ライフサイエンスコーパス: DNA repair

1 r exposure to ionizing radiation and reduced DNA repair.

2 ant nuclear events; chromatin plasticity and DNA repair.

3 strand breaks (DSBs), suggesting defects in DNA repair.

4 the extent of DNA end resection for accurate DNA repair.

5 quently used, form of recombination-mediated DNA repair.

6 is a proximal regulator of DDR that promotes DNA repair.

7 ssing of nuclear dsRNA by p-Dicer to promote DNA repair.

8 t key chromatin constituents that facilitate DNA repair.

9 units or polymers of ADP-ribose to regulate DNA repair.

10 A-PKcs, suggesting a direct role for Tra1 in DNA repair.

11 ke activity suggested to be important during DNA repair.

12 tential chemoresistance mechanisms involving DNA repair.

13 important for DNA damage response (DDR) and DNA repair.

14 and replication that overwhelm high-fidelity DNA repair.

15 age checkpoint termination and inhibition of DNA repair.

16 re and function, including transcription and DNA repair.

17 ich has been previously shown to function in DNA repair.

18 sistant to drugs by down-regulating accurate DNA repair.

19 xidative stress may serve to modulate active DNA repair.

20 TIP60 plays important roles in controlling DNA repair.

21 ses including replication, recombination and DNA repair.

22 ases of which 75% were related to defects in DNA repair.

23 deacetylation of SirT-1 targets involved in DNA repair.

24 and DNA damage accumulation due to defective DNA repair.

25 lated transcripts and consequently defective DNA repair.

26 or transcription-coupled nucleotide excision DNA repair.

27 tions of the PBAF forms to the regulation of DNA repair.

28 ng nuclear architecture, telomere length and DNA repair.

29 ssess how histone ADP-ribosylation regulates DNA repair.

30 (PEV), organization of repetitive DNAs, and DNA repair.

31 ession require homologous recombination (HR) DNA repair.

32 eaks within the repetitive tract followed by DNA repair.

33 patial exclusion of telomerase from sites of DNA repair.

34 n shown to play a role in DDR signalling and DNA repair.

35 s such as gene expression, transcription and DNA repair.

36 as well as increased DNA damage and impaired DNA repair.

37 circuitry for the control of recombinational DNA repair.

38 xpected role for Red1 in recombination-based DNA repair.

39 d mutational signatures suggesting defective DNA repair.

40 /mTOR pathway, altered in 60% of lines; BRCA DNA repair, 44%; and SYNE1-SYNE2, 60%.

41 ition restores PTEN nuclear distribution and DNA repair activities and impairs tumour but not normal

42 e NAD(+) binding site in Parp9 increases the DNA repair activity of the heterodimer.

43 Cryptochromes lack the DNA-repair activity of the closely related DNA photolyas

44 Inhibition of DNA repair and accumulation of DNA breaks was functional

45 zinc, and the level of proteins involved in DNA repair and antioxidant and immune functions were res

46 tance is not controlled by the repertoire of DNA repair and antioxidant enzymes.

47 current ovarian cancer in part by effects on DNA repair and antitumor immune responses.

48 functions in transcription, replication and DNA repair and are hence implicated in development and c

49 understanding of how these kinases regulate DNA repair and associated events has grown profoundly, a

50 on of the cell cycle to allow ample time for DNA repair and cell fate determination.

51 y ADP ribose polymerase-1 (a key molecule in DNA repair and cell survival), leading to SMC apoptosis.

52 A damage, thus drawing a direct link between DNA repair and cellular metabolism.

53 e (DDR) by controlling the levels of various DNA repair and checkpoint proteins; however, how the DDR

54 The compromised DNA repair and chemosensitization induced by SMI#9 or RA

55 ed in the tumors while those responsible for DNA repair and combination, purine metabolism, phenylala

56 n implicated in the regulation of apoptosis, DNA repair and drug resistance.

57 lysis revealed pathways including apoptosis, DNA repair and early estrogen response that were differe

58 has essential roles in nuclear architecture, DNA repair and genome stability, and silencing of transp

59 ensitivity to DNA damaging agents, defective DNA repair and genomic instability.

