually did not enhance removal of

138 Coupled with a uracil-DNA glycosylase inhibitor, dCas9-AIDx converted targeted

139 by either replication-dependent dilution or DNA glycosylase-initiated base excision repair.

140 Because DNA damage is so rare, DNA glycosylases interact for the most part with undamag

141 DNA methyltransferases and 5-methylcytosine DNA glycosylases interact to maintain epigenetic homeost

142 ndonuclease VIII-like protein 1 (NEIL1) is a DNA glycosylase involved in initiating the base excision

143 The bacterial MutY (MUTYH in humans) adenine DNA glycosylase is able to initiate the repair of A:oxoG

144 Ogg1 (8-oxoguanine DNA glycosylase) is one such silenced base excision repa

145 fluenced by either UNG1/2, SMUG1, or thymine-DNA glycosylase knockdown, strongly suggesting that ther

146 Bacillus cereus AlkD is the only DNA glycosylase known to catalyze base excision without

147 anscripts containing dUTP degraded by Uracil DNA glycosylase, leaving only those transcripts produced

148 Although uracil DNA glycosylases limit APOBEC-induced mutation, it is un

149 eport the functional characterization of the DNA glycosylase/lyase DNG701 in rice.

150 ults demonstrate that rice DNG701 is a 5-meC DNA glycosylase/lyase responsible for the demethylation

151 ve DNA demethylation by the 5-methylcytosine DNA glycosylase/lyase ROS1.

152 cing 1 (ROS1) is a multi-domain bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5

153 In Arabidopsis, 5-meC DNA glycosylase/lyases actively remove 5-meC to countera

154 l of eukaryotic and prokaryotic bifunctional DNA glycosylases/lyases (NEIL1, Nei, Fpg, Nth, and NTH1)

155 family of genes that encode 5-methylcytosine DNA glycosylases/lyases.

156 along with the base excision repair pathway DNA glycosylase MAG1 renders the tpa1Deltamag1Delta doub

157 By fusing the yeast 3-methyladenine DNA glycosylase MAG1 to a tetR DNA-binding domain, we ar

158 ting the basal and MMS-induced expression of DNA glycosylase Mag1.

159 Thus, the NEIL DNA glycosylases may be involved in both telomere mainte

160 Here we present the first, to our knowledge, DNA glycosylase mechanism that does not require base fli

161 The mammalian DNA glycosylase--methyl-CpG binding domain protein 4 (MB

162 ue to inefficient turnover of N-methylpurine-DNA glycosylase (MPG), which initiates BER of epsilonA.

163 Mitochondria-targeted human 8-oxoguanine DNA glycosylase (mt-hOgg1) and aconitase-2 (Aco-2) each

164 Mismatch uracil DNA glycosylase (Mug) from Escherichia coli is an initia

165 Family 2 mismatch-specific uracil DNA glycosylase (MUG) from Escherichia coli is known to

166 of strandwise translocation of 8-oxoguanine DNA glycosylase, MutM, along undamaged DNA.

167 8-oxoguanine DNA glycosylase, alkyl-adenine DNA glycosylase, MutY DNA glycosylase, uracil DNA glycos

168 ditional (fifth) viral gene, encoding uracil-DNA glycosylase (MVADelta5-HIV); or (iii) represent the

169 w the presence of the oxidized base-specific DNA glycosylase Nei-like 2 (NEIL2) and the DNA end-proce

170 we demonstrated that the bacterial and human DNA glycosylases Nei and NEIL1 excise unhooked psoralen-

171 Human DNA glycosylase NEIL1 exhibits a superior ability to rem

172 The human DNA glycosylase NEIL1 was recently demonstrated to initi

173 t the DNA base excision repair (BER) enzyme, DNA glycosylase NEIL1, efficiently recognizes and excise

174 e base excision activities of five mammalian DNA glycosylases (NEIL1, NEIL2, mNeil3, NTH1, and OGG1)

175 we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidativ

176 e show that the oxidized base-specific human DNA glycosylase NEIL2 associates with RNA polymerase II

177 nds forming the cross-link is cleaved by the DNA glycosylase NEIL3.

