ライフサイエンスコーパス: DNA sequence

1 ype (reistance to antibiotics) and genotype (DNA sequence).

2 t, a puma response element and a nonspecific DNA sequence.

3 elated with the AT content of the underlying DNA sequence.

4 functional relationship with the underlying DNA sequence.

5 y NHEJ are rarely restored to their original DNA sequence.

6 transcription factor binding beyond just the DNA sequence.

7 edure based on a low cost non-functionalized DNA sequence.

8 ble G-hairpin formed by a natively occurring DNA sequence.

9 changes in phenotype that are not rooted in DNA sequence.

10 ks for AuNPs from 5 to 100 nm and all tested DNA sequences.

11 nd to introduce point mutations or exogenous DNA sequences.

12 the basis of physico-chemical properties of DNA sequences.

13 that would not be possible in simple linear DNA sequences.

14 binding sites and is enabled by alternative DNA sequences.

15 program to predict SINE elements in genomic DNA sequences.

16 e tags that react orthogonally with distinct DNA sequences.

17 NbGlk1 binds to known Golden2-like consensus DNA sequences.

18 5 methyl cytosine (5mC) without altering the DNA sequences.

19 similar affinities and protected overlapping DNA sequences.

20 operties that are controlled by the wrapping DNA sequences.

21 aches to predict open chromatin regions from DNA sequences.

22 dy (GWAS) risk variants reside in non-coding DNA sequences.

23 erent shape changes in response to different DNA sequences.

24 e to challenges with interpreting short-read DNA sequences.

25 al and functional domains present in certain DNA sequences.

26 sist of localized losses and duplications of DNA sequences.

27 ic biology for assembly and rearrangement of DNA sequences.

28 finger domains involved in binding to target DNA sequences.

29 nge of studies from molecular electronics to DNA sequencing.

30 er Center, 10336 patients consented to tumor DNA sequencing.

31 A polymerases and high-throughput short-read DNA sequencing.

32 robust molecular switches to nanoelectronic DNA sequencing.

33 speed and low cost of modern high-throughput DNA sequencing.

34 y amplification; and finally high-throughput DNA sequencing.

35 nterest given potential applications such as DNA sequencing.

36 LFD was coherent with the results found with DNA sequencing.

37 nd have achieved notable success in portable DNA sequencing.

38 ta composition was analyzed by 16S ribosomal DNA sequencing.

39 s, tumor phenotypes, and results of germline DNA sequencing.

40 is one of the main goals of next generation DNA sequencing.

41 be read out with microfluidic barcoding and DNA sequencing.

42 issues limit current CNA calling based upon DNA sequencing.

43 omplexes into the supernatant for paired-end DNA sequencing.

44 SRA contained approximately ten petabases of DNA sequence (10 16 bp).

45 tivated microbial groups known only by their DNA sequences (2-4) .

46 ted, that is, the relevance exists along the DNA sequences; (2) lincRNAs contain some conversed patte

47 Despite recent advances in DNA sequencing, a lack of standardized protocols and com

48 review commemorates the 40th anniversary of DNA sequencing, a period in which we have already witnes

49 3 (fl-p53) tetramer bound to three different DNA sequences: a p21 response element, a puma response e

50 ocument the genetic variation observed after DNA sequencing, alignment and variant calling of a sampl

51 r ability to predict protein expression from DNA sequence alone remains poor, reflecting our limited

52 nd large scales cannot be fully explained by DNA sequences alone.

53 into the study of human genetic disease when DNA sequencing alone is not sufficient to reveal the und

54 rogeneity, and deploying technologies beyond DNA sequencing, among others.

55 and greater genetic diversity as assessed by DNA sequence analysis.

56 DNA sequencing analysis revealed target-dependent mutati

57 nd coarse-grained simulations shows that the DNA sequence and a structural correlation due to topolog

58 nc-binding domain that recognizes a specific DNA sequence and an RNA polymerase domain that catalyzes

59 are positioned according to endogenous yeast DNA sequence and chromatin-remodeling network, as judged

60 we developed a system to examine the role of DNA sequence and genomic context in propagation of a cis

61 eases the efficiency of interpreting patient DNA sequence and helps to identify and prioritize biolog

62 -quadruplex conformation to single strand of DNA sequence and release thrombin.

