ライフサイエンスコーパス: DNA polymerase eta

1 Saccharomyces cerevisiae RAD30 gene encodes DNA polymerase eta.

2 olymerase to be described and hence is named DNA polymerase eta.

3 he nucleotide excision repair pathway and in DNA polymerase eta.

4 t also targets other factors such as E2F and DNA polymerase eta.

5 re overwhelmingly achieved by recruitment of DNA polymerase eta.

6 /MM simulations on a specific Pol, the human DNA polymerase-eta, an enzyme involved in repairing dama

7 tively, which leads to the insertion of A by DNA polymerase eta and defines a probable mechanism for

8 us reports described the bypass of M(1)dG by DNA polymerases eta and Dpo4.

9 Human DNA polymerases eta and iota are best characterized for

10 cesses that include translesion synthesis by DNA polymerases eta and zeta and a Rad5-Mms2-Ubc13-contr

11 replication by DNA polymerase zeta/Rev1 and DNA polymerase eta, and the error-free, recombination-de

12 Human DNA polymerase eta bypass may lead to M(1)dG to dT and f

13 The sequences of full-length human DNA polymerase eta bypass products of M(1)dG were determ

14 Yeast DNA polymerase eta can replicate through cis-syn cyclobu

15 DNA polymerase eta carries out translesion synthesis pas

16 ng activation-induced cytidine deaminase and DNA polymerase-eta, contribute to the molecular lesions

17 of A nucleotides, which are incorporated by DNA polymerase eta, decreased 10-fold before the repetit

18 ntaneous carcinogenesis model in the skin of DNA polymerase eta-deficient mice and found that interst

19 cture of the catalytic core of S. cerevisiae DNA polymerase eta, determined at 2.25A resolution.

20 Native human DNA polymerase eta, DNA and dATP were co-crystallized at

21 ve roles in vivo of Saccharomyces cerevisiae DNA polymerase eta, DNA polymerase zeta, Rev1 protein, a

22 auses RNA polymerase II and limits access of DNA polymerase eta during hypermutation.

23 a partial requirement for the lesion bypass DNA polymerase eta encoded by the human POLH gene.

24 tch occurs to allow translesion synthesis by DNA polymerase eta, followed by another switch that allo

25 Human DNA polymerase eta functions similarly in the bypass of

26 ynthesis (TLS) of this lesion, while loss of DNA polymerase eta has no detectable effect.

27 two non-classical DNA polymerases, Rev1 and DNA polymerase eta, have two architectures: PCNA tool be

28 e investigated the interaction between human DNA polymerase eta (hpol eta) and the Werner syndrome pr

29 Recombinant human DNA polymerase eta (hpol eta) can replicate oligonucleot

30 Human DNA polymerase eta (hPol eta) contributes to anticancer

31 ighly conserved amino acid, within the human DNA polymerase eta (hPol eta) finger domain.

32 ke the other Y-family DNA polymerases, human DNA polymerase eta (hpol eta) has relatively low fidelit

33 Y-family human DNA polymerase eta (hpol eta) is of interest because of

34 Human DNA polymerase eta (hPol eta) is one of the newly identi

35 o analyze in vitro bypass of 8-oxoG by human DNA polymerase eta (hpol eta).

36 Human DNA polymerase eta (hPoleta) functions in the error-free

37 ypass products synthesized by human Y-family DNA polymerases eta (hPoleta), iota (hPoliota) and kappa

38 and Rad3-related (ATR) kinase or translesion DNA polymerase eta (i.e. key proteins that promote the c

39 DNA polymerase eta is the most efficient polymerase for

40 DNA polymerase eta is unique among eukaryotic polymerase

41 proposed to arise from the insertion of A by DNA polymerase eta opposite the T that results from deam

42 pass involves translesion synthesis (TLS) by DNA polymerases eta or zeta or Rad5-dependent postreplic

43 To determine whether DNA polymerase eta plays a role in the hypermutation of

44 Although DNA polymerase eta (Pol eta) and other Y family polymera

45 DNA polymerase eta (Pol eta) bypasses a cis-syn thymine-

46 Mutation of the POLH gene encoding DNA polymerase eta (pol eta) causes the UV-sensitivity s

47 s that inaccurate DNA synthesis by mammalian DNA polymerase eta (pol eta) contributes to somatic hype

48 When human DNA polymerase eta (pol eta) encounters N6-deoxyadenosin

49 A deficiency in mouse DNA polymerase eta (pol eta) enhanced UV-induced Hprt mu

50 DNA polymerase eta (Pol eta) functions in the error-free

51 DNA polymerase eta (Pol eta) functions in the proficient

52 variant (XPV) patients with mutations in the DNA polymerase eta (pol eta) gene are hypersensitive to

53 Here, we report an elevated expression of DNA polymerase eta (Pol eta) in ovarian CSCs isolated fr

54 DNA polymerase eta (Pol eta) is a member of a new class

55 Human DNA polymerase eta (Pol eta) is best known for its role

56 Human DNA polymerase eta (Pol eta) modulates susceptibility to

57 Human DNA polymerase eta (Pol eta) plays an essential protecti

58 o explain how translesion synthesis (TLS) by DNA polymerase eta (pol eta) suppresses ultraviolet ligh