178 ing 8-oxoguanine DNA glycosylase (OGG1), the DNA glycosylase NTH1, and the apurinic endonuclease redo

179 ir pathway, initiated with one of four major DNA glycosylases: NTH1 or OGG1 (of the Nth family) or NE

180 se lesions in the human genome, initiated by DNA glycosylases, occurs via the base excision repair pa

181 nes, which are recognized and cleaved by two DNA glycosylases of the base excision repair pathway, en

182 The 8-oxoguanine DNA glycosylases (Ogg) responsible for the removal of 8-

183 cts supplemented with exogenous 8-oxoguanine DNA glycosylase (OGG1) did so.

184 ssion and enzymatic activity of 8-oxoguanine DNA glycosylase (OGG1) in lung epithelial cells.

185 odulating the DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1) in the PyMT transgenic mouse mode

186 Human 8-oxoguanine DNA glycosylase (OGG1) is a key enzyme involved in remov

187 Human 8-oxoguanine-DNA glycosylase (OGG1) plays a major role in the base ex

188 8-Oxoguanine-DNA glycosylase (OGG1) removes premutagenic lesion 8-oxo

189 repair (BER) enzymes, including 8-oxoguanine DNA glycosylase (OGG1), the DNA glycosylase NTH1, and th

190 g base excision repair (BER) by 8-oxoguanine DNA glycosylase (OGG1), yielding an abasic site (AP).

191 nine (8-oxoG) primarily via the 8-Oxoguanine DNA glycosylase (OGG1).

192 zed by DNA glycosylases such as 8-oxoguanine DNA glycosylase (OGG1).

193 s when not repaired properly by 8-oxoguanine DNA glycosylase (Ogg1).

194 e sugar-phosphate backbone and the action of DNA glycosylases on deaminated, oxidized, and alkylated

195 DNA glycosylases play a major role in the repair of deam

196 Uracil DNA glycosylase plays a key role in DNA maintenance via

197 MutM, a bacterial DNA-glycosylase, plays a critical role in maintaining ge

198 Some DNA glycosylases possess AP lyase activities that nick t

199 DNA glycosylases preserve genome integrity and define th

200 DNA glycosylases protect genomic integrity by locating a

201 n of SMUG1 or thymine-DNA glycosylase uracil-DNA glycosylases, proving that it is base excision by UN

202 oxylcytosine followed by excision by thymine-DNA glycosylase, raises the possibility that active deme

203 y contribute to removal of uracils by uracil DNA glycosylase regardless of the translational or rotat

204 eotide excision repair because humans lack a DNA glycosylase required to initiate base excision repai

205 he immunoprecipitate of human NEIL1, a major DNA glycosylase responsible for oxidized base repair.

206 DME encodes a 5-methylcytosine DNA glycosylase responsible for transcriptional derepres

207 The DNA glycosylase ROS1 was only partially decreased in act

208 ed in flowering or DNA repair, including the DNA glycosylase ROS1, which facilitates DNA demethylatio

209 tructures have captured for the first time a DNA glycosylase scanning the genome for a damaged base i

210 ingle-strand selective monofunctional uracil DNA glycosylase (SMUG1).

211 ision repair, a pathway that is catalyzed by DNA glycosylases such as 8-oxoguanine DNA glycosylase (O

212 The uracil DNA glycosylase superfamily consists of several distinct

213 5fC and 5caC are excised by mammalian DNA glycosylase TDG, implicating 5mC oxidation in DNA de

214 d dinucleotide and purified BER enzymes, the DNA glycosylases TDG and 8-oxoG DNA glycosylase 1 (OGG1)

215 o regenerate unmodified cytosines by thymine-DNA glycosylase (TDG) and base excision repair (BER) pat

216 modulated in the presence of TET and thymine DNA glycosylase (TDG) enzymes.

217 Thymine DNA glycosylase (TDG) excises T from G.T mispairs and is

218 The mammalian thymine DNA glycosylase (TDG) excises the mismatched base, uraci

219 ylcytosine dioxygenase 2 (TET2), and Thymine DNA glycosylase (TDG) genes.

