ライフサイエンスコーパス: DNA synthesis

1 s chemistry to coordinate the first steps of DNA synthesis.

2 h MUS81 and promotes MUS81-dependent mitotic DNA synthesis.

3 yofibrillar and cytosolic protein as well as DNA synthesis.

4 th important implications for lagging strand DNA synthesis.

5 eocapsids (NCs) and the early stage of viral DNA synthesis.

6 n ssDNA generated gradually during 'in situ' DNA synthesis.

7 s of telomeres synthesized by leading strand DNA synthesis.

8 igens and had no appreciable effect on viral DNA synthesis.

9 ial for genome maintenance through templated DNA synthesis.

10 MG activity to DNA polymerases for efficient DNA synthesis.

11 t resulted in premature chain termination of DNA synthesis.

12 mechanism by which UL97 contributes to HCMV DNA synthesis.

13 for coordinated leading- and lagging-strand DNA synthesis.

14 deposition at centromeres is uncoupled from DNA synthesis.

15 replication origins to license new rounds of DNA synthesis.

16 essential component required for processive DNA synthesis.

17 TR) that provides the template for telomeric DNA synthesis.

18 plexes is not restricted to cells undergoing DNA synthesis.

19 aintain their telomeres by homology-directed DNA synthesis.

20 ons in real time during polymerase-catalyzed DNA synthesis.

21 ate the interplay between HR and translesion DNA synthesis.

22 ar NBEs, and is required for efficient viral DNA synthesis.

23 mutagens and primes unscheduled error-prone DNA synthesis.

24 in the DNA polymerase choice during genomic DNA synthesis.

25 ior that is uncoupled from its role in viral DNA synthesis.

26 dRP lyase gap trimming and template-directed DNA synthesis.

27 oost over the energy barrier to catalysis of DNA synthesis.

28 for high-throughput electrical recording of DNA synthesis.

29 he duplex prior to subsequent leading strand DNA synthesis.

30 II with beta allow for rapid exchange during DNA synthesis.

31 They occupy two sites, A and B, for DNA synthesis.

32 cessive, and more mutagenic than replicative DNA synthesis.

33 ogen-bonding interactions during translesion DNA synthesis.

34 low efficiencies for TLS compared to normal DNA synthesis.

35 rallel DNA strands and polarity of enzymatic DNA synthesis.

36 e to the lack of deoxynucleotides needed for DNA synthesis.

37 As as short as 10-12 nt serve as primers for DNA synthesis.

38 ant protein that is functional in processive DNA synthesis.

39 NA polymerases are involved in HR-associated DNA synthesis.

40 CHK1 and gamma-H2AX levels and a decrease in DNA synthesis.

41 the primer terminus on genomic stability and DNA synthesis.

42 shown in vitro to be an essential enzyme in DNA synthesis.

43 ectors is dependent upon viral second-strand DNA synthesis.

44 pBP1 marks sites of and promotes unscheduled DNA synthesis.

45 ls where it provides dNTPs for mitochondrial DNA synthesis.

46 lications for understanding controls of host DNA synthesis.

47 rAAV by MRN is due to limiting second-strand DNA synthesis.

48 se for carrying out both leading and lagging DNA synthesis.

49 ure and reduces fidelity and processivity of DNA synthesis.

50 viding DNA repair factors required for viral DNA synthesis.

51 g a cumulative genotoxicity that deregulated DNA synthesis.

52 ive forms, act as chain terminators of viral DNA synthesis.

53 ing generation of R-lesions by R-loop-primed DNA synthesis.

54 lls, as well as of mechanisms governing host DNA synthesis.

55 lted in inhibition of E2-induced protein and DNA synthesis.

56 can couple strand displacement to processive DNA synthesis.

57 transiently exposed template strands during DNA synthesis.

58 esponse to UV-induced damage for translesion DNA synthesis.

59 a direct and essential role in facilitating DNA synthesis.

60 sis is then shut off and replaced with virus DNA synthesis.

61 a metabolic state that is unable to support DNA synthesis.

62 transition from continuous to discontinuous DNA synthesis.

63 ase holoenzyme and localizes to the sites of DNA synthesis.

64 e needed to cleave MMEJ intermediates before DNA synthesis.

65 strong complex which might be essential for DNA synthesis.

