ライフサイエンスコーパス: DNA polymerase

1 ease that is associated with the replicative DNA polymerase.

2 r a model DNA adduct O(6)-benzylguanine by a DNA polymerase.

3 and verified they are active substrates for DNA polymerase.

4 ZI: TP and BIM: TP) by an engineered KlenTaq DNA polymerase.

5 ing proofreading DNA polymerases but not Taq DNA polymerase.

6 lity affects replication by bacteriophage T7 DNA polymerase.

7 e polymerase (Pol) delta, the lagging strand DNA polymerase.

8 rom bacteriophage T4 and a strand-displacing DNA polymerase.

9 mistry steps in the canonical mechanism of a DNA polymerase.

10 nd influence the enzymatic properties of the DNA polymerase.

11 rimers that are elongated by the replicative DNA polymerases.

12 the clamps serve as processivity factors for DNA polymerases.

13 ics of non-fluorescent native nucleotides by DNA polymerases.

14 alance of dNTP binding and dissociation from DNA polymerases.

15 tspots and lesion bypass fidelity of several DNA polymerases.

16 esizes short RNA primers of defined size for DNA polymerases.

17 on base selectivity and misincorporation by DNA polymerases.

18 that it provides only a minimal obstacle for DNA polymerases.

19 the presence of human translesion synthesis DNA polymerases.

20 NA synthesis resembling those of replicative DNA polymerases.

21 into heteroduplex DNA and to be extended by DNA polymerases.

22 of low-fidelity translesion synthesis (TLS) DNA polymerases.

23 le to be failed in PCR than non-proofreading DNA polymerases.

24 rance mechanism over error-prone translesion DNA polymerases.

25 iginally studied for its role in stimulating DNA polymerases.

26 prepared and tested as substrates for human DNA polymerases.

27 ross-link blocks DNA replication by varphi29 DNA polymerase, a highly processive polymerase enzyme th

28 nclude the Mcm2-7 complex, the CMG helicase, DNA polymerases, a Ctf4 trimer hub and the first look at

29 ovide a view of cis-BP-N (2)-dG adducts in a DNA polymerase active site, and offer a basis for unders

30 ide screen in Saccharomyces cerevisiae using DNA polymerase active-site mutants as a "sensitized muta

31 First, assays were designed to examine DNA polymerase activities including nucleotide incorpora

32 -1 reverse transcriptase (RT) possesses both DNA polymerase activity and RNase H activity that act in

33 which consequently leads to the recovery of DNA polymerase activity inhibited by the detection probe

34 Our approach leverages the DNA polymerase activity of reverse transcriptase to simu

35 We link error-prone DNA polymerase activity to the generation of variants.

36 hat the TGIRT enzyme has surprisingly robust DNA polymerase activity.

37 which relies on the target enzyme-triggered DNA polymerase activity.

38 The two molecules of DNA polymerase adopt a different spatial arrangement at

39 ome, a 340-kilodalton complex of primase and DNA polymerase alpha (Polalpha), synthesizes chimeric RN

40 eptide was able to displace the Ctf4 partner DNA polymerase alpha from the replisome in yeast extract

41 lagging-strand DNA synthesis by facilitating DNA polymerase alpha function at replication forks.

42 Decreased DNA polymerase alpha was followed by checkpoint arrest d

43 However, only PrimPol, DNA polymerase alpha, telomerase, and the mitochondrial

44 duced expression of the catalytic subunit of DNA polymerase alpha.

