ライフサイエンスコーパス: DNA methylation

1 esticide, nor on epigenetic changes, such as DNA methylation.

2 length through a mechanism requiring de novo DNA methylation.

3 variants associated with complex traits and DNA methylation.

4 methyltransferases where it imposes de novo DNA methylation.

5 ese mechanisms may be mediated by changes in DNA methylation.

6 methodologies have been developed to detect DNA methylation.

7 tolerate constitutive, long-term exposure to DNA methylation.

8 olution and its evolutionary consequences on DNA methylation.

9 on, MPO and PRTN3 expression correlated with DNA methylation.

10 hibition of LoxP recombination is not due to DNA methylation.

11 he electrochemical sensing and biosensing of DNA methylation.

12 Silencing did not require H3K9me3 or DNA methylation.

13 broad patterns based on anonymous markers of DNA methylation.

14 ns of gene expression regulated, in part, by DNA methylation.

15 t of sequence variation on proximal CpG site DNA methylation.

16 ), the chromatin remodeler DDM1 (DECREASE IN DNA METHYLATION 1), and histone modifications, including

17 ty) is associated with widespread changes in DNA methylation (187 genetic loci with P < 1 x 10(-7), r

18 DNA methylation, a major epigenetic mark, was investigat

19 To establish a link between DNA methylation, a model epigenetic gene silencing modif

20 DNA methylation aberrations have been implicated in acqu

21 Reversing DNA methylation abnormalities and associated gene silenc

22 The results show frequently aberrant DNA methylation, abundant chromosomal amplifications and

23 Increased DNA methylation accompanied this pattern, particularly a

24 Through a genome-wide analysis of DNA methylation across 19 cell types with T-47D as refer

25 that serum estradiol levels associates with DNA methylation across the genome.

26 Inhibiting DNA methylation activates COL2 expression, and repressin

27 has dominant negative activity that reduces DNA methylation activity by approximately 80% in vitro.

28 DNA methylation alterations are hallmarks of CRC, and ep

29 Future studies need to explore whether DNA methylation alterations influence the risk of AD-ND

30 Variation in DNA methylation, an epigenetic mechanism, is implicated

31 RNA-Seq and DNA methylation analyses showed that Natur-IVF embryos h

32 We present a comprehensive genome-wide DNA methylation analysis using methyl-sequencing to meas

33 stral TBT exposure induces global changes in DNA methylation and altered expression of metabolism-rel

34 tion in MS patients, by assaying genome-wide DNA methylation and comparing smokers, former smokers an

35 DNA methylation and copy number integration with transcr

36 recent studies showed an association between DNA methylation and expression divergence of duplicated

37 hat showed a significant association between DNA methylation and gene expression changes were PYGM, w

38 se strain to examine the genome-wide nuclear DNA methylation and gene expression patterns of brain ti

39 lcytosine (5hmC), resulting in regulation of DNA methylation and gene expression.

40 aphnia characterized by interactions between DNA methylation and gene regulation mechanisms.

41 the transcription start sites of endo-MEGs, DNA methylation and H3K4me3 specifically marked paternal

42 tics studies relied on the identification of DNA methylation and histone modifications at specific ge

43 Alongside DNA methylation and histone modifications, bromodomain a

44 ) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outco

45 utations, gene expression, DNA copy numbers, DNA methylation and protein abundance, all available in

46 Erasure of DNA methylation and repressive chromatin marks in the ma

47 Recent studies have implicated changes in DNA methylation and small RNAs in hybrid performance; ho

48 ort genome-wide analysis of gene expression, DNA methylation and small RNAs in the rice endosperm and

49 investigate a possible relationship between DNA methylation and somatic mutations identified in CPA.

50 DNA methylation and specifically the DNA methyltransfera

51 We identified specific changes in DNA methylation and transcriptome patterns in IECs from

52 ght DROSHA as a novel regulator of mammalian DNA methylation and we propose that DROSHA-mediated proc

53 cific effects of perinatal LPD on both Npy1r DNA-methylation and gene transcription.