220 h 5fC and 5caC subject to removal by thymine DNA glycosylase (TDG) in conjunction with base excision

221 ispair, and this step is followed by thymine DNA glycosylase (TDG) initiated base excision repair (BE

222 Thymine DNA glycosylase (TDG) initiates the repair of G.T mismat

223 Thymine DNA Glycosylase (TDG) is a base excision repair enzyme f

224 Thymine DNA glycosylase (TDG) is an essential enzyme playing mul

225 The mammalian thymine DNA glycosylase (TDG) is implicated in active DNA demeth

226 nactivation of the DNA repair enzyme thymine DNA glycosylase (TDG) leads to embryonic lethality in mi

227 Thymine DNA Glycosylase (TDG) performs essential functions in ma

228 n (TET) enzymes (TET1/TET2/TET3) and thymine DNA glycosylase (TDG) play crucial roles in early embryo

229 Thymine-DNA glycosylase (TDG) plays critical roles in DNA base e

230 l of DNA demethylases, we found that thymine DNA glycosylase (TDG) up-regulated Wnt signaling.

231 sine (caC), excision of fC or caC by thymine DNA glycosylase (TDG), and restoration of cytosine via f

232 electively recognized and excised by thymine DNA glycosylase (TDG), leading to DNA demethylation.

233 are recognized by the monofunctional thymine DNA glycosylase (Tdg), which cleaves the glycosidic bond

234 A key player is thymine DNA glycosylase (TDG), which excises thymine from mutage

235 Many TET2- and thymine-DNA glycosylase (TDG)-dependent 5mC and 5hmC changes dir

236 by replication-dependent dilution or thymine DNA glycosylase (TDG)-dependent base excision repair.

237 sine through iterative oxidation and thymine DNA glycosylase (TDG)-mediated base excision repair.

238 e (5fC)/5-carboxylcytosine (5caC) by thymine DNA glycosylase (TDG).

239 es and excision of oxidized bases by thymine DNA glycosylase (TDG).

240 ied as a function of (i) the lesion type and DNA glycosylase tested, (ii) local sequence context and

241 way, base excision repair (BER), they lack a DNA glycosylase that can initiate BER of dipyrimidine ph

242 Family 4 UDGa is a robust uracil DNA glycosylase that only acts on double-stranded and si

243 hachiroi AlkZ (previously Orf1), a bacterial DNA glycosylase that protects its host by excising ICLs

244 Endonuclease VIII-like 1 (NEIL1) is a DNA glycosylase that recognizes a broad range of oxidati

245 MutM is a bacterial DNA glycosylase that serves as the first line of defense

246 NEIL1 is one of the 11 human DNA glycosylases that catalyze the first step of the BER

247 )-like protein 1], one of the five mammalian DNA glycosylases that excise oxidized DNA base lesions i

248 uble-stranded (ds)DNA scanning enzymes, e.g. DNA glycosylases that excise rare aberrant bases, there

249 AP sites are also generated by DNA glycosylases that initiate DNA base excision repair.

250 e monophosphate, or that lack MutM and MutY, DNA glycosylases that process base pairs involving 8-oxo

251 xcision repair (BER), a process initiated by DNA glycosylases that recognize and remove damaged DNA b

252 Base excision repair is initiated by DNA glycosylases that recognize specific altered bases.

253 ducts of this or any type are not excised by DNA glycosylases that use a traditional base-flipping me

254 As with other DNA glycosylases, the abasic product is potentially more

255 The abilities of the DNA glycosylases to incise the DNA strand adjacent to G*

256 is critically dependent upon the ability of DNA glycosylases to locate rare sites of damage embedded

257 ILENCING 1 (ROS1) family of 5-methylcytosine DNA glycosylases to protect these genes from silencing.

258 The ability of DNA glycosylases to rapidly and efficiently detect lesio

259 rable interest surrounds the question of how DNA glycosylases translocate efficiently along DNA while

260 ylation in plants is mediated by a family of DNA glycosylases typified by Arabidopsis ROS1 (repressor

261 eotide kinase, the DNA repair enzymes uracil-DNA glycosylase (UDG) and formamido-pyrimidine-DNA glyco

262 Uracil-DNA glycosylase (UDG) compromises the replication strate

263 ivity of both bacterial and mammalian uracil-DNA glycosylase (UDG) enzymes.