45 DNA polymerases alpha and delta carry out the initiation

46 MCM-GINS (CMG) replicative DNA helicase with DNA polymerases alpha, delta, and epsilon and other prot

47 OLA1, which encodes the catalytic subunit of DNA polymerase-alpha.

48 We propose that switching between these DNA polymerases also contributes to leading-strand synth

49 nucleic acid processing enzymes, including a DNA polymerase, an RNA polymerase and a DNA ligase, to u

50 a novel protein contact between the Y-family DNA polymerase and the B-family replication polymerase (

51 tations in the replication-repair-associated DNA polymerases and a distinct impact of microsatellite

52 ication of genomes of individual cells using DNA polymerases and high-throughput short-read DNA seque

53 a redefines the traditional concept of human DNA polymerases and indicates potential new functions of

54 Rev1 is a member of the Y-family of DNA polymerases and is known for its deoxycytidyl transf

55 plication forks connects the DNA helicase to DNA polymerases and many other factors.

56 g S phase and associate with the replicative DNA polymerases and other accessory proteins.

57 stoichiometries of the replicative helicase, DNA polymerase, and clamp loader complexes are consisten

58 he HP-MBs here serve together as the T4 PNK, DNA polymerase, and endonuclease recognition probe, and

59 e phage encodes its own primase, DNA ligase, DNA polymerase, and enzymes necessary to synthesize and

60 lowed by the iterative binding of nucleases, DNA polymerases, and the XRCC4-DNA ligase IV (X4-LIV) co

61 A helicase, five domains of RNA primase, two DNA polymerases, and two thioredoxin (processivity facto

62 oside triphosphates were good substrates for DNA polymerases applicable in primer extension or PCR sy

63 DNA polymerases are essential enzymes that faithfully an

64 Multiple DNA polymerases are involved in the ultraviolet response

65 has been believed that the archaeal B-family DNA polymerases are single-subunit enzymes.

66 High fidelity replicative DNA polymerases are unable to synthesize past DNA adduct

67 the genome, whereas FdUTP is incorporated by DNA polymerases as 5-FU in the genome; however, it remai

68 We propose that the configuration of DNA polymerases at stalled forks facilitates the resumpt

69 itive [insertion site c in the gene encoding DNA polymerase B (polB-c)] and intein-negative cells and

70 We find useful ranges of properties for DNA polymerase-based recorders, providing guidance for f

71 eps during nucleotide incorporation by human DNA polymerase beta (hPolbeta) and provide a structural

72 epair of 8-oxoG:dA base pairs requires human DNA polymerase beta (hPolbeta) to bypass 8-oxoG.

73 Here, we have solved structures of human DNA polymerase beta (hPolbeta), in complex with single-n

74 of 8-oxoguanine (8-oxodG) in TNR sequences, DNA polymerase beta (POL beta) can incorporate 8-oxodGMP

75 se excision repair (BER), and in vertebrates DNA polymerase beta (pol beta) provides gap filling and

76 DNA polymerase beta (pol beta) requires nuclear localiza

77 DNA polymerase beta (Pol beta), a member of the DNA poly

78 We have detected DNA polymerase beta (Polbeta), known as a key nuclear ba

79 ternative gap-filling pathways by inhibiting DNA polymerase beta activity.

80 cleosome core are preferentially repaired by DNA polymerase beta and there is a significant reduction

81 n NCPs decreases the gap-filling activity of DNA polymerase beta near the dyad center, with H3K14Ac e

82 alent metal ions are essential components of DNA polymerases both for catalysis of the nucleotidyl tr

83 HGG can cause PCR failure using proofreading DNA polymerases but not Taq DNA polymerase.

84 nts are limited to targeting the herpesvirus DNA polymerases, but with emerging viral resistance and

85 Here we showed that proofreading DNA polymerases can be inhibited by certain primers.

86 DNA polymerases catalyze a metal-dependent nucleotidyl t

87 ewly discovered third divalent metal ion for DNA polymerase-catalyzed nucleotide incorporation.

88 DNA polymerase catalyzes the accurate transfer of geneti

89 us DNA lesions but by a dysregulation in the DNA polymerase choice during genomic DNA synthesis.

90 e lobe in an organization reminiscent of the DNA polymerase clamp loader complexes.