59 the efficient recruitment of the specialized DNA polymerase eta (pol eta) to replication-associated f

60 e other hand, yeast Saccharomyces cerevisiae DNA polymerase eta (pol eta) was able to replicate past

61 s showed that yeast Saccharomyces cerevisiae DNA polymerase eta (pol eta) was able to replicate past

62 ribe here the error specificity of mammalian DNA polymerase eta (pol eta), an enzyme that performs tr

63 DNA polymerase eta (pol eta), encoded by the xeroderma p

64 OLH gene encoding an error-prone polymerase, DNA polymerase eta (pol eta).

65 ein to stimulate nucleotide incorporation by DNA polymerase eta (pol eta).

66 ine dimer, and most undamaged bases by yeast DNA polymerase eta (pol eta).

67 lfataricus DNA polymerase 4 (Dpo4) and human DNA polymerase eta (Pol eta).

68 Human DNA polymerase eta (Pol(eta)), encoded by the Xeroderma

69 DNA polymerase eta (Pol(eta), xeroderma pigmentosum vari

70 hat DNA repair synthesis, catalyzed by human DNA polymerase eta (poleta) acting upon the priming stra

71 Recent studies suggest that DNA polymerase eta (poleta) and DNA polymerase iota (pol

72 DNA polymerase eta (poleta) belongs to the Y-family of D

73 s accumulate in the absence of RAD30-encoded DNA polymerase eta (Poleta) but not in the absence of RE

74 The yeast RAD30-encoded DNA polymerase eta (Poleta) bypasses a cis-syn thymine-t

75 DNA polymerase eta (Poleta) catalyzes the efficient and

76 DNA polymerase eta (Poleta) functions in error-free bypa

77 DNA polymerase eta (Poleta) functions in error-free repl

78 DNA polymerase eta (Poleta) has the unique ability to re

79 DNA polymerase eta (Poleta) has unique and pivotal funct

80 Pre-steady-state kinetic studies on Y-family DNA polymerase eta (Poleta) have suggested that the poly

81 ow evolution might have biochemically shaped DNA polymerase eta (Poleta) in plants, we expressed in E

82 dence for the involvement of yeast and human DNA polymerase eta (Poleta) in the replicative bypass of

83 We have examined the role of DNA polymerase eta (Poleta) in translesion synthesis of

84 DNA polymerase eta (Poleta) is a low-fidelity enzyme abl

85 DNA polymerase eta (Poleta) is unique among eukaryotic D

86 DNA polymerase eta (Poleta) is unique among eukaryotic p

87 Notably, cells depleted of DNA polymerase eta (Poleta) or the E3 ubiquitin ligase R

88 The E3 ubiquitin ligase Rad18 guides DNA Polymerase eta (Poleta) to sites of replication fork

89 The E3 ubiquitin ligase Rad18 chaperones DNA polymerase eta (Poleta) to sites of UV-induced DNA d

90 gmentosum (XPV) is caused by a deficiency in DNA polymerase eta (Poleta), a DNA polymerase that enabl

91 e, we show that Rad18 is targeted to PCNA by DNA polymerase eta (Poleta), the XPV gene product that i

92 Eukaryotic cells possess DNA polymerase eta (Poleta), which has the ability to re

93 With the exception of DNA polymerase eta (poleta), which is defective in human

94 ed bases in vitro but, with the exception of DNA polymerase eta (poleta), which is defective in xerod

95 ed bases in vitro but, with the exception of DNA polymerase eta (poleta), which is defective in xerod

96 free translesion synthesis (TLS) mediated by DNA polymerase eta (Poleta).

97 S via interaction with the catalytic core of DNA polymerase-eta (poleta), and that NPM1 deficiency ca

98 DNA polymerase eta (PolH) is the product of the xeroderm

99 DNA polymerase eta (PolH), a Y family translesion polyme

100 in vitro activities of mammalian translesion DNA polymerase eta: tandem base substitutions, strand sl

101 Human DNA polymerase eta, the product of the skin cancer susce

102 es two key enzymes in translesion synthesis: DNA polymerase eta, the yeast Xeroderma pigmentosum orth

103 e site is the critical feature which enables DNA polymerase eta to replicate through DNA lesions such

104 The ability of recombinant human DNA polymerase eta to synthesize DNA across from M(1)dG

105 , indicating that DNA repair and error-prone DNA polymerase eta usage were unaffected.

106 DNA polymerase eta was found to be involved only rarely

107 Human DNA polymerase eta was used to copy four stereoisomeric

108 Extracts from HeLa cells, which express DNA polymerase eta, were competent to replicate past the

109 bypass of a cyclobutane pyrimidine dimer by DNA polymerase eta (XP-V or Rad30) or bypass of a (6-4)

110 hanism of translesion synthesis by the yeast DNA polymerase eta (yPoleta), a gel retardation techniqu