ライフサイエンスコーパス: DNA replication

1 oduction of infectious virions subsequent to DNA replication.

2 tin, as well as initiation and elongation of DNA replication.

3 maintenance of chromosomal stability during DNA replication.

4 ccommodate transcription, gene silencing and DNA replication.

5 eiotic divisions following a single round of DNA replication.

6 ations in studies on cytoskeletal motors and DNA replication.

7 DNA replication centers and facilitate HBoV1 DNA replication.

8 se activity over the cell cycle is shaped by DNA replication.

9 ome to navigate ubiquitous DNA damage during DNA replication.

10 on is the most common error occurring during DNA replication.

11 Xenopus and human MTBP to assess its role in DNA replication.

12 hromosomes also remain intertwined following DNA replication.

13 ation occurs coincidently with initiation of DNA replication.

14 nd Pol kappa play an important role in HBoV1 DNA replication.

15 one" factory for both gene transcription and DNA replication.

16 hat the PERK branch of the UPR also controls DNA replication.

17 has to be re-established after each round of DNA replication.

18 ssociate with DNA polymerases for processive DNA replication.

19 e is associated with cells undergoing active DNA replication.

20 1 can directly regulate HPV16 E1-E2-mediated DNA replication.

21 ic oligonucleotides at the lagging strand of DNA replication.

22 Mcm10 and HP1a are known to be required for DNA replication.

23 ed as a consequence of disrupting processive DNA replication.

24 eurons following colitis, without observable DNA replication.

25 led the dependence of the circadian clock on DNA replication.

26 dent AAV2 DNA replication and inhibits HSV-1 DNA replication.

27 is essential for mycobacterial high-fidelity DNA replication.

28 pportunity to investigate the intricacies of DNA replication.

29 e is a multiprotein machine that carries out DNA replication.

30 coordinately downregulated genes related to DNA replication.

31 consistent with the observed block in viral DNA replication.

32 acquire genome alterations during the act of DNA replication.

33 ous and required RNA synthesis but not viral DNA replication.

34 actin dynamics and formins are essential for DNA replication.

35 RPA couples nucleosome assembly with ongoing DNA replication.

36 pigenetic information are maintained through DNA replication.

37 ng mechanistic links to histone variants and DNA replication.

38 amp), is rapidly exchanged during processive DNA replication.

39 an essential eukaryotic factor required for DNA replication.

40 in nuclear division and profoundly inhibited DNA replication.

41 stence of alternative mechanisms to initiate DNA replication.

42 lesion synthesis within the replisome during DNA replication.

43 med G144, that supports robust levels of JCV DNA replication, a central part of the JCV life cycle.

44 Genetic and pharmacological inhibition of DNA replication abolished both overt and molecular rhyth

45 of both RECQL5 and WRN severely compromises DNA replication, accumulates genomic instability and ult

46 t vaccinia virus infection by blocking viral DNA replication and abrogating postreplicative intermedi

47 ctivates ATR, CHK1 and WEE1, which shut down DNA replication and attenuate cisplatin induced-lethalit

48 The mechanics of DNA replication and cell cycling are well-characterized

49 egulated, and preferentially associated with DNA replication and cell division.

50 apse microscopy and fluorescent reporters of DNA replication and chromosome positioning to examine th

51 s in chromatin, ensuring the coordination of DNA replication and cotranscriptional processes.

52 chromatin modification, gene expression and DNA replication and damage repair, and a decreased expre

53 clease 1 (FEN1) plays a crucial role in both DNA replication and damage repair.

54 ll population, accumulates DNA damage during DNA replication and decreases apoptosis to both endogeno

55 Thus targeting DNA replication and G2-M cell cycle checkpoint simultane

56 DNA replication and supports Pif1 function, DNA replication and genome integrity.

57 s such as gene interaction, gene regulation, DNA replication and genome methylation.

58 lication fork protein required for mammalian DNA replication and genome stability.