264 undant mutagenic lesion recognized by uracil DNA glycosylase (UDG) in the first step of base excision

265 Enzymes in Uracil DNA glycosylase (UDG) superfamily are essential for the

266 UDGb belongs to family 5 of the uracil DNA glycosylase (UDG) superfamily.

267 s identified five families within the uracil-DNA glycosylase (UDG) superfamily.

268 D4 is also an enzymatically active uracil DNA glycosylase (UDG).

269 pair enzymes, in particular by MutM and MutY DNA glycosylases, ultimately contributes to cell death.

270 d cytidine deaminase are processed by uracil-DNA glycosylase (UNG) and mismatch repair (MMR) pathways

271 sites with a reduced accumulation in uracil DNA glycosylase (UNG) null cells.

272 ion repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective mono

273 plementary pathways, initiated by the uracil-DNA glycosylase (UNG) or the mismatch repair factor MSH2

274 We show that depletion of the uracil DNA glycosylase (UNG) sensitizes tumor cells to FdUrd.

275 and retroviruses encode a dUTPase or uracil-DNA glycosylase (UNG) to counteract uracil incorporation

276 In this study, the activity of uracil-DNA glycosylase (UNG) was successfully detected and quan

277 Processing of dUs by uracil DNA glycosylase (UNG) yields abasic sites, which are exc

278 We investigated the enzyme uracil-DNA glycosylase (UNG), which detects and cleaves uracil

279 l-guanine mismatches are processed by uracil DNA glycosylase (UNG)-mediated base-excision repair and

280 n enzymatic activity, D4 is an active uracil-DNA glycosylase (UNG).

281 rom DNA is accomplished by the enzyme uracil DNA glycosylase (UNG).

282 ation depends on protective repair by uracil-DNA glycosylase (UNG).

283 Uracil DNA glycosylases (UNG) are highly conserved proteins tha

284 ions with base excision repair enzyme uracil DNA glycosylase (UNG2) and crossover junction endonuclea

285 on repair pathway by antagonizing the uracil DNA glycosylase (Ung2) enzyme.

286 Uracil DNA Glycosylase (UNG2) is the primary enzyme in humans t

287 to the recruitment of another target, uracil DNA glycosylase (UNG2), to the CRL4-DCAF1 E3 by Vpr.

288 In conclusion, the Nei-like DNA glycosylases unhook psoralen-derived ICLs in various

289 1/2 but not by knockdown of SMUG1 or thymine-DNA glycosylase uracil-DNA glycosylases, proving that it

290 osylase, alkyl-adenine DNA glycosylase, MutY DNA glycosylase, uracil DNA glycosylase, and APE1 activi

291 e findings support a general mechanism where DNA glycosylases use highly dynamic multidimensional dif

292 hat are commonly employed for studying other DNA glycosylases, we observe an unusual biphasic protein

293 We found that DNA glycosylases were efficiently recruited to DNA damag

294 Repair of A:oxoG is initiated by adenine DNA glycosylase, which catalyzes hydrolytic cleavage of

295 w that cells defective in the N-methylpurine DNA glycosylase, which fail to remove N-methylpurines fr

296 fferent DNA repair pathways, including NEIL1 DNA glycosylase, which initiates base excision repair (B

297 ity arising from DNA damage are mitigated by DNA glycosylases, which initiate the base excision repai

298 coli endonuclease III (Endo III or Nth) is a DNA glycosylase with a broad substrate specificity for o

299 two model enzymes, exonuclease I and uracil DNA glycosylase with high sensitivity and selectivity.

300 d us to detect a previously unknown xanthine DNA glycosylase (XDG) activity in E. coli.