ライフサイエンスコーパス: DNA polymerase beta

1 tic replicating polymerase, is homologous to DNA polymerase beta.

2 by the BER enzymes, DNA ligase IIIalpha and DNA polymerase beta.

3 ylases and reduced DNA synthesis capacity by DNA polymerase beta.

4 ng to a large enzyme superfamily typified by DNA polymerase beta.

5 he critical DNA base excision repair enzyme, DNA polymerase beta.

6 ncoming nucleotide in the active site, as in DNA polymerase beta.

7 ot substitute for PCNA in the stimulation of DNA polymerase beta.

8 ading activity for the relatively inaccurate DNA polymerase beta.

9 air extension ability, relative to wild-type DNA polymerase beta.

10 asic sites to facilitate repair synthesis by DNA polymerase beta.

11 is homologous to part of the 8 kDa domain of DNA polymerase beta.

12 id was also incorporated into position 72 of DNA polymerase beta.

13 s catalytic activity or its interaction with DNA polymerase beta.

14 pendent DNA cleavage and strongly inhibiting DNA polymerase beta.

15 thway by interacting with DNA ligase III and DNA polymerase beta.

16 ened for the ability to irreversibly inhibit DNA polymerase beta.

17 ycle-dependent manner similar to that of the DNA polymerase beta.

18 nt antitumor agents were shown to inactivate DNA polymerase beta.

19 NMR measurements of [methyl-(13)C]methionine DNA polymerase beta.

20 erase that shares 34% sequence identity with DNA polymerase beta.

21 with several replicative DNA polymerases and DNA polymerase beta.

22 DNA polymerase beta, a member of the X family of DNA pol

23 GTP, which forms an active site complex with DNA polymerase beta, a repair enzyme that plays an impor

24 In short-patch repair, DNA polymerase beta accounts for both excision activity

25 he specific catalytic roles of two groups of DNA polymerase beta active site residues identified from

26 the reverse reaction in the confines of the DNA polymerase beta active site.

27 r; this reduces OGG1, AP endonuclease 1, and DNA polymerase beta activities.

28 e near the 3' terminus did not affect either DNA polymerase beta activity or poly(ADP)ribose polymera

29 ternative gap-filling pathways by inhibiting DNA polymerase beta activity.

30 activity correlated tightly with changes in DNA polymerase beta and AP site DNA binding levels.

31 protein-like box sequence in APC that binds DNA polymerase beta and blocks DNA polymerase beta-media

32 between the isolated 8-kDa domain of the rat DNA polymerase beta and DNA have been studied, using the

33 the known repair enzymes, AP-endonuclease 1, DNA polymerase beta and DNA ligase III.

34 with purified human enzymes including APE1, DNA polymerase beta and DNA ligase IIIalpha.

35 n step of long-patch BER with purified human DNA polymerase beta and FEN1.

36 ith downstream base excision repair proteins DNA polymerase beta and flap endonuclease-1 by 4-6-fold.

37 incorporated into double-stranded DNA using DNA polymerase beta and functioned as both the damage si

38 two promising genes in the DNA repair enzyme DNA polymerase beta and in the neuroendocrine transcript

39 een the in vitro replication errors of human DNA polymerase beta and in vivo point mutations of the a

40 -turnover kinetic methods, we examined human DNA polymerase beta and its novel X-family homolog, huma

41 nd the damaged strands that were bypassed by DNA polymerase beta and processed by flap endonuclease 1

42 alized similarity in the catalytic domain to DNA polymerase beta and related nucleotidyltransferases.

43 of cell replication-related proteins such as DNA polymerase beta and subunits of DNA polymerase delta

44 alpha or DNA ligase I, inhibits extension by DNA polymerase beta and that the lesion is resistant to

45 Interactions between human DNA polymerase beta and the template-primer, as well as

46 from apurinic/apyrimidinic endonuclease 1 to DNA polymerase beta and then to DNA ligase.