59 N 5 and 6 (ATXR5/6) regulate heterochromatic DNA replication and genome stability.

60 ifunctional protein, plays a central role in DNA replication and homologous recombination repair, and

61 CMdT, O4-CMdT and O6-CMdG moderately blocked DNA replication and induced substantial frequencies of T

62 ession facilitates cell cycle-dependent AAV2 DNA replication and inhibits HSV-1 DNA replication.

63 lated kinases (VRKs) and is needed for viral DNA replication and likely other stages of the viral lif

64 a dramatic accumulation of the mitochondrial DNA replication and maintenance factors POLG and TFAM.

65 ibonucleotide reductase (hRR) is crucial for DNA replication and maintenance of a balanced dNTP pool,

66 To ensure the completion of DNA replication and maintenance of genome integrity, DNA

67 cell fate decisions, but the contribution of DNA replication and mitosis in stem cell differentiation

68 nd plasticity that underlie the processes of DNA replication and mitosis.

69 opment, in part, by driving TGFbeta1-induced DNA replication and mitotic checkpoint progression.

70 erse brain regions is daytime progression of DNA replication and nighttime mitosis, suggesting system

71 stage is associated with multiple rounds of DNA replication and nuclear division without cytokinesis

72 ion of a duplex HBoV1 genome initiates viral DNA replication and produces progeny virions that are in

73 significantly increased the levels of HSV-1 DNA replication and production of viral progeny in SCG n

74 significantly decreased the levels of HSV-2 DNA replication and production of viral progeny in SCG n

75 NS4), NP1, and BocaSR were required for AAV2 DNA replication and progeny virion formation.

76 ed numerous factors that promote unperturbed DNA replication and protect, repair and restart damaged

77 eins regulate various processes ranging from DNA replication and protein synthesis to cytoskeletal dy

78 ciated with other cellular processes such as DNA replication and proteolysis.

79 e capacity to reactivate, resulting in viral DNA replication and release of infectious virus.

80 BLM, is a RECQ helicase that is involved in DNA replication and repair of DNA double-strand breaks b

81 odel whereby RPA, best known for its role in DNA replication and repair, recruits HIRA to promoters a

82 ctome, which includes proteins with roles in DNA replication and repair, transcription, splicing and

83 BLM, is a yeast DNA helicase functioning in DNA replication and repair.

84 ortant implications for our understanding of DNA replication and repair.

85 e implicated in regulation of transcription, DNA replication and repair.

86 tion Protein A (RPA), which are critical for DNA replication and repair.

87 m Gram-positive bacteria plays a key role in DNA replication and restart as a loader protein for the

88 ugh schizogony, with only the final round of DNA replication and segregation being synchronous and co

89 f located on the lagging strand template for DNA replication and supports Pif1 function, DNA replicat

90 tion of early gene expression to block viral DNA replication and synthesis of viral structural protei

91 lymerases colocalize within centers of viral DNA replication and that Pol eta and Pol kappa play an i

92 are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand s

93 Proteins involved in DNA replication and transcription localized inside the c

94 ene orientation-dependent encounters between DNA replication and transcription machineries.

95 A adducts in the minor groove interfere with DNA replication and transcription to induce apoptosis.

96 effectors, as they control processes such as DNA replication and transcription, and repair or regulat

97 lts in cell-cycle blockade and inhibition of DNA replication and transcription.

98 vely transcribed regions, may interfere with DNA replication and transcription.

99 of the two fundamental biological processes, DNA replication and tRNA selection during the translatio

100 recessive, partial GINS1 deficiency impairs DNA replication and underlies intra-uterine (and postnat

101 The GINS complex is essential for eukaryotic DNA replication, and homozygous null mutations of GINS c

102 ed role of genome architecture in regulating DNA replication, and identifies a molecular mechanism sp

103 deposits histone H3.3 into nucleosomes in a DNA replication- and sequence-independent manner.

104 Because mechanisms of DNA replication are highly conserved, the observations a

105 esponse to cellular stress, such as aberrant DNA replication, are poorly understood.

106 erdependent coupled oscillators and identify DNA replication as a critical process in the circadian m

107 bolishes nuclear transport and initiation of DNA replication, as well as general transcription.