63 DNA sequence and shape analysis of initiation complex si

64 egion, thus enabling the exploration of both DNA sequence and structural diversity of complex genomic

65 ive cytosines, to gain insights into i-motif DNA sequence and structure stability.

66 Further, these activities were sensitive to DNA sequence and structure, with the helicases preferent

67 om but instead depend on both the underlying DNA sequence and the dynamic action of other proteins wi

68 rs from nonusers and had distinct underlying DNA sequences and divergent enhancer activity as marked

69 ases represses transcription from repetitive DNA sequences and ensures genomic stability.

70 oped that converts an arbitrary pattern into DNA sequences and experimental protocols, our assembly m

71 se data also reveal that a wide diversity of DNA sequences and multiple types of genetic elements in

72 ors (TFs) are proteins that bind to specific DNA sequences and regulate expression of genes.

73 g Cell Nuclear Antigen (yPCNA) with modified DNA sequences and structures incorporated within lambda-

74 brary construction, up to a further 36 h for DNA sequencing and <20 h for processing of raw sequencin

75 Inexpensive DNA sequencing and advances in genome editing have made

76 Advances in DNA sequencing and computational approaches have led to

77 We employed restriction-site-associated DNA sequencing and integrated phylogenomic and populatio

78 ram input quantity, a step towards low-input DNA sequencing and mammalian epigenomic mapping of nativ

79 s through a nanoscale channel is critical to DNA sequencing and mapping technologies that are current

80 The ubiquity of DNA sequencing and the advent of medical imaging, electr

81 n sites are typically identified by targeted DNA-sequencing and subsequently assigned to predicted ta

82 rs can be compromised by encoding malware in DNA sequences, and biological threats can be synthesized

83 are assembled with customized core histones, DNA sequences, and chromosomal proteins.

84 ation is energy-dependent, requires upstream DNA sequences, and disrupts TECs to release the nascent

85 CTG repeats are structure-forming repetitive DNA sequences, and expansion beyond a threshold of appro

86 l analysis, methylated and hydroxymethylated DNA sequencing, and gene-specific GC methylation detecti

87 e developed a highly multiplexed single-cell DNA sequencing approach to trace the metastatic lineages

88 Complex DNA sequences are difficult to detect and profile, but a

89 o why human neoplastic translocation fragile DNA sequences are more prone to enzymes or agents that c

90 herited diseases caused by unstable repeated DNA sequences are rare, but together represent a substan

91 Repetitive DNA sequences are ubiquitous in life, and changes in the

92 (AsCpf1) was engineered to recognize altered DNA sequences as the protospacer adjacent motif (PAM), t

93 nanopore by rhodamines could be utilized in DNA sequencing as additional optical sensing owing to br

94 The DNA sequence at regional centromeres is fast evolving wi

95 e to distinguish methylated and unmethylated DNA sequences at single CpG resolution by differentiatin

96 nd solvation energies of all combinations of DNA sequences at the dinucleotide level and calculated t

97 Telomeres consist of tandem repeats of DNA sequences at the end of chromosomes, preventing chro

98 omize the central problem of propagating non-DNA sequence-based information across generations.

99 del without fitting parameters, with genomic DNA sequence being the only input, we further validate t

100 DNA sequencing brings another dimension to exploration o

101 of G-quadruplexes formed by, e.g., telomeric DNA sequences, but are also interesting targets for supr

102 nt begins with the recognition of a specific DNA sequence by the CBF3 complex.

103 ged from the DNA template either at specific DNA sequences, called the terminators, or by a nascent R

104 Collections of DNA sequences can be rationally designed to self-assembl

105 reference comprising 116 098 ordered coding DNA sequence (CDS) gene models.