60 increased therapeutic efficacy by inhibiting DNA repair and HIF1alpha pathway activation in tumor cel

61 atory element at 7p14.3 that associates with DNA repair and hormone-regulated transcript levels and w

62 altering gene expression patterns related to DNA repair and immune activation, with implications for

63 D5 transposase domain as well as end-joining DNA repair and induced structural rearrangements with PS

64 egulating many cellular processes, including DNA repair and inflammatory response, by suppressing dow

65 histone acetylation plays important roles in DNA repair and is sensitive to the availability of acety

66 A activates expression of genes required for DNA repair and lipid trafficking.

67 ns about the role of stochastic processes in DNA repair and mutagenesis.

68 n, which provides a mechanistic link between DNA repair and neurodegeneration.

69 We also identify genes in DNA repair and oncogenic pathways recurrently subject to

70 ependent HR to H2A ubiquitylation to promote DNA repair and preserve genome integrity.

71 its regulation of genes involved in multiple DNA repair and reactive oxygen species defense pathways.

72 slation processes, methylglyoxal metabolism, DNA repair and recombination, and protein and nucleotide

73 on (HJ) resolving enzyme RecU is involved in DNA repair and recombination.

74 on and support an increasingly broad view of DNA repair and replication fork stabilizing proteins as

75 It disrupts DNA repair and replication pathways (and possibly transc

76 lly important biological processes including DNA repair and replication.

77 requirements for DNA binding differ between DNA repair and telomere protection.

78 the MCM proteins playing a critical role in DNA repairing and recombination, was found to have overe

79 The cjj81176_1279 (recR; recombinational DNA repair) and cjj81176_1449 (unknown function) genes w

80 ted in the regulation of gene transcription, DNA repair, and cell cycle.

81 alpha-P induced by UVB diminished G1 arrest, DNA repair, and cellular senescence coincident with enha

82 ew interconnections between DNA replication, DNA repair, and immunity.

83 indle stability and DSB-SPB tethering during DNA repair, and imply that metaphase spindle maintenance

84 4 DMRs related to impaired oxidative stress, DNA repair, and inflammatory pathways could be replicate

85 cesses, including mitochondrial respiration, DNA repair, and iron homeostasis.

86 , including protein homeostasis, cell cycle, DNA repair, and viral infections.

87 ular responses, including cell cycle arrest, DNA repair, apoptosis, metabolism, autophagy, mRNA trans

88 Prokaryotic Ligase D is a conserved DNA repair apparatus processing DNA double-strand breaks

89 Increased mutation burden and defective DNA repair are associated with response to immune checkp

90 e found that a group of proteins involved in DNA repair are enriched in the potential TCTP interactom

91 riched pathways for H2O2 resistance included DNA repair, aromatic amino acid biosynthesis (aroBK), Fe

92 tress, dynamic relocalization events control DNA repair as well as alterations of the transcriptome a

93 s proposed to regulate the action of FEN1 in DNA repair as well as Okazaki fragment maturation.

94 redox-active proteins, iron metabolism, and DNA repair, as well as via biofilm formation.

95 odeling enzyme, which has been implicated in DNA repair, binds ssNucs preferentially over nucleosomes

96 rocesses, most notably immune regulation and DNA repair, but also cellular proliferation and survival

97 168 and the WD40 domain in PALB2, and drives DNA repair by facilitating the assembly of PALB2-contain

98 RAD51D is a key player in DNA repair by homologous recombination (HR), and RAD51D

99 macroH2A1.2, a histone variant that promotes DNA repair by homologous recombination (HR).

100 Remarkably, these defects impair DNA repair by homologous recombination indicating that S

101 hich PARP3 suppresses G4 DNA and facilitates DNA repair by multiple pathways.

102 A system of DNA repair, called the DNA damage response, detects and

103 DNA lesions that have escaped DNA repair can induce replication stress and genomic bre

104 lnerable to endogenous damage and defects in DNA repair can limit their function.

105 stable because of intrinsic defects in their DNA-repair capabilities.