108 is is an essential process that helps resume DNA replication at forks stalled near bulky adducts on t

109 chaperone complex that deposits H3-H4 during DNA replication, binds a single H3-H4 heterodimer in sol

110 Y102F mutant fully supported transient viral DNA replication, BPV genomes encoding this mutation as w

111 icated in Okazaki fragment processing during DNA replication but is thought to be dispensable for DNA

112 DBAN does not hinder ongoing DNA replication, but specifically blocks the serine 345

113 R) pathway corrects errors that occur during DNA replication by coordinating the excision and re-synt

114 herefore, actin dynamics and formins control DNA replication by multiple direct and indirect mechanis

115 The primary function of DDK is to initiate DNA replication by phosphorylating the Mcm2-7 replicativ

116 that subtelomeric CTCF facilitates telomeric DNA replication by promoting TERRA transcription.

117 e a novel mechanism by which Kdm4d regulates DNA replication by reducing the H3K9me3 level to facilit

118 eir persistence is thought to interfere with DNA replication by slowing or impeding replication fork

119 Anomalies in dismantling the machinery of DNA replication can compromise genome integrity and cont

120 Problems that arise during DNA replication can drive genomic alterations that are i

121 Microarray analysis showed enrichment of DNA replication, cell cycle, cell cycle checkpoint and T

122 appa [Pol kappa]) are recruited to the viral DNA replication centers and facilitate HBoV1 DNA replica

123 e the VA RNAs, BocaSR localizes to the viral DNA replication centers of the nucleus and is essential

124 Notably, BocaSR accumulates in the viral DNA replication centers within the nucleus and likely pl

125 g apoptotic sensitivity to inhibitors of the DNA replication checkpoint and suggesting it as a candid

126 duced lethality, because it not only impairs DNA replication checkpoint more profoundly than inhibiti

127 owever, whether mutp53 directly perturbs the DNA replication checkpoint remains unclear.

128 ng slowed replication fork restart, although DNA replication checkpoints are functional.

129 meiosis share many processes, including the DNA replication, chromosome condensation and precisely r

130 demonstrate an intimate relationship between DNA replication, chromosome segregation, and division si

131 DNA replication commences approximately halfway through

132 surements of both total and integrated HIV-1 DNA, replication-competent virus measurement by large ce

133 SIRT1 is part of the E1-E2 DNA replication complex and is recruited to the viral or

134 polymerase, functions in TLS and allows for DNA replication complexes to bypass lesions in DNA.

135 with the core replication proteins to ensure DNA replication continues even when replication challeng

136 Nucleosome assembly following DNA replication controls epigenome maintenance and genom

137 In particular, DNA replication correlates with a build-up of compartmen

138 DNA replication-coupled nucleosome assembly is essential

139 1 mutant cells resulted in severe growth and DNA replication defects, along with diminished RPA signa

140 High-fidelity DNA replication depends on a proofreading 3'-5' exonucle

141 DNA replication depends on primase, the specialised poly

142 The canonical model of DNA replication describes a highly-processive and largel

143 ction between TopBP1 and Treslin and promote DNA replication despite the presence of a Cdk2 inhibitor

144 rious cellular processes like transcription, DNA replication, DNA recombination, repair and modificat

145 t at the hub of new interconnections between DNA replication, DNA repair, and immunity.

146 he I85A mutant, the latter were defective in DNA replication due to impaired binding to both ssDNA an

147 equired for initial and subsequent rounds of DNA replication during schizogony and, in addition, was

148 l populations exhibit heterogeneity in their DNA replication dynamics.

149 rved mechanism exploited by cells to correct DNA replication errors both in growing cells and under n

150 Many mutations first arise as DNA replication errors.

151 tein structure that can obstruct chromosomal DNA replication, especially under conditions of replicat

152 Cellular DNA replication factories depend on ring-shaped hexameri

153 We also show that both cellular DNA replication factors and DNA repair DNA polymerases c

154 Notably, key DNA replication factors and major DNA repair DNA polymer

155 Eukaryotic DNA replication fidelity relies on the concerted action

156 one marrow stromal cells exposed to IR enter DNA replication following p16(INK4a) inactivation.

