ライフサイエンスコーパス: DNA rearrangement

1 ation (NAHR) is one of the key mechanisms of DNA rearrangement.

2 hat transcription is important for efficient DNA rearrangement.

3 ernal element DNA is not required in cis for DNA rearrangement.

4 red for prethymic lymphoid commitment or for DNA rearrangement.

5 cell process that involves intrachromosomal DNA rearrangement.

6 ve evolved by gene duplication, mutation and DNA rearrangement.

7 ized regions, often associated with sites of DNA rearrangement.

8 y an unusual head-to-head dimer with complex DNA rearrangement.

9 ic means to establish a heritable pattern of DNA rearrangement.

10 result from a duplication event followed by DNA rearrangement.

11 xchange, resulting in frequent and extensive DNA rearrangement.

12 o provide a template for correct and precise DNA rearrangement.

13 ntly unrecognized zones of susceptibility to DNA rearrangement.

14 me after which the parental genome can block DNA rearrangement.

15 es for chromatin modification and subsequent DNA rearrangement.

16 amily of tyrosine recombinases that catalyze DNA rearrangements.

17 gests the evolutionary conservation of these DNA rearrangements.

18 her topoisomerases and proteins that perform DNA rearrangements.

19 A and must reflect also solvent and possibly DNA rearrangements.

20 developing somatic macronucleus by specific DNA rearrangements.

21 iosynthesis but appears to be a hot spot for DNA rearrangements.

22 and in productive and non-productive genomic DNA rearrangements.

23 th 3' and 5' strands without massive protein/DNA rearrangements.

24 ermini, with implications for DNA repair and DNA rearrangements.

25 e xisHI genes had no effect on the two other DNA rearrangements.

26 very close to the site of wheat/Arabidopsis DNA rearrangements.

27 ements that are engineered to cause specific DNA rearrangements.

28 play a significant role in triggering these DNA rearrangements.

29 nes in B lineage cells involves two distinct DNA rearrangements.

30 icer-related gene is required for programmed DNA rearrangements.

31 lity factors that control integrase-mediated DNA rearrangements.

32 ipts in combination with evidence for D-J(H) DNA rearrangements.

33 s, the disease phenotype was linked to gross DNA rearrangements (35 and 85 kb deletions and a translo

34 demonstrating the distribution of permanent DNA rearrangements across major NK cell subsets in man.

35 Chromosomal translocations or DNA rearrangements affecting c-myc occur in almost all m

36 ent absence of chromosomal translocations or DNA rearrangements affecting c-myc.

37 s been extensive and sometimes rather recent DNA rearrangement among a number of the linear plasmids.

38 suggest an expanding paradigm of programmed DNA rearrangements among microorganisms.

39 suggest an expanding paradigm of programmed DNA rearrangements among microorganisms.

40 on in the tla2 strain, causing a chromosomal DNA rearrangement and deletion/disruption of five nuclea

41 e-leucine-rich repeat) genes and accelerated DNA rearrangement and gene loss, confer a striking resem

42 cial chromosomes and undergo B-cell-specific DNA rearrangement and hypermutation in the mouse lymphoi

43 y documented and suggests a process of viral DNA rearrangement and loss during malignant progression

44 s information suggested a novel mechanism of DNA rearrangement and raised interesting questions regar

45 NA transport and translational regulation to DNA rearrangement and repair.

46 ments resulted in reproducible mitochondrial DNA rearrangements and a condition of male (pollen) ster

47 onjugating cells during the time of germline DNA rearrangements and degradation.