47 cleosome core are preferentially repaired by DNA polymerase beta and there is a significant reduction

48 R proteins, namely, DNA ligase III alpha and DNA polymerase beta and thus could form a large multipro

49 However, binding of hMYH to DNA polymerases beta and delta was not detected.

50 DNA polymerases beta and eta are among the few eukaryoti

51 determined to be 5.7-7.2 x 10(-4) when using DNA polymerase beta (+/+) and (-/-) cell-free extracts.

52 Efficient repair was observed in both DNA polymerase beta (+/+) and (-/-) cell-free extracts.

53 using homozygous mouse embryonic fibroblast DNA polymerase beta (+/+) and (-/-) cells to determine t

54 A type II DNA topoisomerase, a DNA polymerase beta, and a structure-specific endonuclea

55 nd the BER participants flap endonuclease-1, DNA polymerase beta, and apurinic/apyrimidinic endonucle

56 man uracil DNA glycosylase, AP endonuclease, DNA polymerase beta, and DNA ligase 1 replace uracil opp

57 The scaffold protein XRCC1, DNA polymerase beta, and DNA ligase IIIalpha play pivota

58 , apurinic/apyrimidinic (AP) endonuclease 1, DNA polymerase beta, and DNA ligases.

59 DOB is a potent irreversible inhibitor of DNA polymerase beta, and forms interstrand cross-links i

60 PE1, the DNA strand displacement activity of DNA polymerase beta, and incision of a 1- or 10-nucleoti

61 such as apurinic/apyrimidinic endonuclease, DNA polymerase beta, and ligases, require Mg(2+).

62 itecture of the nucleotide binding pocket of DNA polymerase beta, and that alterations of this residu

63 Mouse fibroblasts, deficient in DNA polymerase beta, are hypersensitive to monofunctiona

64 effect of the protein residues, taking human DNA polymerase beta as a model system.

65 Repair synthesis catalysed by DNA polymerase beta at 1 nt gaps occurs in the main path

66 alize with a type II DNA topoisomerase and a DNA polymerase beta at antipodal sites flanking the kine

67 n aphidicolin-resistant polymerase, probably DNA polymerase-beta, becomes the primary polymerase.

68 In single-nucleotide BER, DNA polymerase beta (beta-pol) accounts for both gap fil

69 e (Aag) recognizes and removes the base, and DNA polymerase beta (beta-pol) contributes the gap tailo

70 ry cAMP response element (CRE)1 in the human DNA polymerase beta (beta-pol) core promoter plays a key

71 To establish the role of DNA polymerase beta (beta-pol) in BER and beta-pol-depen

72 n either BER or its rate-determining enzyme, DNA polymerase beta (beta-pol) is observed in response t

73 DNA polymerase beta (beta-pol) plays a central role in r

74 effect of Sp1 on the activation of the human DNA polymerase beta (beta-pol), a TATA-less promoter.

75 One contributing factor is the abundance of DNA polymerase beta (beta-pol), an enzyme required for B

76 DNA repair protein that forms complexes with DNA polymerase beta (beta-Pol), DNA ligase III and poly-

77 ms a base excision repair (BER) complex with DNA polymerase beta (beta-Pol).

78 ct was partially inhibited by an antibody to DNA polymerase beta (beta-pol).

79 Three regions in human and rat DNA polymerases beta (beta-pol) that resemble the consen

80 tructurally homologous to the palm domain of DNA polymerase beta but has additional structural featur

81 DNA polymerase beta carries out two of the four steps du

82 The mechanism of DNA polymerase beta-catalyzed nucleotidyl transfer consi

83 Addition of p21 peptide or protein to DNA polymerase beta (+/+) cell-free extracts increased t

84 th that observed in the crystal structure of DNA polymerase beta complexed with magnesium and dNTP an

85 escribed a general mutator form of mammalian DNA polymerase beta containing a cysteine substitution f

86 Aging and DNA polymerase beta deficiency (beta-pol(+/-)) interact

87 Using human DNA polymerase beta, deoxyoxanosine triphosphate is only

88 rnative pathways for base excision repair: a DNA polymerase beta-dependent pathway and a proliferatin