54 that are known to affect TF binding (such as DNA methylation) and providing increased specificity as

55 romatin immunoprecipitation, RNA expression, DNA methylation, and chromosome conformation capture exp

56 specific genetic changes to gene expression, DNA methylation, and histone marks but these investigati

57 reconfiguration of chromatin accessibility, DNA methylation, and mRNA expression to induce a default

58 epigenetic processes, such as alterations in DNA methylation, and perhaps through alterations in the

59 t that influences non-coding RNA production, DNA methylation, and transcriptional silencing.

60 utant, though for the majority, decreases in DNA methylation are not sufficient to cause release of s

61 the first to demonstrate the involvement of DNA methylation-associated alterations in patients with

62 with distinct accessibility patterns, where DNA methylation associates with the silencing and inacce

63 Our model, which estimates age based on DNA methylation at 329 unique CpG sites, has a median ab

64 eshold level is required for maximal loss of DNA methylation at all genomic regions, including gene b

65 We interrogated DNA methylation at baseline and 3 hours in peripheral bl

66 rmine the relationship between variations in DNA methylation at birth and the development of allergic

67 We found that DNA methylation at birth differentiated ADHD trajectorie

68 In contrast to the repressive association of DNA methylation at CG dinucleotides (mCG), mCH accumulat

69 d tumors, inflammation-induced tumors gained DNA methylation at CpG islands, some of which are associ

70 Given that the propagation of DNA methylation at CpG sites, mediated in Arabidopsis by

71 DNA methylation at gene promoters in a CG context is ass

72 Chrna1 demonstrated significantly decreased DNA methylation at key time points after disuse-induced

73 in arterial tissues (p = 9.4 x 10(-7) ) and DNA methylation at probe cg16596957 in whole blood (p =

74 DNA methylation at promoters is an important determinant

75 DNA methylation at SLC7A11 was associated with reduced r

76 scue Dnmt3a-mediated insulin resistance, and DNA methylation at the FGF21 locus was elevated in human

77 enon primarily controlled by allele-specific DNA methylation at the imprinting control region (ICR),

78 pression is epigenetically modulated by both DNA methylation at the promoter region and chromatin acc

79 domesticated cotton shows that despite most DNA methylation being conserved and stably inherited, al

80 dentified as most central disease-associated DNA methylation biomarkers.

81 e V (Pol V), two main actors of RNA-directed DNA methylation, but does not depend on Pol IV.

82 marking of genes, later manifesting abnormal DNA methylation by 10 months.

83 Differences in DNA methylation can arise as epialleles, which are loci

84 ably with age across the lifespan, such that DNA methylation can be used as an "epigenetic clock".

85 , we present data that suggest that baseline DNA methylation can predict weight increase in response

86 Epigenetic processes, including DNA methylation, change reliably with age across the lif

87 DNA methylation changes associated with maternal smoking

88 Mutation of PKL results in DNA methylation changes at more than half of the loci th

89 DNA methylation changes can produce meiotically stable e

90 We detected marked DNA methylation changes following HFD alone and in combi

91 opsies from CKD patients and show concordant DNA methylation changes in kidney cortex.

92 is participants, 42 sites showed significant DNA methylation changes of 2% or greater.

93 Altogether, these data demonstrate that DNA methylation changes, including significant hypermeth

94 SD1 mutations, they correspond to a specific DNA methylation cluster.

95 scodor isolates exhibit higher resistance to DNA methylation compared with other fungi.

96 profile of skeletal muscle, indicating that DNA methylation constitutes a rapidly adaptive epigeneti

97 number variations (CNVs) and alterations in DNA methylation contribute to the observed recurrent der

98 transposable elements and genes had reduced DNA methylation correlated with derepression in the pkl

99 vels are reduced, gene bodies show a loss of DNA methylation correlated with transcription levels.

100 Among new insights, transcript versus DNA methylation correlations revealed the epithelial/mes

101 ep, in the subset of participants with DLPFC DNA methylation data (n = 648), we found that residual c

102 t captures both mean and variance signals in DNA methylation data and takes into account the correlat

103 ine toolset for fast analysis of genome-wide DNA methylation data generated using the Illumina human

104 Using genome-wide DNA methylation data measured in a large collection of S

105 Next-generation RNA sequencing and DNA methylation data were generated using frozen tissue

106 . mays), we integrated available genome-wide DNA methylation data with newly generated maps for chrom

107 We report the first whole-genome DNA methylation datasets from single pig blastocysts sho

108 pression of hundreds of loci, acting in both DNA methylation-dependent and methylation-independent pa

109 s the recent developments of electrochemical DNA methylation detection approaches.

