ライフサイエンスコーパス: DNA polymerase gamma

1 (RT), adenylate/guanylate kinase, and human DNA polymerase gamma.

2 s a selective inhibitor of the mitochondrial DNA polymerase gamma.

3 o associated with the mitochondrion-specific DNA polymerase gamma.

4 rate for subsequent gap-filling synthesis by DNA polymerase gamma.

5 ass of template base dFdC catalyzed by human DNA polymerase gamma.

6 chondrial DNA replication catalyzed by human DNA polymerase gamma.

7 to reduce the replication fidelity of human DNA polymerase gamma.

8 ulate the 140 kDa catalytic subunit of human DNA polymerase gamma.

9 ance and high processivity characteristic of DNA polymerase gamma.

10 o site-directed mutant proteins of the human DNA polymerase gamma.

11 ock the action of the 3'-->5' exonuclease of DNA polymerase gamma.

12 ediated indirectly through the inhibition of DNA polymerase-gamma.

13 glycosylase, oxoguanine DNA glycosylase and DNA polymerase gamma activities all co-sedimented with t

14 Deficiency of mitochondrial DNA polymerase gamma activity was found in a patient wit

15 p53+/+ mitochondrial extracts had higher DNA polymerase-gamma activity measured by (32)P-dCTP inc

16 53 complemented p53-/- mitochondrial extract DNA polymerase-gamma activity.

17 ial characterization of the large subunit of DNA polymerase gamma and establishes the baseline for ex

18 1-mer primer-template reduced the binding of DNA polymerase gamma and the efficiency of primer extens

19 e mitochondria, interacts with mitochondrial DNA polymerase gamma, and significantly stimulates polym

20 ndrial lysates permitted isolation of native DNA polymerase gamma as a single subunit, allowing direc

21 Observation of native DNA polymerase gamma both as an Hp140 monomer and as a h

22 Mitochondrial DNA (mtDNA) is replicated by DNA polymerase gamma by a strand displacement mechanism

23 Inducible expression of a dominant negative DNA polymerase-gamma can yield mtDNA-deficient cell line

24 The human DNA polymerase gamma catalytic subunit was overexpressed

25 CSB-dependent depletion of the mitochondrial DNA polymerase-gamma catalytic subunit (POLG1), due to H

26 ed expression of a dominant negative form of DNA polymerase gamma causes a metabolic shift from oxida

27 arameters indicate that the large subunit of DNA polymerase gamma could replicate the mitochondrial g

28 study, we show that the human mitochondrial DNA polymerase gamma discriminates ribonucleotides effic

29 The nuclear-encoded DNA polymerase gamma (DNA POL gamma) is the sole DNA pol

30 plication was mediated through inhibition of DNA polymerase-gamma (DNA pol-gamma), by FIAU triphospha

31 The consensus sequences for the DNA polymerase gamma exonuclease and polymerase domains

32 hat is not found in the other members of the DNA polymerase gamma family, or in other family A DNA po

33 tagenesis of mtDNA by proofreading-deficient DNA-polymerase gamma followed by segregation of the resu

34 Comparison of the four DNA polymerase gamma gene sequences revealed several hig

35 transfected with a plasmid encoding inactive DNA polymerase-gamma harboring a D1135A substitution (PO

36 ed purified mtDNA replication proteins, i.e. DNA polymerase gamma holoenzyme, the mitochondrial singl

37 ers present an obstacle to the mitochondrial DNA polymerase gamma in subsequent rounds of replication

38 e of their potential for inhibition of human DNA polymerase gamma involved in mitochondrial DNA repli

39 DNA polymerase gamma is also proficient in performing si

40 The S.cerevisiae DNA polymerase gamma is atypical in that it includes a 2

41 Human DNA polymerase gamma is composed of a 140-kDa catalytic

42 Human DNA polymerase gamma is composed of a 140-kDa catalytic

43 DNA polymerase gamma is responsible for replication and

44 ion suggests that the large subunit of human DNA polymerase gamma may require accessory factors to in

45 progeroid phenotype of exonuclease-deficient DNA polymerase gamma mice has been intensely debated.