91 are transcribed such that RNA polymerase and DNA polymerase collide head-on.

92 lular DNA replication factors and DNA repair DNA polymerases colocalize within centers of viral DNA r

93 o packaging viral pregenomic RNA (pgRNA) and DNA polymerase complex into nucleocapsids for reverse tr

94 rstanding of the structure and regulation of DNA polymerase complexes that mediate TLS and describe h

95 on probe derived from an aptamer specific to DNA polymerase containing the overhang sequence and the

96 Using a DNA polymerase coupled assay and FRET (Forster resonance

97 In eukaryotes, DNA polymerase delta (pol delta) is responsible for repl

98 DNA polymerase delta (Pol delta) is thought to catalyze

99 ouble mutant allele, which causes defects in DNA polymerase delta (Pol delta) proofreading (pol3-01)

100 telomere damage to establish predominance of DNA polymerase delta (Pol delta) through its POLD3 subun

101 iscontinuous strand that takes place in both DNA polymerase delta (Pol delta)- and DNA polymerase (Po

102 on with three essential replication enzymes: DNA polymerase delta (POLD1), DNA primase (PRIM1), and m

103 The intolerance of DNA polymerase delta (Poldelta) to incorrect base pairin

104 s arrest is not due to 5-FU lesions blocking DNA polymerase delta but instead depends, in part, on th

105 DNA polymerase delta can support leading-strand synthesi

106 DNA polymerase delta is required for lagging-strand synt

107 the Bloom syndrome helicase (BLM) stimulates DNA polymerase delta progression across telomeric G-rich

108 the processivity or proofreading activity of DNA polymerase delta shortened hetDNA length or reduced

109 e SDSA pathway using Rad51, Rad54, RPA, RFC, DNA Polymerase delta with different forms of PCNA.

110 for cells with defects in the lagging-strand DNA polymerase delta.

111 rier for the strand displacement activity of DNA polymerase delta.

112 tations in the POLD1 and POLE genes encoding DNA polymerases delta (Poldelta) and varepsilon (Polvare

113 NA-DNA primers to be extended by replicative DNA polymerases delta and .

114 s with somatic mutations in two of the major DNA polymerases, delta and epsilon, that replicate the g

115 tion depends on the proofreading activity of DNA polymerase-delta, although the repair proteins Msh2,

116 DNA polymerases depend on circular sliding clamps for pr

117 While most DNA polymerases discriminate against ribonucleotide trip

118 are similar, individual trajectories of both DNA polymerases display stochastically switchable rates

119 tions during DNA replication, with different DNA polymerases displaying different ratios of correct o

120 hat the main pathway for error correction is DNA polymerase dissociation-mediated DNA transfer, follo

121 ynthesis does not occur in a fully assembled DNA polymerase-DNA-deoxynucleoside triphosphate complex

122 The replicative DNA polymerase DnaE1 from the major pathogen Mycobacteri

123 d histidinol phosphatase (PHP) domain in the DNA polymerase DnaE1 is essential for mycobacterial high

124 Replicative DNA polymerases (DNAPs) require divalent metal cations f

125 1-MeA presents a block to replicative DNA polymerases due to its inability to participate in W

126 ir recognition proteins with the replicative DNA polymerases during DNA replication has suggested tha

127 erance of evidence supports a model in which DNA polymerase epsilon (Pol epsilon) carries out the bul

128 DNA polymerase epsilon (Pol epsilon) is a replicative DN

129 es during DNA replication has suggested that DNA polymerase epsilon (Pol epsilon) may also play a rol

130 The replicative DNA polymerase epsilon (Pol epsilon) was shown to activa

131 ted) cancers caused by mutations that impair DNA polymerase epsilon (POLE) proofreading.

132 rom this individual identified a mutation in DNA polymerase epsilon (POLE) that associated with an ul

133 ication proteins including Mcm10, RFC140 and DNA polymerase epsilon 255 kDa subunit in S-phase.