110 itats, we also found significant genome wide DNA methylation differences.

111 el analysis, mapping candidate cancer-driver DNA methylation (DNAm) alterations onto a human interact

112 DNA methylation (DNAm) can be used as a biomarker of cel

113 Here we use the genotype and DNA methylation (DNAm) data from cord blood and peripher

114 DNA methylation (DNAme) is an important epigenetic mark

115 We evaluated DNA methylation from blood of female participants in the

116 a better understanding of how resistance to DNA methylation from the A2UCOE is conferred, and whethe

117 sion model to measure the relationship among DNA methylation, genomic segment distribution, different

118 al (mRNA, miRNA, and lncRNA) and epigenetic (DNA methylation, H3K4me3, H3K79me3, and H3K27me3 histone

119 Epigenetic factors, particularly DNA methylation, have recently been proposed to influenc

120 tely 1500 intergenic regions, displaying low DNA methylation, high chromatin accessibility and H3K9ac

121 cells, we performed genome-wide analysis of DNA methylation, histone marking (acetylated lysine 9 in

122 with a primary focus on the reprogramming of DNA methylation, histone posttranslational modifications

123 se embryonic stem cells (ESCs), p53 controls DNA methylation homeostasis by regulating the expression

124 ES)-that includes (1) peripheral measures of DNA methylation (Illumina 450k) at birth (n=817, 49% mal

125 A and miRNA expression, DNA copy number, and DNA methylation in 117 Wilms tumors, followed by targete

126 and PUFA diets increased the mean degree of DNA methylation in adipose tissue, particularly in promo

127 ine the overall effect of overfeeding on the DNA methylation in adipose tissue.The DNA methylation of

128 to identify disease-specific alterations in DNA methylation in B cells.

129 associations of prenatal lead exposure with DNA methylation in cord blood at epigenome-wide signific

130 characterized by frequent acquisition of new DNA methylation in CpG islands.

131 WIF1 is epigenetically silenced via promoter DNA methylation in CS and propose that WIF1 methylation

132 Additionally, DNA methylation in different genomic regions and of diff

133 mine which genes are abnormally regulated by DNA methylation in disease.

134 ith nonrandom XCI to examine allele-specific DNA methylation in frontal cortex.

135 nd Ip3k, indicating extensive involvement of DNA methylation in honeybee olfactory learning and memor

136 the CYP11B1 expression was regulated through DNA methylation in hypercortisolemia with cortisol-produ

137 t revealed an anticorrelation between R2 and DNA methylation in many of the cytosine-guanine dinucleo

138 oliferative disorders in humans, the role of DNA methylation in mast cell biology is not understood.

139 finium MethylationEPIC BeadChip for studying DNA methylation in mouse.

140 d at investigating how smoking affects blood DNA methylation in MS patients, by assaying genome-wide

141 igenetic inheritance, we examined genomewide DNA methylation in partial and complete loss-of-function

142 hylation cycle suggests an important role of DNA methylation in seed dormancy.

143 We explored sex-specific DNA methylation in the cord blood of 39 females and 32 m

144 Insulin increased DNA methylation in the gene body of DAPK3, a gene involv

145 required for its enhancer function and that DNA methylation in the HGE region inhibits the histone m

146 The changes in DNA methylation in the pkl mutant are correlated with ch

147 pioid receptor (Kappa), as well as decreased DNA methylation in the second intron of the Kappa gene.

