ライフサイエンスコーパス: DNA helicase

1 is 100-fold better RNA:DNA helicase than DNA:DNA helicase.

2 nomous ATPase, 3'-to-5' translocase, and RNA:DNA helicase.

3 licase-DNA polymerase complex by stabilizing DNA helicase.

4 is a nucleus-encoded human mitochondrial (mt)DNA helicase.

5 mplex) is required for the activation of the DNA helicase.

6 /G4 regions and supports the binding of Pif1 DNA helicase.

7 and conformation of the human mitochondrial DNA helicase.

8 oteins that arise in the absence of the Sgs1 DNA helicase.

9 they are inviable in the absence of the Sgs1 DNA helicase.

10 756 amino acids) is also a highly processive DNA helicase.

11 ein required for loading the replicative MCM DNA helicase.

12 nded DNA tail provides a loading site for T7 DNA helicase.

13 dependent ATPase and a Ku-dependent 3' to 5' DNA helicase.

14 nwind the replication origin, oriC, and load DNA helicase.

15 ication and uncoupling of DNA polymerase and DNA helicase.

16 R, we identified MPH1, which encodes a 3'-5' DNA helicase.

17 armanus (FacXPD) is a superfamily II 5'-->3' DNA helicase.

18 hexamers (DH) that serve as the replicative DNA helicase.

19 nstrated that it is an ATP-dependent RNA and DNA helicase.

20 m2-7 hexamer forms the core of a replicative DNA helicase.

21 lisomes assemble around the activated Mcm2-7 DNA helicase.

22 a member of the SF2 family of ATP-dependent DNA helicases.

23 and FANCJ genes, respectively, which encode DNA helicases.

24 SIV contains conserved motifs of NTPases and DNA helicases.

25 n in yeast and are considered to function as DNA helicases.

26 B, bacterial XPB are ATP-dependent 3' --> 5' DNA helicases.

27 which encodes a member of the RecQ family of DNA helicases.

28 essential member of the Pif family of 5'-3' DNA helicases.

29 ar DNA processing machineries is provided by DNA helicases.

30 d a region related to the SF1 superfamily of DNA helicases.

31 The F-box DNA helicase 1 (FBH1) is a 3'-5' DNA helicase with a put

32 The RecG DNA helicase a key player in stalled replication fork re

33 ultifunctional Saccharomyces cerevisiae Pif1 DNA helicase, a potent unwinder of G4 structures in vitr

34 RecQ DNA helicases act in conjunction with heterologous partn

35 tem of bacteriophage T7 both DNA primase and DNA helicase activities are contained within a single pr

36 tors of both the G-quadruplex and the duplex DNA helicase activities of T-ag.

37 ino-acid, 50-kDa polypeptide with ATPase and DNA helicase activities.

38 5 protein that has both ubiquitin ligase and DNA helicase activities.

39 a function of MCM proteins apart from their DNA helicase activity and establish a direct link betwee

40 both purified recombinant proteins abolished DNA helicase activity and failed to disrupt the DNA-prot

41 Rim1 stimulated Pif1 DNA helicase activity by 4- to 5-fold, whereas Rim1Delta

42 ukaryotes such as Drosophila, MCM-associated DNA helicase activity has been observed only in the cont

43 e substitutions also diminish SSB-stimulated DNA helicase activity in the variants, although addition

44 locate along ssDNA rapidly and processively, DNA helicase activity in vitro requires a minimum of a U

45 mall fragment derived from it, inhibited the DNA helicase activity of E1 and E1-mediated HPV DNA repl

46 er of Atf1 requires an intact F box, but not DNA helicase activity of Fbh1.

47 The DNA helicase activity of NS3 has been proposed to be opt

48 esults shown in the literature regarding the DNA helicase activity of RecQ4.

49 and selective inhibitors of the G-quadruplex DNA helicase activity of T-ag.