106 understanding interindividual differences in DNA repair capacity (DRC) may enable us to predict and p

107 tion of DNA repair pathways, suggesting that DNA repair capacity (DRC) measurements in cancer cells c

108 assay that provides simultaneous readout of DNA repair capacity across multiple pathways, they show

109 trate the value of assays that determine the DNA repair capacity of cancers in predicting response to

110 -) murine embryonic fibroblasts with reduced DNA repair capacity, which senesce rapidly if grown at a

111 onse, protection from hypoxia, angiogenesis, DNA repair, cell migration and invasiveness, and cell me

112 eurodegeneration due to genetic disorders of DNA repair (Cockayne syndrome and xeroderma pigmentosum)

113 Here we show that the XPC DNA repair complex is a potent accelerator of global and

114 he genes encoding the MRE11/RAD50/NBS1 (MRN) DNA repair complex lead to cancer-prone syndromes.

115 histone H4 at Tyr51, recruiting ABL1 to the DNA repair complexes that participate in the nonhomologo

116 ' "histone code" that is required to recruit DNA repair complexes to DNA breaks.

117 a result, srs2Delta mutants are deficient in DNA repair correlating with extensive DNA processing, bu

118 We evaluated genetic instability and DNA repair defects by direct and indirect assays in 12 b

119 ant sterility, increased germline apoptosis, DNA repair defects, and interactions with small RNA path

120 ed to reveal genetic viable interactions for DNA repair defects.

121 ibosome disorders (SBDS, DNAJC21, RPL5), and DNA repair deficiency (LIG4).

122 FA is a hereditary DNA-repair disorder characterized by various congenital

123 tably, key DNA replication factors and major DNA repair DNA polymerases (polymerase eta [Pol eta] and

124 at both cellular DNA replication factors and DNA repair DNA polymerases colocalize within centers of

125 of FEN1 significantly attenuated homologous DNA repair efficiency and enhanced cytotoxic effects of

126 glyceraldehyde-3-phosphate dehydrogenase and DNA repair enzyme apurinic/apyrimidinic endonuclease I p

127 an apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expre

128 biquitinating activity regulate the cellular DNA repair enzyme polymerase eta and recruit it to poten

129 of tyrosyl-DNA-phosphodiesterase 1 (TDP1), a DNA repair enzyme, in ATL cells.

130 ic endonuclease 1 (Ape1), the major oxidized DNA repair enzyme.

131 X (a marker of double-strand breaks) and the DNA-repair enzyme RAD51.

132 Analysis of the involvement of DNA repair enzymes in trimethoprim-induced cytotoxicity

133 The Rh-PPO mechanism is reminiscent of DNA repair enzymes that displace mismatched bases, and i

134 Maladaptive processing of the DNA damage by DNA repair enzymes, in particular by MutM and MutY DNA g

135 nto a variety of proteins, including several DNA repair enzymes.

136 ptibility protein (BRCA1) affect its role in DNA repair events remain unclear.

137 Aprataxin and PNKP-like factor (APLF) is a DNA repair factor containing a forkhead-associated (FHA)

138 Arabidopsis thaliana are protected by Ku, a DNA repair factor with a high affinity for DNA ends.

139 ish how EBV enlists and manipulates cellular DNA repair factors during the viral lytic cycle, contrib

140 ication and maintenance of genome integrity, DNA repair factors protect stalled replication forks upo

141 Caenorhabditis elegans mutants, we identify DNA repair factors that protect against the genotoxicity

142 f DNA damage and promotes the recruitment of DNA repair factors via their poly ADP-ribose (PAR) bindi

143 s provide a scaffold for docking of multiple DNA repair factors, the absence of histone deposition ma

144 ayer in checkpoint activation and subsequent DNA repair following DNA damage.

145 rs subsequently evade correction by cellular DNA repair, for example, by the well-known DNA mismatch

146 requires nuclear localization to fulfil its DNA repair function.

147 the XRCC4 non-homologous end-joining (NHEJ) DNA repair gene and p53 efficiently induces brain tumour

148 DNA repair gene defects are found in virtually all human

149 e mutations in homologous recombination (HR) DNA repair genes are linked to breast and ovarian cancer

150 Recent studies showed regulation of DNA repair genes by androgen receptor signaling in prost

151 We used CRISPR-Cas9 technology to delete key DNA repair genes in human colon organoids, followed by d

152 d ILF2 and the regulation of RNA splicing of DNA repair genes may be exploited to optimize the use of

153 Cases had more rare inactivating variants in DNA repair genes than controls, even after excluding 13

154 f variants of unknown significance affecting DNA repair genes, and may help personalize HR directed t

155 as used to study the [Fe4S4] clusters in the DNA repair glycosylases EndoIII and MutY to evaluate the

156 Indeed, defects in DNA repair have been associated with several human disea

157 regulation, transcription, RNA biology, and DNA repair have been complemented by recent advances tha

158 cation plays an important role in regulating DNA repair; however, the role of arginine methylation in

159 on of FANCD2:FANCI heterodimer is central to DNA repair in a pathway that is defective in the cancer

160 lays the foundation for an emerging role of DNA repair in bacteria-host pathogenesis.