157 Interestingly, the severity of the defect in DNA replication following the loss of B1 varied between

158 A structures that may originate in vivo from DNA replication fork bypass of an ICL.

159 Reduced rate of DNA replication fork progression and chromosomal shatter

160 One enzyme crucial for DNA replication fork repair and restart of stalled forks

161 is that was attributable to a combination of DNA replication fork slowing and reduced replication ori

162 e-stranded gaps can block progression of the DNA replication fork, causing replicative stress and/or

163 biogenesis and composition of the eukaryotic DNA replication fork, with an emphasis on the enzymes th

164 stress response protein SMARCAL1 stabilizes DNA replication forks and prevents replication fork coll

165 Stalling at DNA replication forks generates stretches of single-stra

166 toxin, formaldehyde, stalls and destabilizes DNA replication forks, engendering structural chromosoma

167 mechanism which evolved to support multiple DNA replication forks.

168 DNA replication greatly enhances expression of the herpe

169 Incorporation of ribonucleotides during DNA replication has severe consequences for genome stabi

170 with the replicative DNA polymerases during DNA replication has suggested that DNA polymerase epsilo

171 ed on from maternal to filial strands during DNA replication; however, cell division can reinforce H3

172 BPLF1, thereby allowing for efficient viral DNA replication.IMPORTANCE Epstein-Barr virus is the cau

173 acting zinc finger protein 1 (CIZ1) promotes DNA replication in association with cyclins and has been

174 tone H3 lysine 9 demethylase Kdm4d regulates DNA replication in eukaryotic cells.

175 e during S phase is key to the initiation of DNA replication in eukaryotic cells.

176 Furthermore, we have determined that JCV DNA replication in G144 cells is stimulated by myristoyl

177 cross-link constituted strong impediments to DNA replication in HEK293T cells, with the bypass effici

178 nd O4-CMdT on the efficiency and fidelity of DNA replication in HEK293T human embryonic kidney cells.

179 acts of the carboxymethylated DNA lesions on DNA replication in human cells, revealed the roles of in

180 cross-link on the efficiency and accuracy of DNA replication in human cells.

181 ow the carboxymethylated DNA lesions perturb DNA replication in human cells.

182 rk for future studies to explore the role of DNA replication in immune cell generation and function.

183 s circadian clocks to gate cell division and DNA replication in many organisms, circadian clocks were

184 udying the regulation of gene expression and DNA replication in mitochondria.

185 in complexes, and that Lon may help regulate DNA replication in response to growth conditions.

186 econd flagellar basal body in late G1 phase, DNA replication in S phase, and dimethylation of histone

187 r Claspin and Chk1 as negative regulators of DNA replication in the absence of genotoxic stress.

188 ate whether MUS81 could similarly facilitate DNA replication in the context of BRCA2 abrogation.

189 AEE788 treatment inhibits DNA replication in the kinetoplast (mitochondrial nucleo

190 Our data uncovered a role for RNH1 in global DNA replication in the mammalian nucleus.

191 isrupts nucleotide homeostasis, which blocks DNA replication in the presence of AZT.

192 ance pathway that oversees the completion of DNA replication in the presence of DNA damage.

193 Our work explores Plasmodium DNA replication in unprecedented detail and opens up tre

194 ut a functional CTM domain are defective for DNA replication in Xenopus egg extracts.

195 6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers are largely unknown.

196 teins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases

197 ity coincided with a peak in Prochlorococcus DNA replication, indicating coordinated diurnal coupling

198 emeric DNA is not required in mammalian cell DNA replication, indicating that drugs targeting the ter

199 ssive histone mark H3K27me3 is delayed after DNA replication, indicative of a decondensed chromatin s

200 R inhibitors (ATRi), but not to a variety of DNA replication inhibitors and DNA-damaging drugs.

201 Eukaryotic DNA replication initiates from multiple discrete sites i

202 In eukaryotes, DNA replication initiates from multiple origins of repli

203 lly expressed proteins identified, Cdc6 is a DNA replication initiation factor and exhibits oncogenic

204 Lowering the DNA replication initiation rate by introducing the dnaA(

205 helicase is the committed step in eukaryotic DNA replication initiation.