50 CMG complex, like the hCMG complex, contains DNA helicase activity that is more salt-resistant than t

51 DnaB(BA) demonstrated a strong DNA helicase activity that required ATP or dATP.

52 TPase activity and ATP- and Mg(2+)-dependent DNA helicase activity with a 3' --> 5' polarity.

53 trate that UvrD assembly state regulates its DNA helicase activity with functional implications for i

54 that P56 inhibited HPV type 18 (HPV18) E1's DNA helicase activity, E2 binding, and HPV Ori sequence-

55 s included analysis of DNA binding affinity, DNA helicase activity, the kinetics of nucleotide hydrol

56 Interestingly Psp68 also shows the unique DNA helicase activity, which is bipolar in nature (unwin

57 revious reports, we show that RECQ4 exhibits DNA helicase activity.

58 tenuated ATPase activity and a highly active DNA helicase activity.

59 Pase activity but possesses a strong 5'-->3' DNA helicase activity.

60 TP hydrolysis activity that is essential for DNA helicase activity.

61 ptide RM enzyme comprising Mrr endonuclease, DNA helicase, adenine methyltransferase and target-recog

62 Mitochondrial DNA helicase, also called Twinkle, is essential for mtDN

63 in Werner syndrome encodes both a 3' --> 5' DNA helicase and a 3' --> 5' DNA exonuclease.

64 stic of an mrr endonuclease, a superfamily 2 DNA helicase and a gamma-family adenine methyltransferas

65 equires the dynamic interactions between the DNA helicase and an accessory protein.

66 Based on the ratio of DNA helicase and ATPase activities, DnaB(BA) is highly e

67 from its G1 to its G2 mode by blocking Srs2 DNA helicase and Casein Kinase 1 (Hhp1).

68 cattering analysis, that the complex between DNA helicase and DNA polymerase/trx is far more compact

69 This new sub-pathway is mediated by RECQ1 DNA helicase and ERCC1-XPF endonuclease in cooperation w

70 ) complex is the core component of mammalian DNA helicase and has been implicated in replication chec

71 The Sgs1 DNA helicase and its mammalian homolog BLM control cross

72 DNA helicase and primase are essential for DNA replicati

73 Pif1p, a DNA helicase and Rad53p target, underwent Rad53p-depende

74 m values of Psp68 are 1.6129 and 1.14 nM for DNA helicase and RNA helicase, respectively.

75 Escherichia coli UvrD is a superfamily 1 DNA helicase and single-stranded DNA (ssDNA) translocase

76 rate that Pol IV interacts in vitro with Rep DNA helicase and that this interaction enhances Rep's he

77 -strand polymerase still associated with the DNA helicase and the lagging-strand polymerase that are

78 redundant pathways consisting of nucleases, DNA helicases and associated proteins.

79 he assay makes it applicable to a variety of DNA helicases and DNA templates.

80 s catalyzed by the coordinated activities of DNA helicases and nucleases.

81 in vertebrates requires multiple specialized DNA helicases and polymerases to prevent genetic and epi

82 WRN is a member of the RecQ family of DNA helicases and possesses exonuclease and ATP-dependen

83 subunits, that it is a rapid and processive DNA helicase, and that it catalyses DNA unwinding using

84 proteins, it is found to be an ATP-dependent DNA helicase, and the putative active site residues invo

85 encodes a member of the RecQ family of 3'-5' DNA helicases, and is proposed to function in recombinat

86 ressed Aae MutL and the putative A. aeolicus DNA helicase (Aq793) proteins in E. coli.