161 tion (HDACi), resulting in reduced levels of DNA repair in bladder cancer cells and radiosensitizatio

162 Two weeks of Bzb treatment accelerated DNA repair in bone-lining osteoblasts and thus promoted

163 Cdc14 is essential to fulfil recombinational DNA repair in budding yeast.

164 ed mediation of homologous recombination and DNA repair in cells.

165 Melatonin and its metabolites enhanced the DNA repair in melanocytes exposed to UVB and stimulated

166 We show that DNA-PKcs is central to DNA repair in nonproliferating cells, and restricts DNA

167 adiation-induced bone damage by accelerating DNA repair in osteoblasts.

168 tial role for EAF2 in androgen regulation of DNA repair in prostate cancer cells.

169 RCA1 recruitment, and subsequent HR-mediated DNA repair in response to DNA damage, thus drawing a dir

170 airing revealed in vitro, that contribute to DNA repair in the more complex cellular milieu.

171 lso activates cell cycle arrest and disrupts DNA repair, in part by increasing p21 expression.

172 lly expressed genes involved in flowering or DNA repair, including the DNA glycosylase ROS1, which fa

173 reatment with AsiDNA, a novel first-in-class DNA repair inhibitor.

174 zing DNA synthesis and removal of a reactive DNA repair intermediate during base excision repair (BER

175 s 5' end resection by negotiating RPA-coated DNA repair intermediates.

176 xamine the interactions of PARP1 with common DNA repair intermediates.

177 We reveal that defective ATM-mediated DNA repair is a consequence of P62 accumulation, which i

178 Various human diseases occur if DNA repair is compromised, and most of these impact the

179 ain, as well as for organismal survival when DNA repair is compromised.

180 DNA repair is essential for life, yet its efficiency dec

181 DNA repair is essential to prevent the cytotoxic or muta

182 central question important to understanding DNA repair is how certain proteins are able to search fo

183 ir proteins and reorganizes chromatin during DNA repair is unclear.

184 bound to BH1 and blocked Mcl-1-stimulated HR DNA repair, leading to sensitization of cancer cells to

185 A binding channel, shielding them from other DNA repair machineries.

186 G2-M checkpoint for adaptation to stress and DNA repair, making G2-M checkpoint inhibition a target f

187 possibility that HDAC4/Ubc9/Rad51 complex in DNA repair may be a target for radiosensitization of HCC

188 Targeting PARP-associated DNA repair may represent a novel therapeutic strategy fo

189 Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms.

190 is one of the most frequently used cellular DNA repair mechanisms and modulates many human pathophys

191 try, unprecedented quantitative insight into DNA repair mechanisms has come from the new-found abilit

192 c regions of chromatin that are deficient in DNA repair mechanisms.

193 We hypothesize that recombination-based DNA-repair mechanisms are at least partially responsible

194 ain expression of AREG and EREG, as blocking DNA repair molecules, TET1 GADD45A, TDG, or PARP-1 decre

195 KI67 labeling index, upregulated glycolysis, DNA repair, mTORC1 signaling, features of the unfolded p

196 myces cerevisiae and focusing on a matrix of DNA repair mutants and genotoxic drugs, we quantify 76 g

197 ophelis, the outbreak strain had a disrupted DNA repair mutY gene caused by insertion of an integrati

198 es, shown to be IL-23R(+), demonstrated that DNA repair of damaged melanocytes requires IL-23.

199 induced by non-homologous end-joining (NHEJ) DNA repair offers a potential treatment option for autos

200 esses that integrates cell-cycle control and DNA repair or apoptosis, which serves to maintain genome

201 Inborn errors of DNA repair or replication underlie a variety of clinical

202 In addition to DNA repair partners, we observed that many Fancd2-intera

203 cates homologous recombination (HR)-mediated DNA repair pathway activity of samples.