106 several sources of data including multilocus DNA sequence, climatic niche models and chromosomal feat

107 DNA sequences coding for PRC2-binding RNA motifs are enr

108 ies (including more than 400 newly generated DNA sequences), comparative phylogenetic methods, geolog

109 As DNA sequencing comprises the fastest growing database of

110 A Miz-1 DNA sequence consensus has recently been identified and

111 B2277, forms a strong monomer complex with a DNA sequence containing 5-AAAGTTT-3.

112 the solution structure of several repetitive DNA sequences containing d(TCGTTCCGT) and related repeat

113 pports mutation rate dependence on the local DNA sequence context for various types of mutations.

114 We anticipate that, as the cost of DNA sequencing continues to fall that our multilocus bar

115 Thus, specific DNA sequences contribute to cis inheritance of H3K9me an

116 stomized chromatin with specifically desired DNA sequences, core histones, and other chromosomal prot

117 reference database giving global context to DNA sequence data and a framework for incorporating data

118 Toward this end, the availability of DNA sequence data from 60,706 people through the Exome A

119 of 100 discrete morphological characters and DNA sequence data from five gene regions.

120 t allele fraction from corresponding RNA and DNA sequence data from patients with breast cancer acqui

121 Extensive DNA sequence data have made it possible to reconstruct h

122 ceae based on plastome and nuclear ribosomal DNA sequence data, the temporal history of the family wa

123 obtain the best performance over intergenic DNA sequence data.

124 rithm that combines a probabilistic model of DNA sequencing data with a enumeration algorithm based o

125 osed SMC algorithm is evaluated on simulated DNA sequence datasets under different mutational models

126 ain correctly associated with the underlying DNA sequence, despite the huge disruption to chromatin s

127 oof-of-principle can be utilized in specific DNA sequence detection.

128 We believe that the DNA sequence-directed versatile assembly of periodic hig

129 both the efficiency of natural selection and DNA sequence diversity are expected to depend upon the e

130 al methods, single-molecule real-time (SMRT) DNA sequencing exhibits longer read lengths than convent

131 We provide evidence that DNA sequence features such as density of CpGs and genomi

132 in part by core promoter elements, which are DNA sequences flanking the transcription start site (TSS

133 Accurate maps and DNA sequences for human subtelomere regions, along with

134 Transcription factors bind low-affinity DNA sequences for only short durations.

135 A specific DNA sequence from E. coli O157:H7 having 22 mers as an a

136 However, reading DNA sequence from sub-nanogram quantities is impractical

137 hod in diagnostics, we amplify human genomic DNA sequences from a approximately 1 muL droplet of whol

138 number of segregating sites between pairs of DNA sequences from a large number of independent loci.

139 ut of the genome by occluding the underlying DNA sequences from DNA-binding proteins that must act on

140 ction, a low fraction of cells acquire short DNA sequences from the invader.

141 e prior birth, was determined by classifying DNA sequences from the V1-V3 region of bacterial 16 S rR

142 ral and plasmid infection by capturing short DNA sequences from these invaders and integrating them i

143 s from THEMIS are validated with single cell DNA sequencing from a clinical tumor biopsy.

144 Whole-exome DNA sequencing (>50 times coverage) was performed on eac

145 DNA sequencing has been extensively and creatively repur

146 studied, the contributions of the underlying DNA sequences have been much less well defined, and exis

147 ecause of its dense packaging and repetitive DNA sequence, heterochromatin is a challenging environme

148 stability and position are regulated through DNA sequence, histone post-translational modifications,

149 High throughput DNA sequencing (HTS) technologies generate an excessive

150 DNA sequences immediately flanking the previously define

151 ping by RecA, Rad51, and Dmc1 is affected by DNA sequence imperfections, such as single and multiple

152 the conservation and divergence of the FIRE DNA sequence in vertebrates.

153 ediate the excision and loss of loxP-flanked DNA sequences in a rapamycin controlled manner.

154 ativity parameters for hundreds of different DNA sequences in a single experiment.

155 many ZFs and whether they recognize and bind DNA sequences in a typical fashion.