87 se RNA processing factors, including the RNA/DNA helicases Aquarius (AQR) and Senataxin (SETX), or by

88 DNA polymerase and DNA helicase are essential components of DNA replication

89 DNA helicases are at the forefront of such processes, ye

90 DNA helicases are ATP-driven motor proteins that unwind

91 RecQ-like DNA helicases are conserved from bacteria to humans.

92 RecQ DNA helicases are critical components of DNA replication

93 DNA helicases are directly responsible for catalytically

94 It has been conventionally thought that DNA helicases are inhibited by bulky covalent DNA adduct

95 Replicative DNA helicases are loaded around origins of DNA replicati

96 DNA helicases are motor proteins that catalyze the unwin

97 DNA helicases are motor proteins that unwind double-stra

98 Bacterial DNA helicases are nucleic acid-dependent NTPases that pl

99 t representative human RecQ and Fe-S cluster DNA helicases are potently blocked by a protein-DNA inte

100 l decline in old HSCs, and highlight the MCM DNA helicase as a potential molecular target for rejuven

101 CM3, an essential subunit of the replicative DNA helicase, as a new substrate.

102 nd was previously thought to link the Mcm2-7 DNA helicase at replication forks to DNA polymerase alph

103 Human DNA helicase B (HELB or HDHB) has been implicated in chr

104 RECQ5 DNA helicase binds to RNA-polymerase (RNAP) II during tr

105 habditis elegans ortholog of the RecQ family DNA helicase BLM, functions in both of these processes.

106 isorder caused by mutations in the RecQ-like DNA helicase BLM, which functions in the maintenance of

107 N helicase activity but did not affect other DNA helicases [Bloom syndrome (BLM), Fanconi anemia grou

108 by their binding partners; one example is a DNA helicase capable of modulating the directionality of

109 re we show that BIR requires the replicative DNA helicase (Cdc45, the GINS, and Mcm2-7 proteins) as w

110 We previously showed that the cellular DNA helicase ChlR1 is required for loading of the bovine

111 irus 16 (HPV16), associate with the cellular DNA helicase ChlR1.

112 In the case of many DNA helicases, closure of the ATP-binding pocket is regu

113 The eukaryotic replicative DNA helicase, CMG, unwinds DNA by an unknown mechanism.

114 The regulated loading of the Mcm2-7 DNA helicase (comprising six related subunits, Mcm2 to M

115 HEL308 is a superfamily II DNA helicase, conserved from archaea through to humans.

116 DNA-dependent ATPase activity and is a 3'-5' DNA helicase dependent on hydrolysis of ATP.

117 leoplasm, where it co-localizes with the RNA/DNA helicase Dhx9 and paraspeckles; as well as GW/P-bodi

118 hese, 2 independent shRNAs targeting the RNA/DNA helicase Dhx9 were found to sensitize lymphomas to A

119 by the thymine glycol damage, whereas other DNA helicases (DinG, DnaB, and UvrD) are not significant

120 volutionarily related cores of other RNA and DNA helicases diverged to use different mechanisms.

121 to ssDNA and contributes to formation of the DNA helicase-DNA polymerase complex by stabilizing DNA h

122 first structural model of a bacteriophage T7 DNA helicase-DNA polymerase complex using a combination

123 ue to changes in interaction with the host's DNA helicase DnaB.

124 rom these two organisms, only the homologous DNA helicase (DnaB(BA)) acted as a positive effector of

125 duplex DNA is carried out by the replicative DNA helicase (DnaB) that couples NTP hydrolysis to 5' to

126 egrity of the MCM2-7 hexamer complex and the DNA helicase domain in MCM5 are essential for the proces

127 The DNA helicase encoded by bacteriophage T7 consists of six

128 The DNA helicase encoded by gene 4 of bacteriophage T7 assem

129 The DNA helicase encoded by gene 4 of bacteriophage T7 forms

130 st helicases use ATP in these processes, the DNA helicase encoded by gene 4 of bacteriophage T7 uses

131 ase superfamily 2 (SF2), which includes many DNA helicase enzymes that display similar structural and

132 s methodology was applied to visualize human DNA helicase F-box-containing DNA helicase (FBH1) acting

133 The RecQ-like DNA helicase family is essential for the maintenance of

134 WRN is a member of the RecQ DNA helicase family with functions in maintaining genome

135 icase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to

136 BRCA1 and the DNA helicase FANCJ (also known as BACH1 or BRIP1) have c

137 n of the BRCA1 and Fanconi anemia-associated DNA helicase FANCJ to sites of UV-induced damage.