66 ialized polymerases that perform translesion DNA synthesis.

67 ment of SLX4 and by facilitating unscheduled DNA synthesis.

68 ownregulated both EMD- and TGF-beta1-induced DNA synthesis.

69 le for histone (H3-H4)2 deposition following DNA synthesis.

70 illomavirus E2 protein onto chromatin during DNA synthesis.

71 nd orchestrates chromatin assembly following DNA synthesis.

72 s observed in G2 after completion of nuclear DNA synthesis.

73 into any DNA oligonucleotide during initial DNA synthesis.

74 S-phase checkpoint monitors the integrity of DNA synthesis.

75 apable of coordinated leading/lagging strand DNA synthesis.

76 ases (RRs) generate deoxyribonucleotides for DNA synthesis.

77 ic acid delivery to Pol alpha and subsequent DNA synthesis.

78 f Pax7(+) cells likely explains the elevated DNA synthesis.

79 ly factor 1 (CAF-1) deposits histones during DNA synthesis.

80 PCNA does much more than promote processive DNA synthesis.

81 DNA, effectively increasing processivity of DNA synthesis.

82 ase on Threonine 530 (T530-pSIRT1) modulates DNA synthesis.

83 rs that block reverse transcriptase-mediated DNA synthesis.

84 ule; Pif1 also allows Pol delta to carry out DNA synthesis across an array of bound Rap1 molecules th

85 ty is often reliant on the ability to direct DNA synthesis across strand breaks, and that polymerase

86 ring-shaped structure to promote processive DNA synthesis, acting as a sliding clamp for polymerases

87 ell types examined, megakaryocytes continued DNA synthesis after loss of Aurka.

88 iate lagging strand DNA synthesis or reprime DNA synthesis after replication fork collapse, but the o

89 stalled forks facilitates the resumption of DNA synthesis after stress removal.

90 he localization of WH at the site of nascent DNA synthesis along with other replication proteins, inc

91 prolonged or arrested S phase, a decrease in DNA synthesis, an increase in phospho-RB and a concomita

92 s measured by RAD51 recruitment, unscheduled DNA synthesis and a CRISPR-Cas9-based gene-targeting ass

93 Advances in DNA synthesis and assembly methods over the past decade

94 ion machinery suggests that, for poxviruses, DNA synthesis and base excision repair is coupled.

95 ase 1 (CHK1) kinases to transiently suppress DNA synthesis and cell cycle progression.

96 neck (SCCHN) cells and resulted in enhanced DNA synthesis and cell cycle progression.

97 to date has been enhanced by improvements in DNA synthesis and computational design.

98 knockdown of Mcm10 and HP1a induced ectopic DNA synthesis and DNA damage without much of ectopic apo

99 rine still attached to host cells, and viral DNA synthesis and early and late gene transcription were

100 still attached to host cells; however, viral DNA synthesis and early E1A and late hexon gene transcri

101 quently disengages from the replisome during DNA synthesis and exchanges with free copies from soluti

102 a novel role for LMO2 in directly promoting DNA synthesis and G1-S progression.

103 y of DNA polymerases involved in translesion DNA synthesis and genome mutagenesis.

104 s HIV reverse transcriptase, which nucleates DNA synthesis and is aided in elongation by murine leuke

105 B vitamins play an essential role in DNA synthesis and methylation, and may protect against o

106 ductase (MTHFR) gene, an enzyme essential in DNA synthesis and methylation, have been associated with

107 single cyclin-Cdk fusion protein can control DNA synthesis and mitosis in a manner that is indistingu

108 ient B cell progenitors displayed defects in DNA synthesis and passage through the G1/S transition, c

109 AP-1 expression correlated with increased MK DNA synthesis and polyploidization, which might explain

110 nd miR-495 robustly stimulated cardiomyocyte DNA synthesis and proliferation.

111 information from damaged RNA genomes during DNA synthesis and promotes frequent recombination to inc

112 ingle-step growth cycle, HSV suppresses host DNA synthesis and promotes viral DNA synthesis in spatia

113 cial role in biological processes, including DNA synthesis and regulation, nervous system function, r

114 '-dideoxynucleotides that randomly terminate DNA synthesis and release 3'-azido-blocked cDNA fragment

115 beta maintains genome fidelity by catalyzing DNA synthesis and removal of a reactive DNA repair inter

116 corresponding deoxyribonucleotides, used in DNA synthesis and repair.