204 tin-conjugating enzyme of the Fanconi anemia DNA repair pathway and it is overexpressed in several ca

205 r study uncovers a critical role for Ape1 in DNA repair pathway choice, and provides a mechanistic un

206 licit a ubiquitylation cascade that controls DNA repair pathway choice.

207 ulatory mechanism for ATM that also controls DNA repair pathway choice.

208 Therapeutic strategies targeting DNA repair pathway defects have been widely explored, bu

209 Targeting the PARP DNA repair pathway extensively sensitized IDH1-mutated g

210 osstalk between glutamine metabolism and the DNA repair pathway identified in this study highlights a

211 Errors in this DNA repair pathway lead to genomic instability and cance

212 The major DNA repair pathway removing DNA lesions caused by exposu

213 The PARP1-associated DNA repair pathway was extensively compromised in mutant

214 d2 is a component of the Fanconi anemia (FA) DNA repair pathway, which is frequently found defective

215 own as EHMT1) are critical components of the DNA repair pathway.

216 G9a is a potential therapeutic target in the DNA repair pathway.

217 DNA repair pathways are aberrant in cancer, enabling tum

218 Efficient DNA repair pathways are crucial in these organelles to f

219 rrangements (LST), and the status of several DNA repair pathways by transcriptome and genome analysis

220 A repair processes, the requirement of known DNA repair pathways for integration is controversial.

221 nvestigations about the involvement of other DNA repair pathways in the removal of these lesions and

222 Other DNA repair pathways involving ATM and DNA-PKcs are unaff

223 l, potential crosstalk between metabolic and DNA repair pathways is poorly understood.

224 Multiple DNA repair pathways maintain genome stability and ensure

225 mediated) nonhomologous end-joining, whereas DNA repair pathways mediated by poly(ADP)ribose polymera

226 Mutations arise either from inactivation of DNA repair pathways or in a repair-competent background

227 ronuclei and LST and specific alterations in DNA repair pathways that essentially monitor DSB repair

228 We propose that errors in DNA repair pathways, such as non-homologous end joining

229 maging therapeutic agents via utilization of DNA repair pathways, suggesting that DNA repair capacity

230 sions and form protein complexes that act in DNA repair pathways.

231 ignificantly altered immune reactivation and DNA repair pathways.

232 related genes are enriched in cell cycle and DNA repair pathways.

233 ting changes to DNA by activation of various DNA repair pathways.

234 ore have been uncovered as being crucial for DNA repair, pluripotency and oncogenesis.

235 Polymerase eta (Pol eta), a specialized DNA repair polymerase, functions in TLS and allows for D

236 is contributes to cell metabolism and to the DNA repair process in a subset of tumors.

237 atalyzes the gap-filling reaction during the DNA repair process of the ASFV virus genome; it is highl

238 s are joined via a nonhomologous end joining DNA repair process.

239 concentrations that are associated with the DNA repair process.

240 omplex and participated in the NHEJ-mediated DNA repair process.

241 Although integration resembles DNA repair processes, the requirement of known DNA repai

242 coli UvrD DNA helicase functions in several DNA repair processes.

243 mbly which is shown to be required for other DNA repair processes.

244 DNA repair protein counteracting oxidative promoter lesi

245 Recognition of each broken DNA end by the DNA repair protein Ku is the first step in NHEJ, followe

246 tein (iRFP670), with the latter fused to the DNA repair protein O(6)-methylguanine-DNA-methyltransfer

247 e localized accumulations of ectopic 53BP1-a DNA repair protein.

248 diphosphate-ribose) polymerase], a critical DNA repair protein.

249 stability including cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodellin

250 eals interactions between PHF11 and multiple DNA repair proteins and suggests that PHF11 mediates 5'

251 llowing DNA damage to phosphorylate specific DNA repair proteins and/or that NMD inactivation may lea

252 DNA repair proteins must locate rare damaged sites withi

253 Migration also causes multiple DNA repair proteins to segregate away from DNA, with cyt

254 terfaces to recruit multiple postreplication DNA repair proteins to the CRL4-DCAF1 E3 ligase for ubiq

255 reduction potential found experimentally in DNA repair proteins, enabling their HiPIP-like redox beh

256 4Fe4S] clusters regulates the ability of two DNA repair proteins, Endonuclease III and DinG, to bind

257 ations that promote efficient recruitment of DNA repair proteins.