138 The F-box DNA helicase Fbh1 constrains homologous recombination in

139 isualize human DNA helicase F-box-containing DNA helicase (FBH1) acting on the DNA structures resembl

140 of the complex consisting of six domains of DNA helicase, five domains of RNA primase, two DNA polym

141 In fission yeast, the DNA helicase Fml1, which is an orthologue of human FANCM

142 Mus81, and is countered by the FANCM-related DNA helicase Fml1.

143 HELQ is a superfamily 2 DNA helicase found in archaea and metazoans.

144 have described a novel essential replicative DNA helicase from Bacillus anthracis, the identification

145 A gene encoding a putative DNA helicase from Staphylococcus aureus USA300 was clone

146 While much is known about hexameric DNA helicases from superfamily 3, the papillomavirus E1

147 asure long-range DNA unwinding of individual DNA helicases from the archaeons Methanothermobacter the

148 nisms, including a detailed understanding of DNA helicase function and synaptonemal complex structure

149 peptide that are essential for mitochondrial DNA helicase function in vivo.

150 The Dna2 ATP-driven 5' to 3' DNA helicase function promotes motion of Dna2 on the fla

151 an Bloom's syndrome helicase BLM, is a yeast DNA helicase functioning in DNA replication and repair.

152 Escherichia coli UvrD DNA helicase functions in several DNA repair processes.

153 We have investigated the role of the GcRecQ DNA helicase (GcRecQ) in this process.

154 The ybiB gene forms an operon with the DNA helicase gene dinG and is under LexA control, being

155 Replicative DNA helicases generally unwind DNA as a single hexamer t

156 DDX11, a super-family 2 iron-sulfur cluster DNA helicase genetically linked to the chromosomal insta

157 The highly conserved RecQ family of DNA helicases has multiple roles in the maintenance of g

158 FANCJ, a G4 DNA helicase, has been shown to be critical for the stab

159 protein DinG, a member of the superfamily 2 DNA helicases, has been implicated in the nucleotide exc

160 DNA helicases have important roles in genome maintenance

161 ons in RECQ4, a member of the RecQ family of DNA helicases, have been linked to the progeroid disease

162 to the helicase domain of the superfamily 2 DNA helicase, Hef.

163 polymerase QDE-1, the Werner and Bloom RecQ DNA helicase homologue QDE-3 and dicers.

164 Purification of FBH1, a UvrD DNA helicase, identified a physical interaction with rep

165 UvrD (DNA helicase II) has been implicated in DNA replication,

166 FANCJ encodes a Q motif DEAH box DNA helicase implicated in Fanconi anemia and breast can

167 FANCJ encodes a DNA helicase implicated in homologous recombination (HR)

168 Senataxin (SETX) is an RNA/DNA helicase implicated in transcription termination and

169 these DNA transactions are promoted by RECQ5 DNA helicase in a manner dependent on its Ser727 phospho

170 es helicase-like transcription factor (HLTF) DNA helicase in a proteasome-dependent manner by redirec

171 s highlighted a role for Smc5/6 and the Sgs1 DNA helicase in preventing the accumulation of unresolve

172 process is the activation of the replicative DNA helicase in situ at each origin of DNA replication.

173 onhydrolyzable ATP analog), contains maximal DNA helicase in the presence of forked DNA structures, a

174 he carboxyl-terminal region in superfamily 4 DNA helicases in general.

175 levant to the roles of RPA, FANCJ, and other DNA helicases in the metabolism of damaged DNA that can

176 aspects of DNA replication; the activity of DNA helicase increases and the sensitivity of DNA polyme

177 nding by XPD helicase, a Superfamily 2 (SF2) DNA helicase involved in DNA repair and transcription in

178 cherichia coli RecBCD is a highly processive DNA helicase involved in double-strand break repair and

179 nterstrand crosslink repair, FANCJ encodes a DNA helicase involved in recombinational repair and repl

180 nteraction between TopBP1 and BACH1/FANCJ, a DNA helicase involved in the repair of DNA crosslinks.