134 Additionally, maximal rates only occur when DNA polymerase epsilon catalyzes leading-strand synthesi

135 stablishing leading-strand synthesis, before DNA polymerase epsilon engagement.

136 DNA polymerase errors provide an important source of gen

137 nerations has provided new insights into how DNA polymerase errors sculpt genetic variation and drive

138 Recombinant human DNA polymerase eta (hpol eta) can replicate oligonucleot

139 Y-family human DNA polymerase eta (hpol eta) is of interest because of

140 and Rad3-related (ATR) kinase or translesion DNA polymerase eta (i.e. key proteins that promote the c

141 free translesion synthesis (TLS) mediated by DNA polymerase eta (Poleta).

142 two non-classical DNA polymerases, Rev1 and DNA polymerase eta, have two architectures: PCNA tool be

143 /MM simulations on a specific Pol, the human DNA polymerase-eta, an enzyme involved in repairing dama

144 niversal PCR Master Mix with two alternative DNA polymerases: ExTaq HS and Immolase.

145 ted in nucleosome core DNA showed a distinct DNA polymerase extension profile in cell-free extracts t

146 studies establish the mechanistic basis for DNA polymerase fidelity during reverse transcription and

147 Pol as a mitochondrial translesion synthesis DNA polymerase for oxidative DNA damage; however, we sho

148 r the subsequent coupling of CMG activity to DNA polymerases for efficient DNA synthesis.

149 roteins that encircle DNA and associate with DNA polymerases for processive DNA replication.

150 The only DNA polymerase found in the apicoplast (apPOL) was putat

151 endent DNA primase and translesion synthesis DNA polymerase found in the nucleus and mitochondria.

152 Increasing the amount of DNA polymerase from 1 to 5 U had a strong effect for ExT

153 DNA polymerase fulfills the strict requirements for fide

154 ongly mutagenic in genetic backgrounds where DNA polymerase function or MMR activity is partially com

155 e establish that leading- and lagging-strand DNA polymerases function independently within a single r

156 ed purified mtDNA replication proteins, i.e. DNA polymerase gamma holoenzyme, the mitochondrial singl

157 rate for subsequent gap-filling synthesis by DNA polymerase gamma.

158 (RT), adenylate/guanylate kinase, and human DNA polymerase gamma.

159 s a selective inhibitor of the mitochondrial DNA polymerase gamma.

160 DSS3Phi8 contains the DNA polymerase gene which is closely related to T7-like

161 th unlabelled proteins (BamHI, EcoRV, and T7 DNA polymerase gp5/trx).

162 enome, making it essential to understand how DNA polymerases handle 8-oxoG.

163 Here, we show that each DNA polymerase has a distinct pattern of association wit

164 The mechanism of nucleotide incorporation by DNA polymerases has been extensively studied structurall

165 The D-stereoselectivity of DNA polymerases has only recently been explored structur

166 The majority of human DNA polymerases have been reported to misinsert ribonucl

167 Thus, multi-subunit replicative DNA polymerase holoenzymes are present in all three doma

168 pha, telomerase, and the mitochondrial human DNA polymerase (hpol) gamma have been shown to tolerate

169 ition, hpol eta, as well as another Y-family DNA polymerase, hpol kappa, accommodates RNA as one of t

170 Of the "translesion" Y-family human DNA polymerases (hpols), hpol eta is most efficient in i

171 se crystallography, we evaluated how a model DNA polymerase, human polymerase beta, accommodates 8-ox

172 ditionally, Cu(II) chelated PyED outcompetes DNA polymerase I to successfully inhibit template strand

173 s by the Klenow fragment of Escherichia coli DNA polymerase I.

174 en verified by primer extension studies with DNA polymerases I and IV from E. coli.