89 DNA polymerase beta discourages ribonucleotide insertion

90 also consistent with the interpretation that DNA polymerase beta discriminates the correct from incor

91 TP analogs (dT) was demonstrated to fit into DNA polymerase beta (DNA pol beta) binding pocket by obt

92 nting gene I protein (XRCC1) in complex with DNA polymerase beta, DNA ligase III, and poly(ADP-ribose

93 ression of XRCC1-associated proteins such as DNA polymerase beta, DNA ligase III, poly(ADP-ribose) po

94 ates the sequential binding and catalysis by DNA polymerase beta, DNA polymerase delta, FEN1, and DNA

95 tides 130-fold tighter, on average, than the DNA polymerase beta-DNA complex, although the base subst

96 olymerase with only one metal ion bound, the DNA polymerase beta-DNA template-primer-chromium(III).2'

97 excision repair pathway, and mice devoid of DNA polymerase beta do not live beyond a few hours after

98 In contrast, the related mammalian DNA polymerase beta does not form a complex with Ku and

99 ay enhance the base substitution fidelity of DNA polymerase beta during single nucleotide BER.

100 DNA constructs in vitro, we find that human DNA polymerase beta effectively catalyzes CAG/CTG triple

101 These data support the hypothesis that DNA polymerase beta errors are an important fraction of

102 ethod, we could follow the activity of human DNA polymerases beta, eta, iota and kappa under differen

103 blocking termini were activated by Ape1 for DNA polymerase beta extension.

104 The hydrophobic hinge of DNA polymerase beta facilitates closing and stabilizatio

105 eotidyltransferase (NTase) and member of the DNA polymerase beta family.

106 osylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta, flap endonuclease-1 (FEN-1), and PA

107 The DNA polymerase beta from the trypanosomatid Crithidia fa

108 Compared to the higher fidelity DNA polymerase beta from the X-family, Dpo4 has a higher

109 Because DNA polymerase beta functions in base excision repair, o

110 Mammalian DNA polymerase beta functions in the base excision DNA r

111 he fidelity of another inefficient mutant of DNA polymerase beta (G274P) is not altered.

112 ed strand is blocked, the intermediate after DNA polymerase beta gap filling is not channeled to the

113 of the catalytic divalent ion to the ternary DNA polymerase beta/gapped DNA/dNTP complex is thought t

114 We also show that DNA polymerase beta has low fidelity at the cisplatin IC

115 DNA polymerase beta has no exonucleolytic proof-reading

116 e excision repair (BER)-deficient model, the DNA polymerase beta heterozygous mouse, to investigate t

117 eps during nucleotide incorporation by human DNA polymerase beta (hPolbeta) and provide a structural

118 epair of 8-oxoG:dA base pairs requires human DNA polymerase beta (hPolbeta) to bypass 8-oxoG.

119 Here, we have solved structures of human DNA polymerase beta (hPolbeta), in complex with single-n

120 tallography to follow 8-oxoG bypass by human DNA polymerase beta (hPolbeta).

121 The transient appearance of DNA polymerase beta in photoreceptors under these experi

122 to a molecule that irreversibly inactivates DNA polymerase beta in solution (IC50 approximately 21 m

123 We determined the error spectrum of DNA polymerase beta in the human APC gene under PCR cond

124 mulates strand displacement DNA synthesis by DNA polymerase beta in this system; this stimulation is

125 tuent was found to be a critical element for DNA polymerase beta inhibition, since compounds 1 and 2

126 The most potent DNA polymerase beta inhibitors were bis(dihydroxyalkylbe

127 DNA polymerase beta is a repair polymerase that provides

128 phenotype and that the Glu-249 side chain of DNA polymerase beta is critical for mispair extension fi

129 The large-scale opening motion of mammalian DNA polymerase beta is followed at atomic resolution by

130 show here that subsequent excision by human DNA polymerase beta is impaired at dL compared with unmo

131 d that SSB repair by DNA ligase IIIalpha and DNA polymerase beta is impaired by the presence of the n