48 Sequence comparison revealed numerous DNA rearrangements and mutations in SCCcap1 and the left

49 nes exhibited multiple transgene and genomic DNA rearrangements and regions of scrambling characteris

50 istinct constellations of somatic structural DNA rearrangements and sequence mutations that commonly

51 RNA-based mechanism that directs genomewide DNA rearrangements and serves to disable invading geneti

52 nt (48 kb) is excised from the chromosome by DNA rearrangement, and a composite gene, sigK (spoIIIC a

53 ping genomes, thereby regulating genome-wide DNA rearrangement, and that these sRNAs can be effective

54 ion of RAG gene expression, light chain gene DNA rearrangements, and expression of lambda-light chain

55 may offer resilience to mutation, including DNA rearrangements, and facilitate the adaptation of T4-

56 aments, the active species in uvsX-catalyzed DNA rearrangements, apparently by helping uvsX displace

57 These DNA rearrangements are commonly found in genic intervals

58 Programmed DNA rearrangements are critical for the development of m

59 of this process has led to speculation that DNA rearrangements are used to limit the expression of o

60 rt in Nature directly rules out irreversible DNA rearrangements as a mechanism for odorant receptor g

61 in the budding yeast Kluyveromyces lactis, a DNA rearrangement associated with mating type switching

62 ll been put forward as mechanisms to explain DNA rearrangements associated with genomic disorders.

63 f the human genome are known to give rise to DNA rearrangements associated with many genetic disorder

64 isruption leads to the type of mitochondrial DNA rearrangements associated with naturally occurring c

65 assay to identify rare homology-independent DNA rearrangements associated with repair of a chromosom

66 havior that involves a significant amount of DNA rearrangement at telomeres and suggest that length r

67 As a first step towards mediating directed DNA rearrangements at non-native Flp recombination targe

68 f modular enzymes that promote high-fidelity DNA rearrangements between specific target sites.

69 nstrate that the defect lies at the level of DNA rearrangements between the Ig switch regions.

70 y topoisomerase IV, which are intramolecular DNA rearrangements but not decatenation of multiply link

71 ale-sterile (CMS) mutants have mitochondrial DNA rearrangements, but they are impaired for mitochondr

72 Serine recombinases promote specific DNA rearrangements by a cut-and-paste mechanism that inv

73 specifically select for switches mediated by DNA rearrangements by inducing VSG RNAi in the presence

74 t regulatory proteins underlines how modular DNA rearrangements can evolve by serving pathogen divers

75 oth direct and inverted repeats, which allow DNA rearrangements, deletion, or duplication; these elem

76 Rather, we found that, whereas illegitimate DNA rearrangement did not play a major role in the devel

77 These DNA rearrangements do not include the putative origin of

78 perform extreme forms of programmed somatic DNA rearrangement during development.

79 trichs, most genes undergo several layers of DNA rearrangement during macronuclear development.

80 mmonly harbor PTCs as a result of programmed DNA rearrangement during normal development, are down-re

81 CMT1A-REP and the creation of novel genes by DNA rearrangement during primate speciation.

82 a are dynamic structures, undergoing massive DNA rearrangement during the formation of a functional m

83 plants, nuclear genes suppress mitochondrial DNA rearrangements during development.

84 Ciliated protozoa carry out remarkable DNA rearrangements during nuclear differentiation, inclu

85 s by which feedback repression of sequential DNA rearrangements ensures that only one autosome expres

86 tween physiological stress and activation of DNA rearrangement functions.

87 A novel DNA rearrangement has been characterised that is both a

88 NA sequences; however, the mechanism of such DNA rearrangements has yet to be elucidated.

89 ng issues of frequency, site preference, and DNA rearrangement in human as well as animal cells.

90 may provide insights into the mechanisms of DNA rearrangement in other disorders.

91 ase family whose members are responsible for DNA rearrangement in prokaryotes, eukaryotes and viruses

92 Class switch recombination (CSR) involves a DNA rearrangement in the Ig heavy chain (IgH) gene that

93 posase by RNA interference leads to abnormal DNA rearrangement in the offspring.

94 ecombinases that catalyze a diverse array of DNA rearrangements in archaebacteria, eubacteria, and ye

95 Somatic DNA rearrangements in B lymphocytes, including V(D)J gen

96 vide a plausible mechanism for site-specific DNA rearrangements in childhood and adult solid tumors.

97 is developmental limitation could be somatic DNA rearrangements in differentiating neural cells.

98 omosome 19 element, which is responsible for DNA rearrangements in episomes propagating AAVS1 DNA, wa

99 lin and T-cell receptor genes, which undergo DNA rearrangements in lymphocytes.