148 al maternal lead exposure and epigenome-wide DNA methylation in umbilical cord blood nucleated cells

149 Girls fed soy formula have altered DNA methylation in vaginal cell DNA which may be associa

150 e tested for association between genome-wide DNA methylation in WBCs and total IgE levels in 2 studie

151 ssment of one epigenetic mark in particular, DNA methylation, in human populations, and the examinati

152 Its expression is also regulated by DNA methylation, including at an upstream enhancer that

153 ded into two groups, on the basis of whether DNA methylation increased or decreased from active disea

154 Roots treated with a DNA methylation inhibitor also showed a significant decr

155 Treatment with decitabine, a DNA methylation inhibitor, either during LT-IH or during

156 DNA methylation is a key epigenetic modification involve

157 DNA methylation is a stable epigenetic mark that disting

158 DNA methylation is altered by environmental factors.

159 DNA methylation is an important epigenetic mechanism in

160 DNA methylation is an important epigenetic mechanism tha

161 DNA methylation is an important tissue-specific epigenet

162 In addition, we show that skin DNA methylation is associated in cis with known genome-w

163 in human populations, and the examination of DNA methylation is becoming increasingly common in psych

164 the 24-nucleotide siRNA pathway that guides DNA methylation is incomplete in sister species of seed

165 In both plants and animals, DNA methylation is involved in the regulation of gene ex

166 DNA methylation is necessary to temporally reorganize ci

167 ylated throughout gestation, suggesting that DNA methylation is not the primary mechanism involved in

168 e association between metabolic syndrome and DNA methylation is of great research interest.

169 DNA methylation is one of the key epigenetic modificatio

170 iption factors within regulatory CGIs, where DNA methylation is rare.

171 ile relatively stable during somatic growth, DNA methylation is reprogrammed genome-wide during mamma

172 lumina's 450k array and showed that aberrant DNA methylation is significantly altered at enhancer reg

173 Our aim was to characterize the whole-genome DNA methylation landscape in human pancreatic islets, to

174 Global DNA methylation level (%5-mC) was quantified using ELISA

175 SAC3B dysfunction does not alter promoter DNA methylation level of the transgene d35S::LUC, althou

176 ensitive enough to detect changes in genomic DNA methylation levels as a function of growth phase in

177 ng (ISIS) method with elastic net penalty to DNA methylation levels at 484,548 CpG markers from 659 h

178 The genome-wide investigation of DNA methylation levels has been limited to reference tra

179 We analyzed DNA methylation levels of inflammasome-related genes in

180 > T TT genotype was associated with reduced DNA methylation levels, while MTHFR c. 1298A > C AC geno

181 ene-transcript behavior by jointly analyzing DNA-methylation levels with the presence of mutations in

182 tigation of these DMRs revealed differential DNA methylation localized to a 600 bp region in the prom

183 e that ORCA coordinates with the histone and DNA methylation machinery to establish a repressive chro

184 ssion of key counteracting components of the DNA methylation machinery.

185 Here, we profiled DNA methylation markers to identify a methylation of TIL

186 oteins play an essential role in translating DNA methylation marks into a downstream transcriptional

187 non-familial and familial NSCLP and altered DNA methylation may be a second hit contributing to pene

188 DNA methylation may be one of the underlying mechanisms

189 These data suggest that DNA methylation may contribute to the maintenance of the

190 ther, these data suggest that differences in DNA methylation may partly explain the enantioselectivit

191 l anchor to help decipher the likely role of DNA methylation measured in peripheral blood in the etio

192 diastolic BP with blood-derived genome-wide DNA methylation measured on the Infinium HumanMethylatio

193 Here we report that the intragenic DNA methylation-mediated binding of Brother of Regulator

194 heral blood to identify SNPs associated with DNA methylation (meQTL lists).

195 comprehensive molecular profiling, including DNA methylation microarray analysis, and did unsupervise

196 ustering method and an R function which uses DNA methylation microarray data to infer tumor subtypes

197 Our study suggests that DNA methylation might play an important role in AF arrhy

198 We hypothesize that DNA methylation might play an important role in the susc

199 We subsequently assessed DNA methylation modifications at these candidate loci in

200 In patients with increased DNA methylation, MPO and PRTN3 expression correlated wit

201 ds of cancer samples, using gene expression, DNA methylation, noncoding microRNA, and copy number var

202 -IH or during recovery from LT-IH, prevented DNA methylation, normalized the expression of AOE genes,

203 However, in hypercortisolemia, the role of DNA methylation of 11beta-hydroxylase (CYP11B1), which c

204 on studies of eGFR and CKD using whole-blood DNA methylation of 2264 ARIC Study and 2595 Framingham H

205 on the DNA methylation in adipose tissue.The DNA methylation of 4875 Cytosine-phosphate-guanine (CpG)

206 HCCs and HBV replicating cells, and examined DNA methylation of a CpG island located downstream from

207 T-IH or during recovery from LT-IH prevented DNA methylation of AOE genes, normalized the expression

208 ogenesis are regulated by dynamic changes in DNA methylation of both virus and host genomes.