132 DNA polymerase beta is known to be a key player in the b

133 oxynucleoside triphosphate, alpha-helix N of DNA polymerase beta is observed to form one face of the

134 DNA polymerase beta is overexpressed in cancer cells and

135 e included in the reaction or when wild type DNA polymerase beta is replaced by DNA polymerase beta v

136 DNA polymerase beta is the predominant crosslinked prote

137 a, a recently identified X-family homolog of DNA polymerase beta, is hypothesized to be a second poly

138 stage embryos and adults are the absence of DNA polymerase-beta, leading to predominance of replicat

139 to human DNA polymerase beta, the C-terminal DNA polymerase beta-like domain alone displays a dramati

140 is comprised of three domains: a C-terminal DNA polymerase beta-like domain, an N-terminal BRCA1 C-t

141 Crystallographic studies of the C-terminal DNA polymerase-beta-like domain of full-length human DNA

142 rating enzymes include several clades of the DNA-polymerase beta-like superfamily (including Vibrio c

143 PC that binds DNA polymerase beta and blocks DNA polymerase beta-mediated strand-displacement synthes

144 f Escherichia coli, we previously isolated a DNA polymerase beta mutant in which Tyr-265 was altered

145 n NCPs decreases the gap-filling activity of DNA polymerase beta near the dyad center, with H3K14Ac e

146 It is a divergent member of the DNA polymerase beta nucleotidyl transferase superfamily,

147 vitro single-nucleotide BER deficiency of a DNA polymerase beta null cell extract.

148 ld-type and, in particular, repair-deficient DNA polymerase beta null cells are highly sensitized to

149 n potential, during DNA replication by human DNA polymerase beta, of several tetranucleotide repeat t

150 DNA polymerase beta offers an attractive system to study

151 activity of the uracil-DNA glycosylases and DNA polymerase beta on nucleosome cores.

152 DNA synthesis by either DNA polymerase beta or exonuclease-deficient T7 DNA poly

153 and 40-fold, respectively, but not those of DNA polymerase beta or Klenow fragment of E.coli DNA pol

154 yribose-5-phosphate lyase activity of either DNA polymerase beta or lambda is believed to occur after

155 ient in x-ray cross-complementing protein 1, DNA polymerase beta, or poly (ADP-ribose) polymerase 1 a

156 the activation of a TATA-containing chimeric DNA polymerase beta (pAS8) promoter.

157 DNA polymerase beta plays a critical role in base-excisi

158 DNA polymerase beta plays a key role in base excision re

159 ) studies on the enzyme-DNA complexes of rat DNA polymerase beta (Pol beta) and African swine fever v

160 bers of the X-family of DNA polymerases: rat DNA polymerase beta (Pol beta) and African swine fever v

161 L1 stably interacts with other BER proteins, DNA polymerase beta (pol beta) and DNA ligase IIIalpha.

162 n vitro, we found that TRF2 physically bound DNA polymerase beta (Pol beta) and flap endonuclease 1 (

163 DNA polymerase beta (pol beta) and flap endonuclease 1 (

164 DNA ligase IIIalpha and also interacts with DNA polymerase beta (Pol beta) and other base excision r

165 t shares a number of characteristics of both DNA polymerase beta (pol beta) and terminal deoxynucleot

166 onuclease from the incised abasic site, both DNA polymerase beta (Pol beta) and the DNA ligase IIIalp

167 teady-state kinetic analyses using wild-type DNA polymerase beta (pol beta) and two active-site mutan

168 We use DNA polymerase beta (pol beta) as a model system to inve

169 of 8-oxoguanine (8-oxodG) in TNR sequences, DNA polymerase beta (POL beta) can incorporate 8-oxodGMP

170 p junctions and whether a specific siRNA for DNA polymerase beta (pol beta) can move from one cell to

171 We investigated DNA polymerase beta (POL beta) capacity to incorporate r

172 DNA polymerase beta (Pol beta) carries out strand displa

173 the R283K mutant of human DNA repair enzyme DNA polymerase beta (pol beta) differing in the number o