175 ymerase X (AsfvPolX) is the most distinctive DNA polymerase identified to date; it lacks two DNA-bind

176 There is a controversy as to whether or not DNA polymerase III holoenzyme (Pol III HE) contains gamm

177 We report here that the DNA polymerase III holoenzyme in a stalled E. coli repli

178 tau binds DNA polymerase III tightly; gamma does not.

179 Escherichia coli has three DNA polymerases implicated in the bypass of DNA damage,

180 tudy, we evaluated the impact of varying the DNA polymerase in chamber-based dPCR for both pure and i

181 We conclude that the choice of DNA polymerase in dPCR is crucial for the accuracy of qu

182 g and lagging strands and the error bias for DNA polymerase in specific sequence contexts.

183 r antigen (PCNA), an essential co-factor for DNA polymerases in both replication and repair.

184 he roles of individual translesion synthesis DNA polymerases in bypassing these lesions, and suggeste

185 Rev1 is unique among translesion synthesis DNA polymerases in employing a protein-template-directed

186 DNA polymerases in family B are workhorses of DNA replic

187 that there is no difference among the tested DNA polymerases in terms of accuracy of absolute quantif

188 is fully biocompatible; it is replicated by DNA polymerases in vitro and encodes a functional iLOV p

189 The eukaryotic B-family DNA polymerases include four members: Polalpha, Poldelta

190 for oligonucleotide preparation by standard DNA polymerases, including Hemo KlenTaq, Vent, and Deep

191 Because Thermococcus DNA polymerases incorporate as many as 1,000 ribonucleot

192 s to integrate the emerging literature about DNA polymerase involvement during HR with the unique asp

193 DNA polymerase iota (Pol iota) is an attractive candidat

194 Here we determine how human DNA polymerase-iota (Poliota) promotes error-free replic

195 Primer utilization by T7 DNA polymerase is slower than primer formation.

196 catalytic subunit of the eukaryotic B-family DNA polymerases is essential for the formation of active

197 DNA elimination is a surprising function for DNA polymerase, it could provide a robust nexus for nucl

198 yl-dGTP was equal to dGTP as a substrate for DNA polymerase kappa (pol kappa), but was a poor substra

199 DNA polymerase kappa (Pol kappa), which has been implica

200 Here we examine how human DNA polymerase lambda (Pol lambda) achieves medium fidel

201 ive 8-oxo-dG:dA mispairs are removed through DNA polymerase lambda (Pol lambda)-dependent MUTYH-initi

202 ribonucleotides, which can be misinserted by DNA polymerases, leading to the most abundant DNA lesion

203 We suggest that the DNA polymerase may play this role more widely and that i

204 ime DNA synthesis by the yeast mitochondrial DNA polymerase Mip1.

205 Replicative DNA polymerases misincorporate ribonucleoside triphospha

206 All DNA polymerases misincorporate ribonucleotides despite t

207 itions in response to DNA lesions that block DNA polymerase movement.

208 ration very effectively, the Family X member DNA polymerase mu (Pol mu) incorporates rNTPs almost as

209 -PKcs and Artemis for trimming the DNA ends; DNA polymerase mu and lambda to add nucleotides; and the

210 When copying DNA, DNA polymerases not only select the base of the incoming

211 n fidelity relies on the concerted action of DNA polymerase nucleotide selectivity, proofreading acti

212 , here simplified as the contribution of the DNA polymerase (nucleotide selectivity and proofreading)

213 ese aberrant CMG complexes interact with the DNA polymerases on human chromatin, these complexes are

214 the regulation of chromosomal proteins like DNA polymerases or kinetochore kinases, are demonstratin

215 mining recording start times and coping with DNA polymerase pausing.