209 P2 methyl-CpG-binding domain (MBD), however, DNA methylation of decoys substantially ( approximately

210 DNA methylation of five genes was quantified by bisulfit

211 DNA methylation of HDAC4 CpG sites were tagged by a near

212 high-risk neuroblastoma is the high level of DNA methylation of putative tumor suppressors.

213 Only a few studies have investigated DNA methylation of selected candidate genes or a very sm

214 ciated vasculitis, we measured gene-specific DNA methylation of the autoantigen genes myeloperoxidase

215 firmed by real-time quantitative RT-PCR, and DNA methylation of their promoter regions was analyzed b

216 sidual cognition was related to differential DNA methylation of UNC5C and ENC1 (false discovery rate

217 ling the transcriptional levels, but not the DNA methylation, of the Peg3 domain.

218 vestigated the impact of genome-wide cardiac DNA methylation on global gene expression in myocardial

219 eously profiling chromatin accessibility and DNA methylation on single molecules.

220 This effect may occur in vivo for DNA methylation outside CpG islands (CGIs) and could fac

221 , this study reveals key tyrosine kinase and DNA methylation pathways in liposarcoma, some with immed

222 tion, is a key regulator of EBV latency type DNA methylation patterning.

223 Although altered DNA methylation patterns and mutations in DNMT3A correla

224 BACKGROUND & AIMS: We analyzed DNA methylation patterns and transcriptomes of primary i

225 Aberrant DNA methylation patterns are a common theme across all c

226 To gain insight into how genomic DNA methylation patterns are regulated during iAs-mediat

227 q recovered characteristic accessibility and DNA methylation patterns at DNase hypersensitive sites (

228 We find that expression and DNA methylation patterns correlate with distinct accessi

229 Using this approach, we identify critical DNA methylation patterns from previously inaccessible co

230 and reliable detection of disease-associated DNA methylation patterns has major potential to advance

231 methyl-donor availability influenced global DNA methylation patterns in both adult mice and their of

232 ot study to examine global transcription and DNA methylation patterns in specific immune cell populat

233 tive control and motivational processes with DNA methylation patterns of 60 candidate genes in boys a

234 uccessfully employed for characterisation of DNA methylation patterns that are essential for the diag

235 EBV latency types are defined by DNA methylation patterns that restrict expression of vir

236 Here, we hypothesized that DNA methylation patterns would help predict disease outc

237 Epigenetic modifications, including DNA methylation, play an important role in the pathogene

238 ian randomization approach to assess whether DNA methylation plays a mediating and causal role in ass

239 DNA methylation plays an important role in physiological

240 Comprehensive studies have shown that DNA methylation plays vital roles in both loss of plurip

241 t the effect of genome sequence variation on DNA methylation precludes a comprehensive assessment of

242 arable in accuracy to other state-of-the-art DNA methylation prediction algorithms.

243 CpGenie produces allele-specific DNA methylation prediction with single-nucleotide sensit

244 sulin and glucose exposure acutely alter the DNA methylation profile of skeletal muscle, indicating t

245 Endometrium has its characteristic DNA methylation profile, although not much is known abou

246 e frequently performed the best, followed by DNA methylation profile.

247 ported that differential gene expression and DNA methylation profiles in blood leukocytes of apparent

248 ed longitudinal changes of genome-wide blood DNA methylation profiles in relation to the development

249 py numbers (CN), gene expression levels, and DNA methylation profiles.

250 outcome and therefore performed genome-wide DNA methylation profiling in a cohort of 39 patients.

251 DNA methylation profiling performed on cancer tissues pr

252 The advent of high-throughput DNA methylation profiling techniques has enabled the pos

253 These data establish de novo DNA-methylation programming as a regulator of T cell exh

254 ation is coupled to preservation of acquired DNA methylation programs.