174 To elucidate how human DNA polymerase beta (pol beta) discriminates dATP from d

175 ssion and short hairpin RNA-mediated loss of DNA polymerase beta (Pol beta) expression in human breas

176 Human DNA polymerase beta (pol beta) fills gaps in DNA as part

177 hich is demonstrated by the observation that DNA polymerase beta (pol beta) gap-filling synthesis act

178 We have identified several mutations of the DNA polymerase beta (pol beta) gene in human colorectal

179 2-AP) as a probe in stopped-flow analyses of DNA polymerase beta (Pol beta) had provided important me

180 While matched nucleotide incorporation by DNA polymerase beta (Pol beta) has been well-studied, a

181 DNA polymerase beta (pol beta) has long been described a

182 Crystallographic characterization of DNA polymerase beta (pol beta) has suggested that multip

183 Mutations in DNA polymerase beta (pol beta) have been associated with

184 filling polymerase activity was not due to a DNA polymerase beta (pol beta) homolog, or to another X-

185 ure of the human base excision repair enzyme DNA polymerase beta (Pol beta) in complex with a 1-nt ga

186 f different intermediate states of mammalian DNA polymerase beta (Pol beta) in its wild-type and an e

187 DNA polymerase beta (Pol beta) is a 39-kDa enzyme that p

188 DNA polymerase beta (pol beta) is a bifunctional enzyme

189 DNA polymerase beta (pol beta) is a central participant

190 During DNA repair, DNA polymerase beta (Pol beta) is a highly dynamic enzym

191 DNA polymerase beta (Pol beta) is a key enzyme in DNA ba

192 Deoxyribose phosphate (dRP) removal by DNA polymerase beta (Pol beta) is a pivotal step in base

193 DNA polymerase beta (pol beta) is an ideal system for st

194 etween the XRCC1 N-terminal domain (NTD) and DNA polymerase beta (Pol beta) is central to base excisi

195 DNA polymerase beta (pol beta) is responsible for gap fi

196 DNA polymerase beta (Pol beta) is responsible for the re

197 DNA polymerase beta (pol beta) is the key gap-filling po

198 DNA polymerase beta (pol beta) is the main polymerase in

199 DNA polymerase beta (pol beta) is the main polymerase in

200 DNA polymerase beta (pol beta) is the only mammalian DNA

201 verse rate of the conformational step in the DNA polymerase beta (Pol beta) kinetic pathway.

202 e template strand, which was skipped over by DNA polymerase beta (pol beta) lesion bypass synthesis.

203 We have examined the mechanism of DNA polymerase beta (pol beta) lesion discrimination usi

204 We have shown earlier that DNA polymerase beta (Pol beta) localizes to the synapton

205 DNA polymerase beta (pol beta) offers a simple system to

206 pyrimidinic/apurinic endonuclease (APE), and DNA polymerase beta (pol beta) on homogeneously damaged,

207 DNA polymerase beta (Pol beta) plays a key role in base

208 se excision repair (BER), and in vertebrates DNA polymerase beta (pol beta) provides gap filling and

209 Earlier results had indicated that purified DNA polymerase beta (pol beta) removes the entire 5'-AMP

210 DNA polymerase beta (pol beta) requires nuclear localiza

211 ported that WRN helicase activity stimulates DNA polymerase beta (pol beta) strand displacement synth

212 ructures of open and closed conformations of DNA polymerase beta (pol beta) suggests that the rate of

213 In contrast, DNA polymerase beta (Pol beta) synthesis is inhibited in

214 are the structure of the catalytic domain of DNA polymerase beta (pol beta) to that of a region of th

215 erichia coli DNA polymerase I (Kfexo(-)) and DNA polymerase beta (pol beta) using (19)F NMR, insertio

216 f human tumors characterized to date express DNA polymerase beta (pol beta) variant proteins.