258 mRNAs leading to synthesis of malfunctioning DNA repair proteins.

259 actor 1 receptor (IGF-1R) and alterations in DNA repair rate, apoptosis, and senescence following UVB

260 donuclease activities participate in various DNA repair, recombination, and replication processes.

261 ecent advances in understanding of mammalian DNA repair regulation and a on the function of PAXX/c9or

262 has received increased attention and several DNA repair related enzymes have been linked to this dysf

263 alterations in homologous recombination (HR) DNA repair-related genes are prevalent across many malig

264 nd joining (NHEJ) repair, the role of DEK in DNA repair remains incompletely understood.

265 activating an endogenous, germline-specific DNA repair response.

266 ssociated with increased DNA damage, reduced DNA repair responses, and elevated cellular senescence.

267 sing effects of environmental DNA damage and DNA repair result in elevated rates of genome rearrangem

268 xtrinsic input in order to specify survival, DNA repair, self-renewal, and proliferation.

269 e is concomitant with defective ATM-mediated DNA repair signaling and accumulation of protein-linked

270 Both the BRCA1 DNA repairing signalling and the Estrogen-mediated G1/S

271 oli, a process that excludes telomerase from DNA repair sites.

272 ion of the SMX tri-nuclease containing three DNA repair structure-selective endonucleases: SLX1-SLX4,

273 utants are strongly affected by mutations in DNA repair, such as ATM and ATR.

274 and provides a mechanistic understanding of DNA repair-supported chemoresistance in glioblastoma cel

275 sites (CFSs) during early mitosis to trigger DNA-repair synthesis that ensures faithful chromosome se

276 DNA base excision repair pathway, the major DNA repair system that deals with oxidative DNA damage.

277 Nucleotide excision repair (NER) is the key DNA repair system that eliminates the majority of DNA he

278 by NER components via transcription-coupled DNA repair (TCR).

279 Cpf1 ribonucleoproteins with single-stranded DNA repair templates results in precise and targeted DNA

280 ded chromatin-remodeling enzyme required for DNA repair that possesses a poly(ADP-ribose) (PAR)-bindi

281 leles, the probability of nonrecombinational DNA repair, the probability of homing-associated loss of

282 xonuclease that is crucial for mitochondrial DNA repair; the enzyme belongs to a nonspecific nuclease

283 induce drug resistance by enhancing DDR and DNA repair through promoting glycolysis and subsequent c

284 tes genes required for lipid trafficking and DNA repair, thus reducing antibiotic entry and quinolone

285 cellular processes, ranging from metabolism, DNA repair to aging.

286 Cells use homology-dependent DNA repair to mend chromosome breaks and restore broken

287 Tumor growth relies on efficient DNA repair to mitigate the detrimental impact of DNA dam

288 tified as critical for telomere maintenance, DNA repair, transcription and other DNA metabolism proce

289 e noncohesive activities of cohesin, such as DNA repair, transcriptional control, chromosome loop for

290 accumulate mutations as a result of impaired DNA repair under such energy-limited conditions.

291 Genetic defects in DNA repair underlie other neurodegenerative disorders (e

292 aused by CRISPR-Cas self targeting indicated DNA repair via microhomology-mediated end joining.

293 and show greatly diminished proficiency for DNA repair via the error-free homologous recombination (

294 e molecular basis for its ability to inhibit DNA repair, we report that 3E10 directly binds to the N-

295 Mutational signatures inferring defects in DNA repair were enriched in those with the highest mutat

296 herichia coli Numerous important insights on DNA repair were obtained, bringing clarity to the respec

297 ast, Sae2 nuclease activity is essential for DNA repair when the Mre11 nuclease is compromised.

298 es in homologous recombination (HR)-mediated DNA repair, which is thought to be critical for tumor su

299 e the down-regulation of BMI1, which impedes DNA repair while elevated levels can sensitize breast ca

300 d homologous recombination and PARP-mediated DNA repair yields potent synthetic lethality in triple-n