206 branched-chain aminotransferase BCAT and the DNA replication initiator protein DnaA.

207 rca2 and Rad51 prevent formation of abnormal DNA replication intermediates, whose processing by Smarc

208 DNA replication involves the inherent risk of genome ins

209 DNA replication is a core biological process that occurs

210 DNA replication is a critical step in cell proliferation

211 Nucleosome assembly in the wake of DNA replication is a key process that regulates cell ide

212 st that, in contrast to the canonical model, DNA replication is a largely discontinuous process in vi

213 replisomes with emphasis on how coordinated DNA replication is achieved.

214 Faithful DNA replication is essential for genome stability.

215 DNA replication is essential for the rhythmic changes of

216 Histone mRNAs are rapidly degraded when DNA replication is inhibited by a 3' to 5' pathway that

217 The role of TopBP1 in host DNA replication is regulated by the class III deacetylas

218 Here, we show that DNA replication is required for circadian clock function

219 exclusively in S/G2-phase cells, while HSV-1 DNA replication is restricted to G1 phase.

220 DNA replication is therefore a critical step of cell pro

221 DNA replication is tightly regulated to occur once and o

222 onsistent with ORCA-bound origins initiating DNA replication late in S-phase.

223 loci/regions pose greater challenges to the DNA replication machinery (i.e., the replisome) than oth

224 Comparing the DNA replication machinery and processes of parasites and

225 sues, is co-expressed with components of the DNA replication machinery, and that Donson is essential

226 gen (PCNA), the platform for assembly of the DNA replication machinery, and that unloading of Rad51 b

227 ase (DHFR), as well as the components of the DNA replication machinery.

228 pply of building blocks necessary to support DNA replication may lead to increased DNA damage and syn

229 omere shortening as a result of conventional DNA replication, new telomeric DNA must be added onto th

230 enome instability resulting from deregulated DNA replication, observed in cancer and other disease st

231 In dividing cells, DNA replication occurs in a precise order, but many ques

232 by AAV2, whereas NS4 is sufficient for viral DNA replication of an AAV2 duplex genome.

233 DNA replication of circular genomes generates physically

234 t, while neither N6-CMdA nor N4-CMdC blocked DNA replication or induced mutations, N3-CMdT, O4-CMdT a

235 y the cell cycle, the DDR triggered by HBoV1 DNA replication or NS1 is not.

236 al cycle that produce free DNA ends, such as DNA replication or packaging.

237 The DNA replication or S-phase checkpoint monitors the integ

238 We show that chromatin enforces DNA replication origin specificity by preventing non-spe

239 replication proteins, and its recruitment to DNA replication origins depends on the two pre-replicati

240 Bidirectional replication from eukaryotic DNA replication origins requires the loading of two ring

241 maintenance (MCM) helicase complexes at many DNA replication origins, an essential process termed ori

242 t to explain how specific proteins recognize DNA replication origins, load the replicative helicase o

243 d direct observation of stochastic firing of DNA replication origins, which differs from cell to cell

244 osed conformation, which enables error-prone DNA replication past the adduct.

245 Chromatin structure affects DNA replication patterns, but the role of specific chrom

246 DRB could not be explained by inhibition of DNA replication per se or loading of RNA polymerase II t

247 complexity of the events involved, cellular DNA replication poses major threats to genomic integrity

248 i-San (GINS) complex, which is essential for DNA replication prior to cell division.

249 the DNA-binding protein Sap1 show defects in DNA replication progression and genome stability and dis

250 During DNA replication, proliferating cell nuclear antigen (PCN

251 a dual regulatory role for chromatin during DNA replication: promoting origin dependence and determi

252 onstrated that HP1a is in close proximity to DNA replication proteins including Mcm10, RFC140 and DNA

253 biological units, such as nucleotides during DNA replication, provides some unifying principles as to

254 its mechanism of action in processes such as DNA replication, repair and telomere maintenance.