181 The conserved RECQ5 DNA helicase is a tumor suppressor in mammalian cells.

182 The metazoan mitochondrial DNA helicase is an integral part of the minimal mitochon

183 In E. coli, the DNA helicase is DnaB and DnaC is its loading partner.

184 hesis, but it has remained unclear whether a DNA helicase is involved in this reaction.

185 The FANCJ DNA helicase is linked to hereditary breast and ovarian

186 he low salt sensitivity of the mitochondrial DNA helicase is mitigated by the presence of magnesium,

187 A component of the replicative DNA helicase is phosphorylated within the replisome in a

188 A good candidate DNA helicase is Pif1, an evolutionarily conserved helica

189 Activation of the Mcm2-7 replicative DNA helicase is the committed step in eukaryotic DNA rep

190 The oligomeric state of Superfamily I DNA helicases is the subject of considerable and ongoing

191 he Q motif, conserved in a number of RNA and DNA helicases, is proposed to be important for ATP bindi

192 omplex is a key component of the replicative DNA helicase, its association with Cdc45 and GINS (the C

193 f defects in the related human mitochondrial DNA helicase may be responsible for inefficient DNA repl

194 ensing and signaling; the cellular pool of a DNA helicase may contain subpopulations of enzymes carry

195 rtnerships between RPA and interacting human DNA helicases may greatly enhance their ability to dislo

196 stressed by dNTP depletion, the replicative DNA helicase, MCM, and the leading-strand DNA polymerase

197 d" during G1 phase by loading of an inactive DNA helicase (Mcm2-7) into pre-replicative complexes (pr

198 e licensed by the loading of the replicative DNA helicase, Mcm2-7.

199 Conserved, multitasking DNA helicases mediate diverse DNA transactions and are r

200 However, the processivity of the DNA helicase might overcome DNA gyrase and topoisomerase

201 e of cofactors and renders the mitochondrial DNA helicase more susceptible to proteolytic digestion.

202 h in budding yeast shows that removal of the DNA helicase Mph1 improves survival of cells with defect

203 In budding yeast the DNA helicase Mph1 prevents genome rearrangements during

204 g yeast Smc5/6 complex directly binds to the DNA helicase Mph1.

205 We demonstrate that BLM, the RecQ DNA helicase mutated in Bloom syndrome, is preferentiall

206 BLM, a RecQ family DNA helicase mutated in Bloom's Syndrome, participates i

207 Mycobacterial AdnAB is a heterodimeric DNA helicase-nuclease and 3' to 5' DNA translocase impli

208 ly linked to mutations in WRN that encodes a DNA helicase-nuclease believed to operate at stalled rep

209 Escherichia coli RecBCD is a DNA helicase/nuclease that functions in double-stranded

210 BLM encodes a DNA helicase of the RECQ family, and associates with Top

211 y contrast, large T antigen, the replicative DNA helicase of the simian virus 40 (SV40), is reported

212 We are interested in the DNA helicases of Mycobacteria, a genus of the phylum Act

213 DNA helicases of the RECQ family are important for maint

214 The translocation of DNA helicases on single-stranded DNA and the unwinding o

215 n DNA replication, but not its activity as a DNA helicase or its ability to bind to ssDNA.

216 In bacteriophage T7, movement of either the DNA helicase or the DNA polymerase alone terminates upon

217 RecQ-like DNA helicases pair with cognate topoisomerase III enzyme

218 The Escherichia coli RecQ DNA helicase participates in a pathway of DNA repair tha

219 rate constants have been determined for the DNA helicase PcrA ATPase cycle when bound to either sing

220 The essential DNA helicase, PcrA, regulates recombination by displacin

221 Here we show that the Pif1 family DNA helicase Pfh1 plays a dual role in promoting replica

222 haromyces pombe encodes a single Pif1 family DNA helicase, Pfh1.