156 ing the identification of bacterial pathogen DNA sequences in complex samples in less than four hours

157 A main goal of performing DNA sequencing in population studies and clinical settin

158 communities and restriction-site-associated-DNA sequencing in the four most ubiquitous species, we f

159 the complex interplay of factors beyond the DNA sequence, including epigenetic modifications, RNA tr

160 activity are important for copying difficult DNA sequences, including simple repeats.

161 hift assay that the C terminus of KNL2 binds DNA sequence-independently and interacts with the centro

162 ociated with somatic variations, advances in DNA sequencing indicate that cell-specific variants affe

163 es, including autonomous chiral inversion of DNA sequence information and chirality-based computing.

164 er development with a vision to link primary DNA sequence information to gene functions in vertebrate

165 MIL breaks each DNA sequence into multiple overlapping subsequences and

166 We first split DNA sequences into k -mers and pre-train k -mer embeddin

167 nucleoprotein complex and short stretches of DNA sequences into porcine zygotes.

168 Writing specific DNA sequences into the human genome is challenging with

169 facilitates the introduction of recombinant DNA sequences into the lambda-phage genome with 90-100%

170 The innate flexibility of a DNA sequence is quantified by the Jacobson-Stockmayer's

171 hromatin-based epigenetic information beyond DNA sequence is stably transmitted along with the disrup

172 ecular diagnosis of specific target bacteria DNA sequences is then performed using a real-time loop-m

173 Body fluid DNA sequencing is a powerful noninvasive approach for th

174 Low-cost shotgun DNA sequencing is transforming the microbial sciences.

175 working electrodes, which were modified with DNA sequences known as estrogen response elements (DNA-E

176 Species identification using DNA sequences, known as DNA barcoding has been widely us

177 n is an important step in the preparation of DNA sequencing libraries prior to high-throughput sequen

178 dNLP-ISWI system can be used with different DNA sequences, linear or circular DNA, bulk genomic DNA,

179 The DNA sequence located in the B chromosome is a pseudogeni

180 Rapid methodological developments in DNA sequencing, macroevolutionary analysis and the integ

181 ed because it does not result in a change in DNA sequence, making recombination between sister chroma

182 Transmitted DNA sequences may encode favourable traits.

183 rring and evaluating patients, and providing DNA sequencing, metabolomic analysis, and functional stu

184 The emergence of high-throughput DNA sequencing methods provides unprecedented opportunit

185 High-throughput DNA sequencing modalities, including single molecule seq

186 d protein that binds to an AT-rich conserved DNA sequence motif and regulates both the shape and the

187 are specified for dosage compensation, since DNA sequence motifs shown to be important for dosage com

188 Analyses of enriched DNA sequence motifs that may act as cis-regulatory eleme

189 e core promoter that comprises the classical DNA sequence motifs, sequence-specific DNA-binding trans

190 Transcription factors (TFs) bind to specific DNA sequence motifs.

191 ing of trans-acting factors to cis-localized DNA sequence motifs.

192 (SD-MMEJ), predicts that differences between DNA sequences near double-strand breaks should alter rep

193 sertions are frequently observed in enhancer DNA sequences near known oncogenes.

194 Next-generation massive-parallel DNA sequencing (NGS) analysis did not detect these genet

195 C-terminal to RRM3 and binding to equivalent DNA sequences occurs with similar affinity.

196 e evolution of this complex gene family, the DNA sequence of a 1.75-Mb genomic region spanning the Gl

197 The challenge is, given the DNA sequence of a new patient, to distinguish disease-ca

198 te was fabricated for detection of consensus DNA sequence of Dengue virus (DENV) using methylene blue

199 of sequence-selectively binding a continuous DNA sequence of more than 500 nt.

200 Pol V transcripts to faithfully reflect the DNA sequence of target loci to which siRNA-Argonaute sil

201 insults leave characteristic imprints on the DNA sequence of tumours, and culminating in empirical ev

202 based on nuclear ribosomal and mitochondrial DNA sequences of four genetic loci (16S rDNA, 28S rDNA,

203 wo related DHBDs that bind preferentially to DNA sequences of higher AT content.