117 ntial for cellular methylation reactions and DNA synthesis and repair.

118 kely confers cell survival through increased DNA synthesis and robust activity stimulation by TPP1-PO

119 Improvements in DNA synthesis and sequencing have underpinned comprehens

120 With the rapid advances in DNA synthesis and sequencing technologies and the contin

121 phorylated residues (TICRR(TESE)) stimulates DNA synthesis and shortens S phase by increasing replica

122 abasic sites ahead of nascent lagging strand DNA synthesis and subsequent bypass by error-free templa

123 uently to facilitate the late stage of viral DNA synthesis and to stabilize NCs containing mature vir

124 ement of an extremely small amount of repair DNA synthesis) and RRS (recovery of RNA synthesis after

125 its own, pol beta fails to copy TNRs during DNA synthesis, and bypasses them on the template strand

126 molecular-genetic mechanisms for DNA repair, DNA synthesis, and cell division.

127 s requires sequential incisions, translesion DNA synthesis, and homologous recombination, but the ful

128 noblot analyses and transfection, infection, DNA synthesis, apoptosis, migration, cell count, and pro

129 resent an economical and streamlined de novo DNA synthesis approach for engineering a synthetic pathw

130 thesis of the myofibrillar fraction, but not DNA synthesis, are elevated in muscle of the contralater

131 for the coordinate inhibition of translesion DNA synthesis as a strategy to improve chemotherapeutic

132 ilon) carries out the bulk of leading strand DNA synthesis at an undisturbed replication fork.

133 ontaining D67N/K70R reversed the error-prone DNA synthesis at codons 65-67 in RT and improved viral r

134 w microhomologies can be created via limited DNA synthesis at secondary-structure forming sequences.

135 infection occurred after completion of viral DNA synthesis, at the step of 2LTR circle and provirus f

136 To complete DNA synthesis before the onset of mitosis, eukaryotic ce

137 hich plays a specific role in protein-primed DNA synthesis beyond simply harboring the site of primin

138 ly the one responsible for the initiation of DNA synthesis blocked by P4.

139 eas removal of glutamate not only suppressed DNA synthesis but also promoted cell death in SK2 and SK

140 metabolites do not block the first round of DNA synthesis but instead arrest cells at the G1/S borde

141 tivity, DNA damage responses, or unscheduled DNA synthesis but to loss of an ATR function at centrome

142 eplicate the damaged DNA, allowing stringent DNA synthesis by a replicative polymerase to resume beyo

143 Lagging strand DNA synthesis by DNA polymerase requires RNA primers pro

144 omotes the regular priming of lagging-strand DNA synthesis by facilitating DNA polymerase alpha funct

145 shots of catalytic events during gap-filling DNA synthesis by pol mu.

146 nd on ring-shaped hexameric helicases to aid DNA synthesis by processively unzipping the parental DNA

147 Bulky DNA damage inhibits DNA synthesis by replicative polymerases and often requi

148 It has been assumed that DNA synthesis by the leading- and lagging-strand polymer

149 rt and long RNAs on ssDNA template and prime DNA synthesis by the yeast mitochondrial DNA polymerase

150 anemia, which results from the inhibition of DNA synthesis by trapping folate cofactors in the form o

151 Nuclear DNA synthesis ceased almost immediately following VACV i

152 ucleotide phosphoramidite monomers using the DNA synthesis chemistry.

153 ction of photosynthesis, light signaling and DNA synthesis/chromatin structure; however, the genes re

154 ned, resulting in a propagating wave of host DNA synthesis continually in advance of infection.

155 Post-DNA synthesis copper-catalyzed azide-alkyne cycloadditio

156 ition in vitro, it is required for efficient DNA synthesis-coupled nucleosome assembly.

157 esses in the lung epithelial system, such as DNA synthesis, cytoskeleton and extracellular matrix, tr

158 Termination involves local completion of DNA synthesis, decatenation of daughter molecules and re

159 HR-associated DNA synthesis determines in large part the fidelity of t

160 s activity enables TGIRT enzymes to initiate DNA synthesis directly at the 3' end of a DNA strand whi

161 l enzyme in folate metabolism is involved in DNA synthesis, DNA repair and DNA methylation.