100 via a unique restricted set of site-specific DNA rearrangements in lymphoid cells, known as V(D)J rec

101 ted repeats, a sequence motif known to cause DNA rearrangements in model organisms.

102 othesis that OR gene choice is controlled by DNA rearrangements in OSNs.

103 mplates provide both an organizing guide for DNA rearrangements in Oxytricha and a template that can

104 Ig DNA rearrangements in plasma may be useful as a lymphoma

105 The RAG1/2 endonuclease initiates programmed DNA rearrangements in progenitor lymphocytes by generati

106 ere also sufficient to mediate PGBD5-induced DNA rearrangements in rhabdoid tumor cells.

107 The models are applied to explain DNA rearrangements in some groups of ciliates, such as S

108 son-like structure, Tlr1 is similar to other DNA rearrangements in Tetrahymena in possessing cis -act

109 Treatment just before DNA rearrangements in the developing macronuclei (anlage

110 sequences, and the fundamental importance of DNA rearrangements in the evolution of sequenced genomes

111 Programmed DNA rearrangements in the single-celled eukaryote Oxytri

112 xin at the locus increases the likelihood of DNA rearrangements in this region.

113 mbination has been used to introduce desired DNA rearrangements in various organisms, having for exam

114 e RAG proteins mediate two other alternative DNA rearrangements in vivo: the rejoining of signal and

115 ces from this 1.4-kb region revealed diverse DNA rearrangements, including an inversion, several dele

116 Programmed DNA rearrangements, including DNA diminution, characteri

117 DNA rearrangements, including insertions, deletions, and

118 These DNA rearrangements involve cleavage by the RAG1 and RAG2

119 t for variation C. fetus uses a mechanism of DNA rearrangement involving inversion of a 6.2 kb segmen

120 hereditary elliptocytosis 4.1Alg, in which a DNA rearrangement involving the exon containing the down

121 Examining potential DNA rearrangements involving the cagY repeats indicated

122 ases are recognized to result from recurrent DNA rearrangements involving unstable genomic regions.

123 ptor (TCR) repertoires, generated by somatic DNA rearrangements, is central to immune system function

124 end processing during the lymphoid-specific DNA rearrangement known as V(D)J recombination, defectiv

125 These programmed DNA rearrangements make this a fascinating system of mat

126 Results from these DNA rearrangements may help explain the CTD copy number

127 itana NS-E has revealed numerous large-scale DNA rearrangements, most of which are associated with CR

128 s similarly indicated that not all three het DNA rearrangements need to reside on a composite molecul

129 H2A.X is phosphorylated when programmed DNA rearrangements occur in developing macronuclei, as f

130 Genome-wide DNA rearrangements occur in many eukaryotes but are most

131 Genomewide DNA rearrangements occur in many eukaryotes during devel

132 Mitochondrial DNA rearrangements occur very frequently in flowering pl

133 uthern blot analysis showed that chromosomal DNA rearrangements occurred in the 1363mel cell line.

134 us is communicated to the other, we assessed DNA rearrangement occurring in wild-type cells that were

135 Additionally, a second mechanism of DNA rearrangement occurs to replace at least one of the

136 B-lymphocyte development involves sequential DNA rearrangements of immunoglobulin (Ig) heavy (mu) and

137 We have observed a number of DNA rearrangements of the T4 genome type, some exhibitin

138 breaking-and-rejoin type mechanism to affect DNA rearrangement on specific DNA sequences.

139 e unstable, suggesting a possible reversible DNA rearrangement or an epigenetic change in the lss mut

140 alterations in genome organization caused by DNA rearrangements or genome size expansion.

141 from an M71-expressing OSN, does not reveal DNA rearrangements or sequence alterations at the M71 lo

142 Although no DNA rearrangements or sequence differences in the 5' reg

143 c/Ds transposable elements often leave short DNA rearrangements, or 'footprints,' at the sites where

144 ion of artificial templates reprogrammes the DNA rearrangement pathway, suggesting that RNA molecules

145 DNA rearrangement permits bacteria to regulate gene cont

146 This extra layer of DNA rearrangement permits novel mechanisms to create gen

147 that much of the polymorphism may be due to DNA rearrangements, possibly resulting from the insertio

148 eptor genes are assembled by a site-specific DNA rearrangement process called V(D)J recombination.