217 scale sequencing studies have indicated that DNA polymerase beta (pol beta) variants are present on a

218 DNA polymerase beta (Pol beta) was implicated recently a

219 DNA polymerase beta (Pol beta), a key enzyme in the DNA

220 DNA polymerase beta (Pol beta), a member of the DNA poly

221 Mammalian DNA polymerase beta (pol beta), a small (39 kDa) member

222 iciently and irreversibly inhibits repair by DNA polymerase beta (Pol beta), an integral enzyme in ba

223 onstrated for the N-terminal 8 kDa domain of DNA polymerase beta (Pol beta), and for the homologous d

224 apurinic/apyrimidinic endonuclease 1 (APE1), DNA polymerase beta (pol beta), flap endonuclease 1 (FEN

225 id (LCA), an inhibitor of the key BER enzyme DNA polymerase beta (pol beta), in cells deficient in ex

226 The DNA repair enzyme, DNA polymerase beta (Pol beta), is among the most discri

227 monstrate large-scale subdomain movements as DNA polymerase beta (pol beta), significant DNA motion e

228 1/HectH9) as an enzyme that can ubiquitylate DNA polymerase beta (Pol beta), the major BER DNA polyme

229 cant proportion of human cancers overexpress DNA polymerase beta (Pol beta), the major DNA polymerase

230 irus reverse transcriptase (AMV-RT) or human DNA polymerase beta (pol beta), was significantly impair

231 opped-flow fluorescence assays for mammalian DNA polymerase beta (Pol beta), we have previously ident

232 lase hNTH1, apurinic endonuclease (APE), and DNA polymerase beta (Pol beta), which catalyze the first

233 n contrast with another X-family polymerase, DNA polymerase beta (pol beta), which inserts G*G mismat

234 purinic/aprymidinic endonuclease 1 (APE) and DNA polymerase beta (Pol beta).

235 both with the AP endonuclease (APE) and with DNA polymerase beta (pol beta).

236 phate is removed by the AP lyase activity of DNA polymerase beta (Pol beta).

237 eoxythymidine (AZT)-resistant mutants of rat DNA polymerase beta (pol beta).

238 in macrophages was heavily reliant upon host DNA polymerase beta (Pol beta).

239 d their structures in ternary complexes with DNA polymerase beta (pol beta).

240 Nanosecond dynamics simulations for DNA polymerase beta (pol beta)/DNA complexes with three

241 ibose-5-phosphate (5'-dRP) lyase activity of DNA polymerase beta (pol beta): here we show, in vitro a

242 We have shown that APC interacts with DNA polymerase beta (Pol-beta) and flap endonuclease 1 (

243 es had shown that an interaction of APC with DNA polymerase beta (pol-beta) blocks strand-displacemen

244 isogenic cells deficient in the BER enzymes DNA polymerase-beta (pol-beta) and alkyladenine DNA glyc

245 G analogue, 2'-fluoro-m7dG (Fm7dG), by human DNA polymerase beta (polbeta) and solved three X-ray str

246 epair, a tight heterodimer complex formed by DNA polymerase beta (Polbeta) and XRCC1 is thought to fa

247 e determined seven x-ray structures of human DNA polymerase beta (polbeta) bound to DNA bearing 8-bro

248 on encountering dL, AP lyase enzymes such as DNA polymerase beta (Polbeta) form dead-end, covalent in

249 lines containing wild-type (MEF-polbeta) or DNA polymerase beta (polbeta) gene-knockout (MEFpolbetaK

250 DNA polymerase beta (Polbeta) has been implicated in bas

251 Human DNA polymerase beta (polbeta) has been suggested to play

252 Human DNA polymerase beta (polbeta) inserts, albeit slowly, T

253 DNA polymerase beta (Polbeta) is a DNA repair protein th

254 DNA polymerase beta (POLbeta) is a highly conserved prot

255 Using a DNA Polymerase beta (Polbeta) variant deficient in polym

256 Normally, DNA polymerase beta (Polbeta) would replace the dC deami

257 DNA polymerase beta (polbeta), a member of the X family

258 coordination of Mg(2+) or in the presence of DNA polymerase beta (polbeta), an interactive protein pa