255 Moreover, these exhaustion-associated DNA-methylation programs were acquired in tumor-infiltra

256 f the loci that are targeted by RNA-directed DNA methylation (RdDM).

257 Recombination rate valleys show increased DNA methylation, reduced doublestranded break initiation

258 DNA methylation regulates eukaryotic gene expression and

259 However, the extent of DNA methylation reprogramming in plants remains unclear.

260 ad decreased 2HG, maintenance of G-CIMP, and DNA methylation reprogramming outside CGI.

261 The DNA methylation scan did not detect a genome-wide signif

262 size and survival rates in combination with DNA methylation sensitive comet assay to determine the e

263 ere, we report that PACE4 pre-mRNA undergoes DNA methylation-sensitive alternative splicing of its te

264 ent of A/B compartments precedes and defines DNA methylation signatures during differentiation and ma

265 ion tests, determination of epitope binding, DNA methylation signatures, and bioinformatics approache

266 a binning method that incorporates bacterial DNA methylation signatures, which are detected using sin

267 ate that DR remodels genome-wide patterns of DNA methylation so that age-related changes are profound

268 ator of the EBV type III latency program and DNA methylation state.IMPORTANCE Epstein-Barr virus (EBV

269 ype I IFN-alpha/beta protein levels with the DNA methylation status as well as the expression profile

270 Thus, changes in the DNA methylation status of the PRTN3 promoter may predict

271 and IL-4, INF-gamma and Foxp3 gene promoter DNA methylation status, and their correlation with final

272 of the locus with expression of ZCCHC14 and DNA methylation suggest the locus acts through changes t

273 ed to identify disease-associated changes in DNA methylation, suggesting mechanisms through which the

274 HG influence position effect variegation and DNA methylation, suggesting that this compound serves to

275 ed liver to have a pattern of acquisition of DNA methylation targeted to candidate enhancers active i

276 characterized by genome-wide alterations to DNA methylation that influence gene expression and genom

277 ods are needed to determine MGMT activity as DNA methylation, the current standard, does not accurate

278 rize the reversibility of the alterations in DNA methylation, the histone landscape, and transcriptio

279 e of independence between genic H3K36me3 and DNA methylation, these findings highlight the generated

280 state during cellular reprogramming requires DNA methylation to silence somatic gene expression and d

281 evealed a correlation of DPP4 expression and DNA methylation to stages of hepatosteatosis and nonalco

282 We precisely map RNA-programmed DNA methylation to targeted CpG sites as a function of d

283 Inhibition of DNA methylation triggers changes in the histone modifica

284 Reversion to the 'dry seed' state of DNA methylation upon re-oxygenation may act to 'reset th

285 d framework that learns a regulatory code of DNA methylation using a deep convolutional neural networ

286 unclear to what extent robust stress-induced DNA methylation variation can underpin stress memory.

287 ms, highlighting the potential importance of DNA methylation variation in genes related to neurodevel

288 Differential DNA methylation was found in only a small subset of symb

289 and PTSD symptoms by longitudinal changes in DNA methylation was observed at several positions and re

290 transcriptase-polymerase chain reaction, and DNA methylation was quantified at 7 CpG sites within the

291 half of the NCR genes, whereas in most genes DNA methylation was unaffected by the ploidy levels and

292 DIP2B, which is involved in DNA methylation, was localized with 5-methylcytosine in

293 -genome bisulfite sequencing, we showed that DNA methylation went through dynamic changes during seed

294 longation is suggested, as no differences in DNA methylation were observed between 24-h aerobically a

295 significant changes in the transcriptome and DNA methylation were observed between 4-day aerobically

296 is a key source of the one-carbon group for DNA methylation, whereas the association and mechanistic

297 nucleotide and a small-molecule inhibitor of DNA methylation, which, together, achieve 30,000-fold ME

298 We then investigated the association of DNA methylation with levels of inflammatory markers usin

299 nduced model of arthritis that the degree of DNA methylation within AC confers their immunomodulatory

300 We have also shown a change in DNA methylation within cardiomyocytes as a result of in