162 However, we find that DNA synthesis does not occur in a fully assembled DNA po

163 We show that DNA synthesis does not slow detectably as forks approach

164 observe two alternate configurations of the DNA synthesis domain in the CMG-bound Pol epsilon.

165 ns implicate PrimPol in promoting restart of DNA synthesis downstream of, but closely coupled to, G4

166 cleotide BENZI: was required for full-length DNA synthesis during bypass of O(6)-CMG.

167 review, we describe mechanistic features of DNA synthesis during different types of HR-mediated DNA

168 ion cycle protein 45 (Cdc45) is required for DNA synthesis during genome duplication, as a component

169 ber of recent studies have demonstrated that DNA synthesis during HR is conservative, less processive

170 ctivity is required to activate compensatory DNA synthesis during mitosis and to resolve mitotic inte

171 Here, we study spatial organization of DNA synthesis during multiround transmission of herpes s

172 ng as the primase to initiate lagging strand DNA synthesis during normal replication and/or to restar

173 of DNA replication origin firing and ongoing DNA synthesis during S-phase itself, respectively, and h

174 Rpo41-Mtf1 complex, which continues to prime DNA synthesis efficiently in the presence of Rim1.

175 47K polymerase and BenziTP, a first round of DNA synthesis enabled subsequent amplification of Benzi-

176 DNA synthesis experiments show that the ATP byproduct ca

177 al an unexpected role for RAD52 in promoting DNA synthesis following replication stress.

178 ve replication, suggesting a role other than DNA synthesis for Pol at the mitochondria.

179 c probe, DNA hybridization and monitoring of DNA synthesis for the sensitive detection of R3500Q muta

180 DNA synthesis (forward reaction) is "balanced," as dicta

181 Eukaryotic chromosomes initiate DNA synthesis from multiple replication origins in a tem

182 A polymerase III, while permitting templated DNA synthesis from the cap guanosine 3'-OH primer by E.

183 Data are most consistent with the extent of DNA synthesis from the invading end being the primary de

184 rDNA-associated protein Tof2 do not perturb DNA synthesis genome-wide, but instead lead to a dramati

185 ons present in pol3-R696W cells for in vitro DNA synthesis greatly decreased the fidelity of Poldelta

186 s of Pol II displace the Pol III core during DNA synthesis in a minimal reconstitution of primer exte

187 age tolerance mechanism that permits ongoing DNA synthesis in cells harbouring damaged genomes.

188 tion of immune responses and reactivation of DNA synthesis in leaf cells.

189 ntileukemic effects, primarily by inhibiting DNA synthesis in proliferating cells.

190 The asymmetric DNA synthesis in rad53-1 cells is suppressed by elevated

191 rate a paracrine effector of uninfected cell DNA synthesis in remote cells continually in advance of

192 resses host DNA synthesis and promotes viral DNA synthesis in spatially segregated compartments withi

193 replication (BIR) caused by defective repair DNA synthesis in the absence of Pif1 helicase leads to t

194 Finally, full-length DNA synthesis in the presence of increasing concentratio

195 The product metal is not observed during DNA synthesis in the presence of magnesium.

196 proximity extension assays and complementary DNA synthesis in the same reaction.

197 d the accompanying inhibition of chromosomal DNA synthesis in UVB-irradiated keratinocytes.

198 ative helicase, is able to stimulate PrimPol DNA synthesis in vitro, suggestive of an as yet unidenti

199 w that ectopic dATM is sufficient to promote DNA synthesis in wild-type fat body cells.

200 CIP-box proteins couples other processes to DNA synthesis, including rDNA copy-number regulation.

201 Salt added to the medium facilitates the DNA synthesis, independently of the osmotic stress respo

202 DNA synthesis inhibition was dependent on the UPR effect

203 eatments, using other topoisomerase poisons, DNA synthesis inhibitors, interstrand cross-linking indu

204 to the genome after treatment with CHK1 and DNA synthesis inhibitors.

205 It involves either translesion DNA synthesis initiated by proliferating cell nuclear an

206 For eukaryotic genomes, DNA synthesis initiates at multiple discrete regions kno

207 The de novo DNA synthesis involves elongation of the G-rich strand o

208 Translesion DNA synthesis is an essential process that helps resume

209 f initiation and terminate replication after DNA synthesis is complete.