259 inic/apyrimidinic endonuclease 1 (Apex1) and DNA polymerase beta (Polbeta), and apoptosis in the brai

260 probing ternary complexes comprised of Ape1, DNA polymerase beta (Polbeta), and different BER DNA int

261 antitatively a number of complexes formed by DNA polymerase beta (Polbeta), apurinic/apyrimidinic end

262 We have detected DNA polymerase beta (Polbeta), known as a key nuclear ba

263 mismatch discrimination mechanisms of human DNA polymerase beta (polbeta), we report four crystal st

264 oss-links (DPCs) with repair enzymes such as DNA polymerase beta (polbeta).

265 While DNA polymerase beta preferentially incorporated dCTP ove

266 In fact, eggs and early stage embryos lack DNA polymerase-beta protein.

267 rect) insertion for a low fidelity mutant of DNA polymerase beta (R283A) and exonuclease-deficient DN

268 DNA polymerase beta readily inserts dideoxynucleoside tr

269 Specific inhibition of DNA polymerase beta reduced the numbers of cells survivi

270 and fidelity, we investigate the role of key DNA polymerase beta residues on subdomain motion through

271 l, strikingly different transition states in DNA polymerase beta's conformational closing for correct

272 binary DNA and ternary DNA-dNTP complexes of DNA polymerase beta, several side chains have been impli

273 Using a complementation system, in which rat DNA polymerase beta substitutes for DNA polymerase I of

274 TUTases belong to the DNA polymerase beta superfamily of nucleotidyltransferas

275 ential conformational changes brings the DNA/DNA polymerase beta system to a state nearly competent f

276 eversible inhibitor of the lyase activity of DNA polymerase beta that works synergistically with a DN

277 ambda has almost identical fidelity to human DNA polymerase beta, the C-terminal DNA polymerase beta-

278 dentically as they are in their complex with DNA polymerase beta, thereby proving that the eubacteria

279 ine residue inhibits DNA repair synthesis by DNA polymerase beta, thus delaying repair.

280 DNA polymerase lambda is more efficient than DNA polymerase beta to fill this oxidized single-nucleot

281 of the model to nonspecific binding of human DNA polymerase beta to ssDNA demonstrates the significan

282 Here, we investigate the ability of DNA polymerase beta to utilize nucleotides with modified

283 explicit solvent, the closing transition of DNA polymerase beta, unravels atomic and energetic detai

284 Our results support a model where DNA polymerase beta utilizes two strategies, steric and

285 The Leu22Pro (L22P) DNA polymerase beta variant was identified in a gastric

286 wild type DNA polymerase beta is replaced by DNA polymerase beta variants that fill single nucleotide

287 nt of the 189 tumors studied to date express DNA polymerase beta variants.

288 In addition, repair reactions catalyzed by DNA polymerase beta were found to be most effective in t

289 Monocytes and DNA polymerase beta were monitored by immunohistochemist

290 es within the 8 kDa amino terminal domain of DNA polymerase beta, which exhibits dRP lyase activity.

291 modeling investigation in the active site of DNA polymerase beta, which is known to incorporate both

292 21 is likely to relate to the utilization of DNA polymerase beta, which is not sensitive to p21, in t

293 With the small-gap-filling human DNA polymerase beta, which lacks intrinsic exonucleolyti

294 t ternary complex crystal structure of human DNA polymerase beta with a G:A mismatch in the active si

295 We report the crystallographic structures of DNA polymerase beta with dG-dAMPCPP and dC-dAMPCPP misma

296 X-ray crystallographic structures of human DNA polymerase beta with nonhydrolyzable analogs contain

297 at 3, 4, and 6 exhibited mixed inhibition of DNA polymerase beta with respect to both activated DNA a

298 the base excision repair pathway, wild-type DNA polymerase beta (WT polbeta) provides most of the ga

299 Human DNA polymerase beta (X family) extends the cap primer pr

300 Variants of DNA polymerase beta, Y265F and Y265W, were analyzed for