ライフサイエンスコーパス: DNA polymerase zeta

1 t, and then progresses past the adduct using DNA polymerase zeta.

2 experiments suggest that extension requires DNA polymerase zeta.

3 known translesion synthesis enzymes Rev1 and DNA polymerase zeta.

4 ile extension involves a complex of Rev1 and DNA polymerase zeta.

5 lication employing the REV1 gene product and DNA polymerase zeta.

6 ase to be described, and is therefore called DNA polymerase zeta.

7 translesion synthesis (TLS) as a subunit of DNA polymerase zeta.

8 yeast gene encodes the catalytic subunit of DNA polymerase zeta, a nonessential enzyme that is thoug

9 These data implicate DNA polymerase zeta, a nonreplicative polymerase, in the

10 Accordingly, DNA polymerase zeta activity was essential for mutagenes

11 s is the first report demonstrating that the DNA polymerase zeta and Rev1 proteins function in the mi

12 t in budding yeast Saccharomyces cerevisiae, DNA polymerase zeta and Rev1 proteins participate in the

13 DNA polymerase zeta catalytic subunit REV3 is known to p

14 7 probably functions with hREV3 in the human DNA polymerase zeta complex.

15 contributes to increasing the proficiency of DNA polymerase zeta-dependent TLS.

16 sed involvement of the mutagenic translesion DNA polymerase zeta during DNA replication.

17 data are best explained by a direct role for DNA polymerase zeta in Ig hypermutation.

18 n of Saccharomyces cerevisiae functions with DNA polymerase zeta in mutagenic trans-lesion synthesis.

19 To examine a role of DNA polymerase zeta in somatic hypermutation, we generat

20 , the gene encoding the catalytic subunit of DNA polymerase zeta involved in translesional synthesis,

21 We show that DNA polymerase zeta is absolutely required for translesi

22 at when cisplatin adducts are present in the DNA, polymerase zeta is an important contributor to cisp

23 The activity of the Rev3 protein (DNA polymerase zeta) is apparently more important for th

24 eukaryotes, and that the REV3, REV7-encoded DNA polymerase zeta mediates the mutagenic bypass of AP

25 REV1 functions in the DNA polymerase zeta mutagenesis pathway.

26 the recombination, which depended neither on DNA polymerase zeta nor on mismatch repair.

27 The DNA polymerase zeta of Saccharomyces cerevisiae is requi

28 To test the hypothesis that DNA polymerase zeta participates in Ig hypermutation, we

29 DNA polymerase zeta participates in translesional bypass

30 DNA polymerase zeta (Pol zeta) and Rev1 are key players

31 Rev3L encodes the catalytic subunit of DNA polymerase zeta (pol zeta) in mammalian cells.

32 DNA polymerase zeta (Pol zeta) is a eukaryotic B-family

33 DNA polymerase zeta (pol zeta) is exceptionally importan

34 DNA polymerase zeta (pol zeta) participates in several D

35 DNA polymerase zeta (Pol zeta) plays a key role in DNA t

36 DNA polymerase zeta (Pol zeta), a heterodimer of Rev3 an

37 DNA polymerase zeta (pol zeta), which is required for DN

38 es, functions in lesion bypass together with DNA polymerase zeta (Pol zeta).

39 The Rev3 and Rev7 proteins are subunits of DNA polymerase-zeta (Pol-zeta), an enzyme whose sole fun

40 HCV induced error-prone DNA polymerase zeta, polymerase iota, and activation-ind

41 spontaneous and induced DNA damage relies on DNA polymerase zeta (Polzeta) activity.

42 DNA polymerase zeta (Polzeta) and Rev1 contribute to the

43 Rev1 and DNA polymerase zeta (Polzeta) are involved in the tolera

44 Although the DNA polymerase zeta (polzeta) catalytic subunit REV3L is

45 cts promote the participation of error-prone DNA polymerase zeta (Polzeta) in replication of undamage

46 DNA polymerase zeta (polzeta) is critical for bypass of

47 In the yeast Saccharomyces cerevisiae, DNA polymerase zeta (Polzeta) is required in a major les

48 Without H2Bub1, DNA polymerase zeta (Polzeta) is responsible for a highl

49 The DNA polymerase zeta (Polzeta) mutagenesis pathway is a m

50 DNA polymerase zeta (Polzeta) participates in translesio

51 DNA polymerase zeta (Polzeta) promotes the mutagenic byp

52 evisiae, the contribution of the error-prone DNA polymerase zeta (Polzeta) to replication and mutagen

53 Rev7/Mad2l2 encodes a subunit of DNA polymerase zeta (Polzeta), 1 of 10 translesion DNA s

54 that include translesion synthesis (TLS) by DNA polymerases zeta (Polzeta) and Poleta and postreplic

55 We argue that DNA polymerase zeta, rather than DNA polymerase delta as

56 However, whereas the activity of DNA polymerase zeta remains unaffected by ubiquitination

57 Saccharomyces cerevisiae DNA polymerase eta, DNA polymerase zeta, Rev1 protein, and the DNA polymeras

58 athway, including translesion replication by DNA polymerase zeta/Rev1 and DNA polymerase eta, and the

59 REV1 and DNA Polymerase zeta (REV3 and REV7) play important roles

60 Together with DNA polymerase zeta (Rev3/7), Rev1 function is required

61 , which forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p.

62 Pol(kappa) is more similar to the unrelated DNA polymerase zeta than it is to the phylogenetically r

63 not only helps to coordinate the delivery of DNA polymerase zeta to a stalled primer terminus but als

64 , which encodes a subunit of the translesion DNA polymerase zeta, was responsible for the majority of