210 In contrast, strong inhibition of DNA synthesis is observed.

211 ches and infects these activated cells, host DNA synthesis is then shut off and replaced with virus D

212 the mutational space and are constrained by DNA synthesis length limitations.

213 merase, Pol epsilon, move beyond the site of DNA synthesis, likely unwinding template DNA.

214 ve chromatin on the leading strand following DNA synthesis may depend upon these lysine methyltransfe

215 ins is their ability to control the onset of DNA synthesis mediated by DNA polymerase-alpha and its i

216 abolism for many cellular pathways including DNA synthesis, metabolism and maintenance.

217 e error correction methods, and to benchmark DNA synthesis methods.

218 sociated replication defects trigger mitotic DNA synthesis (MiDAS) at telomeres in a RAD52-dependent,

219 NR increased DNA synthesis, mitotic index, and mass restoration in th

220 independent of either viral RNA packaging or DNA synthesis, multiple substitutions in the CTD to mimi

221 necessary for formation of red blood cells, DNA synthesis, neural myelination, brain development, an

222 MAGE-A4-depleted cells fail to resume DNA synthesis normally following ultraviolet irradiation

223 eration and cell cycle regulation, including DNA synthesis (NPAT), DNA damage response (ATM), mitosis

224 A time-course of DNA synthesis (nuclear and kinetoplast DNA), duplication

225 R10015 specifically blocks viral DNA synthesis, nuclear migration, and virion release.

226 Although average rates of DNA synthesis on leading and lagging strands are similar

227 Mtf1) is an efficient primase that initiates DNA synthesis on ssDNA coated with the yeast mitochondri

228 core, clamp loader, and beta-clamp initiates DNA synthesis on ssDNA template containing 13-mers of th

229 uding through a failure to properly suppress DNA synthesis on UVB-damaged DNA templates.

230 n binding was coupled to strand-displacement DNA synthesis, only one of the two binding modes was obs

231 n vitro reverse transcription assay assesses DNA synthesis opposite nucleoside analogues inserted int

232 ing a protein-template-directed mechanism of DNA synthesis opposite undamaged and damaged guanine.

233 emarkably, thapsigargin did not inhibit bulk DNA synthesis or activate Chk1 in cells depleted of Clas

234 Inhibition of viral DNA synthesis or cellular DNA sensing and innate immune

235 H3.1/2 and H3.3 occurs independent of viral DNA synthesis or de novo viral gene expression, implicat

236 ne expression independent of a block in rAAV DNA synthesis or downstream damage factors is indicated.

237 , D1/D3 in macrophages, without evidence for DNA synthesis or mitosis.

238 leotide primers that initiate lagging strand DNA synthesis or reprime DNA synthesis after replication

239 terized their influence on hPol eta-mediated DNA synthesis over unmodified and platinated DNA.

240 ances the capability of Poldelta to continue DNA synthesis over UV lesions both in vivo and in vitro

241 DNA polymerases when performing translesion DNA synthesis past the pro-mutagenic DNA adduct O(6)-ben

242 onveniently screen regulators of translesion DNA synthesis pathway and monitor environmental genotoxi

243 rs present the structures of the translesion DNA synthesis polymerase Rev1 in complex with three of t

244 serve the substrate for the REV1 translesion DNA synthesis polymerase to incorporate cytosine across

245 Shear forces promote DNA synthesis, polyploidization, and maturation in MKs,

246 However, the method of solid-phase DNA synthesis presents significant challenges for incorp

247 Telomeric MiDAS is a conservative DNA synthesis process, potentially mediated by break-ind

248 Remarkably, DNA synthesis progresses further along the lagging stran

249 try require progress tracking for team-based DNA synthesis projects.

250 Simultaneous measurement of protein and DNA synthesis provides necessary mechanistic insight abo

251 DNA synthesis rates denote new cell formation of preadip

252 d Esa1 each contribute separately to maximum DNA synthesis rates.

253 t-inverted repeat-induced synthesis in which DNA synthesis, rather than DSB repair, drives the invert

254 Asp256 that serves an important role during DNA synthesis reactions.

255 five orders of magnitude in the past decade, DNA synthesis remains expensive for many applications.