223 haromyces cerevisiae encodes two Pif1 family DNA helicases, Pif1 and Rrm3.

224 nding protein family, PABPC5, and of the RNA/DNA helicase PIF1alpha.

225 s minichromosome maintenance (MCM) 3' --> 5' DNA helicase, PolB, replication factor C, and proliferat

226 Escherichia coli RecBCD is a bipolar DNA helicase possessing two motor subunits (RecB, a 3'-t

227 T7 DNA helicase preferentially utilizes dTTP to unwind dupl

228 NCJ, one of 13 genes linked to FA, encodes a DNA helicase proposed to operate in homologous recombina

229 In biochemical assays, polyamides inhibit DNA helicases, providing a plausible mechanism for S-pha

230 otein displacement is also observed with the DNA helicase RECQ1, suggesting a conserved functional in

231 ist in Arabidopsis, defined by ATP-dependent DNA Helicase RECQ4A, MMS and UV-sensitive protein81, REV

232 s it acts independently of the ATP-dependent DNA helicase RECQ4A.

233 Mutations within the gene encoding the DNA helicase RECQL4 underlie the autosomal recessive can

234 In humans, mutations in the DNA helicase Regulator of Telomere Elongation Helicase1

235 arkably, trypanosomes have six mitochondrial DNA helicases related to yeast PIF1 helicase.

236 , encoding the orthologue of the human FANCM DNA helicase, rescues the DNA damage sensitivity of smc5

237 90s with reports that some well-known duplex DNA helicases resolved these structures in vitro.

238 helicase/translocase Fml1 and the RecQ-type DNA helicase Rqh1 to limit hybrid DNA formation and prom

239 The DNA helicase Rrm3 promotes replication fork progression

240 The RNA/DNA helicase senataxin (SETX) is one of the best charact

241 Leading the replisome, a DNA helicase separates the parental strands that are to

242 or by combined activities of the RecQ family DNA helicase Sgs1 and the helicase/endonuclease Dna2.

243 DNA repair proteins, Rad6 and Rad5, and the DNA helicase Sgs1.

244 tudies indicate that the human mitochondrial DNA helicase shares basic properties with the SF4 replic

245 s for recruitment of the anti-recombinogenic DNA helicase Srs2.

246 t affecting ATP hydrolysis or binding to the DNA helicase substrate, apparently by affecting the stre

247 1 Anchor region, directly interacts with the DNA helicase subunit XPD/Rad3 in native TFIIH and is req

248 r, in contrast with previously identified G4 DNA helicases, such as the Bloom's helicase (BLM), FANCJ

249 Lhr-(1-856) is 100-fold better RNA:DNA helicase than DNA:DNA helicase.

250 of telomere length 1 (RTEL1) is an essential DNA helicase that disassembles telomere loops (T loops)

251 this pathway, FANCJ, is a structure-specific DNA helicase that dissociates guanine quadruplex DNA (G4

252 IH as a heterodimer with the Ssl2 subunit, a DNA helicase that drives promoter melting for the initia

253 The BLM gene mutated in BS encodes a DNA helicase that functions in a protein complex to supp

254 drome (WABS) is caused by defective DDX11, a DNA helicase that is essential for chromatid cohesion.

255 C virus is a 3'-to-5' superfamily 2 RNA and DNA helicase that is essential for the replication of he

256 FANCJ is a DNA helicase that is genetically linked to Fanconi anemi

257 m Deinococcus radiodurans is a superfamily 1 DNA helicase that is homologous to the Escherichia coli

258 tion of PCNA at its lysine 164 residue and a DNA helicase that is specialized for replication fork re

259 MCM proteins are components of a DNA helicase that plays an essential role in DNA replica

260 reen mutant 2) gene encodes an ATP-dependent DNA helicase that regulates homologous recombination in