149 refore, V(D)J recombination, a physiological DNA rearrangement process, activates the ATM/p53 pathway

150 The site-specific DNA rearrangement process, called V(D)J recombination, c

151 f Pdd2p leads to the perturbation of several DNA rearrangement processes in developing zygotic macron

152 in Tetrahymena thermophila requires several DNA rearrangement processes.

153 tep strand refolding is a novel mechanism in DNA rearrangement reactions.

154 eurogenic processes might involve aspects of DNA rearrangement, recent discoveries about the unusual

155 hese results can be explained by a model for DNA rearrangement (recombination) involving DNA replicat

156 DNA rearrangement (recombination) mediated by direct rep

157 s in a hypermutation phenotype likely due to DNA rearrangements, reflected in the rapid appearance of

158 Relocalization occurred in response to a DNA rearrangement replacing a boundary element (IR-R) wi

159 Switching the active VSG gene can involve DNA rearrangements replacing the old VSG with a new one,

160 n cancer, conventional methods for detecting DNA rearrangements require laborious indirect assays.

161 inked DNA dimers, which is an intermolecular DNA rearrangement required for proper segregation of dau

162 a class of diseases that are associated with DNA rearrangements resulting from region-specific genome

163 rthermore, our characterization of this rare DNA rearrangement revealed a more common result of the m

164 sis for BV10 and BV19 transcripts and thymic DNA rearrangements revealed no such selection of in-fram

165 enomenon is mechanistically related to other DNA rearrangements such as V(D)J recombination and retro

166 ic disorders are conditions that result from DNA rearrangements, such as deletions or duplications.

167 enomenon is mechanistically related to other DNA rearrangements, such as V(D)J recombination and retr

168 endonuclease thus seems more appropriate for DNA rearrangements than for restriction.

169 P expression occurs by a mechanism of nested DNA rearrangement that involves the inversion of a 6.2-k

170 es through a series of site-specific somatic DNA rearrangements that are collectively called variable

171 ectural features result in susceptibility to DNA rearrangements that cause disease.

172 Such events can result in DNA rearrangements that cause disease.

173 has considerable flexibility in the types of DNA rearrangements that it can promote.

174 enerate and has neglected the effects of the DNA rearrangements that lead to their formation.

175 act that all ciliates share similar forms of DNA rearrangement, there appears to be great diversity i

176 ric epithelium and possible contributions of DNA rearrangements to genome evolution.

177 Protein catalyzed DNA rearrangements typically require assembly of complex

178 V(D)J recombination is the specialized DNA rearrangement used by cells of the immune system to

179 amily of site-specific recombinases catalyze DNA rearrangements using phosphoryl transfer chemistry t

180 gle non-replicative IS10 element can promote DNA rearrangements usually attributed to replicative tra

181 reaks generated during the lymphoid-specific DNA rearrangement, V(D)J recombination, which is require

182 naplastic Large Cell Lymphoma (ALCL) line, a DNA rearrangement was detected within the hrgr gene regi

183 By directly following Flp-mediated DNA rearrangements we have analyzed the adult expansion

184 ch for new factors involved in developmental DNA rearrangement, we identified two Twi1p-interacting p

185 To define requirements for DNA rearrangement, we performed mutagenesis of the M ele

186 2 (RAG-2) expression and endogenous V-Jkappa DNA rearrangements were found.

187 However, Pim1 DNA rearrangements were frequently sub-stoichiometric an

188 As short-range DNA rearrangements were not detected, giardial VSP switc

189 Frequent DNA rearrangements were observed in the CEN8 region, inc

190 The FGF-4 gene was truncated by DNA rearrangement with a novel gene named GRS.

191 pable of predicting the rates of large-scale DNA rearrangements within a factor of 2.

192 ic recombinases that catalyze intermolecular DNA rearrangements without energetic input.