256 late reductase (DHFR) play essential role in DNA synthesis, repair and cell division by catalyzing tw

257 ary for essential cellular functions such as DNA synthesis, repair, and methylation.

258 oordinate both high fidelity and translesion DNA synthesis requires a means to regulate recruitment a

259 wo commonly used assays are UDS (unscheduled DNA synthesis, requiring a precise measurement of an ext

260 at reconstituting leading and lagging strand DNA synthesis separately and as an integrated replicatio

261 Furthermore, a block to DNA synthesis shows that MutS is only capable of binding

262 When DNA replication stress is encountered, DNA synthesis stalls until the stress is ameliorated.

263 of nucleotides (nts) incorporated during the DNA synthesis step: short patch (SP) repair incorporates

264 step, and is not required for completion of DNA synthesis, strongly suggesting that converging CMGs

265 c1/ATR performs key functions during ongoing DNA synthesis that are distinct from their canonical che

266 of Pol delta reveal a significant slowing of DNA synthesis that can be fully reversed by reduction of

267 provide distinct solutions to a problem for DNA synthesis that is unique to this pathway and play a

268 st thapsigargin led to a rapid inhibition of DNA synthesis that was attributable to a combination of

269 CTD dephosphorylation is associated with HBV DNA synthesis, the CTD state of phosphorylation may not

270 d block HIV-1 reverse transcriptase-mediated DNA synthesis, thereby inhibiting HIV-1 replication.

271 the production of luminescence signals from DNA synthesis through the use of chimeric nucleoside tet

272 , DNA polymerases specialized in translesion DNA synthesis (TLS) aid DNA replication.

273 Translesion DNA synthesis (TLS) during S-phase uses specialized TLS

274 ic inactivating mutations of the translesion DNA synthesis (TLS) gene REV7 (also known as MAD2L2), wh

275 Translesion DNA synthesis (TLS) is the ability of DNA polymerases to

276 ered on the template strand, and translesion DNA synthesis (TLS) is used to rescue progression of sta

277 ted to dsDNA with an appropriate translesion DNA synthesis (TLS) polymerase, followed by PCR amplific

278 In translesion DNA synthesis (TLS), specialized DNA polymerases replica

279 ine incubations indicated active protein and DNA synthesis to -10 degrees C.

280 ase delta (Pol delta) is thought to catalyze DNA synthesis to fill in the gaps resulting from mispair

281 ble-strand break (DSB) repair often requires DNA synthesis to fill the gaps generated upon alignment

282 o replicate a DNA lesion, allowing stringent DNA synthesis to resume beyond the offending damage.

283 lerance (DDT) pathways, allowing replicative DNA synthesis to resume.

284 collapse) rendering it incapable of further DNA synthesis unless recombination intervenes to restart

285 ations for other essential functions such as DNA synthesis via RNR which is required for C. jejuni's

286 DNA synthesis was analyzed by bromodeoxyuridine enzyme-l

287 In each case thapsigargin-resistant DNA synthesis was due to an increase in replication orig

288 This induced DNA synthesis was observed in hundreds of uninfected cel

289 and myofibrillar protein synthesis, but not DNA synthesis, was also elevated.

290 ecise investigation of how H5 contributes to DNA synthesis, we placed the ts57 H5 allele in an otherw

291 le in fork progression during leading strand DNA synthesis, we propose that TWINKLE is involved in re

292 -stranded DNA (ssDNA), DNA hybridization and DNA synthesis were investigated using electrochemical im

293 Addition of glutamate increased DNA synthesis, whereas removal of glutamate not only sup

294 ough an increase in the enzymes required for DNA synthesis, which include nucleotide-biosynthetic enz

295 e1 is required for the reactivation of plant DNA synthesis, which is crucial for tumor progression in

296 a decreased ability to subsequently restart DNA synthesis, which is normally dependent upon HR-media

297 ination mechanism allows rapid completion of DNA synthesis while avoiding premature replisome disasse

298 base minicircle template, we obtained robust DNA synthesis with leading strand products of >20,000 nu

299 s (5meCs) caused by passive dilution through DNA synthesis without daughter strand methylation and ac

300 naB and the associated replisome to continue DNA synthesis without impediment, with leading strand re