261 ghnut-shaped homohexameric ATP-dependent RNA-DNA helicase that releases newly synthesized RNA molecul

262 RecQ family of proteins are highly conserved DNA helicases that have important functions in the maint

263 BLM, encodes a member of the RecQ family of DNA helicases that is needed to suppress genome instabil

264 ding mechanism may be a universal feature of DNA helicases that move along DNA phosphodiester backbon

265 Activation of the eukaryotic replicative DNA helicase, the Mcm2-7 complex, requires phosphorylati

266 The unwinding step is catalyzed by DNA helicases, the major one of which is the Xenopus Wer

267 used by defects in senataxin, a putative RNA/DNA helicase thought to be involved in the termination o

268 It is the only known DNA helicase to contain an F-box, suggesting that one of

269 Ctf4 protein links the Cdc45-MCM-GINS (CMG) DNA helicase to DNA polymerase alpha (Pol alpha) within

270 at eukaryotic replication forks connects the DNA helicase to DNA polymerases and many other factors.

271 methylase ALKBH3 functions in complex with a DNA helicase to eliminate N3-methylcytosine lesions from

272 (NTD) of DnaB to impair the ability of this DNA helicase to interact with primase.

273 protein FANCD2 acts in opposition to the BLM DNA helicase to restrain telomere replication and recomb

274 DNA primase facilitates binding of DNA helicase to ssDNA and contributes to formation of th

275 cally melted DNA is required for replicative DNA helicases to initiate unwinding.

276 e MCM2-7 ATPase, the core of the replicative DNA helicase, to origins.

277 r role in antagonizing both the FANCM-family DNA helicase/translocase Fml1 and the RecQ-type DNA heli

278 Escherichia coli UvrD is an SF1A DNA helicase/translocase that functions in chromosomal D

279 mutant of the homologous human mitochondrial DNA helicase Twinkle, which is linked to diseases such a

280 p is 19 genes which include DNA polymerases, DNA helicase, type B cyclin genes, DNA primases, radiati

281 DNA helicases use energy derived from nucleoside 5'-trip

282 e coordinated activity of DNA polymerase and DNA helicase, whereas synthesis of the lagging strand in

283 ations in the WRN gene that encodes the RecQ DNA helicase which is critical for maintaining genomic s

284 A crystal structure of the PriA SF2 DNA helicase, which governs restart of prematurely termi

285 sential activity is orchestrated by the PriA DNA helicase, which identifies replication forks via str

286 lication origins of the CMG (Cdc45-MCM-GINS) DNA helicase, which is essential for the progression of

287 Mcm2-7 forms the core of the replicative DNA helicase, which is inactive in the pre-RC.

288 Disassembly of the Cdc45-MCM-GINS (CMG) DNA helicase, which unwinds the parental DNA duplex at e

289 case (BLM) is a member of the RecQ family of DNA helicases, which play key roles in the maintenance o

290 the largest subunit of ASCC, encodes a 3'-5' DNA helicase, whose activity is crucial for the generati

291 The F-box DNA helicase 1 (FBH1) is a 3'-5' DNA helicase with a putative function as a negative regu

292 dinates the Cdc45-MCM-GINS (CMG) replicative DNA helicase with DNA polymerases alpha, delta, and epsi

293 cherichia coli RecBC, a rapid and processive DNA helicase with only a single ATPase motor (RecB), pos

294 Mammalian HELQ is a 3'-5' DNA helicase with strand displacement activity.

295 find that Shu1 and Srs2, an anti-recombinase DNA helicase with which the Shu complex physically inter

296 icase and the founding member of a family of DNA helicases with iron-sulphur cluster domains.

297 The RecBC DNA helicase (without the RecD subunit) does not initiat

298 Unwinding of a hairpin by a DNA helicase would help protect against expansions.

299 Loss of the RecQ DNA helicase WRN protein causes Werner syndrome, in whic

300 TFIIH consists of a core that includes the DNA helicase Xeroderma pigmentosum B (XPB) and a kinase