46 rofiles of wild-type and Polg (mitochondrial DNA polymerase gamma) mutant mice, we found that mice wi

47 hen dFdC was encountered as a template base, DNA polymerase gamma paused at the lesion and one downst

48 DNA polymerase gamma (pol gamma ) is required to maintai

49 (APE1), is removed by the lyase activity of DNA polymerase gamma (pol gamma) and polymerase beta in

50 ) is believed to coordinate the functions of DNA polymerase gamma (pol gamma) and the mitochondrial D

51 Xenopus laevis DNA polymerase gamma (pol gamma) exhibits low activity o

52 Mitochondrial DNA polymerase gamma (pol gamma) is active in base excis

53 e to its association with mitochondrial DNA, DNA polymerase gamma (pol gamma) is in an environment to

54 DNA polymerase gamma (pol gamma) is required for replica

55 The human DNA polymerase gamma (Pol gamma) is responsible for DNA

56 DNA polymerase gamma (pol gamma) is responsible for repl

57 Mitochondrial DNA polymerase gamma (pol gamma) is responsible for repl

58 Human mitochondrial DNA polymerase gamma (pol gamma) is solely responsible f

59 The activity of the mitochondrial replicase, DNA polymerase gamma (Pol gamma) is stimulated by anothe

60 Human DNA polymerase gamma (pol gamma) requires association of

61 ochondrial DNA is replicated and repaired by DNA polymerase gamma (pol gamma), encoded by the POLG ge

62 onstrated that the mitochondrial polymerase, DNA polymerase gamma (pol gamma), participates in mitoch

63 mitochondrial DNA depends on the accuracy of DNA polymerase gamma (pol gamma), we investigated the fi

64 Ed4T with wild-type (WT) human mitochondrial DNA polymerase gamma (pol gamma), which is often associa

65 oding the sole mitochondrial DNA polymerase, DNA polymerase gamma (pol gamma).

66 have shown that the small subunit of Xenopus DNA polymerase gamma (pol gammaB) acts as a processivity

67 ) maintenance, we confirmed mutations in the DNA polymerase gamma POLG in positive control cases, and

68 characterized by deficiency in mitochondrial DNA polymerase gamma (POLG) catalytic activity, refracto

69 rtion site is the 3' noncoding region of the DNA polymerase gamma (PolG) gene on chromosome 7.

70 DNA polymerase gamma (POLG) is essential for replication

71 gous for the D257A mutation in mitochondrial DNA polymerase gamma (Polg) or with mice having both mut

72 the gene for the catalytic subunit of human DNA polymerase gamma, POLG, the A467T substitution is th

73 ing proteins identified the alpha-subunit of DNA polymerase gamma (Polga) as a client protein.

74 s in POLG, which codes for the mitochondrial DNA polymerase gamma (polgamma), cause Alpers-Huttenloch

75 cision repair (BER) enzymes, namely EXOG and DNA polymerase gamma (Polgamma), which under oxidative s

76 that expression of the catalytic subunit of DNA polymerase gamma (POLgammaCAT) mRNA varies little am

77 The accessory subunit of mitochondrial DNA polymerase gamma, POLGbeta, functions as a processiv

78 These results demonstrate that the DNA polymerase gamma protein is stable in the absence of

79 t peptide sequences were shown to react with DNA polymerase gamma purified from X.laevis oocyte mitoc

80 Replication of the mitochondrial genome by DNA polymerase gamma requires dNTP precursors that are s

81 ase and polymerase active sites is larger in DNA polymerase gamma than in other members of family A (

82 Mitochondrial DNA polymerase (DNA polymerase gamma), the nuclear-encoded enzyme which

83 d a cDNA encoding the large subunit of human DNA polymerase gamma, the enzyme that replicates the mit

84 own sequence of the Saccharomyces cerevisiae DNA polymerase gamma to clone the genes or cDNAs encodin

85 inant negative form of mitochondria-specific DNA polymerase-gamma to eliminate mitochondrial DNA (mtD