204 The portability and long DNA sequences of RTnS offer great potential for field-ba

205 Pine DNA sequences of these samples showed a high degree of c

206 Large-scale DNA sequencing of immunological repertoires offers an op

207 High-throughput DNA sequencing of microbiota from a diverse collection o

208 Here, Patel et al. use targeted DNA sequencing of MODY patients and large-scale publical

209 Here, we employed genomic DNA sequencing of multiple variable (V) regions of the b

210 We conclude that DNA sequencing of pooled samples of large numbers of bac

211 Plasmid DNA sequencing of previously uncharacterized clinical ex

212 In this study, we demonstrate that sparse DNA sequencing of single-cell nuclei from prostate core

213 Using next-generation DNA sequencing of the 16S rRNA gene, we analyzed the com

214 DNA sequencing of the APOC2 gene in the patient and one

215 DNA sequencing of the lysozyme gene in the patient and h

216 We performed DNA sequencing of the ORAI1 gene, modeling of mutations

217 n, assessed by both 16S rDNA and metagenomic DNA sequencing, of TB cases during antimycobacterial tre

218 t of such variants in the context of altered DNA sequence only; attributes of the resulting transcrip

219 The developed model can be applied to any DNA sequence or genome to characterise sequence-driven i

220 dynamics were independent of the nucleosomal DNA sequence or the asymmetry created by the presence of

221 nscription factors (TFs) binding to specific DNA sequences or motifs, are elementary to the regulatio

222 lly repel the non-complementary and mismatch DNA sequences, overcoming the non-specific binding.

223 the mutation and insertion of virtually any DNA sequence, particularly in cell culture where selecti

224 These results suggest that certain intronic DNA sequences play unexpectedly large roles in directing

225 ts are not random and often co-localize with DNA sequences potentially capable of adopting alternativ

226 down to aM) detection sensitivity for target DNA sequences present in solution.

227 eguides-zeptolitre optical cavities in which DNA sequencing proceeds.

228 Restriction site-associated DNA sequencing (RAD-seq) allows for the genome-wide disc

229 We used restriction-site associated DNA sequencing (RAD-seq) to study the sex chromosomes of

230 s generated with restriction site-associated DNA sequencing (RADseq), in combination with demographic

231 We demonstrate that targeted next-generation DNA sequencing reactions and in situ point mutation dete

232 e homogeneous biosensor for the detection of DNA sequences related to HIV based on fluorescence reson

233 inding and nuclease activation at off-target DNA sequences remains elusive.

234 onary placement and visualization of diverse DNA sequences representing unknown taxa within a robust

235 ntermediates increase the flexibility of the DNA sequence requirements for origin licensing.

236 ts from the assays were 100% concordant with DNA sequencing results.

237 Recent studies of ultra-short DNA sequences revealed a discrepancy of up to six orders

238 ntial enrichment followed by high-throughput DNA sequencing (SELEX-seq) on several floral MADS domain

239 precipitation followed by massively parallel DNA sequencing showed that genes involved in synaptic co

240 DNA sequence signals in the core promoter, such as the i

241 The test combines DNA sequence specific sample prep to reduce the co-extra

242 (Cas9) endonuclease cleaves double-stranded DNA sequences specified by guide RNA molecules and flank

243 The 1.76-kb DNA sequence (SPHINX 1.8), with an iteron before its ORF

244 High-throughput single-stranded DNA sequencing (ssDNA-seq) of cell-free DNA from plasma

245 The potential for genetic discovery in human DNA sequencing studies is greatly diminished if DNA samp

246 that the combination of ligand structure and DNA sequence tailor the transcriptional activity of VDR

247 eparation of the library for high-throughput DNA sequencing takes approximately 7 d and the basic bio

248 With the development of new high-throughput DNA sequencing technologies and decreasing costs, large

249 Availability of next-generation DNA sequencing technologies has facilitated the developm

250 rences in geographical origin.IMPORTANCE New DNA sequencing technologies have made it easier than eve

251 Here, I review developments in DNA sequencing technologies over the past 10 years and l

252 he advent of next generation high-throughput DNA sequencing technologies, omics experiments have beco

253 Recent advances in long-read DNA sequencing technologies, specifically Nanopore seque

254 With the rapid evolution of next-generation DNA sequencing technologies, the cost of sequencing a hu

255 Advances in DNA sequencing technology have provided an unprecedented

256 es with adaptive immunity by employing short DNA sequences, termed spacers, that guide Cas proteins t

257 To determine the mapping between promoter DNA sequence, TF concentration, and gene expression outp

258 DNA sequences that are guanine-rich have received consid

259 rmation represent genetic systems adjunct to DNA sequences that contribute to phenotypic diversity.