216 llow the exchange of the E. coli replicative DNA polymerase Pol IIIcore with the translesion polymera

217 and lagging strands by the three replicative DNA polymerases Pol alpha, Pol delta, and Pol epsilon; a

218 n both DNA polymerase delta (Pol delta)- and DNA polymerase (Pol )-dependent MMR reactions is suppres

219 DNA polymerase (Pol) beta maintains genome fidelity by c

220 The mechanism of DNA polymerase (pol) fidelity is of fundamental importan

221 In the current study, we examined DNA polymerase (pol) gamma and pol beta as possible comp

222 Of the three, DNA polymerase (Pol) II remains the most enigmatic.

223 down-regulation of oxidative stress response DNA polymerase (Pol) lambda caused by hyperactive HUWE1

224 ts biological function in genome maintenance.DNA polymerase (pol) mu functions in DNA double-strand b

225 DNA polymerase (pol) mu is a DNA-dependent polymerase th

226 DNA polymerase (pol) processivity, i.e., the bases a pol

227 Archaeal family-D DNA polymerases (Pol-D) comprise a small (DP1) proofread

228 ve DNA helicase, MCM, and the leading-strand DNA polymerase, Pol epsilon, move beyond the site of DNA

229 ryotic genome is primarily replicated by two DNA polymerases, Pol epsilon and Pol delta, that functio

230 otic cells requires minimally three B-family DNA polymerases: Pol alpha, Pol delta, and Pol .

231 To quantitatively image how the replicative DNA polymerase PolC functions in B. subtilis, we applied

232 performed in human cells by two specialized DNA polymerases, Pollambda and Polmu.

233 he free energy source enabling high-fidelity DNA polymerases (pols) to favor incorporation of correct

234 and strongly blocks synthesis by replicative DNA polymerases (Pols).

235 DNA replication factors and major DNA repair DNA polymerases (polymerase eta [Pol eta] and polymerase

236 Three DNA polymerases, polymerases alpha, delta, and epsilon (

237 4 phage gene product 45 (gp45, also known as DNA polymerase processivity factor or sliding clamp) obt

238 ve site magnesium ion was identified in some DNA polymerase product crystallographic structures, but

239 than genes transcribed codirectionally with DNA polymerase progression due to conflicts between tran

240 Mutations preventing DNA polymerase proofreading activity or MMR function cau

241 missing for all naturally occurring archaeal DNA polymerases, provides a framework for engineering ne

242 trong D-stereoselectivity exhibited by human DNA polymerases relative to viral reverse transcriptases

243 translesion DNA synthesis (TLS), specialized DNA polymerases replicate the damaged DNA, allowing stri

244 s such as pol delta and the bacteriophage T4 DNA polymerase replicating 8-oxo-G in an error-prone man

245 Genomic integrity is compromised by DNA polymerase replication errors, which occur in a sequ

246 Lagging strand DNA synthesis by DNA polymerase requires RNA primers produced by DNA prim

247 nuclear antigen (PCNA) and two non-classical DNA polymerases, Rev1 and DNA polymerase eta, have two a

248 RNA dependent DNA-polymerases, reverse transcriptases, are key enzymes

249 Accurate and complete quantification of a DNA polymerase's error spectrum is challenging because e

250 ication assays in vitro with a high-fidelity DNA polymerase, Saccharomyces cerevisiae polymerase (pol

251 sly reported the evolution of a thermostable DNA polymerase, SFM4-3, that more efficiently accepts su

252 Using a thermostable DNA polymerase, SFM4-3, which was previously evolved to

253 The eukaryotic DNA polymerase sliding clamp, proliferating cell nuclear

254 These results therefore suggest that whereas DNA polymerase stalling at DNA lesions activates ATR to

255 compromises S-phase progression and induces DNA-polymerase stalling and DNA damage.

256 tly been explored structurally and all three DNA polymerases studied to date have demonstrated unique

257 Although high-fidelity DNA polymerases such as pol delta and the bacteriophage

258 Y-family DNA polymerases, such as polymerase eta, polymerase iota

259 However, translesion synthesis (TLS) DNA polymerases, such as Rev1, have the ability to bypas

260 eta) is a low fidelity translesion synthesis DNA polymerase that rescues damage-stalled replication b

261 locks, cells utilize specialized translesion DNA polymerases that are intrinsically error prone and a

262 nstream of the lesion or recruit specialized DNA polymerases that can bypass the lesion via translesi

263 creates a potent inhibitor of several human DNA polymerases that can replicate damaged DNA.