255 The Ctf4/AND-1 protein hub, which links DNA replication, repair, and chromosome segregation, rep

256 ch of engineering the conserved processes of DNA replication, repair, and recombination could be auto

257 ory has elucidated fundamental mechanisms in DNA replication, repair, and recombination.

258 dered a key contributor to transcription and DNA replication, repair, and recombination.

259 DNA replication requires the recruitment of a pre-replic

260 DNA replication results in the doubling of the genome pr

261 portantly, we demonstrate that impairment of DNA replication severely blocks transcriptional switch t

262 symmetrical inversions around the origin of DNA replication, shapes genome structure of both radiati

263 ed LIG1 promotes the recruitment of UHRF1 to DNA replication sites and is required for DNA methylatio

264 leoside depletion and ROS enhancement led to DNA replication stress and activation of an intra-S phas

265 e, we show that loss of VHL alone results in DNA replication stress and damage accumulation, effects

266 Therefore, the cooperative induction of DNA replication stress and damage by ATR inhibition and

267 , and cooperated with cytarabine in inducing DNA replication stress and damage in AML cell lines.

268 NAs and phosphorylation of H2AX, a marker of DNA replication stress induced by the ATM and ATR kinase

269 Furthermore, we find that DNA replication stress induces the release of SF3B1 from

270 DNA replication stress promotes genome instability in ca

271 The DNA replication stress response protein SMARCAL1 stabili

272 Loss of functional WEE1 kinase causes DNA replication stress, DNA damage and unscheduled mitot

273 ogression in some homozygous cells following DNA replication stress.

274 er cells to hydroxyurea- or olaparib-induced DNA replication stress.

275 double-strand break repair and resolution of DNA replication stress.

276 in budding yeast, diminished cell growth and DNA replication, substantially decreased Mcm4 phosphoryl

277 occur in the cytosol at rates sufficient for DNA replication, supporting empirical data indicating th

278 induction more strongly than translation of DNA replication, survival, and DNA damage response mRNAs

279 We show for the T4 bacteriophage DNA replication system that primer-primase complexes hav

280 ibility has not been tested in reconstituted DNA replication systems.

281 re we show that in coinfected cultures, AAV2 DNA replication takes place almost exclusively in S/G2-p

282 this pathway could modulate the response to DNA replication-targeted chemotherapies.

283 trending (0.01FDR<0.02) gene sets related to DNA replication, telomere maintenance and elongation, ce

284 ffers critical insight into the mechanism of DNA replication termination while at the same time raisi

285 r of replisome disassembly during vertebrate DNA replication termination.

286 rst evidence of the DDR-dependent parvovirus DNA replication that occurs in dividing cells and is ind

287 During DNA replication, the single-stranded DNA binding protein

288 gulator that orchestrates multiple rounds of DNA replication throughout schizogony in Plasmodium falc

289 positively correlated with domains of early DNA replication timing (RT) but negatively correlated wi

290 DNA replication timing (RT) is a robust cell type-specif

291 DNA replication timing programs have been extensively st

292 play an important role in the regulation of DNA replication timing.

293 Our findings connect DNA replication to R-loop homeostasis and suggest a mech

294 lation of TopBP1, resulting in a switch from DNA replication to repair functions for this protein and

295 h that modulates bacteria from high-fidelity DNA replication to stress-induced mutagenesis.

296 to nucleocapsids for reverse transcriptional DNA replication to take place, the core protein dimers,

297 of the role of PcrA/UvrD at the interface of DNA replication, transcription and repair are discussed.

298 Topoisomerases play crucial roles in DNA replication, transcription, and recombination.

299 lls from patients, consistent with defective DNA replication underlying the disease phenotype.

300 genes not previously linked to high-fidelity DNA replication, we conducted a genome-wide screen in Sa