260 for multiplexed analysis of disease-specific DNA sequences that utilizes a smartphone camera as the s

261 Intact, near-full-genome HIV-1 DNA sequences that were derived from such clonally expan

262 ce of genomic information independent of the DNA sequence, the epigenetics, as well as gene transcrip

263 Our method purely relies on DNA sequences to predict enhancers in an end-to-end mann

264 Although the contributions of RNA and DNA sequences to termination are largely understood, the

265 We used next-generation DNA sequencing to compare the AM communities from roots

266 duction, with high-throughput 18 S ribosomal DNA sequencing to elucidate the relationship between euk

267 two interacting proteins and next-generation DNA sequencing to identify these interactions en masse.

268 t uses barcode extension and next-generation DNA sequencing to quantitatively measure the incorporati

269 Binding to an ops DNA sequence triggers structural transformation wherein

270 xtreme, individuals carrying the same causal DNA sequence variant but on different backgrounds can be

271 ification and functional characterization of DNA sequence variants associated with disease.

272 Nevertheless, DNA sequence variants co-segregating with TD phenotypes

273 n UK Biobank testing approximately 9 million DNA sequence variants for association with coronary arte

274 enic risk score derived from up to 57 common DNA sequence variants previously associated with coronar

275 ve recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP)

276 Human DNA sequence variants that truncate the CETP gene may pr

277 mes harbour a considerable fraction of total DNA sequence variation, but the functional contribution

278 nces in our knowledge of the contribution of DNA sequence variations to cardiovascular disease and st

279 rone to trigger deletions between repetitive DNA sequences via a mechanism we call Inter-Fork Strand

280 This bio-barcode DNA with known DNA sequence was then detected by fluorescence spectroph

281 DNA sequencing was first introduced in 1977, and next-ge

282 could find application in molecular sensing, DNA sequencing, water desalination, and molecular separa

283 Using assembly-based whole-genome DNA sequencing, we found previously undefined genomic re

284 Through long-read DNA sequencing, we obtained a gap-free genome assembly f

285 thetic biology tools combined with long-read DNA sequencing, we optimize productivity by 50-fold to p

286 de chromatin conformation capture (Hi-C) and DNA sequencing were performed in adult cardiac myocytes

287 ications carrying information independent of DNA sequence, which are heritable through cell division.

288 nm was measured on a doubly Cu(2+) -labeled DNA sequence, which is in exact agreement with the expec

289 on RNA-guided recognition of a complementary DNA sequence, which strictly requires the presence of a

290 tide synthetase adenylation (A) domains from DNA sequences, which enables prioritization and dereplic

291 real-time polymerase chain reaction (PCR) or DNA sequencing, which are typically slow and require exp

292 perimental measurements for most ultra-short DNA sequences, while continuing to accurately describe t

293 ariner transposon is generated by flanking a DNA sequence with short inverted repeats.

294 is modularity and their ability to bind long DNA sequences with high specificity, TALEs have been use

295 DNA sequencing with methylation-specific primers and cDN

296 n be tuned over a wide range by changing the DNA sequence, with AR more sensitive to sequence changes

297 describe a systematic study of cytosine-rich DNA sequences, with varying numbers of consecutive cytos

298 Surprisingly, we find that the DNA sequence within Hel308 affects the kinetics of helic

299 automated fashion from digitally transmitted DNA sequences without human intervention.

300 as surprisingly concluded that 25% of random DNA sequences yield beneficial products when expressed i