264 strand displacement and primer extension by DNA polymerases that resulted in premature chain termina

265 s, forming the CMG helicase, the Pol epsilon DNA polymerase, the RFC clamp loader, the PCNA sliding c

266 in abundance, and blocks primer extension by DNA polymerase, thereby demonstrating the functional sig

267 DNA polymerase theta (Pol theta)-mediated end joining (T

268 DNA polymerase theta (Poltheta) is a unique A-family pol

269 DNA polymerase theta (Poltheta) promotes insertion mutat

270 6) demonstrate a critical role for mammalian DNA polymerase theta in the rejoining of DNA ends that a

271 d annealing factors HR Rad52 and translesion DNA polymerase theta to CSR.

272 s have been made to improve the proofreading DNA polymerases, they are more susceptible to be failed

273 Here, we designed and covalently coupled a DNA polymerase to an alpha-hemolysin (alphaHL) heptamer

274 cs of competitive incorporation reactions by DNA polymerase to be monitored.

275 The heterodimer enables the DNA polymerase to efficiently synthesize extended strand

276 rporated adjacent to the nicking site with a DNA polymerase to label the guide RNA-determined target

277 , we evaluate the ability of a high-fidelity DNA polymerase to perform TLS with 8-oxo-guanine (8-oxo-

278 Using a DNA polymerase to record intracellular calcium levels ha

279 pted to evolve a high-fidelity, thermostable DNA polymerase to use RNA templates efficiently.

280 nslesion synthesis (TLS) employs specialized DNA polymerases to bypass replication fork stalling lesi

281 sphate (dNTP/rNTP) ratios, by the ability of DNA polymerases to discriminate against ribonucleotides,

282 the ability of high-fidelity and specialized DNA polymerases to incorporate natural and modified nucl

283 lesion DNA synthesis (TLS) is the ability of DNA polymerases to incorporate nucleotides opposite and

284 is (TLS) during S-phase uses specialized TLS DNA polymerases to replicate a DNA lesion, allowing stri

285 tes TLS by promoting recruitment of Y-family DNA polymerases to sites of DNA-damage-induced replicati

286 During replication, DNA polymerases tolerate patches of ribonucleotides on t

287 phosphates dA(SR)TP were good substrates for DNA polymerases useful in the enzymatic synthesis of bas

288 A highly processive DNA polymerase was conjugated to the nanopore, and the c

289 where individual translesion synthesis (TLS) DNA polymerases were depleted by the CRISPR/Cas9 genome

290 New work shows that the mitochondrial DNA polymerase, which normally replicates mtDNA, plays a

291 erase epsilon (Pol epsilon) is a replicative DNA polymerase with an associated 3'-5' exonuclease acti

292 This is the first crystal structure of a DNA polymerase with an incoming rNTP opposite a DNA lesi

293 All four derivatives are good substrates for DNA polymerase, with Km values averaging 13-fold higher

294 Co-occupancy of multiple DNA polymerases within the replisome has been observed p

295 ASFV DNA Polymerase X (AsfvPolX) is the most distinctive DNA

296 polymerase beta (Pol beta), a member of the DNA polymerase X family that is involved in base excisio

297 cts promote the participation of error-prone DNA polymerase zeta (Polzeta) in replication of undamage

298 Without H2Bub1, DNA polymerase zeta (Polzeta) is responsible for a highl

299 Accordingly, DNA polymerase zeta activity was essential for mutagenes

300 , the gene encoding the catalytic subunit of DNA polymerase zeta involved in translesional synthesis,